{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T03:47:28Z","timestamp":1794455248476,"version":"4.9.1"},"reference-count":65,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T00:00:00Z","timestamp":1620086400000},"content-version":"vor","delay-in-days":368,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.cub.2020.02.091","type":"journal-article","created":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T10:36:28Z","timestamp":1585218988000},"page":"1703-1715.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":130,"title":["Mapping Cortical Integration of Sensory and Affective Pain Pathways"],"prefix":"10.1016","volume":"30","author":[{"given":"Amrita","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizbeth","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaosheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinling","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Doan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo","family":"Rudy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe S.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cub.2020.02.091_bib1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","article-title":"Cellular and molecular mechanisms of pain","volume":"139","author":"Basbaum","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.cub.2020.02.091_bib2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nrn.2016.162","article-title":"Structural plasticity and reorganisation in chronic pain","volume":"18","author":"Kuner","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"issue":"9 Suppl","key":"10.1016\/j.cub.2020.02.091_bib3","first-page":"T50","article-title":"Toward a Mechanism-Based Approach to Pain Diagnosis","volume":"17","author":"Vardeh","year":"2016","journal-title":"J.\u00a0Pain"},{"key":"10.1016\/j.cub.2020.02.091_bib4","first-page":"958","article-title":"Bilateral cingulumotomy combined with thalamotomy or mesencephalic tractotomy for pain","volume":"134","author":"Turnbull","year":"1972","journal-title":"Surg. Gynecol. Obstet."},{"key":"10.1016\/j.cub.2020.02.091_bib5","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/384258a0","article-title":"Functional imaging of an illusion of pain","volume":"384","author":"Craig","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.cub.2020.02.091_bib6","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1126\/science.277.5328.968","article-title":"Pain affect encoded in human anterior cingulate but not somatosensory cortex","volume":"277","author":"Rainville","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.cub.2020.02.091_bib7","first-page":"353","article-title":"The role of rostral cingulumotomy in \u201cpain\u201d relief","volume":"6","author":"Foltz","year":"1968","journal-title":"Int. J. Neurol."},{"key":"10.1016\/j.cub.2020.02.091_bib8","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3109\/08990229509101503","article-title":"Evaluation of pain perception after anterior capsulotomy: a case report","volume":"12","author":"Talbot","year":"1995","journal-title":"Somatosens. Mot. Res."},{"key":"10.1016\/j.cub.2020.02.091_bib9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0304-3940(00)00894-6","article-title":"During pain-avoidance neurons activated in the macaque anterior cingulate and caudate","volume":"283","author":"Koyama","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.cub.2020.02.091_bib10","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0168-0102(01)00197-3","article-title":"Anterior cingulate activity during pain-avoidance and reward tasks in monkeys","volume":"39","author":"Koyama","year":"2001","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.cub.2020.02.091_bib11","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.pain.2011.03.002","article-title":"Lesion of the rostral anterior cingulate cortex eliminates the aversiveness of spontaneous neuropathic pain following partial or complete axotomy","volume":"152","author":"Qu","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.cub.2020.02.091_bib12","doi-asserted-by":"crossref","first-page":"8077","DOI":"10.1073\/pnas.141218998","article-title":"The affective component of pain in rodents: direct evidence for a contribution of the anterior cingulate cortex","volume":"98","author":"Johansen","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2020.02.091_bib13","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.expneurol.2005.05.008","article-title":"Selective regulation of pain affect following activation of the opioid anterior cingulate cortex system","volume":"197","author":"LaGraize","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.cub.2020.02.091_bib14","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1037\/h0041014","article-title":"Effect of Medial Cortical Lesions on the Avoidance Behavior of the Cat","volume":"58","author":"Lubar","year":"1964","journal-title":"J.\u00a0Comp. Physiol. Psychol."},{"key":"10.1016\/j.cub.2020.02.091_bib15","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1126\/science.150.3699.971","article-title":"Pain mechanisms: a new theory","volume":"150","author":"Melzack","year":"1965","journal-title":"Science"},{"key":"10.1016\/j.cub.2020.02.091_bib16","series-title":"The Skin Senses","first-page":"423","article-title":"Sensory, motivational, and central control determinants of pain: a new conceptual model","author":"Melzack","year":"1968"},{"key":"10.1016\/j.cub.2020.02.091_bib17","doi-asserted-by":"crossref","first-page":"20709","DOI":"10.1073\/pnas.1214605109","article-title":"Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry","volume":"109","author":"Navratilova","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2020.02.091_bib18","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/nn1207","article-title":"Glutamatergic activation of anterior cingulate cortex produces an aversive teaching signal","volume":"7","author":"Johansen","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cub.2020.02.091_bib19","doi-asserted-by":"crossref","first-page":"e25302","DOI":"10.7554\/eLife.25302","article-title":"Chronic pain induces generalized enhancement of aversion","volume":"6","author":"Zhang","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.cub.2020.02.091_bib20","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1038\/s41467-018-06295-x","article-title":"Ketamine reduces aversion in rodent pain models by suppressing hyperactivity of the anterior cingulate cortex","volume":"9","author":"Zhou","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2020.02.091_bib21","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0079-6123(08)62141-X","article-title":"The medial pain system, cingulate cortex, and parallel processing of nociceptive information","volume":"122","author":"Vogt","year":"2000","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.cub.2020.02.091_bib22","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1152\/jn.00024.2010","article-title":"Nociceptive processing by anterior cingulate pyramidal neurons","volume":"103","author":"Shyu","year":"2010","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.cub.2020.02.091_bib23","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.neuron.2019.03.042","article-title":"Microcircuit Mechanisms through which Mediodorsal Thalamic Input to Anterior Cingulate Cortex Exacerbates Pain-Related Aversion","volume":"102","author":"Meda","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2020.02.091_bib24","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/cne.903200202","article-title":"Prefrontal cortical efferents in the rat synapse on unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and on dopamine neurons in the ventral tegmental area","volume":"320","author":"Sesack","year":"1992","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.cub.2020.02.091_bib25","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/cne.902900205","article-title":"Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: an anterograde tract-tracing study with Phaseolus vulgaris leucoagglutinin","volume":"290","author":"Sesack","year":"1989","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.cub.2020.02.091_bib26","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1038\/nn.2407","article-title":"Unmasking the tonic-aversive state in neuropathic pain","volume":"12","author":"King","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cub.2020.02.091_bib27","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.celrep.2018.03.139","article-title":"Scaling Up Cortical Control Inhibits Pain","volume":"23","author":"Dale","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.cub.2020.02.091_bib28","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3389\/fncel.2017.00146","article-title":"Corticostriatal Regulation of Acute Pain","volume":"11","author":"Martinez","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.cub.2020.02.091_bib29","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1126\/science.1191792","article-title":"Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex","volume":"330","author":"Li","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.cub.2020.02.091_bib30","doi-asserted-by":"crossref","first-page":"7445","DOI":"10.1523\/JNEUROSCI.1812-08.2008","article-title":"Presynaptic and postsynaptic amplifications of neuropathic pain in the anterior cingulate cortex","volume":"28","author":"Xu","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cub.2020.02.091_bib31","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1523\/JNEUROSCI.3195-17.2018","article-title":"Hyperactivity of Anterior Cingulate Cortex Areas 24a\/24b Drives Chronic Pain-Induced Anxiodepressive-like Consequences","volume":"38","author":"Sellmeijer","year":"2018","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cub.2020.02.091_bib32","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/nn.4595","article-title":"Activation of cortical somatostatin interneurons prevents the development of neuropathic pain","volume":"20","author":"Cichon","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cub.2020.02.091_bib33","doi-asserted-by":"crossref","first-page":"5477","DOI":"10.1523\/JNEUROSCI.0328-11.2011","article-title":"Rapid synaptic remodeling in the adult somatosensory cortex following peripheral nerve injury and its association with neuropathic pain","volume":"31","author":"Kim","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cub.2020.02.091_bib34","doi-asserted-by":"crossref","first-page":"5754","DOI":"10.1523\/JNEUROSCI.3667-13.2014","article-title":"Nerve injury-induced neuropathic pain causes disinhibition of the anterior cingulate cortex","volume":"34","author":"Blom","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cub.2020.02.091_bib35","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3389\/fncel.2018.00240","article-title":"Inhibition of the Prefrontal Projection to the Nucleus Accumbens Enhances Pain Sensitivity and Affect","volume":"12","author":"Zhou","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.cub.2020.02.091_bib36","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/ana.23922","article-title":"Capturing the aversive state of cephalic pain preclinically","volume":"74","author":"De Felice","year":"2013","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.cub.2020.02.091_bib37","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/8065","article-title":"Pain-related neurons in the human cingulate cortex","volume":"2","author":"Hutchison","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cub.2020.02.091_bib38","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1152\/jn.00190.2005","article-title":"Anterior cingulate cortical neuronal activity during perception of noxious thermal stimuli in monkeys","volume":"94","author":"Iwata","year":"2005","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.cub.2020.02.091_bib39","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0006-8993(96)00561-6","article-title":"Morphological and electrophysiological properties of ACCx nociceptive neurons in rats","volume":"735","author":"Yamamura","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.cub.2020.02.091_bib40","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0006-8993(02)04276-2","article-title":"Contribution of the anterior cingulate cortex to laser-pain conditioning in rats","volume":"970","author":"Kung","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.cub.2020.02.091_bib41","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1152\/jn.00294.2005","article-title":"Comparison of anterior cingulate and primary somatosensory neuronal responses to noxious laser-heat stimuli in conscious, behaving rats","volume":"94","author":"Kuo","year":"2005","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.cub.2020.02.091_bib42","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1152\/jn.1992.68.5.1720","article-title":"Nociceptive neurons in area 24 of rabbit cingulate cortex","volume":"68","author":"Sikes","year":"1992","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.cub.2020.02.091_bib43","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1744-8069-7-64","article-title":"Ensemble encoding of nociceptive stimulus intensity in the rat medial and lateral pain systems","volume":"7","author":"Zhang","year":"2011","journal-title":"Mol. Pain"},{"key":"10.1016\/j.cub.2020.02.091_bib44","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1152\/jn.1999.82.4.1934","article-title":"Pain intensity processing within the human brain: a bilateral, distributed mechanism","volume":"82","author":"Coghill","year":"1999","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.cub.2020.02.091_bib45","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1523\/JNEUROSCI.22-03-00970.2002","article-title":"Dissociable neural responses related to pain intensity, stimulus intensity, and stimulus awareness within the anterior cingulate cortex: a parametric single-trial laser functional magnetic resonance imaging study","volume":"22","author":"B\u00fcchel","year":"2002","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cub.2020.02.091_bib46","doi-asserted-by":"crossref","first-page":"7631","DOI":"10.1523\/JNEUROSCI.0946-11.2011","article-title":"Inter-regional contribution of enhanced activity of the primary somatosensory cortex to the anterior cingulate cortex accelerates chronic pain behavior","volume":"31","author":"Eto","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cub.2020.02.091_bib47","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/s41467-019-08873-z","article-title":"Gamma oscillations in somatosensory cortex recruit prefrontal and descending serotonergic pathways in aversion and nociception","volume":"10","author":"Tan","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2020.02.091_bib48","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41586-018-0515-2","article-title":"Touch and tactile neuropathic pain sensitivity are set by corticospinal projections","volume":"561","author":"Liu","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cub.2020.02.091_bib49","doi-asserted-by":"crossref","first-page":"7705","DOI":"10.1073\/pnas.96.14.7705","article-title":"Pain perception: is there a role for primary somatosensory cortex?","volume":"96","author":"Bushnell","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2020.02.091_bib50","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1126\/science.288.5472.1769","article-title":"Psychological and neural mechanisms of the affective dimension of pain","volume":"288","author":"Price","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.cub.2020.02.091_bib51","doi-asserted-by":"crossref","first-page":"19034","DOI":"10.1523\/JNEUROSCI.2454-13.2013","article-title":"Calcium-permeable AMPA receptors in the nucleus accumbens regulate depression-like behaviors in the chronic neuropathic pain state","volume":"33","author":"Goffer","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cub.2020.02.091_bib52","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.neuron.2014.12.021","article-title":"Coexistence of two forms of LTP in ACC provides a synaptic mechanism for the interactions between anxiety and chronic pain","volume":"85","author":"Koga","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2020.02.091_bib53","doi-asserted-by":"crossref","first-page":"4829","DOI":"10.1523\/JNEUROSCI.2731-17.2018","article-title":"Altered Excitability and Local Connectivity of mPFC-PAG Neurons in a Mouse Model of Neuropathic Pain","volume":"38","author":"Cheriyan","year":"2018","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cub.2020.02.091_bib54","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1523\/JNEUROSCI.4047-15.2016","article-title":"Rescue of Impaired mGluR5-Driven Endocannabinoid Signaling Restores Prefrontal Cortical Output to Inhibit Pain in Arthritic Rats","volume":"36","author":"Kiritoshi","year":"2016","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cub.2020.02.091_bib55","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.neuron.2014.04.031","article-title":"Neural correlates of task switching in prefrontal cortex and primary auditory cortex in a novel stimulus selection task for rodents","volume":"82","author":"Rodgers","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2020.02.091_bib56","doi-asserted-by":"crossref","first-page":"e25784","DOI":"10.7554\/eLife.25784","article-title":"Dynamic representation of partially occluded objects in primate prefrontal and visual cortex","volume":"6","author":"Fyall","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.cub.2020.02.091_bib57","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1126\/science.aaw5842","article-title":"Social transmission of food safety depends on synaptic plasticity in the prefrontal cortex","volume":"364","author":"Loureiro","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.cub.2020.02.091_bib58","doi-asserted-by":"crossref","first-page":"7238","DOI":"10.1523\/JNEUROSCI.4856-08.2009","article-title":"Context-dependent modulation of functional connectivity: secondary somatosensory cortex to prefrontal cortex connections in two-stimulus-interval discrimination tasks","volume":"29","author":"Chow","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cub.2020.02.091_bib59","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.ejpain.2004.11.001","article-title":"Human brain mechanisms of pain perception and regulation in health and disease","volume":"9","author":"Apkarian","year":"2005","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.cub.2020.02.091_bib60","doi-asserted-by":"crossref","first-page":"5247","DOI":"10.1523\/JNEUROSCI.3494-14.2015","article-title":"Activation of corticostriatal circuitry relieves chronic neuropathic pain","volume":"35","author":"Lee","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cub.2020.02.091_bib61","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1021\/acschemneuro.8b00022","article-title":"Pathway-Specific Alterations of Cortico-Amygdala Transmission in an Arthritis Pain Model","volume":"9","author":"Kiritoshi","year":"2018","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.cub.2020.02.091_bib62","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1038\/s41593-019-0481-5","article-title":"A neuronal circuit for activating descending modulation of neuropathic pain","volume":"22","author":"Huang","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cub.2020.02.091_bib63","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.celrep.2015.07.001","article-title":"Role of Prelimbic GABAergic Circuits in Sensory and Emotional Aspects of Neuropathic Pain","volume":"12","author":"Zhang","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.cub.2020.02.091_bib64","doi-asserted-by":"crossref","first-page":"5451","DOI":"10.1523\/JNEUROSCI.0225-10.2010","article-title":"Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation","volume":"30","author":"Ji","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cub.2020.02.091_bib65","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nrn3687","article-title":"The log-dynamic brain: how skewed distributions affect network operations","volume":"15","author":"Buzs\u00e1ki","year":"2014","journal-title":"Nat. Rev. Neurosci."}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982220302980?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982220302980?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T09:42:55Z","timestamp":1760780575000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982220302980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":65,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S0960982220302980"],"URL":"https:\/\/doi.org\/10.1016\/j.cub.2020.02.091","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.737646916.793574213","asserted-by":"object"}]},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mapping Cortical Integration of Sensory and Affective Pain Pathways","name":"articletitle","label":"Article Title"},{"value":"Current Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cub.2020.02.091","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}