{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:54:54Z","timestamp":1785894894280,"version":"3.56.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"16","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T00:00:00Z","timestamp":1503360000000},"content-version":"vor","delay-in-days":386,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.cub.2016.06.025","type":"journal-article","created":{"date-parts":[[2016,7,29]],"date-time":"2016-07-29T18:20:42Z","timestamp":1469816442000},"page":"2188-2193","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":83,"title":["Tyrosine Detoxification Is an Essential Trait in the Life History of Blood-Feeding Arthropods"],"prefix":"10.1016","volume":"26","author":[{"given":"Marcos","family":"Sterkel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo\u00a0D.","family":"Perdomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melina\u00a0G.","family":"Guizzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u00a0Beatriz\u00a0F.","family":"Barletta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo\u00a0D.","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe\u00a0A.","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos\u00a0H.F.","family":"Sorgine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro\u00a0L.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cub.2016.06.025_bib1","volume":"Volume 2015","year":"2014"},{"key":"10.1016\/j.cub.2016.06.025_bib2","doi-asserted-by":"crossref","first-page":"e2594","DOI":"10.1371\/journal.pntd.0002594","article-title":"An insight into the transcriptome of the digestive tract of the bloodsucking bug, Rhodnius prolixus","volume":"8","author":"Ribeiro","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.cub.2016.06.025_bib3","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S1089-3261(05)70142-2","article-title":"Nontransplant treatment of tyrosinemia","volume":"4","author":"Holme","year":"2000","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.cub.2016.06.025_bib4","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/ajmg.c.30092","article-title":"The genetic tyrosinemias","volume":"142C","author":"Scott","year":"2006","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"key":"10.1016\/j.cub.2016.06.025_bib5","doi-asserted-by":"crossref","first-page":"14936","DOI":"10.1073\/pnas.1506226112","article-title":"Genome of Rhodnius prolixus, an insect vector of Chagas disease, reveals unique adaptations to hematophagy and parasite infection","volume":"112","author":"Mesquita","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2016.06.025_bib6","doi-asserted-by":"crossref","first-page":"8030","DOI":"10.1073\/pnas.0602224103","article-title":"A heme-degradation pathway in a blood-sucking insect","volume":"103","author":"Paiva-Silva","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2016.06.025_bib7","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.it.2008.02.009","article-title":"The proPO-system: pros and cons for its role in invertebrate immunity","volume":"29","author":"Cerenius","year":"2008","journal-title":"Trends Immunol."},{"key":"10.1016\/j.cub.2016.06.025_bib8","doi-asserted-by":"crossref","first-page":"e16124","DOI":"10.1371\/journal.pone.0016124","article-title":"From L-dopa to dihydroxyphenylacetaldehyde: a\u00a0toxic biochemical pathway plays a vital physiological function in insects","volume":"6","author":"Vavricka","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cub.2016.06.025_bib9","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.ibmb.2005.01.014","article-title":"Melanogenesis and associated cytotoxic reactions: applications to insect innate immunity","volume":"35","author":"Nappi","year":"2005","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.cub.2016.06.025_bib10","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1001\/archpedi.1980.02130170042014","article-title":"CSF neurotransmitter studies. An infant with ascorbic acid-responsive tyrosinemia","volume":"134","author":"Stoerner","year":"1980","journal-title":"Am. J. Dis. Child."},{"key":"10.1016\/j.cub.2016.06.025_bib11","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ymgme.2010.11.003","article-title":"Increase of CSF tyrosine and impaired serotonin turnover in tyrosinemia type I","volume":"102","author":"Thimm","year":"2011","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.cub.2016.06.025_bib12","doi-asserted-by":"crossref","first-page":"1539S","DOI":"10.1093\/jn\/137.6.1539S","article-title":"Tyrosine, phenylalanine, and catecholamine synthesis and function in the brain","volume":"137","author":"Fernstrom","year":"2007","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.cub.2016.06.025_bib13","doi-asserted-by":"crossref","first-page":"e84865","DOI":"10.1371\/journal.pone.0084865","article-title":"Phenylalanine metabolism regulates reproduction and parasite melanization in the malaria mosquito","volume":"9","author":"Fuchs","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cub.2016.06.025_bib14","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1111\/j.0014-3820.2006.tb00506.x","article-title":"Responses to selection on phenoloxidase activity in yellow dung flies","volume":"60","author":"Schwarzenbach","year":"2006","journal-title":"Evolution"},{"key":"10.1016\/j.cub.2016.06.025_bib15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1042\/bj1580017","article-title":"Haemolysis induced by tyrosine crystals: modifiers and inhibitors","volume":"158","author":"Goldsmith","year":"1976","journal-title":"Biochem. J."},{"key":"10.1016\/j.cub.2016.06.025_bib16","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0300-483X(99)00205-X","article-title":"Tissue distribution of 2-(2-nitro-4-trifluoromethylbenzoyl)-cyclohexane-1,3-dione (NTBC) and its effect on enzymes involved in tyrosine catabolism in the mouse","volume":"144","author":"Lock","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.cub.2016.06.025_bib17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.taap.2006.01.015","article-title":"Tyrosinemia produced by 2-(2-nitro-4-trifluoromethylbenzoyl)-cyclohexane-1,3-dione (NTBC) in experimental animals and its relationship to corneal injury","volume":"215","author":"Lock","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cub.2016.06.025_bib18","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1046\/j.0306-5251.2001.01421.x","article-title":"Pharmacokinetics and pharmacodynamics of NTBC (2-(2-nitro-4-fluoromethylbenzoyl)-1,3-cyclohexanedione) and mesotrione, inhibitors of 4-hydroxyphenyl pyruvate dioxygenase (HPPD) following a single dose to healthy male volunteers","volume":"52","author":"Hall","year":"2001","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.cub.2016.06.025_bib19","doi-asserted-by":"crossref","first-page":"648","DOI":"10.2337\/dc12-0895","article-title":"Branched-chain and aromatic amino acids are predictors of insulin resistance in young adults","volume":"36","author":"W\u00fcrtz","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.cub.2016.06.025_bib20","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2147\/HMER.S79100","article-title":"Tyrosine levels are associated with insulin resistance in patients with nonalcoholic fatty liver disease","volume":"7","author":"Kawanaka","year":"2015","journal-title":"Hepat. Med."},{"key":"10.1016\/j.cub.2016.06.025_bib21","doi-asserted-by":"crossref","first-page":"e1004020","DOI":"10.1371\/journal.pgen.1004020","article-title":"TATN-1 mutations reveal a novel role for tyrosine as a metabolic signal that influences developmental decisions and longevity in Caenorhabditis elegans","volume":"9","author":"Ferguson","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cub.2016.06.025_bib22","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1126\/science.1083614","article-title":"DAF-16 target genes that control C.\u00a0elegans life-span and metabolism","volume":"300","author":"Lee","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.cub.2016.06.025_bib23","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/1526-4998(200102)57:2<120::AID-PS254>3.0.CO;2-E","article-title":"Mesotrione: a new selective herbicide for use in maize","volume":"57","author":"Mitchell","year":"2001","journal-title":"Pest Manag. Sci."},{"key":"10.1016\/j.cub.2016.06.025_bib24","series-title":"Herbicide Handbook","author":"Vencill","year":"2002"},{"key":"10.1016\/j.cub.2016.06.025_bib25","series-title":"The Biology of Blood-Sucking in Insects","author":"Lehane","year":"2005"},{"key":"10.1016\/j.cub.2016.06.025_bib26","first-page":"143","article-title":"Blood-feeding arthropods: live syringes or invertebrate pharmacologists?","volume":"4","author":"Ribeiro","year":"1995","journal-title":"Infect. Agents Dis."},{"key":"10.1016\/j.cub.2016.06.025_bib27","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.ibmb.2006.01.009","article-title":"Adaptations against heme toxicity in blood-feeding arthropods","volume":"36","author":"Gra\u00e7a-Souza","year":"2006","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.cub.2016.06.025_bib28","doi-asserted-by":"crossref","first-page":"4134","DOI":"10.1016\/j.bmc.2009.03.015","article-title":"Herbicidal 4-hydroxyphenylpyruvate dioxygenase inhibitors\u2014a review of the triketone chemistry story from a Syngenta perspective","volume":"17","author":"Beaudegnies","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.cub.2016.06.025_bib29","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1002\/ps.1117","article-title":"The toxicity of herbicides to non-target aquatic plants and algae: assessment of predictive factors and hazard","volume":"61","author":"Cedergreen","year":"2005","journal-title":"Pest Manag. Sci."},{"key":"10.1016\/j.cub.2016.06.025_bib30","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1039\/C4EM00254G","article-title":"Photosynthetic responses and accumulation of mesotrione in two freshwater algae","volume":"16","author":"Ni","year":"2014","journal-title":"Environ. Sci. Process. Impacts"},{"key":"10.1016\/j.cub.2016.06.025_bib31","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.3201\/eid2010.140619","article-title":"Increased pyrethroid resistance in malaria vectors and decreased bed net effectiveness, Burkina Faso","volume":"20","author":"To\u00e9","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.cub.2016.06.025_bib32","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.actatropica.2015.05.014","article-title":"Insecticide resistance in vector Chagas disease: evolution, mechanisms and management","volume":"149","author":"Mougabure-Cueto","year":"2015","journal-title":"Acta Trop."},{"key":"10.1016\/j.cub.2016.06.025_bib33","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1603\/ME11157","article-title":"Unexpected failures to control Chagas disease vectors with pyrethroid spraying in northern Argentina","volume":"49","author":"Gurevitz","year":"2012","journal-title":"J.\u00a0Med. Entomol."},{"key":"10.1016\/j.cub.2016.06.025_bib34","doi-asserted-by":"crossref","first-page":"e1001619","DOI":"10.1371\/journal.pmed.1001619","article-title":"The impact of pyrethroid resistance on the efficacy of insecticide-treated bed nets against African anopheline mosquitoes: systematic review and meta-analysis","volume":"11","author":"Strode","year":"2014","journal-title":"PLoS Med."}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982216306649?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982216306649?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T23:17:13Z","timestamp":1568243833000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982216306649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":34,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S0960982216306649"],"URL":"https:\/\/doi.org\/10.1016\/j.cub.2016.06.025","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tyrosine Detoxification Is an Essential Trait in the Life History of Blood-Feeding Arthropods","name":"articletitle","label":"Article Title"},{"value":"Current Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cub.2016.06.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}