{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:40:59Z","timestamp":1791315659526,"version":"4.3.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"19","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":1786,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004412","name":"Human Frontier Science Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1016\/j.cub.2008.08.053","type":"journal-article","created":{"date-parts":[[2008,10,3]],"date-time":"2008-10-03T04:44:05Z","timestamp":1223009045000},"page":"1456-1465","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":181,"title":["DOCK10-Mediated Cdc42 Activation Is Necessary for Amoeboid Invasion of Melanoma Cells"],"prefix":"10.1016","volume":"18","author":[{"given":"Gilles","family":"Gadea","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Sanz-Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Self","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Godi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cub.2008.08.053_bib1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/nrc1075","article-title":"Tumour-cell invasion and migration: Diversity and escape mechanisms","volume":"3","author":"Friedl","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cub.2008.08.053_bib2","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1083\/jcb.200209006","article-title":"Compensation mechanism in tumor cell migration: Mesenchymal-amoeboid transition after blocking of pericellular proteolysis","volume":"160","author":"Wolf","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cub.2008.08.053_bib3","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.cub.2006.05.065","article-title":"ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in\u00a0vivo","volume":"16","author":"Wyckoff","year":"2006","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2008.08.053_bib4","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/ncb1019","article-title":"Differing modes of tumour cell invasion have distinct requirements for Rho\/ROCK signalling and extracellular proteolysis","volume":"5","author":"Sahai","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cub.2008.08.053_bib5","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/ncb1230","article-title":"Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion","volume":"7","author":"Wilkinson","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cub.2008.08.053_bib6","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0960-9822(99)80067-0","article-title":"Transformation mediated by RhoA requires activity of ROCK kinases","volume":"9","author":"Sahai","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2008.08.053_bib7","first-page":"2504","article-title":"A critical step in metastasis: In vivo analysis of intravasation at the primary tumor","volume":"60","author":"Wyckoff","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.cub.2008.08.053_bib8","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0092-8674(92)90164-8","article-title":"The small GTP-binding protein rac regulates growth factor-induced membrane ruffling","volume":"70","author":"Ridley","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.cub.2008.08.053_bib9","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1126\/science.275.5304.1308","article-title":"Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase","volume":"275","author":"Amano","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.cub.2008.08.053_bib10","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1126\/science.273.5272.245","article-title":"Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)","volume":"273","author":"Kimura","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.cub.2008.08.053_bib11","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1242\/jcs.005942","article-title":"Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells","volume":"120","author":"El-Sibai","year":"2007","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.cub.2008.08.053_bib12","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/ncb1227","article-title":"PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF\/Tiam1","volume":"7","author":"Nishimura","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cub.2008.08.053_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cub.2004.12.040","article-title":"The Cool-2\/alpha-Pix protein mediates a Cdc42-Rac signaling cascade","volume":"15","author":"Baird","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2008.08.053_bib14","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0092-8674(01)00471-8","article-title":"Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta","volume":"106","author":"Etienne-Manneville","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.cub.2008.08.053_bib15","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1042\/bst0230456","article-title":"Rho, rac and cdc42 GTPases: Regulators of actin structures, cell adhesion and motility","volume":"23","author":"Nobes","year":"1995","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.cub.2008.08.053_bib16","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/354311a0","article-title":"Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product","volume":"354","author":"Hart","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.cub.2008.08.053_bib17","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1101\/gad.1003302","article-title":"Guanine nucleotide exchange factors for Rho GTPases: Turning on the switch","volume":"16","author":"Schmidt","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.cub.2008.08.053_bib18","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0955-0674(96)80068-8","article-title":"The Dbl family of oncogenes","volume":"8","author":"Cerione","year":"1996","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.cub.2008.08.053_bib19","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1021\/bi036026v","article-title":"Structural elements, mechanism, and evolutionary convergence of Rho protein-guanine nucleotide exchange factor complexes","volume":"43","author":"Erickson","year":"2004","journal-title":"Biochemistry"},{"key":"10.1016\/j.cub.2008.08.053_bib20","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/ncb835","article-title":"Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins","volume":"4","author":"Meller","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cub.2008.08.053_bib21","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.1242\/jcs.00219","article-title":"Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity","volume":"115","author":"Cote","year":"2002","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.cub.2008.08.053_bib22","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/33163","article-title":"C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180","volume":"392","author":"Wu","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.cub.2008.08.053_bib23","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/35090591","article-title":"Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration","volume":"412","author":"Fukui","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.cub.2008.08.053_bib24","doi-asserted-by":"crossref","first-page":"14331","DOI":"10.1074\/jbc.M311275200","article-title":"MOCA induces membrane spreading by activating Rac1","volume":"279","author":"Namekata","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cub.2008.08.053_bib25","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.febslet.2005.01.006","article-title":"Zizimin2: A novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes","volume":"579","author":"Nishikimi","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cub.2008.08.053_bib26","doi-asserted-by":"crossref","first-page":"35253","DOI":"10.1074\/jbc.M606248200","article-title":"Identification of a DOCK180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc42","volume":"281","author":"Lin","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cub.2008.08.053_bib27","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1083\/jcb.200602085","article-title":"Reassembly of contractile actin cortex in cell blebs","volume":"175","author":"Charras","year":"2006","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cub.2008.08.053_bib28","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1083\/jcb.200802081","article-title":"Cell motility through plasma membrane blebbing","volume":"181","author":"Fackler","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cub.2008.08.053_bib29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0076-6879(06)06004-6","article-title":"In vitro guanine nucleotide exchange activity of DHR-2\/DOCKER\/CZH2 domains","volume":"406","author":"Cote","year":"2006","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.cub.2008.08.053_bib30","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/35020106","article-title":"Genomic analysis of metastasis reveals an essential role for RhoC","volume":"406","author":"Clark","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.cub.2008.08.053_bib31","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1016\/S0959-8049(99)00293-2","article-title":"Rho-like GTPases: Their role in epithelial cell-cell adhesion and invasion","volume":"35","author":"Sander","year":"1999","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.cub.2008.08.053_bib32","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0092-8674(00)80732-1","article-title":"The interaction between N-WASP and the Arp2\/3 complex links Cdc42-dependent signals to actin assembly","volume":"97","author":"Rohatgi","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.cub.2008.08.053_bib33","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1242\/jcs.01586","article-title":"Cortactin regulates cell migration through activation of N-WASP","volume":"118","author":"Kowalski","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.cub.2008.08.053_bib34","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0962-8924(97)01003-9","article-title":"Emerging from the Pak: The p21-activated protein kinase family","volume":"7","author":"Sells","year":"1997","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.cub.2008.08.053_bib35","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1242\/jcs.113.3.471","article-title":"Endothelial cell retraction is induced by PAK2 monophosphorylation of myosin II","volume":"113","author":"Zeng","year":"2000","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.cub.2008.08.053_bib36","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1089\/thy.2006.16.161","article-title":"Gene expression in poorly differentiated papillary thyroid carcinomas","volume":"16","author":"Fluge","year":"2006","journal-title":"Thyroid"},{"key":"10.1016\/j.cub.2008.08.053_bib37","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3109\/15419069809004478","article-title":"Integrins, cell matrix interactions and cell migration strategies: Fundamental differences in leukocytes and tumor cells","volume":"6","author":"Friedl","year":"1998","journal-title":"Cell Adhes. Commun."},{"key":"10.1016\/j.cub.2008.08.053_bib38","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1091\/mbc.01-12-0579","article-title":"Regulation of protein transport from the Golgi complex to the endoplasmic reticulum by CDC42 and N-WASP","volume":"13","author":"Luna","year":"2002","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.cub.2008.08.053_bib39","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/ncb796","article-title":"ROCK and Dia have opposing effects on adherens junctions downstream of Rho","volume":"4","author":"Sahai","year":"2002","journal-title":"Nat. Cell Biol."}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982208011317?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982208011317?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T09:11:43Z","timestamp":1760778703000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982208011317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":39,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["S0960982208011317"],"URL":"https:\/\/doi.org\/10.1016\/j.cub.2008.08.053","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DOCK10-Mediated Cdc42 Activation Is Necessary for Amoeboid Invasion of Melanoma Cells","name":"articletitle","label":"Article Title"},{"value":"Current Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cub.2008.08.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}