{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:23:44Z","timestamp":1785907424742,"version":"3.56.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"21","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/V016318\/1"],"award-info":[{"award-number":["BB\/V016318\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/W004623\/1"],"award-info":[{"award-number":["MR\/W004623\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/P009824\/2"],"award-info":[{"award-number":["MR\/P009824\/2"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/P009824\/1"],"award-info":[{"award-number":["MR\/P009824\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000723","name":"Tenovus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000723","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000882","name":"University of Aberdeen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000882","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018353","name":"European Crohn's and Colitis Organisation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018353","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.cub.2022.09.017","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T13:45:47Z","timestamp":1664545547000},"page":"4699-4706.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Hypothalamic AgRP neurons exert top-down control on systemic TNF-\u03b1 release during endotoxemia"],"prefix":"10.1016","volume":"32","author":[{"given":"Mehdi","family":"Boutagouga Boudjadja","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Culotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela C.","family":"De Paula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Harno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Paulo","family":"Cavalcanti-de-Albuquerque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon M.","family":"Luckman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Hepworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Aviello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3502-4251","authenticated-orcid":false,"given":"Giuseppe","family":"D\u2019Agostino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cub.2022.09.017_bib1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0149-7634(88)80004-6","article-title":"Biological basis of the behavior of sick animals","volume":"12","author":"Hart","year":"1988","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.cub.2022.09.017_bib2","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.cell.2016.07.026","article-title":"Opposing effects of fasting metabolism on tissue tolerance in bacterial and viral inflammation","volume":"166","author":"Wang","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cub.2022.09.017_bib3","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/ajcn\/32.3.593","article-title":"Anorexia of infection as a mechanism of host defense","volume":"32","author":"Murray","year":"1979","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.cub.2022.09.017_bib4","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1128\/iai.28.3.771-776.1980","article-title":"Acute starvation protects mice against Listeria monocytogenes","volume":"28","author":"Wing","year":"1980","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cub.2022.09.017_bib5","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.neuron.2017.06.014","article-title":"Toward a wiring diagram understanding of appetite control","volume":"95","author":"Andermann","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2022.09.017_bib6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/1082","article-title":"Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons","volume":"1","author":"Hahn","year":"1998","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cub.2022.09.017_bib7","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1126\/science.1089459","article-title":"Rapid rewiring of arcuate nucleus feeding circuits by leptin","volume":"304","author":"Pinto","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.cub.2022.09.017_bib8","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1210\/en.2004-1397","article-title":"Fasting induces a large, leptin-dependent increase in the intrinsic action potential frequency of orexigenic\u00a0arcuate nucleus neuropeptide Y\/Agouti-related protein neurons","volume":"146","author":"Takahashi","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.cub.2022.09.017_bib9","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/nn1548","article-title":"Agouti-related peptide-expressing neurons are mandatory for feeding","volume":"8","author":"Gropp","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cub.2022.09.017_bib10","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1126\/science.1115524","article-title":"NPY\/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates","volume":"310","author":"Luquet","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.cub.2022.09.017_bib11","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/nn.2739","article-title":"AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training","volume":"14","author":"Aponte","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cub.2022.09.017_bib12","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.cmet.2013.09.009","article-title":"Rapid versus delayed stimulation of feeding by the endogenously released AgRP neuron mediators GABA, NPY, and AgRP","volume":"18","author":"Krashes","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.cub.2022.09.017_bib13","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.cell.2015.02.024","article-title":"Hypothalamic Agrp neurons drive stereotypic behaviors beyond feeding","volume":"160","author":"Dietrich","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cub.2022.09.017_bib14","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1172\/JCI46229","article-title":"Rapid, reversible activation of AgRP neurons drives feeding behavior in mice","volume":"121","author":"Krashes","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cub.2022.09.017_bib15","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.1016\/j.cub.2021.06.048","article-title":"Hypothalamic control of interoceptive hunger","volume":"31","author":"Siemian","year":"2021","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2022.09.017_bib16","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nature22375","article-title":"Homeostatic circuits selectively gate food cue responses in insular cortex","volume":"546","author":"Livneh","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cub.2022.09.017_bib17","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/35013070","article-title":"Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin","volume":"405","author":"Borovikova","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.cub.2022.09.017_bib18","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nn.4477","article-title":"Neural regulation of immunity: molecular mechanisms and clinical translation","volume":"20","author":"Pavlov","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cub.2022.09.017_bib19","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1159\/000049019","article-title":"Lipopolysaccharide-induced tumor necrosis factor-alpha release is controlled by the central nervous system","volume":"9","author":"Mastronardi","year":"2001","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.cub.2022.09.017_bib20","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41577-020-0387-1","article-title":"Neuronal regulation of immunity: why, how and where?","volume":"21","author":"Schiller","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cub.2022.09.017_bib21","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1074\/jbc.M607809200","article-title":"Food intake regulates oleoylethanolamide formation and degradation in the proximal small intestine","volume":"282","author":"Fu","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cub.2022.09.017_bib22","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/35102582","article-title":"An anorexic lipid mediator regulated by feeding","volume":"414","author":"Rodr\u00edguez de Fonseca","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.cub.2022.09.017_bib23","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1210\/en.2015-2081","article-title":"Lipopolysacharide rapidly and completely suppresses AgRP neuron-mediated food intake in male mice","volume":"157","author":"Liu","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.cub.2022.09.017_bib24","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nature14416","article-title":"Neurons for hunger and thirst transmit a negative-valence teaching signal","volume":"521","author":"Betley","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cub.2022.09.017_bib25","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.46348","article-title":"Sustained NPY signaling enables AgRP neurons to drive feeding","volume":"8","author":"Chen","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.cub.2022.09.017_bib26","doi-asserted-by":"crossref","first-page":"e07122","DOI":"10.7554\/eLife.07122","article-title":"Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales","volume":"4","author":"Mandelblat-Cerf","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.cub.2022.09.017_bib27","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/bies.201500167","article-title":"Making sense of the sensory regulation of hunger neurons","volume":"38","author":"Chen","year":"2016","journal-title":"BioEssays"},{"key":"10.1016\/j.cub.2022.09.017_bib28","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.neuron.2017.09.043","article-title":"Dynamics of gut-brain communication underlying hunger","volume":"96","author":"Beutler","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2022.09.017_bib29","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1016\/j.celrep.2017.11.036","article-title":"Nutritive, post-ingestive signals are the primary regulators of AgRP neuron activity","volume":"21","author":"Su","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.cub.2022.09.017_bib30","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3181\/00379727-61-15291P","article-title":"Development of tolerance to typhoid bacterial pyrogen and its abolition by reticulo-endothelial blockade","volume":"61","author":"Beeson","year":"1946","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.cub.2022.09.017_bib31","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nri1004","article-title":"Innate immune sensing and its roots: the story of endotoxin","volume":"3","author":"Beutler","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cub.2022.09.017_bib32","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/00024382-199605000-00012","article-title":"Partial hepatectomy reduces the endotoxin-induced peak circulating level of tumor necrosis factor in rats","volume":"5","author":"Kumins","year":"1996","journal-title":"Shock"},{"key":"10.1016\/j.cub.2022.09.017_bib33","doi-asserted-by":"crossref","first-page":"e22848","DOI":"10.7554\/eLife.22848","article-title":"mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice","volume":"6","author":"Burke","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.cub.2022.09.017_bib34","doi-asserted-by":"crossref","first-page":"6193","DOI":"10.1073\/pnas.1210644110","article-title":"Hunger-promoting hypothalamic neurons modulate effector and regulatory T-cell responses","volume":"110","author":"Matarese","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2022.09.017_bib35","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nri.2017.1","article-title":"Immune regulation by glucocorticoids","volume":"17","author":"Cain","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cub.2022.09.017_bib36","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1365-2826.1992.tb00207.x","article-title":"Glucocorticoids are required for food deprivation-induced increases in hypothalamic neuropeptide Y expression","volume":"4","author":"Ponsalle","year":"1992","journal-title":"J.\u00a0Neuroendocrinol."},{"key":"10.1016\/j.cub.2022.09.017_bib37","doi-asserted-by":"crossref","first-page":"13776","DOI":"10.1038\/s41598-021-93378-3","article-title":"Chronic glucocorticoid treatment induces hepatic lipid accumulation and hyperinsulinaemia in part through actions on AgRP neurons","volume":"11","author":"Harno","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cub.2022.09.017_bib38","doi-asserted-by":"crossref","first-page":"13670","DOI":"10.1073\/pnas.1901795116","article-title":"Leptin's hunger-suppressing effects are mediated by the hypothalamic-pituitary-adrenocortical axis in rodents","volume":"116","author":"Perry","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2022.09.017_bib39","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1210\/en.2015-1430","article-title":"AgRP neuron-specific deletion of glucocorticoid receptor leads to increased energy expenditure and decreased body weight in female mice on a high-fat diet","volume":"157","author":"Shibata","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.cub.2022.09.017_bib40","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1111\/bph.15189","article-title":"Brain control of appetite during sickness","volume":"178","author":"Aviello","year":"2021","journal-title":"Br. J. Pharmacol."}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982222014610?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982222014610?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T07:26:25Z","timestamp":1778570785000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982222014610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":40,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S0960982222014610"],"URL":"https:\/\/doi.org\/10.1016\/j.cub.2022.09.017","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypothalamic AgRP neurons exert top-down control on systemic TNF-\u03b1 release during endotoxemia","name":"articletitle","label":"Article Title"},{"value":"Current Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cub.2022.09.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}