{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:10:27Z","timestamp":1784740227228,"version":"3.55.0"},"reference-count":83,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":387,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.cub.2022.04.001","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T10:31:49Z","timestamp":1650882709000},"page":"2174-2188.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Glial-secreted Netrins regulate Robo1\/Rac1-Cdc42 signaling threshold levels during Drosophila asymmetric neural stem\/progenitor cell division"],"prefix":"10.1016","volume":"32","author":[{"given":"Ana","family":"de Torres-Jurado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Manzanero-Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1855-7934","authenticated-orcid":false,"given":"Ana","family":"Carmena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cub.2022.04.001_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1741-7007-10-19","article-title":"What does the concept of the stem cell niche really mean today?","volume":"10","author":"Lander","year":"2012","journal-title":"BMC Biol."},{"key":"10.1016\/j.cub.2022.04.001_bib2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cell.2014.02.013","article-title":"Nice neighborhood: emerging concepts of the stem cell niche","volume":"157","author":"Scadden","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.cub.2022.04.001_bib3","first-page":"7","article-title":"The relationship between the spleen colony-forming cell and the haemopoietic stem cell","volume":"4","author":"Schofield","year":"1978","journal-title":"Blood Cells"},{"key":"10.1016\/j.cub.2022.04.001_bib4","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.semcdb.2006.07.004","article-title":"Contrasting mechanisms of stem cell maintenance in Drosophila","volume":"17","author":"Harrison","year":"2006","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.cub.2022.04.001_bib5","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.cell.2008.01.038","article-title":"Stem cells and niches: mechanisms that promote stem cell maintenance throughout life","volume":"132","author":"Morrison","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.cub.2022.04.001_bib6","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.conb.2017.10.025","article-title":"Glial control of neurogenesis","volume":"47","author":"Falk","year":"2017","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.cub.2022.04.001_bib7","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.devcel.2015.01.010","article-title":"It takes a village: constructing the neurogenic niche","volume":"32","author":"Bjornsson","year":"2015","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2022.04.001_bib8","doi-asserted-by":"crossref","first-page":"dev165399","DOI":"10.1242\/dev.165399","article-title":"Signaling in the stem cell niche: regulating cell fate, function and plasticity","volume":"145","author":"Chac\u00f3n-Mart\u00ednez","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.cub.2022.04.001_bib9","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/wdev.27","article-title":"A niche for Drosophila neuroblasts?","volume":"1","author":"Chai","year":"2012","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"key":"10.1016\/j.cub.2022.04.001_bib10","doi-asserted-by":"crossref","first-page":"4297","DOI":"10.1242\/dev.080515","article-title":"Drosophila neuroblasts: a model for stem cell biology","volume":"139","author":"Homem","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.cub.2022.04.001_bib11","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1083\/jcb.200905024","article-title":"The interphase microtubule aster is a determinant of asymmetric division orientation in Drosophila neuroblasts","volume":"188","author":"Januschke","year":"2010","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.cub.2022.04.001_bib12","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.ejcb.2006.02.006","article-title":"A primary cell culture of Drosophila postembryonic larval neuroblasts to study cell cycle and asymmetric division","volume":"85","author":"Ceron","year":"2006","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.cub.2022.04.001_bib13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.devcel.2011.10.027","article-title":"Tre1 GPCR signaling orients stem cell divisions in the Drosophila central nervous system","volume":"22","author":"Yoshiura","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2022.04.001_bib14","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1242\/dev.02429","article-title":"The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila","volume":"133","author":"Bello","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.cub.2022.04.001_bib15","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.cell.2006.01.038","article-title":"Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells","volume":"124","author":"Betschinger","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.cub.2022.04.001_bib16","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.devcel.2008.03.004","article-title":"The tumor suppressors Brat and Numb regulate\u00a0transit-amplifying neuroblast lineages in Drosophila","volume":"14","author":"Bowman","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2022.04.001_bib17","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/377627a0","article-title":"Asymmetric segregation of the homeodomain protein Prospero during Drosophila development","volume":"377","author":"Hirata","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.cub.2022.04.001_bib18","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/377624a0","article-title":"Asymmetric segregation of Numb and Prospero during cell division","volume":"377","author":"Knoblich","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.cub.2022.04.001_bib19","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.devcel.2006.01.017","article-title":"Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal","volume":"10","author":"Lee","year":"2006","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2022.04.001_bib20","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0092-8674(94)90112-0","article-title":"Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells","volume":"76","author":"Rhyu","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.cub.2022.04.001_bib21","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1242\/dev.121.10.3187","article-title":"The Prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila","volume":"121","author":"Spana","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.cub.2022.04.001_bib22","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0092-8674(89)90849-0","article-title":"numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos","volume":"58","author":"Uemura","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.cub.2022.04.001_bib23","doi-asserted-by":"crossref","first-page":"20998","DOI":"10.1073\/pnas.1113077108","article-title":"Inscuteable and NuMA proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisions","volume":"108","author":"Culurgioni","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2022.04.001_bib24","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1016\/j.cub.2015.08.064","article-title":"The hippo pathway core cassette regulates asymmetric cell division","volume":"25","author":"Keder","year":"2015","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2022.04.001_bib25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1006\/dbio.1996.0052","article-title":"inscuteable, a neural precursor gene of Drosophila, encodes a candidate for a cytoskeleton adaptor protein","volume":"174","author":"Kraut","year":"1996","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cub.2022.04.001_bib26","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/383050a0","article-title":"Role of inscuteable in orienting asymmetric cell divisions in Drosophila","volume":"383","author":"Kraut","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.cub.2022.04.001_bib27","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/S0960-9822(98)00016-5","article-title":"Control of spindle orientation in Drosophila by the Par-3-related PDZ-domain protein Bazooka","volume":"8","author":"Kuchinke","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2022.04.001_bib28","doi-asserted-by":"crossref","first-page":"RC84","DOI":"10.1523\/JNEUROSCI.20-14-j0003.2000","article-title":"Rapsynoid\/partner of inscuteable controls asymmetric division of larval neuroblasts in Drosophila","volume":"20","author":"Parmentier","year":"2000","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cub.2022.04.001_bib29","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/35050550","article-title":"DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila","volume":"3","author":"Petronczki","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cub.2022.04.001_bib30","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0092-8674(01)00521-9","article-title":"Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system","volume":"107","author":"Schaefer","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.cub.2022.04.001_bib31","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0960-9822(00)00401-2","article-title":"A protein complex containing Inscuteable and the Galpha-binding protein Pins orients asymmetric cell divisions in Drosophila","volume":"10","author":"Schaefer","year":"2000","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2022.04.001_bib32","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/990135","article-title":"Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts","volume":"402","author":"Schober","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.cub.2022.04.001_bib33","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1083\/jcb.150.6.1361","article-title":"Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts","volume":"150","author":"Wodarz","year":"2000","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.cub.2022.04.001_bib34","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/990128","article-title":"Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts","volume":"402","author":"Wodarz","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.cub.2022.04.001_bib35","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1083\/jcb.200303174","article-title":"Distinct roles of Galphai and Gbeta13F subunits of the heterotrimeric G protein complex in the mediation of Drosophila neuroblast asymmetric divisions","volume":"162","author":"Yu","year":"2003","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.cub.2022.04.001_bib36","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0092-8674(00)80676-5","article-title":"Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization","volume":"100","author":"Yu","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.cub.2022.04.001_bib37","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.cub.2008.04.072","article-title":"The PDZ protein Canoe regulates the asymmetric division of Drosophila neuroblasts and muscle progenitors","volume":"18","author":"Speicher","year":"2008","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2022.04.001_bib38","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1083\/jcb.201108112","article-title":"The Rap1-Rgl-Ral signaling network regulates neuroblast cortical polarity and spindle orientation","volume":"195","author":"Carmena","year":"2011","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.cub.2022.04.001_bib39","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/ncb1412","article-title":"The NuMA-related Mud protein binds Pins and regulates spindle orientation in Drosophila neuroblasts","volume":"8","author":"Siller","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cub.2022.04.001_bib40","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.devcel.2006.05.005","article-title":"The Drosophila NuMA Homolog Mud regulates spindle orientation in asymmetric cell division","volume":"10","author":"Bowman","year":"2006","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2022.04.001_bib41","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/ncb1409","article-title":"Drosophila Pins-binding protein Mud regulates spindle-polarity coupling and centrosome organization","volume":"8","author":"Izumi","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cub.2022.04.001_bib42","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1242\/dev.125.11.2149","article-title":"Environmental control of the cell cycle in Drosophila: nutrition activates mitotic and endoreplicative cells by distinct mechanisms","volume":"125","author":"Britton","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.cub.2022.04.001_bib43","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1242\/dev.02211","article-title":"Extrinsic cues orient the cell division axis in Drosophila embryonic neuroblasts","volume":"133","author":"Siegrist","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.cub.2022.04.001_bib44","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.cell.2015.09.020","article-title":"Antioxidant role for lipid droplets in a stem cell niche of Drosophila","volume":"163","author":"Bailey","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cub.2022.04.001_bib45","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.cell.2011.06.040","article-title":"Anaplastic lymphoma kinase spares organ growth during nutrient restriction in Drosophila","volume":"146","author":"Cheng","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.cub.2022.04.001_bib46","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ydbio.2005.04.024","article-title":"Morphogenesis and proliferation of the larval brain glia in Drosophila","volume":"283","author":"Pereanu","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cub.2022.04.001_bib47","doi-asserted-by":"crossref","first-page":"e30413","DOI":"10.7554\/eLife.30413","article-title":"Systemic and local cues drive neural stem cell niche remodelling during neurogenesis in Drosophila","volume":"7","author":"Sp\u00e9der","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.cub.2022.04.001_bib49","doi-asserted-by":"crossref","first-page":"10035","DOI":"10.1523\/JNEUROSCI.6342-11.2012","article-title":"The actin-binding protein Canoe\/AF-6 forms a complex with Robo and is required for Slit-Robo signaling during axon pathfinding at the CNS midline","volume":"32","author":"Slov\u00e1kov\u00e1","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cub.2022.04.001_bib48","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1749-8104-4-44","article-title":"Postembryonic development of transit amplifying neuroblast lineages in the Drosophila brain","volume":"4","author":"Izergina","year":"2009","journal-title":"Neural Dev."},{"key":"10.1016\/j.cub.2022.04.001_bib50","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.stem.2011.02.022","article-title":"Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi","volume":"8","author":"Neum\u00fcller","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cub.2022.04.001_bib51","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1534\/genetics.104.036863","article-title":"Slit-roundabout signaling neutralizes netrin-Frazzled-mediated attractant cue to specify the lateral positioning of longitudinal axon pathways","volume":"170","author":"Bhat","year":"2005","journal-title":"Genetics"},{"key":"10.1016\/j.cub.2022.04.001_bib52","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1126\/science.1058445","article-title":"Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo\/DCC receptor complex","volume":"291","author":"Stein","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.cub.2022.04.001_bib53","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nn1612","article-title":"ROBO directs axon crossing of segmental boundaries by suppressing responsiveness to relocalized netrin","volume":"9","author":"Hiramoto","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cub.2022.04.001_bib54","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0092-8674(00)80883-1","article-title":"Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor","volume":"101","author":"Bashaw","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.cub.2022.04.001_bib55","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1242\/dev.093831","article-title":"Distinct functional domains of the Abelson tyrosine kinase control axon guidance responses to Netrin and Slit to regulate the assembly of neural circuits","volume":"140","author":"O'Donnell","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.cub.2022.04.001_bib56","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1242\/dev.01736","article-title":"The Abelson tyrosine kinase, the Trio GEF and enabled interact with the Netrin receptor frazzled in Drosophila","volume":"132","author":"Forsthoefel","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.cub.2022.04.001_bib57","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/sj.emboj.7601495","article-title":"aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb","volume":"26","author":"Smith","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.cub.2022.04.001_bib58","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1073\/pnas.0409325102","article-title":"Cross GTPase-activating protein (CrossGAP)\/Vilse links the Roundabout receptor to Rac to regulate midline repulsion","volume":"102","author":"Hu","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2022.04.001_bib59","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1101\/gad.310204","article-title":"Vilse, a conserved Rac\/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons","volume":"18","author":"Lundstr\u00f6m","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.cub.2022.04.001_bib60","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0896-6273(03)00591-9","article-title":"Slit stimulation recruits Dock and Pak to the roundabout receptor and increases Rac activity to regulate axon repulsion at the CNS midline","volume":"40","author":"Fan","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2022.04.001_bib61","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.neuron.2006.09.039","article-title":"Son of sevenless directly links the Robo receptor to rac activation to control axon repulsion at the midline","volume":"52","author":"Yang","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2022.04.001_bib62","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/S0960-9822(98)00398-4","article-title":"Actin cytoskeleton organization regulated by the PAK family of protein kinases","volume":"8","author":"Eby","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2022.04.001_bib63","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1128\/MCB.16.5.1896","article-title":"A Drosophila homolog of the Rac- and Cdc42-activated serine\/threonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures","volume":"16","author":"Harden","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cub.2022.04.001_bib64","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.1242\/jcs.014902","article-title":"Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC","volume":"120","author":"Atwood","year":"2007","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.cub.2022.04.001_bib65","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/35019573","article-title":"The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42","volume":"2","author":"Joberty","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cub.2022.04.001_bib66","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0960-9822(00)00535-2","article-title":"A human homolog of the C.\u00a0elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation","volume":"10","author":"Qiu","year":"2000","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2022.04.001_bib67","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/35019582","article-title":"A mammalian PAR-3-PAR-6 complex implicated in Cdc42\/Rac1 and aPKC signalling and cell polarity","volume":"2","author":"Lin","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cub.2022.04.001_bib68","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1242\/jcs.113.18.3267","article-title":"The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1","volume":"113","author":"Johansson","year":"2000","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.cub.2022.04.001_bib69","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.stem.2007.07.003","article-title":"The adult Drosophila malpighian tubules are maintained by multipotent stem cells","volume":"1","author":"Singh","year":"2007","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cub.2022.04.001_bib70","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.jgg.2014.11.001","article-title":"Differential Notch activity is required for homeostasis of malpighian tubules in adult Drosophila","volume":"41","author":"Li","year":"2014","journal-title":"J.\u00a0Genet. Genomics"},{"key":"10.1016\/j.cub.2022.04.001_bib71","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.celrep.2012.07.008","article-title":"FACS purification and transcriptome analysis of drosophila neural stem cells reveals a role for Klumpfuss in self-renewal","volume":"2","author":"Berger","year":"2012","journal-title":"Cell Rep."},{"key":"10.1016\/j.cub.2022.04.001_bib72","doi-asserted-by":"crossref","first-page":"e79588","DOI":"10.1371\/journal.pone.0079588","article-title":"Long-term live cell imaging and automated 4D analysis of drosophila neuroblast lineages","volume":"8","author":"Homem","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cub.2022.04.001_bib73","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.neuron.2012.08.003","article-title":"Slit\/Robo signaling modulates the proliferation of central nervous system progenitors","volume":"76","author":"Borrell","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2022.04.001_bib74","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.ydbio.2007.10.052","article-title":"The role of Slit-Robo signaling in the generation, migration and morphological differentiation of cortical interneurons","volume":"313","author":"Andrews","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cub.2022.04.001_bib75","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1242\/dev.128.16.3161","article-title":"Slit signaling promotes the terminal asymmetric division of neural precursor cells in the Drosophila CNS","volume":"128","author":"Mehta","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.cub.2022.04.001_bib76","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.celrep.2015.09.006","article-title":"Mammary stem cell self-renewal is regulated by Slit2\/Robo1 signaling through SNAI1 and mINSC","volume":"13","author":"Ballard","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.cub.2022.04.001_bib77","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/j.celrep.2014.05.024","article-title":"Slit\/Robo signaling regulates cell fate decisions in the intestinal stem cell lineage of Drosophila","volume":"7","author":"Biteau","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.cub.2022.04.001_bib78","doi-asserted-by":"crossref","first-page":"5082","DOI":"10.1038\/s41467-018-07474-6","article-title":"Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors","volume":"9","author":"Escot","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2022.04.001_bib79","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.stem.2010.11.030","article-title":"Robo4 cooperates with CXCR4 to specify hematopoietic stem cell localization to bone marrow niches","volume":"8","author":"Smith-Berdan","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cub.2022.04.001_bib80","doi-asserted-by":"crossref","first-page":"e1004713","DOI":"10.1371\/journal.pgen.1004713","article-title":"Coordinate regulation of stem cell competition by Slit-Robo and JAK-STAT signaling in the Drosophila testis","volume":"10","author":"Stine","year":"2014","journal-title":"PLOS Genet."},{"key":"10.1016\/j.cub.2022.04.001_bib81","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/367040a0","article-title":"A brain serine\/threonine protein kinase activated by Cdc42 and Rac1","volume":"367","author":"Manser","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.cub.2022.04.001_bib82","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1242\/dev.148171","article-title":"Synergism between canoe and scribble mutations causes tumor-like overgrowth via Ras activation in neural stem cells and epithelia","volume":"144","author":"Rives-Quinto","year":"2017","journal-title":"Development"},{"key":"10.1016\/j.cub.2022.04.001_bib83","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ydbio.2008.08.028","article-title":"Slit and Robo regulate dendrite branching and elongation of space-filling neurons in Drosophila","volume":"324","author":"Dimitrova","year":"2008","journal-title":"Dev. Biol."}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982222005668?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982222005668?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:03:39Z","timestamp":1760781819000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982222005668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":83,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S0960982222005668"],"URL":"https:\/\/doi.org\/10.1016\/j.cub.2022.04.001","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glial-secreted Netrins regulate Robo1\/Rac1-Cdc42 signaling threshold levels during Drosophila asymmetric neural stem\/progenitor cell division","name":"articletitle","label":"Article Title"},{"value":"Current Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cub.2022.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}