{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:21:12Z","timestamp":1790965272975,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"20","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":1020,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.cub.2010.09.055","type":"journal-article","created":{"date-parts":[[2010,10,15]],"date-time":"2010-10-15T08:43:59Z","timestamp":1287132239000},"page":"1875-1879","source":"Crossref","is-referenced-by-count":32,"title":["LIN-14 Inhibition of LIN-12 Contributes to Precision and Timing of C. elegans Vulval Fate Patterning"],"prefix":"10.1016","volume":"20","author":[{"given":"Ji","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iva","family":"Greenwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cub.2010.09.055_bib1","unstructured":"Sternberg, P.W. (2005). Vulval development. In WormBook, The C.\u00a0elegans Research Community, ed. 10.1895\/wormbook.1.6.1, http:\/\/www.wormbook.org."},{"key":"10.1016\/j.cub.2010.09.055_bib2","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.devcel.2008.09.011","article-title":"Plasticity and errors of a robust developmental system in different environments","volume":"15","author":"Braendle","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2010.09.055_bib3","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1101\/gad.1330605","article-title":"The love-hate relationship between Ras and Notch","volume":"19","author":"Sundaram","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.cub.2010.09.055_bib4","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/0092-8674(83)90377-X","article-title":"The lin-12 locus specifies cell fates in Caenorhabditis elegans","volume":"34","author":"Greenwald","year":"1983","journal-title":"Cell"},{"key":"10.1016\/j.cub.2010.09.055_bib5","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/326259a0","article-title":"A genetic pathway for the specification of the vulval cell lineages of Caenorhabditis elegans","volume":"326","author":"Ferguson","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.cub.2010.09.055_bib6","doi-asserted-by":"crossref","first-page":"R425","DOI":"10.1016\/j.cub.2007.03.043","article-title":"Heterochronic genes and the nature of developmental time","volume":"17","author":"Moss","year":"2007","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2010.09.055_bib7","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1002\/dvdy.22260","article-title":"miRNAs give worms the time of their lives: Small RNAs and temporal control in Caenorhabditis elegans","volume":"239","author":"Resnick","year":"2010","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.cub.2010.09.055_bib8","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/dvdy.21837","article-title":"The Caenorhabditis elegans heterochronic gene lin-14 coordinates temporal progression and maturation in the egg-laying system","volume":"238","author":"Johnson","year":"2009","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.cub.2010.09.055_bib9","doi-asserted-by":"crossref","first-page":"20368","DOI":"10.1073\/pnas.0709989104","article-title":"Wnt signal from multiple tissues and lin-3\/EGF signal from the gonad maintain vulval precursor cell competence in Caenorhabditis elegans","volume":"104","author":"Myers","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2010.09.055_bib10","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S1534-5807(04)00021-8","article-title":"The lateral signal for LIN-12\/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins","volume":"6","author":"Chen","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2010.09.055_bib11","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.devcel.2006.04.001","article-title":"SynMuv genes redundantly inhibit lin-3\/EGF expression to prevent inappropriate vulval induction in C. elegans","volume":"10","author":"Cui","year":"2006","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2010.09.055_bib12","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0092-8674(00)81045-4","article-title":"Heterochronic genes control cell cycle progress and developmental competence of C. elegans vulva precursor cells","volume":"84","author":"Euling","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.cub.2010.09.055_bib13","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0092-8674(81)90501-8","article-title":"Mutations that lead to reiterations in the cell lineages of C. elegans","volume":"24","author":"Chalfie","year":"1981","journal-title":"Cell"},{"key":"10.1016\/j.cub.2010.09.055_bib14","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1242\/dev.126.9.1947","article-title":"Cell cycle-dependent sequencing of cell fate decisions in Caenorhabditis elegans vulva precursor cells","volume":"126","author":"Ambros","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.cub.2010.09.055_bib15","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1002\/dvdy.20572","article-title":"Post-embryonic expression of C.\u00a0elegans microRNAs belonging to the lin-4 and let-7 families in the hypodermis and the reproductive system","volume":"234","author":"Esquela-Kerscher","year":"2005","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.cub.2010.09.055_bib16","unstructured":"Greenwald, I. (2005). LIN-12\/Notch signaling in C. elegans. In WormBook, The C. elegans Research Community, ed. 10.1895\/wormbook.1.10.1, http:\/\/www.wormbook.org."},{"key":"10.1016\/j.cub.2010.09.055_bib17","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","article-title":"The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14","volume":"75","author":"Lee","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.cub.2010.09.055_bib18","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0092-8674(93)90530-4","article-title":"Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans","volume":"75","author":"Wightman","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.cub.2010.09.055_bib19","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0092-8674(00)81906-6","article-title":"The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA","volume":"88","author":"Moss","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.cub.2010.09.055_bib20","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S1534-5807(03)00127-8","article-title":"The Caenorhabditis elegans hunchback-like gene lin-57\/hbl-1 controls developmental time and is regulated by microRNAs","volume":"4","author":"Abrahante","year":"2003","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2010.09.055_bib21","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S1534-5807(03)00124-2","article-title":"The C elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target","volume":"4","author":"Lin","year":"2003","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2010.09.055_bib22","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1101\/gad.5.10.1813","article-title":"Negative regulatory sequences in the lin-14 3\u2032-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development","volume":"5","author":"Wightman","year":"1991","journal-title":"Genes Dev."},{"key":"10.1016\/j.cub.2010.09.055_bib23","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1101\/gad.1.4.398","article-title":"The lin-14 locus of Caenorhabditis elegans controls the time of expression of specific postembryonic developmental events","volume":"1","author":"Ambros","year":"1987","journal-title":"Genes Dev."},{"key":"10.1016\/j.cub.2010.09.055_bib24","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/genetics\/157.1.199","article-title":"Isoform-specific mutations in the Caenorhabditis elegans heterochronic gene lin-14 affect stage-specific patterning","volume":"157","author":"Reinhart","year":"2001","journal-title":"Genetics"},{"key":"10.1016\/j.cub.2010.09.055_bib25","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1101\/gad.5.10.1825","article-title":"Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28","volume":"5","author":"Arasu","year":"1991","journal-title":"Genes Dev."},{"key":"10.1016\/j.cub.2010.09.055_bib26","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1242\/dev.125.16.3101","article-title":"LIN-12 protein expression and localization during vulval development in C. elegans","volume":"125","author":"Levitan","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.cub.2010.09.055_bib27","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/338313a0","article-title":"The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch","volume":"338","author":"Ruvkun","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.cub.2010.09.055_bib28","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.6494891","article-title":"Heterochronic mutants of the nematode Caenorhabditis elegans","volume":"226","author":"Ambros","year":"1984","journal-title":"Science"},{"key":"10.1016\/j.cub.2010.09.055_bib29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0092-8674(89)90171-2","article-title":"A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans","volume":"57","author":"Ambros","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.cub.2010.09.055_bib30","doi-asserted-by":"crossref","first-page":"11059","DOI":"10.1128\/MCB.25.24.11059-11072.2005","article-title":"The Caenorhabditis elegans heterochronic regulator LIN-14 is a novel transcription factor that controls the developmental timing of transcription from the insulin\/insulin-like growth factor gene ins-33 by direct DNA binding","volume":"25","author":"Hristova","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cub.2010.09.055_bib31","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/0092-8674(90)90060-R","article-title":"Cell-cell interactions prevent a potential inductive interaction between soma and germline in C. elegans","volume":"61","author":"Seydoux","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.cub.2010.09.055_bib32","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.ydbio.2006.09.049","article-title":"Transcriptional control of Notch signaling by a HOX and a PBX\/EXD protein during vulval development in C. elegans","volume":"302","author":"Tak\u00e1cs-Vellai","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cub.2010.09.055_bib33","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/35002607","article-title":"The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans","volume":"403","author":"Reinhart","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.cub.2010.09.055_bib34","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1126\/science.1065062","article-title":"An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans","volume":"294","author":"Lau","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.cub.2010.09.055_bib35","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1101\/gad.1074403","article-title":"The microRNAs of Caenorhabditis elegans","volume":"17","author":"Lim","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.cub.2010.09.055_bib36","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.devcel.2005.07.009","article-title":"The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans","volume":"9","author":"Abbott","year":"2005","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2010.09.055_bib37","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/j.cub.2010.05.062","article-title":"Loss of individual microRNAs causes mutant phenotypes in sensitized genetic backgrounds in C. elegans","volume":"20","author":"Brenner","year":"2010","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2010.09.055_bib38","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/nature01234","article-title":"Endocytosis-mediated downregulation of LIN-12\/Notch upon Ras activation in Caenorhabditis elegans","volume":"420","author":"Shaye","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.cub.2010.09.055_bib39","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1101\/gad.1291905","article-title":"Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs","volume":"19","author":"Lai","year":"2005","journal-title":"Genes Dev."}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982210012121?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982210012121?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T12:05:44Z","timestamp":1711886744000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982210012121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":39,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S0960982210012121"],"URL":"https:\/\/doi.org\/10.1016\/j.cub.2010.09.055","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}