{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:17:20Z","timestamp":1783030640079,"version":"3.54.6"},"reference-count":79,"publisher":"Elsevier BV","issue":"20","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003825","name":"Hungarian Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011019","name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.cub.2025.09.006","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T04:42:33Z","timestamp":1758948153000},"page":"4970-4987.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Store-independent activation of STIM1-ORAI1 by SPCA2 determines the basal CFTR activity in secretory epithelial cells"],"prefix":"10.1016","volume":"35","author":[{"given":"Aletta Kata","family":"Kiss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1rp\u00e1d","family":"Varga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marietta","family":"G\u00f6r\u00f6g","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Mad\u00e1csy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Young","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Pallagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikt\u00f3ria","family":"Szab\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Sus\u00e1nszki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enik\u0151","family":"K\u00fathy-Sutus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e1niel","family":"Varga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"B\u00edr\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid Hegnes","family":"Sendstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Crul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boldizs\u00e1r","family":"J\u00f3j\u00e1rt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1lint","family":"T\u00e9l","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zs\u00f3fia","family":"Horv\u00e1th","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szintia","family":"Barnai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Bal\u00e1zs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gy\u00f6rgy","family":"L\u00e1z\u00e1r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikl\u00f3s","family":"Erd\u00e9lyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shmuel","family":"Muallem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5768-3090","authenticated-orcid":false,"given":"J\u00f3zsef","family":"Mal\u00e9th","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cub.2025.09.006_bib1","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a035279","article-title":"Ca2+ Signaling in Exocrine Cells","volume":"12","author":"Ahuja","year":"2020","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.cub.2025.09.006_bib2","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.ceca.2014.01.006","article-title":"cAMP and Ca2+ signaling in secretory epithelia: crosstalk and synergism","volume":"55","author":"Ahuja","year":"2014","journal-title":"Cell Calcium"},{"key":"10.1016\/j.cub.2025.09.006_bib3","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.cub.2005.05.055","article-title":"STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx","volume":"15","author":"Liou","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2025.09.006_bib4","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nature05122","article-title":"Orai1 is an essential pore subunit of the CRAC channel","volume":"443","author":"Prakriya","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.cub.2025.09.006_bib5","doi-asserted-by":"crossref","first-page":"4303","DOI":"10.1172\/JCI89056","article-title":"Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function","volume":"126","author":"Concepcion","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cub.2025.09.006_bib6","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.bbamcr.2018.11.001","article-title":"STIM1 and Orai1 regulate Ca2+ microdomains for activation of transcription","volume":"1866","author":"Schober","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.cub.2025.09.006_bib7","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.82281","article-title":"A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels","volume":"12","author":"Yeung","year":"2023","journal-title":"eLife"},{"key":"10.1016\/j.cub.2025.09.006_bib8","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.bbamcr.2018.03.007","article-title":"Store-independent coupling between the Secretory Pathway Ca2+ transport ATPase SPCA1 and Orai1 in Golgi stress and Hailey-Hailey disease","volume":"1865","author":"Smaardijk","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.cub.2025.09.006_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067348","article-title":"SPCA2 regulates Orai1 trafficking and store independent Ca2+ entry in a model of lactation","volume":"8","author":"Cross","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cub.2025.09.006_bib10","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cell.2010.08.040","article-title":"Store-independent activation of Orai1 by SPCA2 in mammary tumors","volume":"143","author":"Feng","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.cub.2025.09.006_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-37602-7","article-title":"Original association of ion transporters mediates the ECM-induced breast cancer cell survival: Kv10.1-Orai1-SPCA2 partnership","volume":"9","author":"Peretti","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cub.2025.09.006_bib12","first-page":"251","article-title":"The N and C-termini of SPCA2 regulate differently Kv10.1 function: role in the collagen 1-induced breast cancer cell survival","volume":"11","author":"Girault","year":"2021","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.cub.2025.09.006_bib13","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1152\/physrev.00029.2001","article-title":"Molecular structure and physiological function of chloride channels","volume":"82","author":"Jentsch","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cub.2025.09.006_bib14","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1152\/physrev.00039.2014","article-title":"Airway Gland Structure and Function","volume":"95","author":"Widdicombe","year":"2015","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cub.2025.09.006_bib15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/112_2015_5002","article-title":"CFTR: A New Horizon in the Pathomechanism and Treatment of Pancreatitis","volume":"170","author":"Hegyi","year":"2016","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.cub.2025.09.006_bib16","first-page":"212","article-title":"Cystic fibrosis: lessons from the sweat gland","volume":"22","author":"Quinton","year":"2007","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.cub.2025.09.006_bib17","doi-asserted-by":"crossref","DOI":"10.1007\/s00018-022-04287-1","article-title":"Impaired regulation of PMCA activity by defective CFTR expression promotes epithelial cell damage in alcoholic pancreatitis and hepatitis","volume":"79","author":"Mad\u00e1csy","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cub.2025.09.006_bib18","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/nsmb1278","article-title":"CFTR regulatory region interacts with NBD1 predominantly via multiple transient helices","volume":"14","author":"Baker","year":"2007","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.cub.2025.09.006_bib19","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a009522","article-title":"Dynamics intrinsic to cystic fibrosis transmembrane conductance regulator function and stability","volume":"3","author":"Chong","year":"2013","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.cub.2025.09.006_bib20","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nature04712","article-title":"The ABC protein turned chloride channel whose failure causes cystic fibrosis","volume":"440","author":"Gadsby","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.cub.2025.09.006_bib21","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1113\/jphysiol.2009.171595","article-title":"Gating of the CFTR Cl- channel by ATP-driven nucleotide-binding domain dimerisation","volume":"587","author":"Hwang","year":"2009","journal-title":"J. Physiol."},{"key":"10.1016\/j.cub.2025.09.006_bib22","doi-asserted-by":"crossref","first-page":"4728","DOI":"10.1038\/sj.emboj.7601373","article-title":"In vivo phosphorylation of CFTR promotes formation of a nucleotide-binding domain heterodimer","volume":"25","author":"Mense","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.cub.2025.09.006_bib23","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.tips.2017.11.006","article-title":"cAMP: From Long-Range Second Messenger to Nanodomain Signalling","volume":"39","author":"Musheshe","year":"2018","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.cub.2025.09.006_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2022.119293","article-title":"Spatial and temporal crosstalk between the cAMP and Ca2+ signaling systems","volume":"1869","author":"Arige","year":"2022","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.cub.2025.09.006_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2002299","article-title":"Direct binding between Orai1 and AC8 mediates dynamic interplay between Ca2+ and cAMP signaling","volume":"5","author":"Willoughby","year":"2012","journal-title":"Sci. Signal."},{"key":"10.1016\/j.cub.2025.09.006_bib26","doi-asserted-by":"crossref","first-page":"4274","DOI":"10.1096\/fj.11-187682","article-title":"Enhanced Ca2+ entry due to Orai1 plasma membrane insertion increases IL-8 secretion by cystic fibrosis airways","volume":"25","author":"Balghi","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.cub.2025.09.006_bib27","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/s41374-019-0300-3","article-title":"Mouse pancreatic ductal organoid culture as a relevant model to study exocrine pancreatic ion secretion","volume":"100","author":"Moln\u00e1r","year":"2020","journal-title":"Lab. Invest."},{"key":"10.1016\/j.cub.2025.09.006_bib28","doi-asserted-by":"crossref","DOI":"10.1007\/s00018-023-04836-2","article-title":"Human pancreatic ductal organoids with controlled polarity provide a novel ex vivo tool to study epithelial cell physiology","volume":"80","author":"Varga","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cub.2025.09.006_bib29","doi-asserted-by":"crossref","first-page":"17404","DOI":"10.1073\/pnas.0408030101","article-title":"Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensor","volume":"101","author":"Palmer","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2025.09.006_bib30","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11751","article-title":"Store-independent modulation of Ca(2+) entry through Orai by Septin 7","volume":"7","author":"Deb","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2025.09.006_bib31","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1002\/jcp.25391","article-title":"Atp2c2 Is Transcribed From a Unique Transcriptional Start Site in Mouse Pancreatic Acinar Cells","volume":"231","author":"Fenech","year":"2016","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.cub.2025.09.006_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2019.118567","article-title":"The pancreas-specific form of secretory pathway calcium ATPase 2 regulates multiple pathways involved in calcium homeostasis","volume":"1867","author":"Fenech","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.cub.2025.09.006_bib33","doi-asserted-by":"crossref","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based map of the human proteome","volume":"347","author":"Uhl\u00e9n","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.cub.2025.09.006_bib34","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1113\/JP282203","article-title":"Bile acid- and ethanol-mediated activation of Orai1 damages pancreatic ductal secretion in acute pancreatitis","volume":"600","author":"Pallagi","year":"2022","journal-title":"J. Physiol."},{"key":"10.1016\/j.cub.2025.09.006_bib35","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1083\/jcb.200604014","article-title":"Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane","volume":"174","author":"Wu","year":"2006","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cub.2025.09.006_bib36","doi-asserted-by":"crossref","first-page":"24979","DOI":"10.1074\/jbc.M604589200","article-title":"Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1","volume":"281","author":"Mercer","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cub.2025.09.006_bib37","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1152\/physrev.00020.2014","article-title":"Store-Operated Calcium Channels","volume":"95","author":"Prakriya","year":"2015","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cub.2025.09.006_bib38","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2018101452","article-title":"Anoctamin 8 tethers endoplasmic reticulum and plasma membrane for assembly of Ca2+ signaling complexes at the ER\/PM compartment","volume":"38","author":"Jha","year":"2019","journal-title":"EMBO J."},{"key":"10.1016\/j.cub.2025.09.006_bib39","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2301410120","article-title":"PtdSer as a signaling lipid determined by privileged localization of ORP5 and ORP8 at ER\/PM junctional foci to determine PM and ER PtdSer\/PI(4)P ratio and cell function","volume":"120","author":"Chung","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2025.09.006_bib40","doi-asserted-by":"crossref","first-page":"3672","DOI":"10.1091\/mbc.e14-06-1107","article-title":"Single-molecule analysis of diffusion and trapping of STIM1 and Orai1 at endoplasmic reticulum-plasma membrane junctions","volume":"25","author":"Wu","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.cub.2025.09.006_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102240","article-title":"Secretory pathway Ca2+-ATPase SPCA2 regulates mitochondrial respiration and DNA damage response through store-independent calcium entry","volume":"50","author":"Makena","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.cub.2025.09.006_bib42","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1136\/gut.2009.192153","article-title":"Non-conjugated chenodeoxycholate induces severe mitochondrial damage and inhibits bicarbonate transport in pancreatic duct cells","volume":"60","author":"Mal\u00e9th","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.cub.2025.09.006_bib43","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1053\/j.gastro.2013.03.047","article-title":"Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice","volume":"145","author":"Park","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cub.2025.09.006_bib44","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1113\/jphysiol.2012.249698","article-title":"Adenylyl cyclase 6 mediates the action of cyclic AMP-dependent secretagogues in mouse pancreatic exocrine cells via protein kinase A pathway activation","volume":"591","author":"Sabbatini","year":"2013","journal-title":"J. Physiol."},{"key":"10.1016\/j.cub.2025.09.006_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms6843","article-title":"Translocation between PI(4,5)P2-poor and PI(4,5)P2-rich microdomains during store depletion determines STIM1 conformation and Orai1 gating","volume":"5","author":"Mal\u00e9th","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2025.09.006_bib46","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12896","article-title":"A plasma membrane microdomain compartmentalizes ephrin-generated cAMP signals to prune developing retinal axon arbors","volume":"7","author":"Averaimo","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2025.09.006_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/s18072164","article-title":"Targeting FRET-Based Reporters for cAMP and PKA Activity Using AKAP79","volume":"18","author":"Musheshe","year":"2018","journal-title":"Sensors (Basel)"},{"key":"10.1016\/j.cub.2025.09.006_bib48","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1152\/physrev.00057.2003","article-title":"Store-operated calcium channels","volume":"85","author":"Parekh","year":"2005","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cub.2025.09.006_bib49","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cmet.2017.02.007","article-title":"Orai1-Mediated Antimicrobial Secretion from Pancreatic Acini Shapes the Gut Microbiome and Regulates Gut Innate Immunity","volume":"25","author":"Ahuja","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.cub.2025.09.006_bib50","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.167645","article-title":"Orai1 calcium channel inhibition prevents progression of chronic pancreatitis","volume":"8","author":"Szab\u00f3","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.cub.2025.09.006_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21114005","article-title":"Intracellular Ca2+ Signalling in the Pathogenesis of Acute Pancreatitis: Recent Advances and Translational Perspectives","volume":"21","author":"Pallagi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cub.2025.09.006_bib52","doi-asserted-by":"crossref","first-page":"9895","DOI":"10.1074\/jbc.272.15.9895","article-title":"PMR1, a Ca2+-ATPase in yeast Golgi, has properties distinct from sarco\/endoplasmic reticulum and plasma membrane calcium pumps","volume":"272","author":"Sorin","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cub.2025.09.006_bib53","doi-asserted-by":"crossref","first-page":"22800","DOI":"10.1074\/jbc.M501026200","article-title":"The secretory pathway Ca2+\/Mn2+-ATPase 2 is a Golgi-localized pump with high affinity for Ca2+ ions","volume":"280","author":"Vanoevelen","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cub.2025.09.006_bib54","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.celrep.2013.09.038","article-title":"Feedback Regulation of Receptor-Induced Ca2+ Signaling Mediated by E-Syt1 and Nir2 at Endoplasmic Reticulum-Plasma Membrane Junctions","volume":"5","author":"Chang","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.cub.2025.09.006_bib55","doi-asserted-by":"crossref","first-page":"5273","DOI":"10.1113\/jphysiol.2012.236893","article-title":"Bicarbonate-dependent chloride transport drives fluid secretion by the human airway epithelial cell line Calu-3","volume":"590","author":"Shan","year":"2012","journal-title":"J. Physiol."},{"key":"10.1016\/j.cub.2025.09.006_bib56","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.187951","article-title":"The potentiator ivacaftor is essential for pharmacological restoration of F508del-CFTR function and mucociliary clearance in cystic fibrosis","volume":"10","author":"Bal\u00e1zs","year":"2025","journal-title":"JCI Insight"},{"key":"10.1016\/j.cub.2025.09.006_bib57","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2015.04.015","article-title":"Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models","volume":"149","author":"Wen","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cub.2025.09.006_bib58","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a009704","article-title":"The stress of protein misfolding: from single cells to multicellular organisms","volume":"3","author":"Gidalevitz","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.cub.2025.09.006_bib59","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a004143","article-title":"Regulation by Ca2+-signaling pathways of adenylyl cyclases","volume":"3","author":"Halls","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.cub.2025.09.006_bib60","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1053\/j.gastro.2010.04.004","article-title":"Dynamic regulation of CFTR bicarbonate permeability by [Cl-]i and its role in pancreatic bicarbonate secretion","volume":"139","author":"Park","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cub.2025.09.006_bib61","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/ncb1850","article-title":"Store-operated cyclic AMP signalling mediated by STIM1","volume":"11","author":"Lefkimmiatis","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cub.2025.09.006_bib62","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1091\/mbc.e09-12-1004","article-title":"CFTR-adenylyl cyclase I association responsible for UTP activation of CFTR in well-differentiated primary human bronchial cell cultures","volume":"21","author":"Namkung","year":"2010","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.cub.2025.09.006_bib63","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cellsig.2018.01.008","article-title":"Compartmentalized crosstalk of CFTR and TMEM16A (ANO1) through EPAC1 and ADCY1","volume":"44","author":"L\u00e9rias","year":"2018","journal-title":"Cell. Signal."},{"key":"10.1016\/j.cub.2025.09.006_bib64","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.ceca.2015.04.004","article-title":"Store-operated Ca2+-entry and adenylyl cyclase","volume":"58","author":"Cooper","year":"2015","journal-title":"Cell Calcium"},{"key":"10.1016\/j.cub.2025.09.006_bib65","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1124\/mol.117.110825","article-title":"cAMP Signaling Compartmentation: Adenylyl Cyclases as Anchors of Dynamic Signaling Complexes","volume":"93","author":"Johnstone","year":"2018","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.cub.2025.09.006_bib66","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.bpj.2015.04.042","article-title":"Cholesterol modulates CFTR confinement in the plasma membrane of primary epithelial cells","volume":"109","author":"Abu-Arish","year":"2015","journal-title":"Biophys. J."},{"key":"10.1016\/j.cub.2025.09.006_bib67","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1038\/s44318-025-00470-9","article-title":"Lipid transporters E-Syt3 and ORP5 regulate epithelial ion transport by controlling phosphatidylserine enrichment at ER\/PM junctions","volume":"44","author":"Sarkar","year":"2025","journal-title":"EMBO J."},{"key":"10.1016\/j.cub.2025.09.006_bib68","doi-asserted-by":"crossref","first-page":"C515","DOI":"10.1152\/ajpcell.00330.2013","article-title":"Cellular calcium dynamics in lactation and breast cancer: from physiology to pathology","volume":"306","author":"Cross","year":"2014","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.cub.2025.09.006_bib69","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jcmgh.2017.11.013","article-title":"Cftr Modulates Wnt\/\u03b2-Catenin Signaling and Stem Cell Proliferation in Murine Intestine","volume":"5","author":"Strubberg","year":"2018","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cub.2025.09.006_bib70","doi-asserted-by":"crossref","DOI":"10.3390\/cells10051246","article-title":"Store Operated Calcium Entry in Cell Migration and Cancer Metastasis","volume":"10","author":"Hammad","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.cub.2025.09.006_bib71","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2014.11.002","article-title":"Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis","volume":"148","author":"Mal\u00e9th","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cub.2025.09.006_bib72","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1113\/JP279047","article-title":"TRPM2-mediated extracellular Ca2+ entry promotes acinar cell necrosis in biliary acute pancreatitis","volume":"598","author":"Fanczal","year":"2020","journal-title":"J. Physiol."},{"key":"10.1016\/j.cub.2025.09.006_bib73","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.cell.2014.12.021","article-title":"Organoid models of human and mouse ductal pancreatic cancer","volume":"160","author":"Boj","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cub.2025.09.006_bib74","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nature11826","article-title":"In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration","volume":"494","author":"Huch","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.cub.2025.09.006_bib75","doi-asserted-by":"crossref","DOI":"10.1002\/cpz1.70045","article-title":"Human Pancreas-Derived Organoids with Controlled Polarity: Detailed Protocols and Experimental Timeline","volume":"4","author":"Kiss","year":"2024","journal-title":"Curr. Protoc."},{"key":"10.1016\/j.cub.2025.09.006_bib76","doi-asserted-by":"crossref","first-page":"E2086","DOI":"10.1073\/pnas.1613546114","article-title":"Synergy of cAMP and calcium signaling pathways in CFTR regulation","volume":"114","author":"Bozoky","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2025.09.006_bib77","doi-asserted-by":"crossref","first-page":"e177","DOI":"10.1097\/CCM.0000000000000101","article-title":"The role of pancreatic ductal secretion in protection against acute pancreatitis in mice\u2217","volume":"42","author":"Pallagi","year":"2014","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.cub.2025.09.006_bib78","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/978-1-4939-7831-1_8","article-title":"Comparison of Mitochondrial Incubation Media for Measurement of Respiration and Hydrogen Peroxide Production","volume":"1782","author":"Koml\u00f3di","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.cub.2025.09.006_bib79","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-55618-5","article-title":"Ca(2+)N It Be Measured? Detection of Extramitochondrial Calcium Movement With High-Resolution FluoRespirometry","volume":"9","author":"N\u00e1szai","year":"2019","journal-title":"Sci. Rep."}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982225011765?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982225011765?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T21:26:08Z","timestamp":1783027568000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982225011765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":79,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S0960982225011765"],"URL":"https:\/\/doi.org\/10.1016\/j.cub.2025.09.006","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Store-independent activation of STIM1-ORAI1 by SPCA2 determines the basal CFTR activity in secretory epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Current Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cub.2025.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}