{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T01:26:39Z","timestamp":1777598799163,"version":"3.51.4"},"reference-count":20,"publisher":"Elsevier BV","issue":"20","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,10,26]],"date-time":"2013-10-26T00:00:00Z","timestamp":1382745600000},"content-version":"vor","delay-in-days":390,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.cub.2012.09.017","type":"journal-article","created":{"date-parts":[[2012,10,22]],"date-time":"2012-10-22T12:45:49Z","timestamp":1350909949000},"page":"R884-R886","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Brain Plasticity: Paradoxical Case of a Neurodegenerative Disease?"],"prefix":"10.1016","volume":"22","author":[{"given":"Pedro","family":"Cardoso-Leite","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Ascher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daphne","family":"Bavelier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cub.2012.09.017_bib1","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1016\/j.cub.2012.08.012","article-title":"Faster perceptual learning through excitotoxic neurodegeneration","volume":"22","author":"Beste","year":"2012","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2012.09.017_bib2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.conb.2008.05.009","article-title":"Critical period revisited: impact on vision","volume":"18","author":"Morishita","year":"2008","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.cub.2012.09.017_bib3","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nature09119","article-title":"Developmental sensory experience balances cortical excitation and inhibition","volume":"465","author":"Dorrn","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.cub.2012.09.017_bib4","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/WCO.0b013e3283550c97","article-title":"Huntington's disease","volume":"25","author":"Ha","year":"2012","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.cub.2012.09.017_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1037\/a0020937","article-title":"Neurocognitive signs in prodromal Huntington disease","volume":"25","author":"Stout","year":"2011","journal-title":"Neuropsychology"},{"key":"10.1016\/j.cub.2012.09.017_bib6","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.cub.2011.03.065","article-title":"Improvement and impairment of visually guided behavior through LTP- and LTD-like exposure-based visual learning","volume":"21","author":"Beste","year":"2011","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2012.09.017_bib7","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.psychres.2011.09.005","article-title":"Patterns of serotonergic antidepressant usage in prodromal Huntington disease","volume":"196","author":"Rowe","year":"2012","journal-title":"Psychiatr. Res."},{"key":"10.1016\/j.cub.2012.09.017_bib8","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1126\/science.1150516","article-title":"The antidepressant fluoxetine restores plasticity in the adult visual cortex","volume":"320","author":"Maya Vetencourt","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.cub.2012.09.017_bib9","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cub.2009.01.063","article-title":"Attention alters visual plasticity during exposure-based learning","volume":"19","author":"Gutnisky","year":"2009","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2012.09.017_bib10","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.neuron.2005.08.034","article-title":"NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII","volume":"48","author":"Barria","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2012.09.017_bib11","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1523\/JNEUROSCI.4022-09.2010","article-title":"Distinct roles of NR2A and NR2B cytoplasmic tails in long-term potentiation","volume":"30","author":"Foster","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cub.2012.09.017_bib12","doi-asserted-by":"crossref","first-page":"13843","DOI":"10.1523\/JNEUROSCI.4486-07.2007","article-title":"Interactions between the NR2B receptor and\u00a0CaMKII modulate synaptic plasticity and\u00a0spatial learning","volume":"27","author":"Zhou","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cub.2012.09.017_bib13","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/43432","article-title":"Genetic enhancement of learning and memory in mice","volume":"401","author":"Tang","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.cub.2012.09.017_bib14","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.tins.2010.08.002","article-title":"Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease","volume":"33","author":"Milnerwood","year":"2010","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.cub.2012.09.017_bib15","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/nm.2056","article-title":"Balance between synaptic versus\u00a0extrasynaptic NMDA receptor activity\u00a0influences inclusions and neurotoxicity\u00a0of mutant huntingtin","volume":"15","author":"Okamoto","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.cub.2012.09.017_bib16","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuron.2010.01.008","article-title":"Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice","volume":"65","author":"Milnerwood","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2012.09.017_bib17","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/ncpneuro0355","article-title":"Mechanisms of Disease: astrocytes in neurodegenerative disease","volume":"2","author":"Maragakis","year":"2006","journal-title":"Nat. Clin. Pract. Neurol."},{"key":"10.1016\/j.cub.2012.09.017_bib18","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1126\/science.1085423","article-title":"Pharmacological modulation of perceptual learning and associated cortical reorganization","volume":"301","author":"Dinse","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.cub.2012.09.017_bib19","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.1523\/JNEUROSCI.4883-05.2006","article-title":"Low doses of memantine disrupt memory in adult rats","volume":"26","author":"Creeley","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cub.2012.09.017_bib20","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nrn2911","article-title":"Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders","volume":"11","author":"Hardingham","year":"2010","journal-title":"Nat. Rev. Neurosci."}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982212010809?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982212010809?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T09:23:33Z","timestamp":1760779413000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982212010809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":20,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0960982212010809"],"URL":"https:\/\/doi.org\/10.1016\/j.cub.2012.09.017","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain Plasticity: Paradoxical Case of a Neurodegenerative Disease?","name":"articletitle","label":"Article Title"},{"value":"Current Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cub.2012.09.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.cub.2012.08.012","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}