{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T21:36:38Z","timestamp":1773524198679,"version":"3.50.1"},"reference-count":110,"publisher":"Elsevier BV","issue":"21","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010097","name":"China Association for Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012660","name":"Guangdong Provincial Key Laboratory of Prevention and Control for Severe Clinical Animal Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012660","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007955","name":"Jiaying University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007955","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.cub.2025.09.012","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T04:42:23Z","timestamp":1758948143000},"page":"5150-5166.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Reduced oxytocin signaling in the dBNST drives the transition from acute pain to persistent anxiety"],"prefix":"10.1016","volume":"35","author":[{"given":"Shunchang","family":"Fang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanbing","family":"Lian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufang","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yishuai","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Dan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shana","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiankai","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhui","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songhai","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boxing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianyan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cub.2025.09.012_bib1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.tics.2023.01.008","article-title":"Sensory emotion regulation","volume":"27","author":"Rodriguez","year":"2023","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.cub.2025.09.012_bib2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neuron.2020.05.024","article-title":"What Is the Relationship between Pain and Emotion? Bridging Constructs and Communities","volume":"107","author":"Gilam","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2025.09.012_bib3","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1126\/science.abn2479","article-title":"Molecular and neural basis of pleasant touch sensation","volume":"376","author":"Liu","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.cub.2025.09.012_bib4","doi-asserted-by":"crossref","first-page":"5373","DOI":"10.1523\/JNEUROSCI.2067-21.2022","article-title":"GABAergic CaMKII\u03b1+ Amygdala Output Attenuates Pain and Modulates Emotional-Motivational Behavior via Parabrachial Inhibition","volume":"42","author":"Hogri","year":"2022","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cub.2025.09.012_bib5","article-title":"Propofol Alleviates Anxiety-Like Behaviors Associated with Pain by Inhibiting the Hyperactivity of PVNCRH Neurons via GABAA Receptor \u03b23 Subunits","volume":"11","author":"Yu","year":"2024","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.cub.2025.09.012_bib6","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/s41401-024-01426-1","article-title":"Differential regulation of pruritic sensation and emotion by cannabinoid type 1 receptors on mPFC glutamatergic and GABAergic neurons","volume":"46","author":"Zhanmu","year":"2025","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.cub.2025.09.012_bib7","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nn.4208","article-title":"Laterodorsal tegmentum interneuron subtypes oppositely regulate olfactory cue-induced innate fear","volume":"19","author":"Yang","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cub.2025.09.012_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114946","article-title":"Separate anterior paraventricular thalamus projections differentially regulate sensory and affective aspects of pain","volume":"43","author":"Mindaye","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.cub.2025.09.012_bib9","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.cub.2024.02.060","article-title":"An insular cortical circuit required for itch sensation and aversion","volume":"34","author":"Zheng","year":"2024","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2025.09.012_bib10","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1016\/j.pain.2013.08.005","article-title":"Does severe acute pain provoke lasting changes in attentional and emotional mechanisms of pain-related processing? A longitudinal study","volume":"154","author":"Dimova","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.cub.2025.09.012_bib11","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1038\/s41593-019-0468-2","article-title":"A neural circuit for comorbid depressive symptoms in chronic pain","volume":"22","author":"Zhou","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cub.2025.09.012_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-024-07372-2","article-title":"Berberine alleviates chronic pain-induced anxiety-like behaviors by inhibiting the activation of VLT-projecting cACC (Cg2) neurons","volume":"7","author":"He","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.cub.2025.09.012_bib13","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1001\/jamapediatrics.2024.3039","article-title":"Anxiety and Depression in Youth With Chronic Pain: A Systematic Review and Meta-Analysis","volume":"178","author":"Dudeney","year":"2024","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.cub.2025.09.012_bib14","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1097\/j.pain.0000000000003056","article-title":"Co-occurrence of chronic pain and anxiety\/depression symptoms in U.S. adults: prevalence, functional impacts, and opportunities","volume":"165","author":"De La Rosa","year":"2024","journal-title":"Pain"},{"key":"10.1016\/j.cub.2025.09.012_bib15","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1016\/S0140-6736(21)00393-7","article-title":"Chronic pain: an update on burden, best practices, and new advances","volume":"397","author":"Cohen","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.cub.2025.09.012_bib16","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/mp.2016.1","article-title":"Overshadowed by the amygdala: the bed nucleus of the stria terminalis emerges as key to psychiatric disorders","volume":"21","author":"Lebow","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.cub.2025.09.012_bib17","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1038\/s41386-023-01569-5","article-title":"BNST PKC\u03b4 neurons are activated by specific aversive conditions to promote anxiety-like behavior","volume":"48","author":"Williford","year":"2023","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.cub.2025.09.012_bib18","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1016\/j.neuron.2021.09.008","article-title":"Mitophagy in the basolateral amygdala mediates increased anxiety induced by aversive social experience","volume":"109","author":"Duan","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2025.09.012_bib19","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.46525","article-title":"Bed nucleus of the stria terminalis regulates fear to unpredictable threat signals","volume":"8","author":"Goode","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.cub.2025.09.012_bib20","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1038\/s41386-023-01678-1","article-title":"Glutamatergic and GABAergic anteroventral BNST projections to PVN CRH neurons regulate maternal separation-induced visceral pain","volume":"48","author":"Huang","year":"2023","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.cub.2025.09.012_bib21","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.1038\/s41380-020-0816-3","article-title":"A new GABAergic somatostatin projection from the BNST onto accumbal parvalbumin neurons controls anxiety","volume":"26","author":"Xiao","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.cub.2025.09.012_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112799","article-title":"Dorsal BNST DRD2+ neurons mediate sex-specific anxiety-like behavior induced by chronic social isolation","volume":"42","author":"Zheng","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.cub.2025.09.012_bib23","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1038\/mp.2017.165","article-title":"Serotonin inputs to the dorsal BNST modulate anxiety in a 5-HT1A receptor-dependent manner","volume":"23","author":"Garcia-Garcia","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.cub.2025.09.012_bib24","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.biopsych.2012.11.008","article-title":"Opposing catecholamine changes in the bed nucleus of the stria terminalis during intracranial self-stimulation and its extinction","volume":"74","author":"Park","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.cub.2025.09.012_bib25","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nature12041","article-title":"Distinct extended amygdala circuits for divergent motivational states","volume":"496","author":"Jennings","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.cub.2025.09.012_bib26","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12961","article-title":"Glutamatergic input from the insula to the ventral bed nucleus of the stria terminalis controls reward-related behavior","volume":"26","author":"Girven","year":"2021","journal-title":"Addict. Biol."},{"key":"10.1016\/j.cub.2025.09.012_bib27","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/npp.2015.185","article-title":"The Human BNST: Functional Role in Anxiety and Addiction","volume":"41","author":"Avery","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.cub.2025.09.012_bib28","doi-asserted-by":"crossref","first-page":"7949","DOI":"10.1523\/JNEUROSCI.0704-20.2020","article-title":"Anxiety and the Neurobiology of Temporally Uncertain Threat Anticipation","volume":"40","author":"Hur","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cub.2025.09.012_bib29","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.biopsych.2015.06.004","article-title":"Oxytocin in General Anxiety and Social Fear: A Translational Approach","volume":"79","author":"Neumann","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.cub.2025.09.012_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2024.105935","article-title":"Is the \"social hormone\" oxytocin relevant to psychotherapy treatment outcomes? A systematic review of observational and experimental studies","volume":"167","author":"Hohl","year":"2024","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.cub.2025.09.012_bib31","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.tins.2012.08.004","article-title":"Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors","volume":"35","author":"Neumann","year":"2012","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.cub.2025.09.012_bib32","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.neuron.2016.01.041","article-title":"A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing","volume":"89","author":"Eliava","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2025.09.012_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-45626-z","article-title":"Social buffering in rats reduces fear by oxytocin triggering sustained changes in central amygdala neuronal activity","volume":"15","author":"Hegoburu","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2025.09.012_bib34","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.neuron.2023.12.022","article-title":"Single-neuron projectomes of mouse paraventricular hypothalamic nucleus oxytocin neurons reveal mutually exclusive projection patterns","volume":"112","author":"Li","year":"2024","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2025.09.012_bib35","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1152\/physrev.00031.2017","article-title":"The Oxytocin Receptor: From Intracellular Signaling to Behavior","volume":"98","author":"Jurek","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cub.2025.09.012_bib36","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41380-020-0802-9","article-title":"Brain oxytocin: how puzzle stones from animal studies translate into psychiatry","volume":"26","author":"Grinevich","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.cub.2025.09.012_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108601","article-title":"Oxytocin excites BNST interneurons and inhibits BNST output neurons to the central amygdala","volume":"192","author":"Francesconi","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.cub.2025.09.012_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115768","article-title":"Vasopressin and oxytocin excite BNST neurons via oxytocin receptors, which reduce anxious arousal","volume":"44","author":"Francesconi","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.cub.2025.09.012_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-019-0474-x","article-title":"Oxytocin receptors in the dorsolateral bed nucleus of the stria terminalis (BNST) bias fear learning toward temporally predictable cued fear","volume":"9","author":"Martinon","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.cub.2025.09.012_bib40","doi-asserted-by":"crossref","first-page":"8922","DOI":"10.1523\/JNEUROSCI.0963-18.2018","article-title":"Dorsal BNST \u03b12A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors","volume":"38","author":"Harris","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cub.2025.09.012_bib41","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1038\/s41380-021-01053-w","article-title":"Reciprocal control of obesity and anxiety-depressive disorder via a GABA and serotonin neural circuit","volume":"26","author":"Xia","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.cub.2025.09.012_bib42","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nature19318","article-title":"Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala","volume":"537","author":"Marcinkiewcz","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cub.2025.09.012_bib43","doi-asserted-by":"crossref","first-page":"15476","DOI":"10.1523\/JNEUROSCI.2429-12.2012","article-title":"Oxytocin promotes long-term potentiation by enhancing epidermal growth factor receptor-mediated local translation of protein kinase M\u03b6","volume":"32","author":"Lin","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cub.2025.09.012_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2021.110211","article-title":"The MAP kinase ERK5\/MAPK7 is a downstream effector of oxytocin signaling in myometrial cells","volume":"90","author":"Devost","year":"2022","journal-title":"Cell. Signal."},{"key":"10.1016\/j.cub.2025.09.012_bib45","doi-asserted-by":"crossref","first-page":"5917","DOI":"10.1038\/s41388-020-01415-8","article-title":"The oxytocin receptor signalling system and breast cancer: a critical review","volume":"39","author":"Liu","year":"2020","journal-title":"Oncogene"},{"key":"10.1016\/j.cub.2025.09.012_bib46","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/s41587-022-01561-2","article-title":"A genetically encoded sensor measures temporal oxytocin release from different neuronal compartments","volume":"41","author":"Qian","year":"2023","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cub.2025.09.012_bib47","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/j.cell.2019.05.006","article-title":"Single-Cell Multi-omic Integration Compares and Contrasts Features of Brain Cell Identity","volume":"177","author":"Welch","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cub.2025.09.012_bib48","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.neuron.2018.09.008","article-title":"Oxytocin Transforms Firing Mode of CA2 Hippocampal Neurons","volume":"100","author":"Tirko","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2025.09.012_bib49","first-page":"7707","article-title":"Oxytocin-Modulated Ion Channel Ensemble Controls Depolarization, Integration and Burst Firing in CA2 Pyramidal Neurons","volume":"42","author":"Liu","year":"2022","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cub.2025.09.012_bib50","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.tins.2016.01.006","article-title":"Neural Mechanisms Underlying Anxiety-Chronic Pain Interactions","volume":"39","author":"Zhuo","year":"2016","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.cub.2025.09.012_bib51","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.neubiorev.2019.08.007","article-title":"Optogenetics and its application in pain and anxiety research","volume":"105","author":"Jarrin","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.cub.2025.09.012_bib52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0262076","article-title":"Dispositional and situational personal features and acute post-collision head and neck pain: Double mediation of pain catastrophizing and pain sensitivity","volume":"17","author":"Granot","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.cub.2025.09.012_bib53","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1097\/j.pain.0000000000001581","article-title":"How are pain and traumatic stress symptoms related in acute whiplash-associated disorders? An investigation of the role of pain-related fear in a daily diary study","volume":"160","author":"Eather","year":"2019","journal-title":"Pain"},{"key":"10.1016\/j.cub.2025.09.012_bib54","doi-asserted-by":"crossref","first-page":"e395","DOI":"10.1016\/j.pmn.2024.06.006","article-title":"Catastrophic Cognition Is a Stronger Predictor Than Emotional Factors of Acute Postoperative Pain in Patients With Traumatic Orthopedic Injuries","volume":"25","author":"Cheng","year":"2024","journal-title":"Pain Manag. Nurs."},{"key":"10.1016\/j.cub.2025.09.012_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.ienj.2023.101375","article-title":"The relationship between acute pain and other types of suffering in pre-hospital trauma victims: An observational study","volume":"71","author":"Mota","year":"2023","journal-title":"Int. Emerg. Nurs."},{"key":"10.1016\/j.cub.2025.09.012_bib56","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1523\/JNEUROSCI.1578-21.2022","article-title":"A Distinct Metabolically Defined Central Nucleus Circuit Bidirectionally Controls Anxiety-Related Behaviors","volume":"42","author":"Ren","year":"2022","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cub.2025.09.012_bib57","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1038\/s41380-020-0846-x","article-title":"Functional deletion of neuropeptide Y receptors type 2 in local synaptic networks of anteroventral BNST facilitates recall and increases return of fear","volume":"26","author":"Bartsch","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.cub.2025.09.012_bib58","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.scib.2020.03.028","article-title":"Anxiety-related cell-type-specific neural circuits in the anterior-dorsal bed nucleus of the stria terminalis","volume":"65","author":"Wang","year":"2020","journal-title":"Sci. Bull. (Beijing)"},{"key":"10.1016\/j.cub.2025.09.012_bib59","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2016.128","article-title":"Altered responsiveness of BNST and amygdala neurons in trauma-induced anxiety","volume":"6","author":"Rodr\u00edguez-Sierra","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.cub.2025.09.012_bib60","article-title":"Synergism between two BLA-to-BNST pathways for appropriate expression of anxiety-like behaviors in male mice","volume":"15","author":"Han","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2025.09.012_bib61","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14456","article-title":"NMDA-receptor-dependent plasticity in the bed nucleus of the stria terminalis triggers long-term anxiolysis","volume":"8","author":"Glangetas","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2025.09.012_bib62","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abj5586","article-title":"Chronic pain-induced neuronal plasticity in the bed nucleus of the stria terminalis causes maladaptive anxiety","volume":"8","author":"Yamauchi","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cub.2025.09.012_bib63","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/s41593-018-0198-x","article-title":"Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states","volume":"21","author":"Giardino","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cub.2025.09.012_bib64","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nature12018","article-title":"Diverging neural pathways assemble a behavioural state from separable features in anxiety","volume":"496","author":"Kim","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.cub.2025.09.012_bib65","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/npp.2009.83","article-title":"The neurocircuitry of fear, stress, and anxiety disorders","volume":"35","author":"Shin","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.cub.2025.09.012_bib66","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.neuropharm.2017.04.039","article-title":"Oxytocin receptor neurotransmission in the dorsolateral bed nucleus of the stria terminalis facilitates the acquisition of cued fear in the fear-potentiated startle paradigm in rats","volume":"121","author":"Moaddab","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.cub.2025.09.012_bib67","doi-asserted-by":"crossref","first-page":"26406","DOI":"10.1073\/pnas.2011890117","article-title":"Extrahypothalamic oxytocin neurons drive stress-induced social vigilance and avoidance","volume":"117","author":"Duque-Wilckens","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2025.09.012_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.yhbeh.2022.105203","article-title":"Oxytocin receptor behavioral effects and cell types in the bed nucleus of the stria terminalis","volume":"143","author":"Luo","year":"2022","journal-title":"Horm. Behav."},{"key":"10.1016\/j.cub.2025.09.012_bib69","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1002\/cne.23954","article-title":"Genetic cell targeting uncovers specific neuronal types and distinct subregions in the bed nucleus of the stria terminalis","volume":"524","author":"Nguyen","year":"2016","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.cub.2025.09.012_bib70","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1523\/JNEUROSCI.1944-20.2020","article-title":"Somatostatin Neurons of the Bed Nucleus of Stria Terminalis Enhance Associative Fear Memory Consolidation in Mice","volume":"41","author":"Bruzsik","year":"2021","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cub.2025.09.012_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2021.113401","article-title":"Cell-type diversity in the bed nucleus of the stria terminalis to regulate motivated behaviors","volume":"411","author":"Ortiz-Juza","year":"2021","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.cub.2025.09.012_bib72","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1152\/jn.00382.2007","article-title":"Differential expression of intrinsic membrane currents in defined cell types of the anterolateral bed nucleus of the stria terminalis","volume":"98","author":"Hammack","year":"2007","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.cub.2025.09.012_bib73","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1002\/cne.24202","article-title":"A comparative analysis of the physiological properties of neurons in the anterolateral bed nucleus of the stria terminalis in the Mus musculus, Rattus norvegicus, and Macaca mulatta","volume":"525","author":"Daniel","year":"2017","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.cub.2025.09.012_bib74","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.neuron.2012.09.025","article-title":"Neuromodulation by oxytocin and vasopressin","volume":"76","author":"Stoop","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2025.09.012_bib75","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.neuron.2018.07.016","article-title":"Interplay between Oxytocin and Sensory Systems in the Orchestration of Socio-Emotional Behaviors","volume":"99","author":"Grinevich","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2025.09.012_bib76","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007857","article-title":"Blocking skeletal muscle DHPRs\/Ryr1 prevents neuromuscular synapse loss in mutant mice deficient in type III Neuregulin 1 (CRD-Nrg1)","volume":"15","author":"Liu","year":"2019","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cub.2025.09.012_bib77","doi-asserted-by":"crossref","DOI":"10.1186\/s13041-021-00892-6","article-title":"Progress on the roles of MEF2C in neuropsychiatric diseases","volume":"15","author":"Zhang","year":"2022","journal-title":"Mol. Brain"},{"key":"10.1016\/j.cub.2025.09.012_bib78","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1093\/cercor\/bhh141","article-title":"Activity-dependent regulation of synapse and dendritic spine morphology in developing barrel cortex requires phospholipase C-beta1 signalling","volume":"15","author":"Spires","year":"2005","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.cub.2025.09.012_bib79","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-021-01396-6","article-title":"Reduced cue-induced reinstatement of cocaine-seeking behavior in Plcb1 +\/- mice","volume":"11","author":"Cabana-Dom\u00ednguez","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.cub.2025.09.012_bib80","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.81407","article-title":"CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles","volume":"12","author":"Mueller","year":"2023","journal-title":"eLife"},{"key":"10.1016\/j.cub.2025.09.012_bib81","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2102265118","article-title":"RyR-mediated Ca2+ release elicited by neuronal activity induces nuclear Ca2+ signals, CREB phosphorylation, and Npas4\/RyR2 expression","volume":"118","author":"Lobos","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2025.09.012_bib82","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1139\/cjpp-2012-0413","article-title":"Altered expression of genes for Kir ion channels in dilated cardiomyopathy","volume":"91","author":"Szuts","year":"2013","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.cub.2025.09.012_bib83","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.mcn.2011.01.011","article-title":"A transcriptomic analysis of type I-III neurons in the bed nucleus of the stria terminalis","volume":"46","author":"Hazra","year":"2011","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.cub.2025.09.012_bib84","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2021.711065","article-title":"Effect of Estrous Cycle on Behavior of Females in Rodent Tests of Anxiety","volume":"12","author":"Lovick","year":"2021","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.cub.2025.09.012_bib85","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1677\/joe.0.1360305","article-title":"Variations in oxytocin secretion during the 4-day oestrous cycle of the rat","volume":"136","author":"Windle","year":"1993","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.cub.2025.09.012_bib86","doi-asserted-by":"crossref","DOI":"10.3390\/nu14245350","article-title":"Changes in Serum Oxytocin Levels under Physiological and Supraphysiological Gonadal Steroid Hormone Conditions in Women of Reproductive Age: A Preliminary Study","volume":"14","author":"Tachibana","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.cub.2025.09.012_bib88","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2023.1185243","article-title":"Differences in the neural basis and transcriptomic patterns in acute and persistent pain-related anxiety-like behaviors","volume":"16","author":"Fang","year":"2023","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.cub.2025.09.012_bib96","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cub.2025.09.012_bib97","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cub.2025.09.012_bib98","doi-asserted-by":"crossref","first-page":"10357","DOI":"10.1523\/JNEUROSCI.2119-09.2009","article-title":"The bed nucleus of the stria terminalis mediates inter-individual variations in anxiety and fear","volume":"29","author":"Duvarci","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cub.2025.09.012_bib99","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cub.2025.09.012_bib100","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.cub.2025.09.012_bib101","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb.)"},{"key":"10.1016\/j.cub.2025.09.012_bib106","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cub.2025.09.012_bib109","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cub.2025.09.012_bib87","doi-asserted-by":"crossref","first-page":"4433","DOI":"10.1007\/s00213-015-4071-2","article-title":"Differential effects of general anesthetics on anxiety-like behavior in formalin-induced pain: involvement of ERK activation in the anterior cingulate cortex","volume":"232","author":"Luo","year":"2015","journal-title":"Psychopharmacol. (Berl.)"},{"key":"10.1016\/j.cub.2025.09.012_bib89","first-page":"176","article-title":"Repeated administration of tribromoethanol in C57BL\/6NHsd mice","volume":"52","author":"Hill","year":"2013","journal-title":"J. Am. Assoc. Lab. Anim. Sci."},{"key":"10.1016\/j.cub.2025.09.012_bib90","article-title":"The spared nerve injury (SNI) model of induced mechanical allodynia in mice","volume":"54","author":"Richner","year":"2011","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.cub.2025.09.012_bib91","article-title":"Alloferon-1 ameliorates acute inflammatory responses in \u03bb-carrageenan-induced paw edema in mice","volume":"12","author":"Zhang","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cub.2025.09.012_bib92","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/j.neuron.2024.02.001","article-title":"Sexually dimorphic control of affective state processing and empathic behaviors","volume":"112","author":"Fang","year":"2024","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2025.09.012_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109411","article-title":"Oxytocin in the anterior cingulate cortex attenuates neuropathic pain and emotional anxiety by inhibiting presynaptic long-term potentiation","volume":"36","author":"Li","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.cub.2025.09.012_bib94","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.neuron.2016.03.033","article-title":"Oxytocin Enhances Social Recognition by Modulating Cortical Control of Early Olfactory Processing","volume":"90","author":"Oettl","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2025.09.012_bib95","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001337","article-title":"BDNF produced by cerebral microglia promotes cortical plasticity and pain hypersensitivity after peripheral nerve injury","volume":"19","author":"Huang","year":"2021","journal-title":"PLoS Biol."},{"key":"10.1016\/j.cub.2025.09.012_bib102","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.neuron.2019.05.002","article-title":"SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse","volume":"103","author":"Koopmans","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2025.09.012_bib103","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cub.2025.09.012_bib104","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1093\/bioinformatics\/btu393","article-title":"circlize Implements and enhances circular visualization in R","volume":"30","author":"Gu","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cub.2025.09.012_bib105","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cub.2025.09.012_bib107","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrg1272","article-title":"Network biology: understanding the cell's functional organization","volume":"5","author":"Barab\u00e1si","year":"2004","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.cub.2025.09.012_bib108","doi-asserted-by":"crossref","DOI":"10.1126\/science.adg5136","article-title":"Single-cell multi-cohort dissection of the schizophrenia transcriptome","volume":"384","author":"Ruzicka","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.cub.2025.09.012_bib110","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2021.613025","article-title":"Extended Amygdala Neuropeptide Circuitry of Emotional Arousal: Waking Up on the Wrong Side of the Bed Nuclei of Stria Terminalis","volume":"15","author":"Giardino","year":"2021","journal-title":"Front. Behav. Neurosci."}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982225011820?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982225011820?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T13:25:32Z","timestamp":1766755532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982225011820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":110,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0960982225011820"],"URL":"https:\/\/doi.org\/10.1016\/j.cub.2025.09.012","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reduced oxytocin signaling in the dBNST drives the transition from acute pain to persistent anxiety","name":"articletitle","label":"Article Title"},{"value":"Current Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cub.2025.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}