{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:44:46Z","timestamp":1788871486909,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":1627,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014037","name":"National Defense Science and Engineering Graduate","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014037","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM084040"],"award-info":[{"award-number":["GM084040"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.cub.2008.12.044","type":"journal-article","created":{"date-parts":[[2009,2,10]],"date-time":"2009-02-10T08:05:05Z","timestamp":1234253105000},"page":"253-259","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Neutrophils Establish Rapid and Robust WAVE Complex Polarity in an Actin-Dependent Fashion"],"prefix":"10.1016","volume":"19","author":[{"given":"Arthur","family":"Millius","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheel N.","family":"Dandekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Houk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orion D.","family":"Weiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cub.2008.12.044_bib1","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/S0960-9822(98)00015-3","article-title":"Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2\/3 complex","volume":"8","author":"Machesky","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2008.12.044_bib2","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/j.cub.2003.10.005","article-title":"Abi, Sra1, and Kette control the stability and localization of SCAR\/WAVE to regulate the formation of actin-based protrusions","volume":"13","author":"Kunda","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2008.12.044_bib3","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/sj.emboj.7600084","article-title":"Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation","volume":"23","author":"Steffen","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.cub.2008.12.044_bib4","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ceb.2005.12.003","article-title":"Protein complexes regulating Arp2\/3-mediated actin assembly","volume":"18","author":"Stradal","year":"2006","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.cub.2008.12.044_bib5","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1371\/journal.pbio.0040038","article-title":"Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis","volume":"4","author":"Weiner","year":"2006","journal-title":"PLoS Biol."},{"key":"10.1016\/j.cub.2008.12.044_bib6","doi-asserted-by":"crossref","first-page":"e221","DOI":"10.1371\/journal.pbio.0050221","article-title":"An actin-based wave generator organizes cell motility","volume":"5","author":"Weiner","year":"2007","journal-title":"PLoS Biol."},{"key":"10.1016\/j.cub.2008.12.044_bib7","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.devcel.2004.12.007","article-title":"A local coupling model and compass parameter for eukaryotic chemotaxis","volume":"8","author":"Arrieumerlou","year":"2005","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2008.12.044_bib8","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/ncb1536","article-title":"Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions","volume":"9","author":"Andrew","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cub.2008.12.044_bib9","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ydbio.2008.09.023","article-title":"The WAVE\/SCAR complex promotes polarized cell movements and actin enrichment in epithelia during C. elegans embryogenesis","volume":"324","author":"Patel","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cub.2008.12.044_bib10","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1083\/jcb.200109057","article-title":"SCAR is a primary regulator of Arp2\/3-dependent morphological events in Drosophila","volume":"156","author":"Zallen","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cub.2008.12.044_bib11","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1083\/jcb.200303023","article-title":"Molecular requirements for actin-based lamella formation in Drosophila S2 cells","volume":"162","author":"Rogers","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cub.2008.12.044_bib12","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1242\/dev.02473","article-title":"Axis specification and morphogenesis in the mouse embryo require Nap1, a regulator of WAVE-mediated actin branching","volume":"133","author":"Rakeman","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.cub.2008.12.044_bib13","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0014-5793(01)02239-6","article-title":"Scar\/WAVE is localised at the tips of protruding lamellipodia in living cells","volume":"492","author":"Hahne","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cub.2008.12.044_bib14","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/emboj.2008.34","article-title":"Arp2\/3 complex interactions and actin network turnover in lamellipodia","volume":"27","author":"Lai","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.cub.2008.12.044_bib15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0092-8674(00)81784-5","article-title":"G protein signaling events are activated at the leading edge of chemotactic cells","volume":"95","author":"Parent","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.cub.2008.12.044_bib16","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1093\/emboj\/18.8.2092","article-title":"Chemoattractant-mediated transient activation and membrane localization of Akt\/PKB is required for efficient chemotaxis to cAMP in Dictyostelium","volume":"18","author":"Meili","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.cub.2008.12.044_bib17","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1126\/science.287.5455.1037","article-title":"Polarization of chemoattractant receptor signaling during neutrophil chemotaxis","volume":"287","author":"Servant","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.cub.2008.12.044_bib18","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1083\/jcb.89.3.585","article-title":"Cell polarity: An examination of its behavioral expression and its consequences for polymorphonuclear leukocyte chemotaxis","volume":"89","author":"Zigmond","year":"1981","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cub.2008.12.044_bib19","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/ncb1517","article-title":"PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis","volume":"9","author":"Ferguson","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cub.2008.12.044_bib20","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.cub.2007.04.004","article-title":"Chemotaxis in the absence of PIP3 gradients","volume":"17","author":"Hoeller","year":"2007","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2008.12.044_bib21","doi-asserted-by":"crossref","first-page":"9296","DOI":"10.1073\/pnas.0703153104","article-title":"Polarity reveals intrinsic cell chirality","volume":"104","author":"Xu","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2008.12.044_bib22","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0092-8674(03)00555-5","article-title":"Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils","volume":"114","author":"Xu","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.cub.2008.12.044_bib23","doi-asserted-by":"crossref","first-page":"8951","DOI":"10.1073\/pnas.0402152101","article-title":"Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton","volume":"101","author":"Janetopoulos","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2008.12.044_bib24","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1083\/jcb.200611096","article-title":"Locally controlled inhibitory mechanisms are involved in eukaryotic GPCR-mediated chemosensing","volume":"178","author":"Xu","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cub.2008.12.044_bib25","doi-asserted-by":"crossref","first-page":"20445","DOI":"10.1074\/jbc.R300010200","article-title":"Eukaryotic chemotaxis: Distinctions between directional sensing and polarization","volume":"278","author":"Devreotes","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cub.2008.12.044_bib26","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1083\/jcb.200406177","article-title":"Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement","volume":"167","author":"Sasaki","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cub.2008.12.044_bib27","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/0006-291X(85)90309-2","article-title":"Pertussis but not cholera toxin inhibits the stimulated increase in actin association with the cytoskeleton in rabbit neutrophils: Role of the \u201cG proteins\u201d in stimulus-response coupling","volume":"126","author":"Shefcyk","year":"1985","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cub.2008.12.044_bib28","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1083\/jcb.129.6.1667","article-title":"The G protein beta subunit is essential for multiple responses to chemoattractants in Dictyostelium","volume":"129","author":"Wu","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cub.2008.12.044_bib29","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/S0021-9258(17)35304-8","article-title":"Molecular genetic analysis of two G alpha protein subunits in Dictyostelium","volume":"266","author":"Kumagai","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cub.2008.12.044_bib30","doi-asserted-by":"crossref","first-page":"3758","DOI":"10.1182\/blood-2004-03-0781","article-title":"Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass","volume":"104","author":"Sun","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.cub.2008.12.044_bib31","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.devcel.2007.03.005","article-title":"PLA2 and PI3K\/PTEN pathways act in parallel to mediate chemotaxis","volume":"12","author":"Chen","year":"2007","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2008.12.044_bib32","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1083\/jcb.200709180","article-title":"Four key signaling pathways mediating chemotaxis in Dictyostelium discoideum","volume":"180","author":"Veltman","year":"2008","journal-title":"J. Cell Biol."}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982209005375?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982209005375?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T09:12:19Z","timestamp":1760778739000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982209005375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0960982209005375"],"URL":"https:\/\/doi.org\/10.1016\/j.cub.2008.12.044","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neutrophils Establish Rapid and Robust WAVE Complex Polarity in an Actin-Dependent Fashion","name":"articletitle","label":"Article Title"},{"value":"Current Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cub.2008.12.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}