{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:54:36Z","timestamp":1770486876126,"version":"3.49.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T00:00:00Z","timestamp":1497916800000},"content-version":"vor","delay-in-days":384,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.cub.2016.05.021","type":"journal-article","created":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T15:26:51Z","timestamp":1466436411000},"page":"R508-R511","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Innate Immunity: ER Stress Recruits NOD1 and NOD2 for Delivery of Inflammation"],"prefix":"10.1016","volume":"26","author":[{"given":"Roberta","family":"Caruso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cub.2016.05.021_bib1","doi-asserted-by":"crossref","first-page":"14560","DOI":"10.1074\/jbc.274.21.14560","article-title":"Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB","volume":"274","author":"Inohara","year":"1999","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cub.2016.05.021_bib2","doi-asserted-by":"crossref","first-page":"4812","DOI":"10.1074\/jbc.M008072200","article-title":"Nod2, a Nod1\/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB","volume":"276","author":"Ogura","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cub.2016.05.021_bib3","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1074\/jbc.M009728200","article-title":"Human Nod1 confers\u00a0responsiveness to bacterial lipopolysaccharides","volume":"276","author":"Inohara","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cub.2016.05.021_bib4","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1126\/science.1084677","article-title":"Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan","volume":"300","author":"Girardin","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.cub.2016.05.021_bib5","doi-asserted-by":"crossref","first-page":"5509","DOI":"10.1074\/jbc.C200673200","article-title":"Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn\u2019s disease","volume":"278","author":"Inohara","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cub.2016.05.021_bib6","doi-asserted-by":"crossref","first-page":"8869","DOI":"10.1074\/jbc.C200651200","article-title":"Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection","volume":"278","author":"Girardin","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cub.2016.05.021_bib7","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.immuni.2009.04.011","article-title":"Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors\u00a0NOD1 and NOD2","volume":"30","author":"Bertrand","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.cub.2016.05.021_bib8","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.cub.2009.06.038","article-title":"ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways","volume":"19","author":"Tao","year":"2009","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2016.05.021_bib9","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/ni.2669","article-title":"Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis","volume":"14","author":"Yang","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cub.2016.05.021_bib10","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/sj.emboj.7601962","article-title":"A critical role of RICK\/RIP2 polyubiquitination in Nod-induced NF-kappaB activation","volume":"27","author":"Hasegawa","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.cub.2016.05.021_bib11","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1074\/jbc.M110.189308","article-title":"A novel motif in the Crohn\u2019s disease susceptibility protein, NOD2, allows TRAF4 to down-regulate innate immune responses","volume":"286","author":"Marinis","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cub.2016.05.021_bib12","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/nature17631","article-title":"NOD1 and NOD2 signalling links ER stress with inflammation","volume":"532","author":"Keestra-Gounder","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cub.2016.05.021_bib13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nrmicro3393","article-title":"Bacteria, the endoplasmic reticulum and the unfolded protein response: friends or foes?","volume":"13","author":"Celli","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.cub.2016.05.021_bib14","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jcpa.2008.10.004","article-title":"Pathological, immunohistochemical and bacteriological study of tissues and milk of cows and fetuses experimentally infected with Brucella abortus","volume":"140","author":"Xavier","year":"2009","journal-title":"J.\u00a0Comp. Pathol."},{"key":"10.1016\/j.cub.2016.05.021_bib15","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1111\/j.1462-5822.2007.00922.x","article-title":"Brucella requires a functional Type IV secretion system to elicit innate immune responses in mice","volume":"9","author":"Roux","year":"2007","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.cub.2016.05.021_bib16","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1111\/j.1365-2958.2008.06487.x","article-title":"Identification of VceA and VceC, two members of the VjbR regulon that are translocated into\u00a0macrophages by the Brucella type IV secretion system","volume":"70","author":"de Jong","year":"2008","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.cub.2016.05.021_bib17","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00418-12","article-title":"Sensing of bacterial type IV secretion via the unfolded protein response","volume":"4","author":"de Jong","year":"2013","journal-title":"MBio"},{"key":"10.1016\/j.cub.2016.05.021_bib18","doi-asserted-by":"crossref","first-page":"861426","DOI":"10.1155\/2012\/861426","article-title":"Nucleotide-binding oligomerization domain-1 and -2 play no role in controlling Brucella abortus infection in mice","volume":"2012","author":"Oliveira","year":"2012","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.cub.2016.05.021_bib19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ni.1823","article-title":"Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry","volume":"11","author":"Travassos","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cub.2016.05.021_bib20","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nature12599","article-title":"Paneth cells as a site of origin for intestinal inflammation","volume":"503","author":"Adolph","year":"2013","journal-title":"Nature"}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982216304791?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982216304791?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T20:23:07Z","timestamp":1568060587000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982216304791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S0960982216304791"],"URL":"https:\/\/doi.org\/10.1016\/j.cub.2016.05.021","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Innate Immunity: ER Stress Recruits NOD1 and NOD2 for Delivery of Inflammation","name":"articletitle","label":"Article Title"},{"value":"Current Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cub.2016.05.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}