{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:00:21Z","timestamp":1786114821215,"version":"build-2736575974"},"reference-count":110,"publisher":"Elsevier BV","issue":"15","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T00:00:00Z","timestamp":1719705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"MRC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019684","name":"Wellcome Trust-Cancer Research UK Gurdon Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019684","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022011","name":"CRUK","doi-asserted-by":"publisher","award":["A17196"],"award-info":[{"award-number":["A17196"]}],"id":[{"id":"10.13039\/501100022011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022011","name":"CRUK","doi-asserted-by":"publisher","award":["A24450"],"award-info":[{"award-number":["A24450"]}],"id":[{"id":"10.13039\/501100022011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022011","name":"CRUK","doi-asserted-by":"publisher","award":["A31287"],"award-info":[{"award-number":["A31287"]}],"id":[{"id":"10.13039\/501100022011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.cub.2024.06.081","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T11:47:27Z","timestamp":1721908047000},"page":"3564-3581.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Biogenesis of lysosome-related organelles complex-2 is an evolutionarily ancient proto-coatomer complex"],"prefix":"10.1016","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3104-8392","authenticated-orcid":false,"given":"Peter A.","family":"Thomason","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6488-0495","authenticated-orcid":false,"given":"Ryan","family":"Corbyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3142-7640","authenticated-orcid":false,"given":"Sergio","family":"Lilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9004-4079","authenticated-orcid":false,"given":"David","family":"Sumpton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5677-3318","authenticated-orcid":false,"given":"Thomas","family":"Gilbey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4898-040X","authenticated-orcid":false,"given":"Robert H.","family":"Insall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cub.2024.06.081_bib1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/sj.jid.5700034","article-title":"Genetic Testing for Oculocutaneous Albinism Type 1 and 2 and Hermansky\u2013Pudlak Syndrome Type 1 and 3 Mutations in Puerto Rico","volume":"126","author":"Santiago Borrero","year":"2006","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.cub.2024.06.081_bib2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3109\/13816819009020986","article-title":"Hermansky-Pudlak syndrome (HPS): An epidemiologic study","volume":"11","author":"Witkop","year":"1990","journal-title":"Ophthalmic Paediatr. Genet."},{"key":"10.1016\/j.cub.2024.06.081_bib3","first-page":"755","article-title":"A Gene Causing Hermansky-Pudlak Syndrome in a Puerto Rican Population Maps to Chromosome I Oq2","volume":"57","author":"Wildenberg","year":"1995","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.cub.2024.06.081_bib4","series-title":"GeneReviews [Internet]","first-page":"1","article-title":"Hermansky-Pudlak Syndrome","author":"Introne","year":"2000"},{"key":"10.1016\/j.cub.2024.06.081_bib5","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/pcmr.12916","article-title":"Genetic variants and mutational spectrum of Chinese Hermansky\u2013Pudlak syndrome patients","volume":"34","author":"Liu","year":"2021","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.cub.2024.06.081_bib6","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/pcmr.12982","article-title":"Genetics of non-syndromic and syndromic oculocutaneous albinism in human and mouse","volume":"34","author":"Fern\u00e1ndez","year":"2021","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.cub.2024.06.081_bib7","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/pcmr.13030","article-title":"New insights into the pathogenesis of Hermansky\u2013Pudlak syndrome","volume":"35","author":"Li","year":"2022","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.cub.2024.06.081_bib8","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1600-0749.2005.00289.x","article-title":"Hermansky\u2013Pudlak syndrome: a disease of protein trafficking and organelle function","volume":"19","author":"Wei","year":"2006","journal-title":"Pigment Cell Res."},{"key":"10.1016\/j.cub.2024.06.081_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.644671","article-title":"Hermansky-Pudlak Syndrome and Lung Disease: Pathogenesis and Therapeutics","volume":"12","author":"Vel\u00e1zquez-D\u00edaz","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cub.2024.06.081_bib10","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1146\/annurev.genom.9.081307.164303","article-title":"Disorders of Lysosome-Related Organelle Biogenesis: Clinical and Molecular Genetics","volume":"9","author":"Huizing","year":"2008","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"10.1016\/j.cub.2024.06.081_bib11","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/tra.12646","article-title":"The road to lysosome-related organelles: Insights from Hermansky-Pudlak syndrome and other rare diseases","volume":"20","author":"Bowman","year":"2019","journal-title":"Traffic"},{"key":"10.1016\/j.cub.2024.06.081_bib12","doi-asserted-by":"crossref","first-page":"3702","DOI":"10.3390\/cells11223702","article-title":"Overlapping Machinery in Lysosome-Related Organelle Trafficking: A Lesson from Rare Multisystem Disorders","volume":"11","author":"Banushi","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.cub.2024.06.081_bib13","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.ceb.2007.05.001","article-title":"Lysosome-related organelles: driving post-Golgi compartments into specialisation","volume":"19","author":"Raposo","year":"2007","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib14","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.ceb.2013.04.008","article-title":"Lysosome-related organelles: unusual compartments become mainstream","volume":"25","author":"Marks","year":"2013","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib15","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a016840","article-title":"The Biogenesis of Lysosomes and Lysosome-Related Organelles","volume":"6","author":"Luzio","year":"2014","journal-title":"Cold Spring Harb Perspect. Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib16","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.MCHD-0030-2016","article-title":"Secretion from Myeloid Cells: Secretory Lysosomes","volume":"4","author":"Griffiths","year":"2016","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.cub.2024.06.081_bib17","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ceb.2019.05.003","article-title":"Lysosome-related organelles as functional adaptations of the endolysosomal system","volume":"59","author":"Delevoye","year":"2019","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib18","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1196\/annals.1315.018","article-title":"Insights into the Biogenesis of Lysosome-Related Organelles from the Study of the Hermansky-Pudlak Syndrome","volume":"1038","author":"Bonifacino","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.cub.2024.06.081_bib19","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.ceb.2004.05.001","article-title":"The building BLOC(k)s of lysosomes and related organelles","volume":"16","author":"Dell\u2019Angelica","year":"2004","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib20","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1046\/j.1523-1747.2002.19535.x","article-title":"Melanosome Morphologies in Murine Models of Hermansky\u2013Pudlak Syndrome Reflect Blocks in Organelle Development","volume":"119","author":"Nguyen","year":"2002","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.cub.2024.06.081_bib21","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/bies.20042","article-title":"Murine Hermansky\u2013Pudlak syndrome genes: regulators of lysosome-related organelles","volume":"26","author":"Li","year":"2004","journal-title":"BioEssays"},{"key":"10.1016\/j.cub.2024.06.081_bib22","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/j.1600-0854.2006.00431.x","article-title":"Interaction of Hermansky-Pudlak Syndrome Genes in the Regulation of Lysosome-Related Organelles","volume":"7","author":"Gautam","year":"2006","journal-title":"Traffic"},{"key":"10.1016\/j.cub.2024.06.081_bib23","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1083\/jcb.133.4.749","article-title":"A novel adaptor-related protein complex","volume":"133","author":"Simpson","year":"1996","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib24","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1093\/emboj\/16.5.917","article-title":"AP-3: an adaptor-like protein complex with ubiquitous expression","volume":"16","author":"Dell\u2019Angelica","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.cub.2024.06.081_bib25","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1083\/jcb.137.4.835","article-title":"Characterization of the Adaptor-related Protein Complex, AP-3","volume":"137","author":"Simpson","year":"1997","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib26","doi-asserted-by":"crossref","first-page":"15078","DOI":"10.1074\/jbc.272.24.15078","article-title":"\u03b23A-adaptin, a Subunit of the Adaptor-like Complex AP-3","volume":"272","author":"Dell\u2019Angelica","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cub.2024.06.081_bib27","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.ceb.2009.04.014","article-title":"AP-3-dependent trafficking and disease: the first decade","volume":"21","author":"Dell\u2019Angelica","year":"2009","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib28","doi-asserted-by":"crossref","first-page":"5882","DOI":"10.1074\/jbc.M111.325746","article-title":"Assembly and Architecture of Biogenesis of Lysosome-related Organelles Complex-1 (BLOC-1)","volume":"287","author":"Lee","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cub.2024.06.081_bib29","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1091\/mbc.e13-02-0088","article-title":"The WASH complex, an endosomal Arp2\/3 activator, interacts with the Hermansky\u2013Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type II\u03b1","volume":"24","author":"Ryder","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.cub.2024.06.081_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cub.2015.11.020","article-title":"BLOC-1 Brings Together the Actin and Microtubule Cytoskeletons to Generate Recycling Endosomes","volume":"26","author":"Delevoye","year":"2016","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib31","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202110132","article-title":"PI4P and BLOC-1 remodel endosomal membranes into tubules","volume":"221","author":"Jani","year":"2022","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib32","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202005173","article-title":"A BLOC-1\u2013AP-3 super-complex sorts a cis-SNARE complex into endosome-derived tubular transport carriers","volume":"220","author":"Bowman","year":"2021","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib33","doi-asserted-by":"crossref","first-page":"20332","DOI":"10.1074\/jbc.M300090200","article-title":"The Hermansky-Pudlak Syndrome 1 (HPS1) and HPS4 Proteins Are Components of Two Complexes, BLOC-3 and BLOC-4, Involved in the Biogenesis of Lysosome-related Organelles","volume":"278","author":"Chiang","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cub.2024.06.081_bib34","doi-asserted-by":"crossref","first-page":"29376","DOI":"10.1074\/jbc.M301294200","article-title":"BLOC-3, a Protein Complex Containing the Hermansky-Pudlak Syndrome Gene Products HPS1 and HPS4","volume":"278","author":"Martina","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cub.2024.06.081_bib35","doi-asserted-by":"crossref","first-page":"8770","DOI":"10.1073\/pnas.1532040100","article-title":"Biogenesis of lysosome-related organelles complex 3 (BLOC-3): A complex containing the Hermansky\u2013Pudlak syndrome (HPS) proteins HPS1 and HPS4","volume":"100","author":"Nazarian","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2024.06.081_bib36","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/j.cub.2012.09.020","article-title":"BLOC-3 Mutated in Hermansky-Pudlak Syndrome Is a Rab32\/38 Guanine Nucleotide Exchange Factor","volume":"22","author":"Gerondopoulos","year":"2012","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib37","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1083\/jcb.201605090","article-title":"BLOC-1 and BLOC-3 regulate VAMP7 cycling to and from melanosomes via distinct tubular transport carriers","volume":"214","author":"Dennis","year":"2016","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib38","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/ng1087","article-title":"Ru2 and Ru encode mouse orthologs of the genes mutated in human Hermansky-Pudlak syndrome types 5 and 6","volume":"33","author":"Zhang","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cub.2024.06.081_bib39","doi-asserted-by":"crossref","first-page":"12935","DOI":"10.1074\/jbc.M311311200","article-title":"The Hermansky-Pudlak Syndrome 3 (Cocoa) Protein Is a Component of the Biogenesis of Lysosome-related Organelles Complex-2 (BLOC-2)","volume":"279","author":"Gautam","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cub.2024.06.081_bib40","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1600-0854.2004.0171.x","article-title":"Characterization of BLOC-2, a Complex Containing the Hermansky\u2013Pudlak Syndrome Proteins HPS3, HPS5 and HPS6","volume":"5","author":"Di Pietro","year":"2004","journal-title":"Traffic"},{"key":"10.1016\/j.cub.2024.06.081_bib41","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.1091\/mbc.e06-05-0379","article-title":"BLOC-1 Interacts with BLOC-2 and the AP-3 Complex to Facilitate Protein Trafficking on Endosomes","volume":"17","author":"Di Pietro","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.cub.2024.06.081_bib42","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1083\/jcb.201410026","article-title":"BLOC-2 targets recycling endosomal tubules to melanosomes for cargo delivery","volume":"209","author":"Dennis","year":"2015","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib43","doi-asserted-by":"crossref","first-page":"19550","DOI":"10.1074\/jbc.M112.351908","article-title":"BLOC-2, AP-3, and AP-1 Proteins Function in Concert with Rab38 and Rab32 Proteins to Mediate Protein Trafficking to Lysosome-related Organelles","volume":"287","author":"Bultema","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cub.2024.06.081_bib44","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.devcel.2014.10.007","article-title":"Toward a Comprehensive Map of the Effectors of Rab GTPases","volume":"31","author":"Gillingham","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2024.06.081_bib45","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201845918","article-title":"Rab22A recruits BLOC -1 and BLOC -2 to promote the biogenesis of recycling endosomes","volume":"19","author":"Shakya","year":"2018","journal-title":"EMBO Rep."},{"key":"10.1016\/j.cub.2024.06.081_bib46","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.45916","article-title":"In\u00a0vivo identification of GTPase interactors by mitochondrial relocalization and proximity biotinylation","volume":"8","author":"Gillingham","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.cub.2024.06.081_bib47","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1471-2121-6-33","article-title":"Association of the Hermansky-Pudlak syndrome type-3 protein with clathrin","volume":"6","author":"Helip-Wooley","year":"2005","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib48","first-page":"4574","article-title":"HPS6 interacts with dynactin p150Glued to mediate retrograde trafficking and maturation of lysosomes","volume":"127","author":"Li","year":"2014","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.cub.2024.06.081_bib49","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/j.1600-0854.2010.01044.x","article-title":"Early Origin of Genes Encoding Subunits of Biogenesis of Lysosome-related Organelles Complex-1, -2 and -3","volume":"11","author":"Cheli","year":"2010","journal-title":"Traffic"},{"key":"10.1016\/j.cub.2024.06.081_bib50","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.devcel.2015.02.011","article-title":"BORC, a Multisubunit Complex that Regulates Lysosome Positioning","volume":"33","author":"Pu","year":"2015","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2024.06.081_bib51","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1083\/jcb.201009119","article-title":"Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis","volume":"193","author":"Carnell","year":"2011","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib52","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.devcel.2012.12.014","article-title":"Cyclical Action of the WASH Complex: FAM21 and Capping Protein Drive WASH Recycling, Not Initial Recruitment","volume":"24","author":"Park","year":"2013","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2024.06.081_bib53","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1242\/jcs.197210","article-title":"Mroh1, a lysosomal regulator localised by WASH-generated actin","volume":"130","author":"Thomason","year":"2017","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.cub.2024.06.081_bib54","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1111\/j.1600-0854.2007.00567.x","article-title":"The BEACH Protein LvsB Is Localized on Lysosomes and Postlysosomes and Limits Their Fusion with Early Endosomes","volume":"8","author":"Kypri","year":"2007","journal-title":"Traffic"},{"key":"10.1016\/j.cub.2024.06.081_bib55","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1242\/jcs.009001","article-title":"A LYST\/beige homolog is involved in biogenesis of Dictyostelium secretory lysosomes","volume":"120","author":"Charette","year":"2007","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.cub.2024.06.081_bib56","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/tra.12058","article-title":"Antagonistic Control of Lysosomal Fusion by Rab14 and the Lyst-Related Protein LvsB","volume":"14","author":"Kypri","year":"2013","journal-title":"Traffic"},{"key":"10.1016\/j.cub.2024.06.081_bib57","first-page":"4356","article-title":"Dictyostelium LvsB has a regulatory role in endosomal vesicle fusion","volume":"127","author":"Falkenstein","year":"2014","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.cub.2024.06.081_bib58","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.semcdb.2010.11.001","article-title":"Dictyostelium as a model for human lysosomal and trafficking diseases","volume":"22","author":"Maniak","year":"2011","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib59","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1387\/ijdb.190236jk","article-title":"The endocytic pathways of Dictyostelium discoideum","volume":"63","author":"Vines","year":"2019","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib60","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1091\/mbc.01-08-0392","article-title":"Morphology and\u00a0Dynamics of the Endocytic Pathway in Dictyostelium discoideum","volume":"13","author":"Neuhaus","year":"2002","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.cub.2024.06.081_bib61","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/j.bbamcr.2008.03.015","article-title":"The RCC1 superfamily: from genes, to function, to disease","volume":"1783","author":"Hadjebi","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cub.2024.06.081_bib62","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0962-8924(98)01270-7","article-title":"Not just pretty eyes: Drosophila eye-colour mutations and lysosomal delivery","volume":"8","author":"Lloyd","year":"1998","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib63","doi-asserted-by":"crossref","first-page":"11652","DOI":"10.1073\/pnas.0401926101","article-title":"Lightoid and Claret: A rab GTPase and its putative guanine nucleotide exchange factor in biogenesis of Drosophila eye pigment granules","volume":"101","author":"Ma","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2024.06.081_bib64","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1091\/mbc.e05-01-0060","article-title":"Genetic Analysis of Lysosomal Trafficking in Caenorhabditis elegans","volume":"16","author":"Hermann","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.cub.2024.06.081_bib65","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic Local Alignment Search Tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib66","doi-asserted-by":"crossref","first-page":"W200","DOI":"10.1093\/nar\/gky448","article-title":"HMMER web server: 2018 update","volume":"46","author":"Potter","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cub.2024.06.081_bib67","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1016\/j.jmb.2017.12.007","article-title":"A Completely Reimplemented MPI Bioinformatics Toolkit with a New HHpred Server at its Core","volume":"430","author":"Zimmermann","year":"2018","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib68","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nature03481","article-title":"The genome of the social amoeba Dictyostelium discoideum","volume":"435","author":"Eichinger","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.cub.2024.06.081_bib69","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1242\/jcs.111.1.61","article-title":"Targeted gene disruption reveals a role for vacuolin B in the late endocytic pathway and exocytosis","volume":"111","author":"Jenne","year":"1998","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.cub.2024.06.081_bib70","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tree.2019.08.008","article-title":"The New Tree of Eukaryotes","volume":"35","author":"Burki","year":"2020","journal-title":"Trends Ecol. Evol."},{"key":"10.1016\/j.cub.2024.06.081_bib71","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/s41586-019-1923-7","article-title":"Improved protein structure prediction using potentials from deep learning","volume":"577","author":"Senior","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cub.2024.06.081_bib72","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41559-019-0796-3","article-title":"Concepts of the last eukaryotic common ancestor","volume":"3","author":"O\u2019Malley","year":"2019","journal-title":"Nat. Ecol. Evol."},{"key":"10.1016\/j.cub.2024.06.081_bib73","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3109\/10409238.2013.821444","article-title":"Molecular paleontology and complexity in the last eukaryotic common ancestor","volume":"48","author":"Koumandou","year":"2013","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib74","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.ceb.2009.05.007","article-title":"Vps-C complexes: gatekeepers of endolysosomal traffic","volume":"21","author":"Nickerson","year":"2009","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib75","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ceb.2018.06.001","article-title":"Evolutionary origins and specialisation of membrane transport","volume":"53","author":"Dacks","year":"2018","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib76","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1146\/annurev-biochem-061516-044643","article-title":"The Evolution of Organellar Coat\u00a0Complexes and Organization of the Eukaryotic Cell","volume":"86","author":"Rout","year":"2017","journal-title":"Annu. Rev.\u00a0Biochem."},{"key":"10.1016\/j.cub.2024.06.081_bib77","doi-asserted-by":"crossref","first-page":"E5906","DOI":"10.1073\/pnas.1524532113","article-title":"WASH drives early recycling from macropinosomes and phagosomes to maintain surface phagocytic receptors","volume":"113","author":"Buckley","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2024.06.081_bib78","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/pcmr.12434","article-title":"Rab9A is required for delivery of cargo from recycling endosomes to melanosomes","volume":"29","author":"Mahanty","year":"2016","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.cub.2024.06.081_bib79","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1600-0854.2006.00514.x","article-title":"The Drosophila Pigmentation Gene pink ( p ) Encodes a Homologue of Human Hermansky\u2013Pudlak Syndrome 5 (HPS5)","volume":"8","author":"Falc\u00f3n-P\u00e9rez","year":"2007","journal-title":"Traffic"},{"key":"10.1016\/j.cub.2024.06.081_bib80","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1093\/hmg\/ddp555","article-title":"Genetic modifiers of abnormal organelle biogenesis in a Drosophila model of BLOC-1 deficiency","volume":"19","author":"Cheli","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cub.2024.06.081_bib81","first-page":"1746","article-title":"The small GTPase Arl8b regulates assembly of the mammalian HOPS complex to lysosomes","volume":"128","author":"Khatter","year":"2015","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.cub.2024.06.081_bib82","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1111\/j.1600-0854.2006.00478.x","article-title":"A Role for Adaptor Protein-3 Complex in the Organization of the Endocytic Pathway in Dictyostelium","volume":"7","author":"Charette","year":"2006","journal-title":"Traffic"},{"key":"10.1016\/j.cub.2024.06.081_bib83","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/j.1600-0854.2008.00706.x","article-title":"Altered Composition and Secretion of Lysosome-Derived Compartments in Dictyostelium AP-3 Mutant Cells","volume":"9","author":"Charette","year":"2008","journal-title":"Traffic"},{"key":"10.1016\/j.cub.2024.06.081_bib84","doi-asserted-by":"crossref","first-page":"16951","DOI":"10.1074\/jbc.M109.078501","article-title":"Functional Characterization of Wiskott-Aldrich Syndrome Protein and Scar Homolog (WASH), a Bi-modular Nucleation-promoting Factor Able to Interact with Biogenesis of Lysosome-related Organelle Subunit 2 (BLOS2) and \u03b3-Tubulin","volume":"285","author":"Monfregola","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cub.2024.06.081_bib85","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abd5956","article-title":"The Arp1\/11\u00a0minifilament of dynactin primes the endosomal Arp2\/3 complex","volume":"7","author":"Fokin","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cub.2024.06.081_bib86","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/s41586-024-07249-8","article-title":"The HEAT repeat protein HPO-27 is a lysosome fission factor","volume":"628","author":"Li","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.cub.2024.06.081_bib87","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.molbiopara.2016.07.003","article-title":"Resolving the homology\u2014function relationship through comparative genomics of membrane-trafficking machinery and parasite cell biology","volume":"209","author":"Klinger","year":"2016","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.cub.2024.06.081_bib88","doi-asserted-by":"crossref","first-page":"R553","DOI":"10.1016\/j.cub.2020.03.068","article-title":"Evolution and Natural History of Membrane Trafficking in Eukaryotes","volume":"30","author":"More","year":"2020","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib89","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1091\/mbc.e12-02-0101","article-title":"Trafficking defects in WASH- knockout fibroblasts originate from collapsed endosomal and lysosomal networks","volume":"23","author":"Gomez","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.cub.2024.06.081_bib90","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0039774","article-title":"Actin Polymerization Controls the Organization of WASH Domains at the Surface of Endosomes","volume":"7","author":"Derivery","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cub.2024.06.081_bib91","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.ceb.2012.05.013","article-title":"Structures and mechanisms of vesicle coat components and multisubunit tethering complexes","volume":"24","author":"Jackson","year":"2012","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib92","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a016048","article-title":"Missing Pieces of an Ancient Puzzle: Evolution of the Eukaryotic Membrane-Trafficking System","volume":"6","author":"Schlacht","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib93","doi-asserted-by":"crossref","first-page":"R943","DOI":"10.1016\/j.cub.2010.09.015","article-title":"Multisubunit Tethering Complexes and Their Role in Membrane Fusion","volume":"20","author":"Br\u00f6cker","year":"2010","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib94","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.cellbio.042308.113327","article-title":"Tethering Factors as Organizers of Intracellular Vesicular Traffic","volume":"26","author":"Yu","year":"2010","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib95","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ceb.2019.04.010","article-title":"Transport carrier tethering\u00a0\u2013 how vesicles are captured by organelles","volume":"59","author":"Gillingham","year":"2019","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib96","article-title":"Protein complex prediction with AlphaFold-Multimer","author":"Evans","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.cub.2024.06.081_bib97","doi-asserted-by":"crossref","first-page":"D1539","DOI":"10.1093\/nar\/gkac1040","article-title":"The ProteomeXchange consortium at 10 years: 2023 update","volume":"51","author":"Deutsch","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cub.2024.06.081_bib98","doi-asserted-by":"crossref","first-page":"D543","DOI":"10.1093\/nar\/gkab1038","article-title":"The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences","volume":"50","author":"Perez-Riverol","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cub.2024.06.081_bib99","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cub.2024.06.081_bib100","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.plasmid.2008.11.003","article-title":"A new set of small, extrachromosomal expression vectors for Dictyostelium discoideum","volume":"61","author":"Veltman","year":"2009","journal-title":"Plasmid"},{"key":"10.1016\/j.cub.2024.06.081_bib101","first-page":"201","article-title":"Restriction Enzyme-Mediated Integration (REMI) Mutagenesis. In Dictyostelium discoideum Protocols","volume":"346","author":"Kuspa","year":"2006","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib102","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/s41556-018-0198-9","article-title":"Fam49\/CYRI interacts with Rac1 and locally suppresses protrusions","volume":"20","author":"Fort","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cub.2024.06.081_bib103","doi-asserted-by":"crossref","first-page":"D676","DOI":"10.1093\/nar\/gks1064","article-title":"dictyBase 2013: integrating multiple Dictyostelid species","volume":"41","author":"Basu","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cub.2024.06.081_bib104","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1093\/bioinformatics\/btm404","article-title":"Clustal W and Clustal X version 2.0","volume":"23","author":"Larkin","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cub.2024.06.081_bib105","doi-asserted-by":"crossref","first-page":"i263","DOI":"10.1093\/bioinformatics\/bty278","article-title":"Protein threading using residue co-variation and deep learning","volume":"34","author":"Zhu","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cub.2024.06.081_bib106","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1109\/MCSE.2021.3059263","article-title":"Jupyter: Thinking and Storytelling With Code and Data","volume":"23","author":"Granger","year":"2021","journal-title":"Comput. Sci. Eng."},{"key":"10.1016\/j.cub.2024.06.081_bib107","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41592-020-01018-x","article-title":"Cellpose: a generalist algorithm for cellular segmentation","volume":"18","author":"Stringer","year":"2021","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cub.2024.06.081_bib108","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1038\/s41592-022-01663-4","article-title":"Cellpose 2.0: how to train your own model","volume":"19","author":"Pachitariu","year":"2022","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cub.2024.06.081_bib109","doi-asserted-by":"crossref","first-page":"16878","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image\u00a0analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cub.2024.06.081_bib110","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41592-019-0686-2","article-title":"SciPy 1.0: fundamental algorithms for scientific computing in Python","volume":"17","author":"Virtanen","year":"2020","journal-title":"Nat. Methods"}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982224008996?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982224008996?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T21:43:22Z","timestamp":1785966202000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982224008996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":110,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S0960982224008996"],"URL":"https:\/\/doi.org\/10.1016\/j.cub.2024.06.081","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biogenesis of lysosome-related organelles complex-2 is an evolutionarily ancient proto-coatomer complex","name":"articletitle","label":"Article Title"},{"value":"Current Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cub.2024.06.081","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}