{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:53:02Z","timestamp":1792673582034,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T00:00:00Z","timestamp":1549843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1UF1NS108213"],"award-info":[{"award-number":["1UF1NS108213"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01NS061908"],"award-info":[{"award-number":["5R01NS061908"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["BRAIN 5U01NS094296"],"award-info":[{"award-number":["BRAIN 5U01NS094296"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000893","name":"Simons Foundation","doi-asserted-by":"publisher","award":["5T32HD007430-18"],"award-info":[{"award-number":["5T32HD007430-18"]}],"id":[{"id":"10.13039\/100000893","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005270","name":"McKnight Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014036","name":"Multidisciplinary University Research Initiative","doi-asserted-by":"publisher","award":["W911NF-12-1-0594"],"award-info":[{"award-number":["W911NF-12-1-0594"]}],"id":[{"id":"10.13039\/100014036","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.cub.2019.01.060","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T10:35:02Z","timestamp":1551954902000},"page":"935-944.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":129,"title":["Characterization of Proprioceptive System Dynamics in Behaving Drosophila Larvae Using High-Speed Volumetric Microscopy"],"prefix":"10.1016","volume":"29","author":[{"given":"Rebecca D.","family":"Vaadia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenze","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatakaushik","family":"Voleti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Singhania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.C.","family":"Hillman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley B.","family":"Grueber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cub.2019.01.060_bib1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.conb.2017.08.006","article-title":"Quantifying behavior to solve sensorimotor transformations: advances from worms and flies","volume":"46","author":"Calhoun","year":"2017","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.cub.2019.01.060_bib2","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.neuron.2012.06.006","article-title":"The Brain Activity Map Project and the challenge of functional connectomics","volume":"74","author":"Alivisatos","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2019.01.060_bib3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.conb.2011.12.002","article-title":"Functional imaging in freely moving animals","volume":"22","author":"Kerr","year":"2012","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.cub.2019.01.060_bib4","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1152\/jn.00731.2015","article-title":"Imaging fictive locomotor patterns in larval Drosophila","volume":"114","author":"Pulver","year":"2015","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.cub.2019.01.060_bib5","doi-asserted-by":"crossref","first-page":"e29869","DOI":"10.1371\/journal.pone.0029869","article-title":"Microfluidic chips for in\u00a0vivo imaging of cellular responses to neural injury in Drosophila larvae","volume":"7","author":"Ghannad-Rezaie","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cub.2019.01.060_bib6","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/nmeth.3632","article-title":"Whole-animal functional and developmental imaging with isotropic spatial resolution","volume":"12","author":"Chhetri","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cub.2019.01.060_bib7","doi-asserted-by":"crossref","first-page":"7924","DOI":"10.1038\/ncomms8924","article-title":"Whole-central nervous system functional imaging in larval Drosophila","volume":"6","author":"Lemon","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2019.01.060_bib8","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1038\/nbt.3708","article-title":"Adaptive light-sheet microscopy for long-term, high-resolution imaging in living organisms","volume":"34","author":"Royer","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cub.2019.01.060_bib9","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nphoton.2014.323","article-title":"Swept confocally-aligned planar excitation (SCAPE) microscopy for high speed volumetric imaging of behaving organisms","volume":"9","author":"Bouchard","year":"2015","journal-title":"Nat. Photonics"},{"key":"10.1016\/j.cub.2019.01.060_bib10","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.conb.2018.03.007","article-title":"High-speed 3D imaging of cellular activity in the brain using axially-extended beams and light sheets","volume":"50","author":"Hillman","year":"2018","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.cub.2019.01.060_bib11","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1098\/rspb.1958.0037","article-title":"The structure and function of abdominal stretch receptors in insects","volume":"148","author":"Finlayson","year":"1958","journal-title":"Proc. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.cub.2019.01.060_bib12","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.asd.2006.08.014","article-title":"Dorsal longitudinal stretch receptor of Drosophila melanogaster larva\u2014fine structure and maturation","volume":"36","author":"Schrader","year":"2007","journal-title":"Arthropod Struct. Dev."},{"key":"10.1016\/j.cub.2019.01.060_bib13","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1242\/dev.129.12.2867","article-title":"Tiling of the Drosophila epidermis by multidendritic sensory neurons","volume":"129","author":"Grueber","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.cub.2019.01.060_bib14","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.mcn.2007.04.001","article-title":"A sensory feedback circuit coordinates muscle activity in Drosophila","volume":"35","author":"Hughes","year":"2007","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.cub.2019.01.060_bib15","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1242\/dev.130906","article-title":"Dendritic diversification through transcription factor-mediated suppression of alternative morphologies","volume":"143","author":"Corty","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.cub.2019.01.060_bib16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/BF00402027","article-title":"Morphological differentiation of the embryonic peripheral neurons in Drosophila","volume":"196","author":"Bodmer","year":"1987","journal-title":"Rouxs Arch. Dev. Biol."},{"key":"10.1016\/j.cub.2019.01.060_bib17","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1523\/JNEUROSCI.15-03-01755.1995","article-title":"Central projections of sensory neurons in the Drosophila embryo correlate with sensory modality, soma position, and proneural gene function","volume":"15","author":"Merritt","year":"1995","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cub.2019.01.060_bib18","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/1096-9861(20000911)425:1<34::AID-CNE4>3.0.CO;2-G","article-title":"Central projections of Drosophila sensory neurons in the transition from embryo to larva","volume":"425","author":"Schrader","year":"2000","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.cub.2019.01.060_bib19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1242\/dev.02666","article-title":"Projections of Drosophila multidendritic neurons in the\u00a0central nervous system: links with peripheral dendrite morphology","volume":"134","author":"Grueber","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.cub.2019.01.060_bib20","doi-asserted-by":"crossref","first-page":"12460","DOI":"10.1523\/JNEUROSCI.0222-12.2012","article-title":"Characterization of Drosophila larval crawling at the level of organism, segment, and somatic body wall musculature","volume":"32","author":"Heckscher","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cub.2019.01.060_bib21","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.neuron.2010.07.004","article-title":"The role of the TRP channel NompC in Drosophila larval and adult locomotion","volume":"67","author":"Cheng","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2019.01.060_bib22","doi-asserted-by":"crossref","first-page":"e0130969","DOI":"10.1371\/journal.pone.0130969","article-title":"Piezo Is Essential for Amiloride-Sensitive Stretch-Activated Mechanotransduction in Larval Drosophila Dorsal Bipolar Dendritic Sensory Neurons","volume":"10","author":"Suslak","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cub.2019.01.060_bib23","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.neuron.2011.10.033","article-title":"Integrins establish dendrite-substrate relationships that promote dendritic self-avoidance and patterning in Drosophila sensory neurons","volume":"73","author":"Kim","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2019.01.060_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.cub.2019.02.025","article-title":"Direction selectivity in Drosophila proprioceptors requires the mechanosensory channel TMC","author":"He","year":"2019","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2019.01.060_bib25","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1152\/physrev.00048.2011","article-title":"The proprioceptive senses: their roles in signaling body shape, body position and movement, and muscle force","volume":"92","author":"Proske","year":"2012","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cub.2019.01.060_bib26","doi-asserted-by":"crossref","first-page":"e12059","DOI":"10.7554\/eLife.12059","article-title":"Quantitative neuroanatomy for connectomics in Drosophila","volume":"5","author":"Schneider-Mizell","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.cub.2019.01.060_bib27","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1016\/j.cub.2014.09.026","article-title":"A group of segmental premotor interneurons regulates the speed of axial locomotion in Drosophila larvae","volume":"24","author":"Kohsaka","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2019.01.060_bib28","doi-asserted-by":"crossref","first-page":"e13253","DOI":"10.7554\/eLife.13253","article-title":"A circuit mechanism for the propagation of waves of muscle contraction in Drosophila","volume":"5","author":"Fushiki","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.cub.2019.01.060_bib29","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.neuron.2015.09.009","article-title":"Even-Skipped(+) Interneurons Are Core Components of a Sensorimotor Circuit that Maintains Left-Right Symmetric Muscle Contraction Amplitude","volume":"88","author":"Heckscher","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2019.01.060_bib30","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0092-8674(03)00160-0","article-title":"Different levels of the homeodomain protein Cut regulate distinct dendrite branching patterns of Drosophila multidendritic neurons","volume":"112","author":"Grueber","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.cub.2019.01.060_bib31","doi-asserted-by":"crossref","first-page":"20306","DOI":"10.1364\/OE.16.020306","article-title":"Optically sectioned imaging by oblique plane microscopy","volume":"16","author":"Dunsby","year":"2008","journal-title":"Opt. Express"},{"key":"10.1016\/j.cub.2019.01.060_bib32","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nature12354","article-title":"Ultrasensitive fluorescent proteins for imaging neuronal activity","volume":"499","author":"Chen","year":"2013","journal-title":"Nature"}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982219300892?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982219300892?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T09:34:39Z","timestamp":1760780079000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982219300892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S0960982219300892"],"URL":"https:\/\/doi.org\/10.1016\/j.cub.2019.01.060","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/467274","asserted-by":"object"}]},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of Proprioceptive System Dynamics in Behaving Drosophila Larvae Using High-Speed Volumetric Microscopy","name":"articletitle","label":"Article Title"},{"value":"Current Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cub.2019.01.060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.cub.2019.02.025","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}