{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:50:05Z","timestamp":1790398205438,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":392,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003500","name":"UNIPD","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003500","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["MOBEC008"],"award-info":[{"award-number":["MOBEC008"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["2014-2020.4.01.16-0030"],"award-info":[{"award-number":["2014-2020.4.01.16-0030"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002301","name":"Estonian Research Council","doi-asserted-by":"publisher","award":["PUT PRG243"],"award-info":[{"award-number":["PUT PRG243"]}],"id":[{"id":"10.13039\/501100002301","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"Horizon 2020 MSCA","doi-asserted-by":"publisher","award":["765937"],"award-info":[{"award-number":["765937"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"Horizon 2020","doi-asserted-by":"publisher","award":["810645"],"award-info":[{"award-number":["810645"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007821","name":"Tartu \u00dclikool","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007821","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.cub.2022.01.046","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T10:28:49Z","timestamp":1644316129000},"page":"1412-1419.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Ancestral genomic contributions to complex traits in contemporary Europeans"],"prefix":"10.1016","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9573-0601","authenticated-orcid":false,"given":"Davide","family":"Marnetto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasili","family":"Pankratov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayukh","family":"Mondal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Montinaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katri","family":"P\u00e4rna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0590-6333","authenticated-orcid":false,"given":"Leonardo","family":"Vallini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovica","family":"Molinaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lehti","family":"Saag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liisa","family":"Loog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2800-9923","authenticated-orcid":false,"given":"Sara","family":"Montagnese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3099-9161","authenticated-orcid":false,"given":"Mait","family":"Metspalu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Pagani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cub.2022.01.046_bib1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nature13673","article-title":"Ancient human genomes suggest three ancestral populations for present-day Europeans","volume":"513","author":"Lazaridis","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.cub.2022.01.046_bib2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature14317","article-title":"Massive migration from the steppe was a source for Indo-European languages in Europe","volume":"522","author":"Haak","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cub.2022.01.046_bib3","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nature14507","article-title":"Population genomics of Bronze Age Eurasia","volume":"522","author":"Allentoft","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cub.2022.01.046_bib4","doi-asserted-by":"crossref","first-page":"8989","DOI":"10.1073\/pnas.1920051117","article-title":"The spatiotemporal spread of human migrations during the European Holocene","volume":"117","author":"Racimo","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2022.01.046_bib5","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nature12960","article-title":"Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European","volume":"507","author":"Olalde","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.cub.2022.01.046_bib6","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nature16152","article-title":"Genome-wide patterns of selection in 230 ancient Eurasians","volume":"528","author":"Mathieson","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cub.2022.01.046_bib7","doi-asserted-by":"crossref","first-page":"eabd6535","DOI":"10.1126\/sciadv.abd6535","article-title":"Genetic ancestry changes in Stone to Bronze Age transition in the East European plain","volume":"7","author":"Saag","year":"2021","journal-title":"Science Advances"},{"key":"10.1016\/j.cub.2022.01.046_bib8","doi-asserted-by":"crossref","first-page":"21484","DOI":"10.1073\/pnas.1910606116","article-title":"Genetic contributions to variation in human stature in prehistoric Europe","volume":"116","author":"Cox","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2022.01.046_bib9","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2009227118","article-title":"The evolution of skin pigmentation-associated variation in West Eurasia","volume":"118","author":"Ju","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2022.01.046_bib10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.13110\/humanbiology.89.1.01","article-title":"The genomic health of ancient hominins","volume":"89","author":"Berens","year":"2017","journal-title":"Hum. Biol."},{"key":"10.1016\/j.cub.2022.01.046_bib11","doi-asserted-by":"crossref","first-page":"e1004412","DOI":"10.1371\/journal.pgen.1004412","article-title":"A population genetic signal of polygenic adaptation","volume":"10","author":"Berg","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cub.2022.01.046_bib12","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1534\/genetics.117.300489","article-title":"Detecting Polygenic Adaptation in Admixture Graphs","volume":"208","author":"Racimo","year":"2018","journal-title":"Genetics"},{"key":"10.1016\/j.cub.2022.01.046_bib13","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1093\/ije\/dyt268","article-title":"Cohort profile: Estonian biobank of the Estonian genome center, university of Tartu","volume":"44","author":"Leitsalu","year":"2015","journal-title":"Int. J. Epidemiol."},{"issue":"D1","key":"10.1016\/j.cub.2022.01.046_bib14","doi-asserted-by":"crossref","first-page":"D1005","DOI":"10.1093\/nar\/gky1120","article-title":"The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019","volume":"47","author":"Buniello","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cub.2022.01.046_bib15","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s13059-018-1522-1","article-title":"Genes reveal traces of common recent demographic history for most of the Uralic-speaking populations","volume":"19","author":"Tambets","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.cub.2022.01.046_bib16","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.cub.2019.04.026","article-title":"The Arrival of Siberian Ancestry Connecting the Eastern Baltic to Uralic Speakers further East","volume":"29","author":"Saag","year":"2019","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2022.01.046_bib17","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/s41586-018-0094-2","article-title":"137 ancient human genomes from across the Eurasian steppes","volume":"557","author":"Damgaard","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cub.2022.01.046_bib18","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1038\/s41431-020-0699-4","article-title":"Differences in local population history at the finest level: the case of the Estonian population","volume":"28","author":"Pankratov","year":"2020","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.cub.2022.01.046_bib19","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/ng.3390","article-title":"Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index","volume":"47","author":"Yang","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cub.2022.01.046_bib20","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ssresearch.2019.04.008","article-title":"Genetic architecture of socioeconomic outcomes: Educational attainment, occupational status, and wealth","volume":"82","author":"Liu","year":"2019","journal-title":"Soc. Sci. Res."},{"key":"10.1016\/j.cub.2022.01.046_bib21","doi-asserted-by":"crossref","first-page":"eaay0328","DOI":"10.1126\/sciadv.aay0328","article-title":"Population phenomena inflate genetic associations of complex social traits","volume":"6","author":"Morris","year":"2020","journal-title":"Science Advances"},{"key":"10.1016\/j.cub.2022.01.046_bib22","doi-asserted-by":"crossref","first-page":"e1008384","DOI":"10.1371\/journal.pgen.1008384","article-title":"An approximate full-likelihood method for inferring selection and allele frequency trajectories from DNA sequence data","volume":"15","author":"Stern","year":"2019","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cub.2022.01.046_bib23","doi-asserted-by":"crossref","first-page":"10775","DOI":"10.1038\/ncomms10775","article-title":"Human adaptation and population differentiation in the light of ancient genomes","volume":"7","author":"Key","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2022.01.046_bib24","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1086\/421051","article-title":"Genetic signatures of strong recent positive selection at the lactase gene","volume":"74","author":"Bersaglieri","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.cub.2022.01.046_bib25","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1101\/gr.087577.108","article-title":"Signals of recent positive selection in a worldwide sample of human populations","volume":"19","author":"Pickrell","year":"2009","journal-title":"Genome Res."},{"key":"10.1016\/j.cub.2022.01.046_bib26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1471-2350-12-55","article-title":"Geographic differences in allele frequencies of susceptibility SNPs for cardiovascular disease","volume":"12","author":"Ding","year":"2011","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.cub.2022.01.046_bib27","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.aaz1776","article-title":"The GTEx Consortium atlas of genetic regulatory effects across human tissues","volume":"369","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.cub.2022.01.046_bib28","doi-asserted-by":"crossref","first-page":"921","DOI":"10.7150\/ijbs.42300","article-title":"Aldehyde dehydrogenase, liver disease and cancer","volume":"16","author":"Wang","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.cub.2022.01.046_bib29","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.ajhg.2014.03.003","article-title":"Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures","volume":"94","author":"Zhang","year":"2014","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.cub.2022.01.046_bib30","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1093\/molbev\/msx103","article-title":"Selection in Europeans on Fatty Acid Desaturases Associated with Dietary Changes","volume":"34","author":"Buckley","year":"2017","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.cub.2022.01.046_bib31","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1093\/molbev\/msy180","article-title":"FADS1 and the Timing of Human Adaptation to Agriculture","volume":"35","author":"Mathieson","year":"2018","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.cub.2022.01.046_bib38","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation","volume":"526","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cub.2022.01.046_bib39","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13742-015-0047-8","article-title":"Second-generation PLINK: rising to the challenge of larger and richer datasets","volume":"4","author":"Chang","year":"2015","journal-title":"GigaScience"},{"key":"10.1016\/j.cub.2022.01.046_bib40","doi-asserted-by":"crossref","first-page":"e190","DOI":"10.1371\/journal.pgen.0020190","article-title":"Population Structure and Eigenanalysis","volume":"2","author":"Patterson","year":"2006","journal-title":"PLoS Genetics"},{"key":"10.1016\/j.cub.2022.01.046_bib33","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1534\/genetics.115.183913","article-title":"Admixture, population structure, and f-statistics","volume":"202","author":"Peter","year":"2016","journal-title":"Genetics"},{"key":"10.1016\/j.cub.2022.01.046_bib32","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nature08365","article-title":"Reconstructing Indian population history","volume":"461","author":"Reich","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.cub.2022.01.046_bib36","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/s41588-019-0484-x","article-title":"A method for genome-wide genealogy estimation for thousands of samples","volume":"51","author":"Speidel","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cub.2022.01.046_bib34","doi-asserted-by":"crossref","first-page":"e1004842","DOI":"10.1371\/journal.pcbi.1004842","article-title":"Efficient coalescent simulation and genealogical analysis for large sample sizes","volume":"12","author":"Kelleher","year":"2016","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.cub.2022.01.046_bib35","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/s41588-020-0600-y","article-title":"Evaluating and improving heritability models using summary statistics","volume":"52","author":"Speed","year":"2020","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cub.2022.01.046_bib37","article-title":"Advantages of genotype imputation with ethnically matched reference panel for rare variant association analyses","author":"Kals","year":"2019","journal-title":"bioRxiv"}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982222001087?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982222001087?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T07:26:28Z","timestamp":1778570788000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982222001087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S0960982222001087"],"URL":"https:\/\/doi.org\/10.1016\/j.cub.2022.01.046","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ancestral genomic contributions to complex traits in contemporary Europeans","name":"articletitle","label":"Article Title"},{"value":"Current Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cub.2022.01.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}