{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:33:10Z","timestamp":1791397990060,"version":"4.3.3"},"reference-count":38,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":2670,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1016\/j.cub.2006.04.005","type":"journal-article","created":{"date-parts":[[2006,5,12]],"date-time":"2006-05-12T11:22:58Z","timestamp":1147432978000},"page":"1041-1049","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":324,"title":["The miRNA-Processing Enzyme Dicer Is Essential for the Morphogenesis and Maintenance of Hair Follicles"],"prefix":"10.1016","volume":"16","author":[{"given":"Thomas","family":"Andl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth P.","family":"Murchison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Yunta-Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Tobias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia D.","family":"Andl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Seykora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory J.","family":"Hannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Millar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cub.2006.04.005_bib1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nrg1379","article-title":"MicroRNAs: Small RNAs with a big role in gene regulation","volume":"5","author":"He","year":"2004","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.cub.2006.04.005_bib2","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: Genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.cub.2006.04.005_bib3","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1046\/j.0022-202x.2001.01670.x","article-title":"Molecular mechanisms regulating hair follicle development","volume":"118","author":"Millar","year":"2002","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.cub.2006.04.005_bib4","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.devcel.2005.11.003","article-title":"Distinct stem cell populations regenerate the follicle and interfollicular epidermis","volume":"9","author":"Levy","year":"2005","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2006.04.005_bib5","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1101\/gad.14.10.1181","article-title":"Wnt signaling maintains the hair-inducing activity of the dermal papilla","volume":"14","author":"Kishimoto","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.cub.2006.04.005_bib6","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/0092-8674(90)90696-C","article-title":"Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesis","volume":"61","author":"Cotsarelis","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.cub.2006.04.005_bib7","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt950","article-title":"Capturing and profiling adult hair follicle stem cells","volume":"22","author":"Morris","year":"2004","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cub.2006.04.005_bib8","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cell.2004.08.012","article-title":"Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche","volume":"118","author":"Blanpain","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.cub.2006.04.005_bib9","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/nm1328","article-title":"Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis","volume":"11","author":"Ito","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.cub.2006.04.005_bib10","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nature04138","article-title":"The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development","volume":"438","author":"Hornstein","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.cub.2006.04.005_bib11","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1126\/science.1062039","article-title":"A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans","volume":"293","author":"Knight","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.cub.2006.04.005_bib12","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1126\/science.1109020","article-title":"MicroRNAs regulate brain morphogenesis in zebrafish","volume":"308","author":"Giraldez","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.cub.2006.04.005_bib13","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/ng1253","article-title":"Dicer is essential for mouse development","volume":"35","author":"Bernstein","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cub.2006.04.005_bib14","doi-asserted-by":"crossref","first-page":"12135","DOI":"10.1073\/pnas.0505479102","article-title":"Characterization of Dicer-deficient murine embryonic stem cells","volume":"102","author":"Murchison","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2006.04.005_bib15","doi-asserted-by":"crossref","first-page":"9330","DOI":"10.1074\/jbc.M413394200","article-title":"Dicer is required for embryonic angiogenesis during mouse development","volume":"280","author":"Yang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cub.2006.04.005_bib16","doi-asserted-by":"crossref","first-page":"10898","DOI":"10.1073\/pnas.0504834102","article-title":"The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb","volume":"102","author":"Harfe","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2006.04.005_bib17","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1084\/jem.20050678","article-title":"Aberrant T cell differentiation in the absence of Dicer","volume":"202","author":"Muljo","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cub.2006.04.005_bib18","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1084\/jem.20050572","article-title":"T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer","volume":"201","author":"Cobb","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cub.2006.04.005_bib19","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1073\/pnas.0510839103","article-title":"Dicer function is essential for lung epithelium morphogenesis","volume":"103","author":"Harris","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2006.04.005_bib20","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S1534-5807(02)00167-3","article-title":"WNT signals are required for the initiation of hair follicle development","volume":"2","author":"Andl","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2006.04.005_bib21","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.1242\/dev.01347","article-title":"Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis","volume":"131","author":"Chu","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.cub.2006.04.005_bib22","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1242\/dev.01125","article-title":"Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development","volume":"131","author":"Andl","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.cub.2006.04.005_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/dbio.1998.9103","article-title":"Essential role for Sonic hedgehog during hair follicle morphogenesis","volume":"205","author":"Chiang","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cub.2006.04.005_bib24","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/S0960-9822(98)70443-9","article-title":"Sonic hedgehog signaling is essential for hair development","volume":"8","author":"St-Jacques","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2006.04.005_bib25","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.devcel.2004.09.014","article-title":"gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis","volume":"7","author":"Pan","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2006.04.005_bib26","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/ng1099","article-title":"Notch1 functions as a tumor suppressor in mouse skin","volume":"33","author":"Nicolas","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cub.2006.04.005_bib27","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1126\/science.1113579","article-title":"Stem cell depletion through epidermal deletion of Rac1","volume":"309","author":"Benitah","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.cub.2006.04.005_bib28","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1242\/jcs.111.21.3179","article-title":"The C8\/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells","volume":"111","author":"Lyle","year":"1998","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.cub.2006.04.005_bib29","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1046\/j.1523-1747.2003.12600.x","article-title":"Keratin 15 promoter targets putative epithelial stem cells in the hair follicle bulge","volume":"121","author":"Liu","year":"2003","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.cub.2006.04.005_bib30","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.cub.2005.06.064","article-title":"Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment","volume":"15","author":"Vidal","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2006.04.005_bib31","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1083\/jcb.143.2.469","article-title":"Onset of keratin 17 expression coincides with the definition of major epithelial lineages during skin development","volume":"143","author":"McGowan","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cub.2006.04.005_bib32","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1083\/jcb.103.6.2593","article-title":"Acidic and basic hair\/nail (\u201chard\u201d) keratins: Their colocalization in upper cortical and cuticle cells of the human hair follicle and their relationship to \u201csoft\u201d keratins","volume":"103","author":"Lynch","year":"1986","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cub.2006.04.005_bib33","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1046\/j.1523-1747.1998.00385.x","article-title":"Gene expression of mouse S100A3, a cysteine-rich calcium-binding protein, in developing hair follicle","volume":"111","author":"Kizawa","year":"1998","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.cub.2006.04.005_bib34","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1101\/gad.1115203","article-title":"GATA-3: An unexpected regulator of cell lineage determination in skin","volume":"17","author":"Kaufman","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.cub.2006.04.005_bib35","doi-asserted-by":"crossref","first-page":"e331","DOI":"10.1371\/journal.pbio.0030331","article-title":"Molecular dissection of mesenchymal-epithelial interactions in the hair follicle","volume":"3","author":"Rendl","year":"2005","journal-title":"PLoS Biol."},{"key":"10.1016\/j.cub.2006.04.005_bib36","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1534-5807(04)00024-3","article-title":"A dual role for ikkalpha in tooth development","volume":"6","author":"Ohazama","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2006.04.005_bib37","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1046\/j.1523-1747.2002.19644.x","article-title":"Label-retaining cells in the bulge region are directed to cell death after plucking, followed by healing from the surviving hair germ","volume":"119","author":"Ito","year":"2002","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.cub.2006.04.005_bib38","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1046\/j.0022-202x.2001.01369.x","article-title":"Expression of calcium-binding S100 proteins A4 and A6 in regions of the epithelial sac associated with the onset of hair follicle regeneration","volume":"116","author":"Ito","year":"2001","journal-title":"J. Invest. Dermatol."}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982206014667?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982206014667?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T09:06:36Z","timestamp":1760778396000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982206014667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["S0960982206014667"],"URL":"https:\/\/doi.org\/10.1016\/j.cub.2006.04.005","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1032447.373131","asserted-by":"object"}]},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2006,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The miRNA-Processing Enzyme Dicer Is Essential for the Morphogenesis and Maintenance of Hair Follicles","name":"articletitle","label":"Article Title"},{"value":"Current Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cub.2006.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}