{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:57:18Z","timestamp":1790794638043,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T00:00:00Z","timestamp":1643068800000},"content-version":"vor","delay-in-days":389,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.cub.2020.10.045","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T10:34:40Z","timestamp":1605263680000},"page":"381-393.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Dysfunction of Orbitofrontal GABAergic Interneurons Leads to Impaired Reversal Learning in a Mouse Model of Obsessive-Compulsive Disorder"],"prefix":"10.1016","volume":"31","author":[{"given":"Zicheng","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunyuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimeng","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cub.2020.10.045_bib1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/mp.2008.94","article-title":"The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication","volume":"15","author":"Ruscio","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.cub.2020.10.045_bib2","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.neuroscience.2016.07.030","article-title":"Cognitive inflexibility in obsessive-compulsive disorder","volume":"345","author":"Gruner","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.cub.2020.10.045_bib3","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s11920-016-0720-3","article-title":"Cognitive dysfunction in obsessive-compulsive disorder","volume":"18","author":"Benzina","year":"2016","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.cub.2020.10.045_bib4","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1017\/S0033291717003464","article-title":"Impaired cognitive plasticity and goal-directed control in adolescent obsessive-compulsive disorder","volume":"48","author":"Gottwald","year":"2018","journal-title":"Psychol. Med."},{"key":"10.1016\/j.cub.2020.10.045_bib5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neuroscience.2016.03.021","article-title":"The neural basis of reversal learning: an updated perspective","volume":"345","author":"Izquierdo","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.cub.2020.10.045_bib6","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1001\/archpsyc.63.11.1225","article-title":"Reduced orbitofrontal-striatal activity on a reversal learning task in obsessive-compulsive disorder","volume":"63","author":"Remijnse","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.cub.2020.10.045_bib7","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1017\/S0033291708005072","article-title":"Differential frontal-striatal and paralimbic activity during reversal learning in major depressive disorder and obsessive-compulsive disorder","volume":"39","author":"Remijnse","year":"2009","journal-title":"Psychol. Med."},{"key":"10.1016\/j.cub.2020.10.045_bib8","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1126\/science.1154433","article-title":"Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives","volume":"321","author":"Chamberlain","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.cub.2020.10.045_bib9","doi-asserted-by":"crossref","first-page":"10972","DOI":"10.1523\/JNEUROSCI.1521-08.2008","article-title":"Lesions of the medial striatum in monkeys produce perseverative impairments during reversal learning similar to those produced by lesions of the orbitofrontal cortex","volume":"28","author":"Clarke","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cub.2020.10.045_bib10","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/cercor\/bhy276","article-title":"Selective role of the putamen in serial reversal learning in the marmoset","volume":"29","author":"Jackson","year":"2019","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.cub.2020.10.045_bib11","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/380069a0","article-title":"Dissociation in prefrontal cortex of affective and attentional shifts","volume":"380","author":"Dias","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.cub.2020.10.045_bib12","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1097\/00001756-200205070-00030","article-title":"Orbitofrontal lesions in rats impair reversal but not acquisition of go, no-go odor discriminations","volume":"13","author":"Schoenbaum","year":"2002","journal-title":"Neuroreport"},{"key":"10.1016\/j.cub.2020.10.045_bib13","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.bbr.2010.02.017","article-title":"Selective lesions of the dorsomedial striatum impair serial spatial reversal learning in rats","volume":"210","author":"Casta\u00f1\u00e9","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.cub.2020.10.045_bib14","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.neuron.2019.05.042","article-title":"Orbitofrontal circuits control multiple reinforcement-learning processes","volume":"103","author":"Groman","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2020.10.045_bib15","doi-asserted-by":"crossref","first-page":"11124","DOI":"10.1523\/JNEUROSCI.2820-08.2008","article-title":"Double dissociation of the effects of medial and orbital prefrontal cortical lesions on attentional and affective shifts in mice","volume":"28","author":"Bissonette","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cub.2020.10.045_bib16","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/gbb.12191","article-title":"Behavioral flexibility in rats and mice: contributions of distinct frontocortical regions","volume":"14","author":"Hamilton","year":"2015","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.cub.2020.10.045_bib17","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1523\/JNEUROSCI.2951-16.2016","article-title":"Orbitofrontal cortex signals expected outcomes with predictive codes when stable contingencies promote the integration of reward history","volume":"37","author":"Riceberg","year":"2017","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cub.2020.10.045_bib18","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/s41593-019-0408-1","article-title":"Single-cell activity tracking reveals that orbitofrontal neurons acquire and maintain a long-term memory to guide behavioral adaptation","volume":"22","author":"Namboodiri","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cub.2020.10.045_bib19","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.cell.2020.05.022","article-title":"Behavior- and modality-general representation of confidence in orbitofrontal cortex","volume":"182","author":"Masset","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.cub.2020.10.045_bib20","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/s41586-019-1816-9","article-title":"Frontal cortex neuron types categorically encode single decision variables","volume":"576","author":"Hirokawa","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cub.2020.10.045_bib21","doi-asserted-by":"crossref","first-page":"10234","DOI":"10.1523\/JNEUROSCI.3216-13.2014","article-title":"Orbitofrontal cortical neurons encode expectation-driven initiation of reward-seeking","volume":"34","author":"Moorman","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cub.2020.10.045_bib22","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/j.celrep.2018.11.010","article-title":"Early life stress drives sex-selective impairment in reversal learning by affecting parvalbumin interneurons in orbitofrontal cortex of mice","volume":"25","author":"Goodwill","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.cub.2020.10.045_bib23","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.biopsych.2014.07.023","article-title":"Interneurons are necessary for coordinated activity during reversal learning in orbitofrontal cortex","volume":"77","author":"Bissonette","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.cub.2020.10.045_bib24","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/j.neuron.2018.08.002","article-title":"Monitoring and updating of action selection for goal-directed behavior through the striatal direct and indirect pathways","volume":"99","author":"Nonomura","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2020.10.045_bib25","doi-asserted-by":"crossref","first-page":"R267","DOI":"10.1016\/j.cub.2016.02.036","article-title":"Direct and indirect dorsolateral striatum pathways reinforce different action strategies","volume":"26","author":"Vicente","year":"2016","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2020.10.045_bib26","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/s41467-017-02817-1","article-title":"Differential coding of reward and movement information in the dorsomedial striatal direct and indirect pathways","volume":"9","author":"Shin","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2020.10.045_bib27","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.neuron.2010.05.011","article-title":"Distinct roles of synaptic transmission in direct and indirect striatal pathways to reward and aversive behavior","volume":"66","author":"Hikida","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2020.10.045_bib28","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/nn.3100","article-title":"Distinct roles for direct and indirect pathway striatal neurons in reinforcement","volume":"15","author":"Kravitz","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cub.2020.10.045_bib29","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00429-018-1780-4","article-title":"Medium spiny neurons of the anterior dorsomedial striatum mediate reversal learning in a cell-type-dependent manner","volume":"224","author":"Wang","year":"2019","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.cub.2020.10.045_bib30","doi-asserted-by":"crossref","first-page":"e46050","DOI":"10.7554\/eLife.46050","article-title":"Distinct roles of striatal direct and indirect pathways in value-based decision making","volume":"8","author":"Kwak","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.cub.2020.10.045_bib31","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature06104","article-title":"Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice","volume":"448","author":"Welch","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.cub.2020.10.045_bib32","doi-asserted-by":"crossref","first-page":"e12557","DOI":"10.1111\/gbb.12557","article-title":"Behavioral flexibility in a mouse model for obsessive-compulsive disorder: Impaired Pavlovian reversal learning in SAPAP3 mutants","volume":"18","author":"van den Boom","year":"2019","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.cub.2020.10.045_bib33","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1038\/s41386-018-0307-2","article-title":"Impaired instrumental reversal learning is associated with increased medial prefrontal cortex activity in Sapap3 knockout mouse model of compulsive behavior","volume":"44","author":"Manning","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.cub.2020.10.045_bib34","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1037\/a0031721","article-title":"Reduced behavioral flexibility in autism spectrum disorders","volume":"27","author":"D\u2019Cruz","year":"2013","journal-title":"Neuropsychology"},{"key":"10.1016\/j.cub.2020.10.045_bib35","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.conb.2013.11.003","article-title":"Inhibitory neurons in human cortical circuits: substrate for cognitive dysfunction in schizophrenia","volume":"26","author":"Lewis","year":"2014","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.cub.2020.10.045_bib36","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1503\/jpn.180032","article-title":"Lateral orbitofrontal dysfunction in the Sapap3 knockout mouse model of obsessive\u2013compulsive disorder","volume":"44","author":"Lei","year":"2019","journal-title":"J.\u00a0Psychiatry Neurosci."},{"key":"10.1016\/j.cub.2020.10.045_bib37","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1126\/science.aaa7484","article-title":"NEUROSCIENCE. Natural light-gated anion channels: a family of microbial rhodopsins for advanced optogenetics","volume":"349","author":"Govorunova","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.cub.2020.10.045_bib38","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/nn.4619","article-title":"Functions and dysfunctions of neocortical inhibitory neuron subtypes","volume":"20","author":"Hattori","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cub.2020.10.045_bib39","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fncir.2018.00037","article-title":"PV interneurons: critical regulators of E\/I balance for prefrontal cortex-dependent behavior and psychiatric disorders","volume":"12","author":"Ferguson","year":"2018","journal-title":"Front. Neural Circuits"},{"key":"10.1016\/j.cub.2020.10.045_bib40","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.neulet.2007.12.024","article-title":"The orbital cortex in rats topographically projects to central parts of the caudate-putamen complex","volume":"432","author":"Schilman","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.cub.2020.10.045_bib41","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nn.3397","article-title":"Convergent cortical innervation of striatal projection neurons","volume":"16","author":"Kress","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cub.2020.10.045_bib42","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41592-019-0435-6","article-title":"High-performance calcium sensors for imaging activity in neuronal populations and microcompartments","volume":"16","author":"Dana","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cub.2020.10.045_bib43","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1176\/ajp.2006.163.7.1282","article-title":"Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania","volume":"163","author":"Chamberlain","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.cub.2020.10.045_bib44","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.psychres.2012.06.010","article-title":"Behavioral and cognitive impulsivity in obsessive-compulsive disorder and eating disorders","volume":"200","author":"Boisseau","year":"2012","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.cub.2020.10.045_bib45","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1093\/brain\/awm205","article-title":"Neurocognitive endophenotypes of obsessive-compulsive disorder","volume":"130","author":"Menzies","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.cub.2020.10.045_bib46","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1111\/j.1460-9568.2010.07438.x","article-title":"Dissociable regulation of instrumental action within mouse prefrontal cortex","volume":"32","author":"Gourley","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.cub.2020.10.045_bib47","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1523\/JNEUROSCI.3366-15.2016","article-title":"Multifaceted contributions by different regions of the orbitofrontal and medial prefrontal cortex to probabilistic reversal learning","volume":"36","author":"Dalton","year":"2016","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cub.2020.10.045_bib48","doi-asserted-by":"crossref","first-page":"6398","DOI":"10.1523\/JNEUROSCI.6620-10.2011","article-title":"Dissociable effects of lesions to orbitofrontal cortex subregions on impulsive choice in the rat","volume":"31","author":"Mar","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cub.2020.10.045_bib49","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1126\/science.1232380","article-title":"Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors","volume":"340","author":"Burgui\u00e8re","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.cub.2020.10.045_bib50","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1126\/science.1234733","article-title":"Repeated cortico-striatal stimulation generates persistent OCD-like behavior","volume":"340","author":"Ahmari","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.cub.2020.10.045_bib51","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1523\/JNEUROSCI.1728-18.2018","article-title":"Strengthened inputs from secondary motor cortex to striatum in a mouse model of compulsive behavior","volume":"39","author":"Corbit","year":"2019","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cub.2020.10.045_bib52","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/cne.20060","article-title":"Differential mRNA expression and protein localization of the SAP90\/PSD-95-associated proteins (SAPAPs) in the nervous system of the mouse","volume":"472","author":"Welch","year":"2004","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.cub.2020.10.045_bib53","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/cne.20661","article-title":"Mediodorsal thalamic afferents to layer III of the rat prefrontal cortex: synaptic relationships to subclasses of interneurons","volume":"490","author":"Rotaru","year":"2005","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.cub.2020.10.045_bib54","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1523\/JNEUROSCI.5195-08.2009","article-title":"Dopamine DRD2 polymorphism alters reversal learning and associated neural activity","volume":"29","author":"Jocham","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cub.2020.10.045_bib55","doi-asserted-by":"crossref","first-page":"7291","DOI":"10.1523\/JNEUROSCI.0363-11.2011","article-title":"Dorsal striatal D2-like receptor availability covaries with sensitivity to positive reinforcement during discrimination learning","volume":"31","author":"Groman","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cub.2020.10.045_bib56","doi-asserted-by":"crossref","first-page":"35809","DOI":"10.1038\/srep35809","article-title":"Distinct roles for primate caudate dopamine D1 and D2 receptors in visual discrimination learning revealed using shRNA knockdown","volume":"6","author":"Takaji","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cub.2020.10.045_bib57","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s00213-008-1341-2","article-title":"Dopamine D2\/D3 receptor agonist quinpirole impairs spatial reversal learning in rats: investigation of D3 receptor involvement in persistent behavior","volume":"202","author":"Boulougouris","year":"2009","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.cub.2020.10.045_bib58","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1038\/sj.npp.1301337","article-title":"Dopamine D2\/D3 receptors play a specific role in the reversal of a learned visual discrimination in monkeys","volume":"32","author":"Lee","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.cub.2020.10.045_bib59","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/s41386-020-0612-4","article-title":"Dorsal and ventral striatal dopamine D1 and D2 receptors differentially modulate distinct phases of serial visual reversal learning","volume":"45","author":"Sala-Bayo","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.cub.2020.10.045_bib60","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/s41386-018-0272-9","article-title":"D2 receptors and cognitive flexibility in marmosets: tri-phasic dose-response effects of intra-striatal quinpirole on serial reversal performance","volume":"44","author":"Horst","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.cub.2020.10.045_bib61","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1007\/s00213-019-05296-y","article-title":"Dopamine D2-like receptor stimulation blocks negative feedback in visual and spatial reversal learning in the rat: behavioural and computational evidence","volume":"236","author":"Alsi\u00f6","year":"2019","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.cub.2020.10.045_bib62","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1007\/s00213-019-05292-2","article-title":"Dopaminergic drug treatment remediates exaggerated cingulate prediction error responses in obsessive-compulsive disorder","volume":"236","author":"Murray","year":"2019","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.cub.2020.10.045_bib63","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1177\/0004867412461958","article-title":"Pharmacotherapy of obsessive-compulsive disorder: evidence-based treatment and beyond","volume":"47","author":"Fineberg","year":"2013","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"10.1016\/j.cub.2020.10.045_bib64","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1007\/s00213-019-05325-w","article-title":"Computational modelling reveals contrasting effects on reinforcement learning and cognitive flexibility in stimulant use disorder and obsessive-compulsive disorder: remediating effects of dopaminergic D2\/3 receptor agents","volume":"236","author":"Kanen","year":"2019","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.cub.2020.10.045_bib65","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1038\/nn.4430","article-title":"A viral strategy for targeting and manipulating interneurons across vertebrate species","volume":"19","author":"Dimidschstein","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cub.2020.10.045_bib66","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1364\/BOE.6.003919","article-title":"Multi-channel fiber photometry for population neuronal activity recording","volume":"6","author":"Guo","year":"2015","journal-title":"Biomed. Opt. Express"}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982220315888?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982220315888?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T09:47:14Z","timestamp":1760780834000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982220315888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":66,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S0960982220315888"],"URL":"https:\/\/doi.org\/10.1016\/j.cub.2020.10.045","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dysfunction of Orbitofrontal GABAergic Interneurons Leads to Impaired Reversal Learning in a Mouse Model of Obsessive-Compulsive Disorder","name":"articletitle","label":"Article Title"},{"value":"Current Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cub.2020.10.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}