{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T21:02:38Z","timestamp":1784667758900,"version":"3.55.0"},"reference-count":124,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,6,8]],"date-time":"2027-06-08T00:00:00Z","timestamp":1812412800000},"content-version":"am","delay-in-days":372,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011605","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011605","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001021","name":"Damon Runyon Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001021","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.cub.2026.04.048","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T20:18:57Z","timestamp":1778789937000},"page":"2744-2758.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Reciprocal E-cadherin signaling aligns apical surfaces between neighboring epithelial tissues to complete the C. elegans digestive tract"],"prefix":"10.1016","volume":"36","author":[{"given":"Lauren E.","family":"Cote","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria D.","family":"Sallee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel K.","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa A.","family":"Pickett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9my","family":"Magescas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5210-5045","authenticated-orcid":false,"given":"Jessica L.","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cub.2026.04.048_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.887107","article-title":"Won\u2019t you be my neighbor: how epithelial cells connect together to build global tissue polarity","volume":"10","author":"Cote","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1146\/annurev-ecolsys-120213-091627","article-title":"Animal phylogeny and its evolutionary implications","volume":"45","author":"Dunn","year":"2014","journal-title":"Annu. Rev. Ecol. Evol. Syst."},{"key":"10.1016\/j.cub.2026.04.048_bib3","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/s41580-022-00465-y","article-title":"Apical\u2013basal polarity and the control of epithelial form and function","volume":"23","author":"Buckley","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib4","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1006\/dbio.1999.9471","article-title":"Organogenesis of the Caenorhabditis elegans intestine","volume":"216","author":"Leung","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib5","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/ncb0901-831","article-title":"Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly","volume":"3","author":"O\u2019Brien","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib6","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1146\/annurev-cellbio-100818-125134","article-title":"A polarizing issue: diversity in the mechanisms underlying apico-basolateral polarization in vivo","volume":"35","author":"Pickett","year":"2019","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib7","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.248757","article-title":"How cells tell up from down and stick together to construct multicellular tissues \u2013 interplay between apicobasal polarity and cell\u2013cell adhesion","volume":"134","author":"V\u00e1squez","year":"2021","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.cub.2026.04.048_bib8","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nrm3871","article-title":"Molecular mechanisms of de novo lumen formation","volume":"15","author":"Sigurbj\u00f6rnsd\u00f3ttir","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib9","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4161\/org.25225","article-title":"The luminal connection: From animal development to lumopathies","volume":"9","author":"Kao","year":"2013","journal-title":"Organogenesis"},{"key":"10.1016\/j.cub.2026.04.048_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.620774","article-title":"Closing the gap: mechanisms of epithelial fusion during optic fissure closure","volume":"8","author":"Chan","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib11","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/andr.12631","article-title":"We, the developing rete testis, efferent ducts, and Wolffian duct, all hereby agree that we need to connect","volume":"7","author":"De Mello Santos","year":"2019","journal-title":"Andrology"},{"key":"10.1016\/j.cub.2026.04.048_bib12","doi-asserted-by":"crossref","DOI":"10.1242\/dev.202820","article-title":"The dynamics of tubulogenesis in development and disease","volume":"152","author":"Romero","year":"2025","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.04.048_bib13","series-title":"Current Topics in Developmental Biology Nematode Models of Development and Disease","first-page":"161","article-title":"Chapter Six \u2013 Epithelial morphogenesis, tubulogenesis and forces in organogenesis","author":"Shaye","year":"2021"},{"key":"10.1016\/j.cub.2026.04.048_bib14","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a029223","article-title":"Hold me, but not too tight\u2014endothelial cell\u2013cell junctions in angiogenesis","volume":"10","author":"Szymborska","year":"2018","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib15","doi-asserted-by":"crossref","DOI":"10.1242\/dev.150920","article-title":"The endoderm: a divergent cell lineage with many commonalities","volume":"146","author":"Nowotschin","year":"2019","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.04.048_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2015.7","article-title":"Spina bifida","volume":"1","author":"Copp","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.cub.2026.04.048_bib17","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1002\/ajmg.a.31925","article-title":"Urorectal septum malformation sequence: Prenatal progression, clinical report, and embryology review","volume":"143A","author":"Escobar","year":"2007","journal-title":"Am. J. Med. Genet., A"},{"key":"10.1016\/j.cub.2026.04.048_bib18","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1136\/jmg.2004.025494","article-title":"Ocular coloboma: a reassessment in the age of molecular neuroscience","volume":"41","author":"Gregory-Evans","year":"2004","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.cub.2026.04.048_bib19","doi-asserted-by":"crossref","first-page":"723","DOI":"10.2215\/CJN.12581019","article-title":"A primer on congenital anomalies of the kidneys and urinary tracts (CAKUT)","volume":"15","author":"Murugapoopathy","year":"2020","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cub.2026.04.048_bib20","doi-asserted-by":"crossref","first-page":"205","DOI":"10.4291\/wjgp.v5.i3.205","article-title":"Pathophysiology of fistula formation in Crohn\u2019s disease","volume":"5","author":"Scharl","year":"2014","journal-title":"World J. Gastrointest. Pathophysiol."},{"key":"10.1016\/j.cub.2026.04.048_bib21","doi-asserted-by":"crossref","first-page":"4645","DOI":"10.1016\/j.cub.2022.09.065","article-title":"Post-embryonic remodeling of the C. elegans motor circuit","volume":"32","author":"Mulcahy","year":"2022","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib22","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1242\/dev.047647","article-title":"PAR-3 mediates the initial clustering and apical localization of junction and polarity proteins during C. elegans intestinal epithelial cell polarization","volume":"137","author":"Achilleos","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.04.048_bib23","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.ydbio.2004.01.003","article-title":"The apical disposition of the Caenorhabditis elegans intestinal terminal web is maintained by LET-413","volume":"268","author":"Bossinger","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib24","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.cub.2012.02.044","article-title":"A role for the centrosome and PAR-3 in the hand-off of MTOC function during epithelial polarization","volume":"22","author":"Feldman","year":"2012","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib25","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/35017046","article-title":"LET-413 is a basolateral protein required for the assembly of adherens junctions in Caenorhabditis elegans","volume":"2","author":"Legouis","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib26","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1242\/jcs.114.12.2265","article-title":"Assembly of C. elegans apical junctions involves positioning and compaction by LET-413 and protein aggregation by the MAGUK protein DLG-1","volume":"114","author":"McMahon","year":"2001","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.cub.2026.04.048_bib27","doi-asserted-by":"crossref","DOI":"10.1242\/dev.200325","article-title":"Separable mechanisms drive local and global polarity establishment in the Caenorhabditis elegans intestinal epithelium","volume":"149","author":"Pickett","year":"2022","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.04.048_bib28","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1242\/dev.02833","article-title":"PAR-6 is required for junction formation but not apicobasal polarization in C. elegans embryonic epithelial cells","volume":"134","author":"Totong","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.04.048_bib29","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/0012-1606(83)90201-4","article-title":"The embryonic cell lineage of the nematode Caenorhabditis elegans","volume":"100","author":"Sulston","year":"1983","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib30","series-title":"C. elegans II","article-title":"Feeding and defecation","author":"Avery","year":"1997"},{"key":"10.1016\/j.cub.2026.04.048_bib31","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1242\/dev.124.20.3919","article-title":"The PAX gene egl-38 mediates developmental patterning in Caenorhabditis elegans","volume":"124","author":"Chamberlin","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.04.048_bib32","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/genetics\/153.2.731","article-title":"Characterization of seven genes affecting Caenorhabditis elegans hindgut development","volume":"153","author":"Chamberlin","year":"1999","journal-title":"Genetics"},{"key":"10.1016\/j.cub.2026.04.048_bib33","first-page":"1","article-title":"Notch signaling in the C. elegans embryo","author":"Priess","year":"2005","journal-title":"WormBook"},{"key":"10.1016\/j.cub.2026.04.048_bib34","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1006\/dbio.2000.9977","article-title":"Zygotic expression of the caudal homolog pal-1 is required for posterior patterning in Caenorhabditis elegans embryogenesis","volume":"229","author":"Edgar","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib35","article-title":"Morphogenesis of the C. elegans intestine involves axon guidance genes","volume":"12","author":"Asan","year":"2016","journal-title":"PLOS Genet."},{"key":"10.1016\/j.cub.2026.04.048_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2010.09.012","article-title":"Internalization of multiple cells during C. elegans gastrulation depends on common cytoskeletal mechanisms but different cell polarity and cell fate regulators","volume":"350","author":"Harrell","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-58878-0","article-title":"Cell lineage-resolved embryonic morphological map reveals signaling associated with cell fate and size asymmetry","volume":"16","author":"Guan","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2026.04.048_bib38","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/bs.ctdb.2023.02.007","article-title":"Context matters: Lessons in epithelial polarity from the Caenorhabditis elegans intestine and other tissues","volume":"154","author":"Naturale","year":"2023","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib39","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1681\/ASN.2012030283","article-title":"Invasion of distal nephron precursors associates with tubular interconnection during nephrogenesis","volume":"23","author":"Kao","year":"2012","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cub.2026.04.048_bib40","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.matbio.2018.05.009","article-title":"Tissue linkage through adjoining basement membranes: The long and the short term of it","volume":"75\u201376","author":"Keeley","year":"2019","journal-title":"Matrix Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib41","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/ncb2233","article-title":"Basement membrane sliding and targeted adhesion remodels tissue boundaries during uterine\u2013vulval attachment in Caenorhabditis elegans","volume":"13","author":"Ihara","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2014.09.029","article-title":"Hedgehog activity controls opening of the primary mouth","volume":"396","author":"Tabler","year":"2014","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib43","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.devcel.2020.05.022","article-title":"Comprehensive endogenous tagging of basement membrane components reveals dynamic movement within the matrix scaffolding","volume":"54","author":"Keeley","year":"2020","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2026.04.048_bib44","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1083\/jcb.142.4.1105","article-title":"Mechanisms of epithelial cell\u2013cell adhesion and cell compaction revealed by high-resolution tracking of E-cadherin\u2013green fluorescent protein","volume":"142","author":"Adams","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceb.2025.102559","article-title":"E-cadherin: A conductor of cellular signaling","volume":"95","author":"Kehrberg","year":"2025","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003772","article-title":"Cell interactions and patterned intercalations shape and link epithelial tubes in C. elegans","volume":"9","author":"Rasmussen","year":"2013","journal-title":"PLOS Genet."},{"key":"10.1016\/j.cub.2026.04.048_bib47","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.cub.2025.11.044","article-title":"Mechanical feedback between a transient core cell and a contractile valve ensures robust organ morphogenesis in C. elegans","volume":"36","author":"Suhag","year":"2026","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib48","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1016\/j.devcel.2023.07.008","article-title":"Persistent cell contacts enable E-cadherin\/HMR-1- and PAR-3-based symmetry breaking within a developing C. elegans epithelium","volume":"58","author":"Naturale","year":"2023","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2026.04.048_bib49","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ydbio.2015.03.002","article-title":"PAR-6, but not E-cadherin and \u03b2-integrin, is necessary for epithelial polarization in C. elegans","volume":"403","author":"Von Stetina","year":"2015","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib50","doi-asserted-by":"crossref","first-page":"4640","DOI":"10.1242\/dev.115048","article-title":"Repurposing an endogenous degradation system for rapid and targeted depletion of C. elegans proteins","volume":"141","author":"Armenti","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.04.048_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2005189","article-title":"Tissue-specific degradation of essential centrosome components reveals distinct microtubule populations at microtubule organizing centers","volume":"16","author":"Sallee","year":"2018","journal-title":"PLOS Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib52","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1016\/j.cub.2021.06.039","article-title":"Inherited apicobasal polarity defines the key features of axon-dendrite polarity in a sensory neuron","volume":"31","author":"Lee","year":"2021","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib53","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/s41592-021-01216-1","article-title":"A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis","volume":"18","author":"Ma","year":"2021","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cub.2026.04.048_bib54","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1101\/gr.131920.111","article-title":"Multidimensional regulation of gene expression in the C. elegans embryo","volume":"22","author":"Murray","year":"2012","journal-title":"Genome Res."},{"key":"10.1016\/j.cub.2026.04.048_bib55","doi-asserted-by":"crossref","DOI":"10.1126\/science.aax1971","article-title":"A lineage-resolved molecular atlas of C. elegans embryogenesis at single-cell resolution","volume":"365","author":"Packer","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.cub.2026.04.048_bib102","series-title":"Studies on the development and organisation of the nervous system of Caenorhabditis elegans","author":"Durbin","year":"1987"},{"key":"10.1016\/j.cub.2026.04.048_bib56","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.cell.2006.11.033","article-title":"Structure of the protein phosphatase 2A holoenzyme","volume":"127","author":"Xu","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.cub.2026.04.048_bib57","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.devcel.2012.11.019","article-title":"Interplay between the dividing cell and its neighbors regulates adherens junction formation during cytokinesis in epithelial tissue","volume":"24","author":"Herszterg","year":"2013","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2026.04.048_bib58","article-title":"Mitotic polarity oscillation promotes epithelial tumor progression","author":"Jeyanathan","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.cub.2026.04.048_bib59","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.1016\/j.cub.2022.08.063","article-title":"aPKC regulates apical constriction to prevent tissue rupture in the Drosophila follicular epithelium","volume":"32","author":"Osswald","year":"2022","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib60","doi-asserted-by":"crossref","DOI":"10.1091\/mbc.E22-05-0176","article-title":"Rap1 regulates apical contractility to allow embryonic morphogenesis without tissue disruption and acts in part via Canoe-independent mechanisms","volume":"34","author":"Perez-Vale","year":"2023","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.cub.2026.04.048_bib61","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.64437","article-title":"Apical PAR complex proteins protect against programmed epithelial assaults to create a continuous and functional intestinal lumen","volume":"10","author":"Sallee","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.cub.2026.04.048_bib62","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/dvdy.10112","article-title":"Cell reorganisation during epithelial fusion and perforation: The case of ascidian branchial fissures","volume":"224","author":"Manni","year":"2002","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.cub.2026.04.048_bib63","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1006\/dbio.2001.0235","article-title":"Early morphogenesis of the Caenorhabditis elegans pharynx","volume":"233","author":"Portereiko","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib64","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1242\/dev.100313","article-title":"Single continuous lumen formation in the zebrafish gut is mediated by smoothened-dependent tissue remodeling","volume":"141","author":"Alvers","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.04.048_bib65","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2416887121","article-title":"Epithelial tubule interconnection driven by HGF-Met signaling in the kidney","volume":"121","author":"L\u00f3pez-Garc\u00eda","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2026.04.048_bib66","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1242\/dev.056564","article-title":"p120 catenin is required for normal renal tubulogenesis and glomerulogenesis","volume":"138","author":"Marciano","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.04.048_bib67","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.104164.3","article-title":"Drosophila hamlet mediates epithelial tissue assembly of the reproductive system","volume":"13","author":"Wang","year":"2025","journal-title":"eLife"},{"key":"10.1016\/j.cub.2026.04.048_bib68","doi-asserted-by":"crossref","DOI":"10.1242\/dev.205074","article-title":"Reciprocal inhibition of Wnt signaling pathways pattern the interconnection of epithelial tubules in the regenerating zebrafish kidney","volume":"153","author":"Kamei","year":"2026","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.04.048_bib69","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.semcdb.2014.03.018","article-title":"Tube fusion: Making connections in branched tubular networks","volume":"31","author":"Caviglia","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib70","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.devcel.2015.12.013","article-title":"Emergence of an apical epithelial cell surface in vivo","volume":"36","author":"Sedzinski","year":"2016","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2026.04.048_bib71","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34586","article-title":"Vertex sliding drives intercalation by radial coupling of adhesion and actomyosin networks during Drosophila germband extension","volume":"7","author":"Vanderleest","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.cub.2026.04.048_bib72","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.65169","article-title":"A polarity pathway for exocyst-dependent intracellular tube extension","volume":"10","author":"Abrams","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.cub.2026.04.048_bib73","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.cub.2009.12.043","article-title":"In vivo coupling of cell elongation and lumen formation in a single cell","volume":"20","author":"Gervais","year":"2010","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib74","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.devcel.2023.03.018","article-title":"Multicellular rosettes link mesenchymal-epithelial transition to radial intercalation in the mouse axial mesoderm","volume":"58","author":"Gredler","year":"2023","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2026.04.048_bib75","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.mod.2010.04.002","article-title":"Mesenchymal-to-epithelial transition of intercalating cells in Drosophila renal tubules depends on polarity cues from epithelial neighbours","volume":"127","author":"Campbell","year":"2010","journal-title":"Mech. Dev."},{"key":"10.1016\/j.cub.2026.04.048_bib76","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1242\/dev.02417","article-title":"Radial intercalation of ciliated cells during Xenopus skin development","volume":"133","author":"Stubbs","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.04.048_bib77","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1083\/jcb.201312045","article-title":"Radial intercalation is regulated by the Par complex and the microtubule-stabilizing protein CLAMP\/Spef1","volume":"206","author":"Werner","year":"2014","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib78","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/ncb1621","article-title":"Genetic control of single lumen formation in the zebrafish gut","volume":"9","author":"Bagnat","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib79","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ydbio.2009.03.015","article-title":"Tube formation by complex cellular processes in Ciona intestinalis notochord","volume":"330","author":"Dong","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib80","doi-asserted-by":"crossref","first-page":"4295","DOI":"10.1242\/dev.052993","article-title":"Epithelial dynamics of pancreatic branching morphogenesis","volume":"137","author":"Villasenor","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.04.048_bib81","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/s41556-018-0211-3","article-title":"Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation","volume":"20","author":"Christodoulou","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.cdev.2025.204022","article-title":"Three-dimensional rosettes in epithelial formation","volume":"184","author":"Neahring","year":"2025","journal-title":"Cells Dev."},{"key":"10.1016\/j.cub.2026.04.048_bib83","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ydbio.2025.03.008","article-title":"Shroom3 facilitates optic fissure closure via tissue alignment and reestablishment of apical-basal polarity during epithelial fusion","volume":"522","author":"Herstine","year":"2025","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib84","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1002\/dvdy.215","article-title":"Fusion of airways during avian lung development constitutes a novel mechanism for the formation of continuous lumena in multicellular epithelia","volume":"249","author":"Palmer","year":"2020","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.cub.2026.04.048_bib85","doi-asserted-by":"crossref","DOI":"10.1186\/1476-4598-9-179","article-title":"Breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition","volume":"9","author":"Chao","year":"2010","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.cub.2026.04.048_bib86","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/s41586-019-1526-3","article-title":"E-cadherin is required for metastasis in multiple models of breast cancer","volume":"573","author":"Padmanaban","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cub.2026.04.048_bib87","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1016\/j.devcel.2021.08.018","article-title":"Cooperation between melanoma cell states promotes metastasis through heterotypic cluster formation","volume":"56","author":"Campbell","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2026.04.048_bib88","doi-asserted-by":"crossref","DOI":"10.1091\/mbc.E23-03-0087","article-title":"Remodeling of E-cadherin subcellular localization during cell dissemination","volume":"34","author":"Cabrera","year":"2023","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.cub.2026.04.048_bib89","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70608","article-title":"E-Cadherin is a structuring component of invadopodia in pancreatic cancer","volume":"29","author":"Dobric","year":"2025","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.cub.2026.04.048_bib107","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.77918","article-title":"Cross-modality synthesis of EM time series and live fluorescence imaging","volume":"11","author":"Santella","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.cub.2026.04.048_bib108","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.57874","article-title":"A multi-layered and dynamic apical extracellular matrix shapes the vulva lumen in Caenorhabditis elegans","volume":"9","author":"Cohen","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.cub.2026.04.048_bib109","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1534\/genetics.120.303085","article-title":"The role of pkc-3 and genetic suppressors in Caenorhabditis elegans epithelial cell junction formation","volume":"214","author":"Montoyo-Rosario","year":"2020","journal-title":"Genetics"},{"key":"10.1016\/j.cub.2026.04.048_bib110","article-title":"Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants","volume":"3","author":"O\u2019Rourke","year":"2007","journal-title":"PLOS Genet."},{"key":"10.1016\/j.cub.2026.04.048_bib111","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ydbio.2007.11.028","article-title":"UNC-45 is required for NMY-2 contractile function in early embryonic polarity establishment and germline cellularization in C. elegans","volume":"314","author":"Kachur","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib95","doi-asserted-by":"crossref","DOI":"10.1242\/dev.185850","article-title":"A developmental gene regulatory network for C. elegans anchor cell invasion","volume":"147","author":"Medwig-Kinney","year":"2020","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.04.048_bib112","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1083\/jcb.201903124","article-title":"\u03b1-Integrins dictate distinct modes of type IV collagen recruitment to basement membranes","volume":"218","author":"Jayadev","year":"2019","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib113","doi-asserted-by":"crossref","first-page":"14976","DOI":"10.1073\/pnas.0706941104","article-title":"The Rho GTPase-activating proteins RGA-3 and RGA-4 are required to set the initial size of PAR domains in Caenorhabditis elegans one-cell embryos","volume":"104","author":"Schonegg","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2026.04.048_bib99","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1016\/j.cub.2021.03.022","article-title":"Centriole-less pericentriolar material serves as a microtubule organizing center at the base of C. elegans sensory cilia","volume":"31","author":"Magescas","year":"2021","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib114","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202409133","article-title":"Cell signaling facilitates apical constriction by basolaterally recruiting Arp2\/3 via Rac and WAVE","volume":"224","author":"Zhang","year":"2025","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib115","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.1016\/j.cub.2021.06.021","article-title":"Proximity labeling reveals non-centrosomal microtubule-organizing center components required for microtubule growth and localization","volume":"31","author":"Sanchez","year":"2021","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib116","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nmeth933","article-title":"A recombineering pipeline for functional genomics applied to Caenorhabditis elegans","volume":"3","author":"Sarov","year":"2006","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cub.2026.04.048_bib117","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1038\/s41593-024-01728-x","article-title":"An activity-regulated transcriptional program directly drives synaptogenesis","volume":"27","author":"Yee","year":"2024","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cub.2026.04.048_bib118","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.23866","article-title":"The interplay of stiffness and force anisotropies drives embryo elongation","volume":"6","author":"Vuong-Brender","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.cub.2026.04.048_bib120","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.devcel.2017.07.024","article-title":"A single-cell biochemistry approach reveals PAR complex dynamics during cell polarization","volume":"42","author":"Dickinson","year":"2017","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2026.04.048_bib119","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.ydbio.2024.10.008","article-title":"The Pax transcription factor EGL-38 links EGFR signaling to assembly of a cell type-specific apical extracellular matrix in the Caenorhabditis elegans vulva","volume":"517","author":"Schmidt","year":"2025","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib121","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1242\/dev.150094","article-title":"A toolkit for GFP-mediated tissue-specific protein degradation in C. elegans","volume":"144","author":"Wang","year":"2017","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.04.048_bib122","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1016\/j.cub.2016.06.010","article-title":"MRCK-1 drives apical constriction in C. elegans by linking developmental patterning to force generation","volume":"26","author":"Marston","year":"2016","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib91","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.devcel.2019.01.020","article-title":"Assessment and maintenance of unigametic germline inheritance for C. elegans","volume":"48","author":"Artiles","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2026.04.048_bib100","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cub.2026.04.048_bib106","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41592-019-0686-2","article-title":"SciPy 1.0: fundamental algorithms for scientific computing in Python","volume":"17","author":"Virtanen","year":"2020","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cub.2026.04.048_bib90","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/genetics\/77.1.95","article-title":"The DNA of Caenorhabditis elegans","volume":"77","author":"Sulston","year":"1974","journal-title":"Genetics"},{"key":"10.1016\/j.cub.2026.04.048_bib92","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1534\/genetics.115.178335","article-title":"Streamlined genome engineering with a self-excising drug selection cassette","volume":"200","author":"Dickinson","year":"2015","journal-title":"Genetics"},{"key":"10.1016\/j.cub.2026.04.048_bib93","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1534\/genetics.120.303564","article-title":"Melting dsDNA donor molecules greatly improves precision genome editing in Caenorhabditis elegans","volume":"216","author":"Ghanta","year":"2020","journal-title":"Genetics"},{"key":"10.1016\/j.cub.2026.04.048_bib94","article-title":"Improved CRISPR\/Cas9 knock-in efficiency via the self-excising cassette (SEC) selection method in C. elegans","volume":"2021","author":"Huang","year":"2021","journal-title":"MicroPublication Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib96","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1534\/genetics.120.303388","article-title":"Efficient transgenesis in Caenorhabditis elegans using Flp recombinase-mediated cassette exchange","volume":"215","author":"Nonet","year":"2020","journal-title":"Genetics"},{"key":"10.1016\/j.cub.2026.04.048_bib97","article-title":"Creation and manipulation of bipartite expression transgenes in C. elegans using phiC31 recombinase","author":"Nonet","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.cub.2026.04.048_bib98","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1091\/mbc.11.9.3089","article-title":"C. elegans nuclear envelope proteins emerin, MAN1, lamin, and nucleoporins reveal unique timing of nuclear envelope breakdown during mitosis","volume":"11","author":"Lee","year":"2000","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.cub.2026.04.048_bib101","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1242\/dev.116.4.1113","article-title":"Cell interactions involved in development of the bilaterally symmetrical intestinal valve cells during embryogenesis in Caenorhabditis elegans","volume":"116","author":"Bowerman","year":"1992","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.04.048_bib103","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.devcel.2023.12.001","article-title":"MAP9\/MAPH-9 supports axonemal microtubule doublets and modulates motor movement","volume":"59","author":"Tran","year":"2024","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2026.04.048_bib104","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/0012-1606(77)90158-0","article-title":"Post-embryonic cell lineages of the nematode, Caenorhabditis elegans","volume":"56","author":"Sulston","year":"1977","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cub.2026.04.048_bib105","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abl7663","article-title":"Small RNAs couple embryonic developmental programs to gut microbes","volume":"8","author":"Ohno","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cub.2026.04.048_bib123","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.12688\/f1000research.27171.1","article-title":"Bleach correction ImageJ plugin for compensating the photobleaching of time-lapse sequences","volume":"9","author":"Miura","year":"2020","journal-title":"F1000Res"},{"key":"10.1016\/j.cub.2026.04.048_bib124","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006205","article-title":"Integrity of narrow epithelial tubes in the C. elegans excretory system requires a transient luminal matrix","volume":"12","author":"Gill","year":"2016","journal-title":"PLOS Genet."}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096098222600518X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096098222600518X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T20:16:37Z","timestamp":1784664997000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096098222600518X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":124,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S096098222600518X"],"URL":"https:\/\/doi.org\/10.1016\/j.cub.2026.04.048","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.10.06.680605","asserted-by":"object"}]},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reciprocal E-cadherin signaling aligns apical surfaces between neighboring epithelial tissues to complete the C. elegans digestive tract","name":"articletitle","label":"Article Title"},{"value":"Current Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cub.2026.04.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}