{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:01:35Z","timestamp":1790834495820,"version":"4.1.0"},"reference-count":99,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.cub.2023.01.039","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T12:48:28Z","timestamp":1676378908000},"page":"940-956.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection"],"prefix":"10.1016","volume":"33","author":[{"given":"Andrew E.","family":"Prendergast","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kin Ki","family":"Jim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Marnas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Desban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng B.","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Djenoune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Laghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Hocquemiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias T.","family":"Lunsford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Roussel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Keiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois-Xavier","family":"Lejeune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahalakshmi","family":"Dhanasekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Luc","family":"Bardet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Levraud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diederik","family":"van de Beek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M.J.E.","family":"Vandenbroucke-Grauls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1668-4975","authenticated-orcid":false,"given":"Claire","family":"Wyart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cub.2023.01.039_bib1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature12479","article-title":"Bacteria activate sensory neurons that modulate pain and inflammation","volume":"501","author":"Chiu","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.cub.2023.01.039_bib2","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1126\/science.1173869","article-title":"Motile cilia of human airway epithelia are chemosensory","volume":"325","author":"Shah","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.cub.2023.01.039_bib3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF02593586","article-title":"\u00dcber ein zentrales Sinnesorgan (?) bei den Vertebraten","volume":"66","author":"Agduhr","year":"1922","journal-title":"Z.\u00a0Anat. Entwicklungsgesch."},{"key":"10.1016\/j.cub.2023.01.039_bib4","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1007\/BF02593657","article-title":"Das 'Sagitallorgan' der Wirbeltiere","volume":"60","author":"Kolmer","year":"1921","journal-title":"Z.\u00a0Anat. Entwickl. Gesch."},{"key":"10.1016\/j.cub.2023.01.039_bib5","doi-asserted-by":"crossref","first-page":"10866","DOI":"10.1038\/ncomms10866","article-title":"CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits","volume":"7","author":"B\u00f6hm","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2023.01.039_bib6","doi-asserted-by":"crossref","first-page":"10002","DOI":"10.1038\/ncomms10002","article-title":"Ciliated neurons lining the central canal sense both fluid movement and pH through ASIC3","volume":"7","author":"Jalalvand","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2023.01.039_bib7","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.cub.2019.12.071","article-title":"Sensory neurons contacting the cerebrospinal fluid require the reissner fiber to detect spinal curvature in\u00a0vivo","volume":"30","author":"Orts-Del'Immagine","year":"2020","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2023.01.039_bib8","doi-asserted-by":"crossref","first-page":"3804","DOI":"10.1038\/s41467-018-06225-x","article-title":"Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature","volume":"9","author":"Sternberg","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2023.01.039_bib10","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1016\/j.cub.2015.09.070","article-title":"State-dependent modulation of locomotion by GABAergic spinal sensory neurons","volume":"25","author":"Fidelin","year":"2015","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2023.01.039_bib11","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1016\/j.cub.2016.08.026","article-title":"Intraspinal sensory neurons provide powerful inhibition to motor circuits ensuring postural control during locomotion","volume":"26","author":"Hubbard","year":"2016","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2023.01.039_bib12","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1016\/j.cub.2021.05.042","article-title":"Spinal sensory neurons project onto the hindbrain to stabilize posture and enhance locomotor speed","volume":"31","author":"Wu","year":"2021","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2023.01.039_bib13","doi-asserted-by":"crossref","first-page":"e59469","DOI":"10.7554\/eLife.59469","article-title":"Adrenergic activation modulates the signal from the Reissner fiber to cerebrospinal fluid-contacting neurons during development","volume":"9","author":"Cantaut-Belarif","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.cub.2023.01.039_bib14","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1016\/j.cub.2018.05.079","article-title":"The reissner fiber in the cerebrospinal fluid controls morphogenesis of the body axis","volume":"28","author":"Cantaut-Belarif","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2023.01.039_bib15","doi-asserted-by":"crossref","first-page":"e0119290","DOI":"10.1371\/journal.pone.0119290","article-title":"Comparative distribution and in\u00a0vitro activities of the urotensin II-related peptides URP1 and URP2 in zebrafish: evidence for their colocalization in spinal cerebrospinal fluid-contacting neurons","volume":"10","author":"Quan","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.cub.2023.01.039_bib16","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1038\/s41588-018-0260-3","article-title":"Cilia-driven cerebrospinal fluid flow directs expression of urotensin neuropeptides to straighten the vertebrate body axis","volume":"50","author":"Zhang","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cub.2023.01.039_bib17","doi-asserted-by":"crossref","first-page":"bio052027","DOI":"10.1242\/bio.052027","article-title":"Reissner fibre-induced urotensin signalling from cerebrospinal fluid-contacting neurons prevents scoliosis of the vertebrate spine","volume":"9","author":"Lu","year":"2020","journal-title":"Biol. Open"},{"key":"10.1016\/j.cub.2023.01.039_bib18","doi-asserted-by":"crossref","first-page":"210065","DOI":"10.1098\/rsob.210065","article-title":"Conserved role of the urotensin II receptor 4 signalling pathway to control body straightness in a tetrapod","volume":"11","author":"Alejevski","year":"2021","journal-title":"Open Biol."},{"key":"10.1016\/j.cub.2023.01.039_bib19","doi-asserted-by":"crossref","first-page":"e83883","DOI":"10.7554\/eLife.83883","article-title":"Urotensin II-related peptides, Urp1 and Urp2, control zebrafish spine morphology","volume":"11","author":"Bearce","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.cub.2023.01.039_bib20","series-title":"Urp1 and Urp2 act redundantly to maintain spine shape in zebrafish larvae","author":"Gaillard","year":"2022"},{"key":"10.1016\/j.cub.2023.01.039_bib21","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fnana.2014.00026","article-title":"Investigation of spinal cerebrospinal fluid-contacting neurons expressing PKD2L1: evidence for a conserved system from fish to primates","volume":"8","author":"Djenoune","year":"2014","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.cub.2023.01.039_bib22","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/nature05084","article-title":"The cells and logic for mammalian sour taste detection","volume":"442","author":"Huang","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.cub.2023.01.039_bib23","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1113\/jphysiol.2012.227959","article-title":"Properties of subependymal cerebrospinal fluid contacting neurones in the dorsal vagal complex of the mouse brainstem","volume":"590","author":"Orts-Del'immagine","year":"2012","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.cub.2023.01.039_bib24","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3390\/toxins13020137","article-title":"Botulinum neurotoxin injections in childhood opisthotonus","volume":"13","author":"Hull","year":"2021","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.cub.2023.01.039_bib25","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s12974-016-0655-y","article-title":"Infection of zebrafish embryos with live fluorescent Streptococcus pneumoniae as a real-time pneumococcal meningitis model","volume":"13","author":"Jim","year":"2016","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.cub.2023.01.039_bib26","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/S1474-4422(18)30387-9","article-title":"Global, regional, and national burden of meningitis, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"17","author":"Zunt","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.cub.2023.01.039_bib27","doi-asserted-by":"crossref","first-page":"16074","DOI":"10.1038\/nrdp.2016.74","article-title":"Community-acquired bacterial meningitis","volume":"2","author":"van de Beek","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.cub.2023.01.039_bib28","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/S0140-6736(21)00883-7","article-title":"Community-acquired bacterial meningitis","volume":"398","author":"van de Beek","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.cub.2023.01.039_bib29","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1056\/NEJMra052116","article-title":"Community-acquired bacterial meningitis in adults","volume":"354","author":"van de Beek","year":"2006","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cub.2023.01.039_bib30","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1056\/NEJMoa040845","article-title":"Clinical features and prognostic factors in adults with bacterial meningitis","volume":"351","author":"van de Beek","year":"2004","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cub.2023.01.039_bib31","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1212\/01.wnl.0000288178.91614.5d","article-title":"Seizures in adults with bacterial meningitis","volume":"70","author":"Zoons","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.cub.2023.01.039_bib32","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1242\/jeb.203.17.2565","article-title":"Locomotor repertoire of the larval zebrafish: swimming, turning and prey capture","volume":"203","author":"Budick","year":"2000","journal-title":"J.\u00a0Exp. Biol."},{"key":"10.1016\/j.cub.2023.01.039_bib33","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1097\/WCO.0000000000000817","article-title":"The biological basis of chronic fatigue: neuroinflammation and innate immunity","volume":"33","author":"Omdal","year":"2020","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.cub.2023.01.039_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neubiorev.2020.06.010","article-title":"Seizing the moment: zebrafish epilepsy models","volume":"116","author":"Gawel","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.cub.2023.01.039_bib35","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/nrmicro1871","article-title":"The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease","volume":"6","author":"Kadioglu","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.cub.2023.01.039_bib36","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.1099\/mic.0.062687-0","article-title":"Characterization of volatile metabolites taken up by or released from Streptococcus pneumoniae and Haemophilus influenzae by using GC-MS","volume":"158","author":"Filipiak","year":"2012","journal-title":"Microbiology (Reading)"},{"key":"10.1016\/j.cub.2023.01.039_bib37","doi-asserted-by":"crossref","first-page":"9824","DOI":"10.1074\/jbc.RA117.001005","article-title":"Activation of airway epithelial bitter taste receptors by Pseudomonas aeruginosa quinolones modulates calcium, cyclic-AMP, and nitric oxide signaling","volume":"293","author":"Freund","year":"2018","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cub.2023.01.039_bib38","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1177\/1753425913503386","article-title":"Mouse nasal epithelial innate immune responses to Pseudomonas aeruginosa quorum-sensing molecules require taste signaling components","volume":"20","author":"Lee","year":"2014","journal-title":"Innate Immun."},{"key":"10.1016\/j.cub.2023.01.039_bib39","doi-asserted-by":"crossref","first-page":"6075","DOI":"10.1073\/pnas.1402251111","article-title":"Cholinergic neurotransmission links solitary chemosensory cells to nasal inflammation","volume":"111","author":"Saunders","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2023.01.039_bib40","doi-asserted-by":"crossref","first-page":"3210","DOI":"10.1073\/pnas.0911934107","article-title":"Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signals","volume":"107","author":"Tizzano","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2023.01.039_bib41","doi-asserted-by":"crossref","first-page":"e0181302","DOI":"10.1371\/journal.pone.0181302","article-title":"The human bitter taste receptor T2R38 is broadly tuned for bacterial compounds","volume":"12","author":"Verbeurgt","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.cub.2023.01.039_bib42","doi-asserted-by":"crossref","first-page":"e1003311","DOI":"10.1371\/journal.ppat.1003311","article-title":"Volatile metabolites of pathogens: a systematic review","volume":"9","author":"Bos","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cub.2023.01.039_bib43","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fcell.2017.00005","article-title":"Identification and expression analysis of the complete family of zebrafish pkd genes","volume":"5","author":"England","year":"2017","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cub.2023.01.039_bib44","first-page":"880","article-title":"The late and dual origin of cerebrospinal fluid-contacting neurons in the mouse spinal cord","volume":"143","author":"Petracca","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.cub.2023.01.039_bib45","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3389\/fnins.2018.00170","article-title":"Tal1, Gata2a, and Gata3 have distinct functions in the development of V2b and cerebrospinal fluid-contacting KA spinal neurons","volume":"12","author":"Andrzejczuk","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.cub.2023.01.039_bib46","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1242\/dev.001602","article-title":"Notch signaling regulates neural precursor allocation and binary neuronal fate decisions in zebrafish","volume":"134","author":"Shin","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.cub.2023.01.039_bib47","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1242\/dev.048470","article-title":"Regulatory interactions specifying Kolmer-Agduhr interneurons","volume":"137","author":"Yang","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.cub.2023.01.039_bib48","doi-asserted-by":"crossref","first-page":"e3000235","DOI":"10.1371\/journal.pbio.3000235","article-title":"Regulation of the apical extension morphogenesis tunes the mechanosensory response of microvilliated neurons","volume":"17","author":"Desban","year":"2019","journal-title":"PLoS Biol."},{"key":"10.1016\/j.cub.2023.01.039_bib49","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0304-3940(91)90516-V","article-title":"Co-localized GABA and somatostatin use different ionic mechanisms to hyperpolarize target neurons in the lamprey spinal cord","volume":"134","author":"Christenson","year":"1991","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.cub.2023.01.039_bib50","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41598-017-00350-1","article-title":"The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes","volume":"7","author":"Djenoune","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cub.2023.01.039_bib51","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/(SICI)1096-9861(19960819)372:2<229::AID-CNE6>3.0.CO;2-5","article-title":"Synaptic and nonsynaptic monoaminergic neuron systems in the lamprey spinal cord","volume":"372","author":"Schotland","year":"1996","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.cub.2023.01.039_bib52","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fncir.2015.00078","article-title":"A 3D searchable database of transgenic zebrafish Gal4 and Cre lines for functional neuroanatomy studies","volume":"9","author":"Marquart","year":"2015","journal-title":"Front. Neural Circuits"},{"key":"10.1016\/j.cub.2023.01.039_bib53","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1016\/j.cub.2016.06.037","article-title":"Optimization of a neurotoxin to investigate the contribution of excitatory interneurons to speed modulation in\u00a0vivo","volume":"26","author":"Sternberg","year":"2016","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2023.01.039_bib54","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fncir.2018.00078","article-title":"Peptide cotransmitters as dynamic, intrinsic modulators of network activity","volume":"12","author":"Cropper","year":"2018","journal-title":"Front. Neural Circuits"},{"key":"10.1016\/j.cub.2023.01.039_bib55","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.1096\/fj.07-101907","article-title":"Expression, transport, and axonal sorting of neuronal CCL21 in large dense-core vesicles","volume":"22","author":"de Jong","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.cub.2023.01.039_bib56","doi-asserted-by":"crossref","first-page":"pe26","DOI":"10.1126\/stke.3382006pe26","article-title":"Differential secretion of cytokines","volume":"2006","author":"Moqbel","year":"2006","journal-title":"Sci. STKE"},{"key":"10.1016\/j.cub.2023.01.039_bib57","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cub.2023.01.039_bib58","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1007\/s00018-008-8088-0","article-title":"Highly specific interactions between botulinum neurotoxins and synaptic vesicle proteins","volume":"65","author":"Brunger","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cub.2023.01.039_bib59","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.mimet.2005.09.003","article-title":"Detection of volatile metabolites produced by bacterial growth in blood culture media by selected ion flow tube mass spectrometry (SIFT-MS)","volume":"65","author":"Allardyce","year":"2006","journal-title":"J.\u00a0Microbiol. Methods"},{"key":"10.1016\/j.cub.2023.01.039_bib60","doi-asserted-by":"crossref","first-page":"366","DOI":"10.2500\/ajra.2014.28.4077","article-title":"Sinonasal solitary chemosensory cells \"taste\" the upper respiratory environment to regulate innate immunity","volume":"28","author":"Lee","year":"2014","journal-title":"Am. J. Rhinol. Allergy"},{"key":"10.1016\/j.cub.2023.01.039_bib61","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1139\/cjm-2014-0652","article-title":"Odor fingerprinting of Listeria monocytogenes recognized by SPME-GC-MS and E-nose","volume":"61","author":"Yu","year":"2015","journal-title":"Can. J. Microbiol."},{"key":"10.1016\/j.cub.2023.01.039_bib62","first-page":"847","article-title":"Imaging of viral neuroinvasion in the zebrafish reveals that Sindbis and chikungunya viruses favour different entry routes","volume":"10","author":"Passoni","year":"2017","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.cub.2023.01.039_bib63","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.regpep.2009.11.014","article-title":"The antimicrobial peptides derived from chromogranin\/secretogranin family, new actors of innate immunity","volume":"165","author":"Shooshtarizadeh","year":"2010","journal-title":"Regul. Pept."},{"key":"10.1016\/j.cub.2023.01.039_bib64","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1084\/jem.189.11.1783","article-title":"Thioredoxin, a redox enzyme released in infection and inflammation, is a unique chemoattractant for neutrophils, monocytes, and T\u00a0cells","volume":"189","author":"Bertini","year":"1999","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cub.2023.01.039_bib65","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1007\/s00726-014-1816-x","article-title":"C-type natriuretic peptide attenuates LPS-induced endothelial activation: involvement of p38, Akt, and NF-kappaB pathways","volume":"46","author":"Chen","year":"2014","journal-title":"Amino Acids"},{"key":"10.1016\/j.cub.2023.01.039_bib66","doi-asserted-by":"crossref","first-page":"E344","DOI":"10.1152\/ajpendo.00048.2003","article-title":"Expression of somatostatin, cortistatin, and somatostatin receptors in human monocytes, macrophages, and dendritic cells","volume":"285","author":"Dalm","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.cub.2023.01.039_bib67","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/S0196-9781(00)00347-8","article-title":"Peptides as regulators of the immune system: emphasis on somatostatin","volume":"21","author":"Krantic","year":"2000","journal-title":"Peptides"},{"key":"10.1016\/j.cub.2023.01.039_bib68","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1172\/JCI72094","article-title":"Bitter and sweet taste receptors regulate human upper respiratory innate immunity","volume":"124","author":"Lee","year":"2014","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cub.2023.01.039_bib69","doi-asserted-by":"crossref","first-page":"14729","DOI":"10.1073\/pnas.0506233102","article-title":"Netrin-1 inhibits leukocyte migration in\u00a0vitro and in\u00a0vivo","volume":"102","author":"Ly","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2023.01.039_bib70","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.4049\/jimmunol.1300758","article-title":"PC3-secreted microprotein is a novel chemoattractant protein and functions as a high-affinity ligand for CC chemokine receptor 2","volume":"192","author":"Pei","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.cub.2023.01.039_bib71","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neulet.2015.12.053","article-title":"Higher level of NT-proCNP in cerebrospinal fluid of patients with meningitis","volume":"614","author":"Tomasiuk","year":"2016","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.cub.2023.01.039_bib72","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev-genet-071719-020342","article-title":"Genotype-phenotype relationships in the context of transcriptional adaptation and genetic robustness","volume":"55","author":"Jakutis","year":"2021","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.cub.2023.01.039_bib73","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.immuni.2015.08.016","article-title":"Nociceptive sensory fibers drive interleukin-23 production from CD301b+ dermal dendritic cells and drive protective cutaneous immunity","volume":"43","author":"Kashem","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.cub.2023.01.039_bib74","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neuron.2015.06.007","article-title":"Silencing nociceptor neurons reduces allergic airway inflammation","volume":"87","author":"Talbot","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2023.01.039_bib75","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.3389\/fimmu.2017.01463","article-title":"Sense and immunity: context-dependent neuro-immune interplay","volume":"8","author":"Foster","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cub.2023.01.039_bib76","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.00152-12","article-title":"Complete genome sequence of Listeria monocytogenes LL195, a serotype 4b strain from the 1983\u20131987 Listeriosis epidemic in Switzerland","volume":"1","author":"Weinmaier","year":"2013","journal-title":"Genome Announc."},{"key":"10.1016\/j.cub.2023.01.039_bib77","first-page":"Unit15B1","article-title":"Sindbis virus: propagation, quantification, and storage","volume":"Chapter 15","author":"Hernandez","year":"2010","journal-title":"Curr. Protoc. Microbiol."},{"key":"10.1016\/j.cub.2023.01.039_bib78","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1084\/jem.79.2.137","article-title":"Studies on the chemical nature of the substance inducing transformation of pneumococcal types: induction of transformation by a desoxyribonucleic acid\u00a0fraction isolated from pneumococcus type Iii","volume":"79","author":"Avery","year":"1944","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cub.2023.01.039_bib79","first-page":"9971","article-title":"Deep genome annotation of the opportunistic human pathogen Streptococcus pneumoniae D39","volume":"46","author":"Slager","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cub.2023.01.039_bib80","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1128\/JB.02221-14","article-title":"Bright fluorescent Streptococcus pneumoniae for live-cell imaging of host-pathogen interactions","volume":"197","author":"Kjos","year":"2015","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.cub.2023.01.039_bib81","doi-asserted-by":"crossref","first-page":"7244","DOI":"10.1128\/AEM.02033-15","article-title":"Red fluorescent proteins for gene expression and protein localization studies in Streptococcus pneumoniae and efficient transformation with DNA assembled via the Gibson assembly method","volume":"81","author":"Beilharz","year":"2015","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.cub.2023.01.039_bib82","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1365-2958.1995.tb02250.x","article-title":"The recA gene of Streptococcus pneumoniae is part of a competence-induced operon and controls lysogenic induction.","volume":"15","author":"Martin","year":"1995","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.cub.2023.01.039_bib83","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1242\/dev.128.7.1099","article-title":"An instructive function for Notch in promoting gliogenesis in the zebrafish retina","volume":"128","author":"Scheer","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.cub.2023.01.039_bib84","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1182\/blood-2006-05-024075","article-title":"A transgenic zebrafish model of neutrophilic inflammation","volume":"108","author":"Renshaw","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.cub.2023.01.039_bib85","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cub.2023.01.039_bib86","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/B978-0-12-374814-0.00023-9","article-title":"Advances in zebrafish husbandry and management","volume":"104","author":"Lawrence","year":"2011","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.cub.2023.01.039_bib87","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/bs.mcb.2016.04.015","article-title":"New frontiers for zebrafish management","volume":"135","author":"Lawrence","year":"2016","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.cub.2023.01.039_bib88","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1084\/jem.149.2.297","article-title":"Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Inductions of transformation by a desoxyribonucleic acid fraction isolated from pneumococcus type III","volume":"149","author":"Avery","year":"1979","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cub.2023.01.039_bib89","doi-asserted-by":"crossref","DOI":"10.1101\/pdb.prot069633","article-title":"Fluorescence-activated cell sorting (FACS) of fluorescently tagged cells from zebrafish larvae for RNA isolation","volume":"2012","author":"Manoli","year":"2012","journal-title":"Cold Spring Harb. Protoc."},{"key":"10.1016\/j.cub.2023.01.039_bib90","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1038\/nprot.2009.192","article-title":"Determination of gene expression patterns using in\u00a0situ hybridization to Drosophila testes","volume":"4","author":"Morris","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cub.2023.01.039_bib91","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nprot.2007.514","article-title":"High-resolution in\u00a0situ hybridization to whole-mount zebrafish embryos","volume":"3","author":"Thisse","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cub.2023.01.039_bib92","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nprot.2009.69","article-title":"Multichannel wholemount fluorescent and fluorescent\/chromogenic in\u00a0situ hybridization in Xenopus embryos","volume":"4","author":"Vize","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cub.2023.01.039_bib93","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.modgep.2006.04.006","article-title":"GFAP transgenic zebrafish","volume":"6","author":"Bernardos","year":"2006","journal-title":"Gene Expr. Patterns"},{"key":"10.1016\/j.cub.2023.01.039_bib94","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1002\/glia.22990","article-title":"Gfap-positive radial glial cells are an essential progenitor population for later-born neurons and glia in the zebrafish spinal cord","volume":"64","author":"Johnson","year":"2016","journal-title":"Glia"},{"key":"10.1016\/j.cub.2023.01.039_bib95","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1038\/nprot.2006.230","article-title":"Evaluating the biological relevance of putative enhancers using Tol2 transposon-mediated transgenesis in zebrafish","volume":"1","author":"Fisher","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cub.2023.01.039_bib96","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1002\/dvdy.21343","article-title":"The Tol2kit: a multisite gateway-based construction kit for Tol2 transposon transgenesis constructs","volume":"236","author":"Kwan","year":"2007","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.cub.2023.01.039_bib97","doi-asserted-by":"crossref","first-page":"W242","DOI":"10.1093\/nar\/gky354","article-title":"CRISPOR: intuitive guide selection for CRISPR\/Cas9 genome editing experiments and screens","volume":"46","author":"Concordet","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cub.2023.01.039_bib98","doi-asserted-by":"crossref","first-page":"418","DOI":"10.7554\/eLife.05061","article-title":"Deletion of a kinesin I motor unmasks a mechanism of homeostatic branching control by neurotrophin-3","volume":"4","author":"Auer","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.cub.2023.01.039_bib100","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.3389\/fimmu.2018.01084","article-title":"A model of superinfection of virus-infected zebrafish larvae: increased susceptibility to bacteria associated with neutrophil death","volume":"9","author":"Boucontet","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cub.2023.01.039_bib99","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3389\/fncir.2013.00107","article-title":"ZebraZoom: an automated program for high-throughput behavioral analysis and categorization","volume":"7","author":"Mirat","year":"2013","journal-title":"Front. Neural Circuits"}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982223000738?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982223000738?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:08:31Z","timestamp":1760782111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982223000738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":99,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S0960982223000738"],"URL":"https:\/\/doi.org\/10.1016\/j.cub.2023.01.039","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection","name":"articletitle","label":"Article Title"},{"value":"Current Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cub.2023.01.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}