{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:55:03Z","timestamp":1777470903206,"version":"3.51.4"},"reference-count":39,"publisher":"Elsevier BV","issue":"23","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":959,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["640872"],"award-info":[{"award-number":["640872"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.cub.2010.11.016","type":"journal-article","created":{"date-parts":[[2010,11,26]],"date-time":"2010-11-26T09:13:13Z","timestamp":1290762793000},"page":"2144-2149","source":"Crossref","is-referenced-by-count":53,"title":["SPIKE1 Signals Originate from and Assemble Specialized Domains of the Endoplasmic Reticulum"],"prefix":"10.1016","volume":"20","author":[{"given":"Chunhua","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simeon O.","family":"Kotchoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Lacey","family":"Samuels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel B.","family":"Szymanski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cub.2010.11.016_bib1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cell.2004.12.026","article-title":"Arabidopsis interdigitating cell growth requires two antagonistic pathways with opposing action on cell morphogenesis","volume":"120","author":"Fu","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.cub.2010.11.016_bib2","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1091\/mbc.E04-07-0562","article-title":"Ectopic expression of an activated RAC in Arabidopsis disrupts membrane cycling","volume":"16","author":"Bloch","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.cub.2010.11.016_bib3","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.cub.2007.04.038","article-title":"A Novel ROP\/RAC effector links cell polarity, root-meristem maintenance, and vesicle trafficking","volume":"17","author":"Lavy","year":"2007","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2010.11.016_bib4","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1104\/pp.108.122150","article-title":"Regulation of membrane trafficking, cytoskeleton dynamics, and cell polarity by ROP\/RAC GTPases","volume":"147","author":"Yalovsky","year":"2008","journal-title":"Plant Physiol."},{"key":"10.1016\/j.cub.2010.11.016_bib5","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.pbi.2009.10.005","article-title":"Plant cells taking shape: new insights into cytoplasmic control","volume":"12","author":"Szymanski","year":"2009","journal-title":"Curr. Opin. Plant Biol."},{"key":"10.1016\/j.cub.2010.11.016_bib6","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.plaphy.2007.12.008","article-title":"Structure and function of Rho-type molecular switches in plants","volume":"46","author":"Berken","year":"2008","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.cub.2010.11.016_bib7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1105\/tpc.010346","article-title":"The Arabidopsis SPIKE1 gene is required for normal cell shape control and tissue development","volume":"14","author":"Qiu","year":"2002","journal-title":"Plant Cell"},{"key":"10.1016\/j.cub.2010.11.016_bib8","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1073\/pnas.0710294105","article-title":"A SPIKE1 signaling complex controls actin-dependent cell morphogenesis through the heteromeric WAVE and ARP2\/3 complexes","volume":"105","author":"Basu","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2010.11.016_bib9","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/ncb1280","article-title":"A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling","volume":"7","author":"C\u00f4t\u00e9","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cub.2010.11.016_bib10","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1126\/science.1170179","article-title":"Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis","volume":"324","author":"Nishikimi","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.cub.2010.11.016_bib11","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/sj.cr.7310055","article-title":"A RHOse by any other name: a comparative analysis of animal and plant Rho GTPases","volume":"16","author":"Brembu","year":"2006","journal-title":"Cell Res."},{"key":"10.1016\/j.cub.2010.11.016_bib12","doi-asserted-by":"crossref","unstructured":"Bassham, D.C., Brandizzi, F., Otegui, M.S., and Sanderfoot, A.A. (2008). The secretory system of Arabidopsis. In The Arabidopsis Book. (Rockville, MD: American Society of Plant Biologists). 10.1199\/tab.0116, www.aspb.org\/publications\/arabidopsis\/","DOI":"10.1199\/tab.0116"},{"key":"10.1016\/j.cub.2010.11.016_bib13","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pbi.2004.11.004","article-title":"Breaking the WAVE complex: the point of Arabidopsis trichomes","volume":"8","author":"Szymanski","year":"2005","journal-title":"Curr. Opin. Plant Biol."},{"key":"10.1016\/j.cub.2010.11.016_bib14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/mp\/ssm011","article-title":"The subcellular localization and blue-light-induced movement of phototropin 1-GFP in etiolated seedlings of Arabidopsis thaliana","volume":"1","author":"Wan","year":"2008","journal-title":"Mol Plant"},{"key":"10.1016\/j.cub.2010.11.016_bib15","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1104\/pp.108.120477","article-title":"Functional analysis of Arabidopsis postprenylation CaaX processing enzymes and their function in subcellular protein targeting","volume":"148","author":"Bracha-Drori","year":"2008","journal-title":"Plant Physiol."},{"key":"10.1016\/j.cub.2010.11.016_bib16","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1104\/pp.125.1.241","article-title":"Dynamic localization of rop GTPases to the tonoplast during vacuole development","volume":"125","author":"Lin","year":"2001","journal-title":"Plant Physiol."},{"key":"10.1016\/j.cub.2010.11.016_bib17","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1023\/A:1006341210147","article-title":"Localization of AtROP4 and AtROP6 and interaction with the guanine nucleotide dissociation inhibitor AtRhoGDI1 from Arabidopsis","volume":"42","author":"Bischoff","year":"2000","journal-title":"Plant Mol. Biol."},{"key":"10.1016\/j.cub.2010.11.016_bib18","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1007\/s00425-004-1283-9","article-title":"Localization to the rhizoid tip implicates a Fucus distichus Rho\u00a0family GTPase in a conserved cell polarity pathway","volume":"219","author":"Fowler","year":"2004","journal-title":"Planta"},{"key":"10.1016\/j.cub.2010.11.016_bib19","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.cub.2010.03.057","article-title":"An\u00a0S-acylation switch of conserved G domain cysteines is required for\u00a0polarity signaling by ROP GTPases","volume":"20","author":"Sorek","year":"2010","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2010.11.016_bib20","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0896-6273(03)00397-0","article-title":"NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals","volume":"39","author":"Delcroix","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2010.11.016_bib21","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1105\/tpc.104.026757","article-title":"Dynamics of COPII vesicles and the Golgi apparatus in cultured Nicotiana tabacum BY-2 cells provides evidence for transient association of Golgi stacks with endoplasmic reticulum exit sites","volume":"17","author":"Yang","year":"2005","journal-title":"Plant Cell"},{"key":"10.1016\/j.cub.2010.11.016_bib22","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.pbi.2006.09.016","article-title":"Traffic between the plant endoplasmic reticulum and Golgi apparatus: to the Golgi and beyond","volume":"9","author":"Matheson","year":"2006","journal-title":"Curr. Opin. Plant Biol."},{"key":"10.1016\/j.cub.2010.11.016_bib23","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1104\/pp.114.1.315","article-title":"Characterization of AtSEC12 and AtSAR1. Proteins likely involved in endoplasmic reticulum and Golgi transport","volume":"114","author":"Bar-Peled","year":"1997","journal-title":"Plant Physiol."},{"key":"10.1016\/j.cub.2010.11.016_bib24","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1105\/tpc.022673","article-title":"Endoplasmic reticulum export sites and Golgi bodies behave as single mobile secretory units in plant cells","volume":"16","author":"daSilva","year":"2004","journal-title":"Plant Cell"},{"key":"10.1016\/j.cub.2010.11.016_bib25","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1104\/pp.108.120618","article-title":"Nanoscale architecture of endoplasmic reticulum export sites and of Golgi membranes as determined by electron tomography","volume":"147","author":"Staehelin","year":"2008","journal-title":"Plant Physiol."},{"key":"10.1016\/j.cub.2010.11.016_bib26","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1104\/pp.121.4.1127","article-title":"Stop-and-go movements of plant Golgi stacks are mediated by the acto-myosin system","volume":"121","author":"Nebenf\u00fchr","year":"1999","journal-title":"Plant Physiol."},{"key":"10.1016\/j.cub.2010.11.016_bib27","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1046\/j.1365-313X.1997.11061151.x","article-title":"The plant ER: a dynamic organelle composed of a large number of discrete functional domains","volume":"11","author":"Staehelin","year":"1997","journal-title":"Plant J."},{"key":"10.1016\/j.cub.2010.11.016_bib28","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1105\/tpc.109.068262","article-title":"A missense mutation in the Arabidopsis COPII coat protein Sec24A induces the formation of clusters of the endoplasmic reticulum and Golgi apparatus","volume":"21","author":"Faso","year":"2009","journal-title":"Plant Cell"},{"key":"10.1016\/j.cub.2010.11.016_bib29","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1046\/j.0960-7412.2002.01252.x","article-title":"Redistribution of membrane proteins between the Golgi apparatus and endoplasmic reticulum in plants is reversible and not dependent on cytoskeletal networks","volume":"29","author":"Saint-Jore","year":"2002","journal-title":"Plant J."},{"key":"10.1016\/j.cub.2010.11.016_bib30","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0092-8674(80)90128-2","article-title":"Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway","volume":"21","author":"Novick","year":"1980","journal-title":"Cell"},{"key":"10.1016\/j.cub.2010.11.016_bib31","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1104\/pp.010636","article-title":"Molecular characterization of two Arabidopsis Ire1 homologs, endoplasmic reticulum-located transmembrane protein kinases","volume":"127","author":"Koizumi","year":"2001","journal-title":"Plant Physiol."},{"key":"10.1016\/j.cub.2010.11.016_bib32","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1471-2229-8-134","article-title":"Arabidopsis eIF2alpha kinase GCN2 is essential for growth in stress conditions and is activated by wounding","volume":"8","author":"Lageix","year":"2008","journal-title":"BMC Plant Biol."},{"key":"10.1016\/j.cub.2010.11.016_bib33","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1105\/tpc.001537","article-title":"The ROP2 GTPase controls the formation of cortical fine F-actin and the early phase of directional cell expansion during Arabidopsis organogenesis","volume":"14","author":"Fu","year":"2002","journal-title":"Plant Cell"},{"key":"10.1016\/j.cub.2010.11.016_bib34","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/j.1365-313X.2004.02065.x","article-title":"DISTORTED2 encodes an ARPC2 subunit of the putative Arabidopsis ARP2\/3 complex","volume":"38","author":"El-Din El-Assal","year":"2004","journal-title":"Plant J."},{"key":"10.1016\/j.cub.2010.11.016_bib35","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1104\/pp.106.094110","article-title":"De novo formation of plant endoplasmic reticulum export sites is membrane cargo induced and signal mediated","volume":"143","author":"Hanton","year":"2007","journal-title":"Plant Physiol."},{"key":"10.1016\/j.cub.2010.11.016_bib36","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.ceb.2009.03.003","article-title":"On vesicle formation and tethering in the ER-Golgi shuttle","volume":"21","author":"Spang","year":"2009","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.cub.2010.11.016_bib37","doi-asserted-by":"crossref","first-page":"23296","DOI":"10.1074\/jbc.M102962200","article-title":"Degradation of endoplasmic reticulum (ER) quality control substrates requires transport between the ER and Golgi","volume":"276","author":"Caldwell","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cub.2010.11.016_bib38","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.devcel.2005.09.015","article-title":"Efficient protein trafficking requires trailer hitch, a component of a ribonucleoprotein complex localized to the ER in Drosophila","volume":"9","author":"Wilhelm","year":"2005","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2010.11.016_bib39","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1038\/emboj.2010.170","article-title":"Cellular responses to extracellular guidance cues","volume":"29","author":"Berzat","year":"2010","journal-title":"EMBO J."}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982210014417?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982210014417?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T15:54:49Z","timestamp":1544111689000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982210014417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":39,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0960982210014417"],"URL":"https:\/\/doi.org\/10.1016\/j.cub.2010.11.016","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}