{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:54:33Z","timestamp":1785887673185,"version":"3.56.0"},"reference-count":114,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,7,6]],"date-time":"2027-07-06T00:00:00Z","timestamp":1814832000000},"content-version":"am","delay-in-days":370,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000199","name":"US Department of Agriculture","doi-asserted-by":"publisher","award":["2024-70410-43730"],"award-info":[{"award-number":["2024-70410-43730"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["1R35GM156119"],"award-info":[{"award-number":["1R35GM156119"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007015","name":"University of Wisconsin-Madison","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007631","name":"Canadian Institute for Advanced Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007631","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["5R01AI172451-03"],"award-info":[{"award-number":["5R01AI172451-03"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["5R01AI170543-04"],"award-info":[{"award-number":["5R01AI170543-04"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.cub.2026.05.047","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T14:47:59Z","timestamp":1781794079000},"page":"3258-3270.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Aneuploidy promotes transient stress adaptation and metabolic flexibility in the human fungal pathogen Aspergillus fumigatus"],"prefix":"10.1016","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8544-9292","authenticated-orcid":false,"given":"Anna E.","family":"Lehmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Aguilar Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy P.","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Heitman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cub.2026.05.047_bib1","doi-asserted-by":"crossref","first-page":"e428","DOI":"10.1016\/S1473-3099(23)00692-8","article-title":"Global incidence and mortality of severe fungal disease","volume":"24","author":"Denning","year":"2024","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.cub.2026.05.047_bib2","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1039\/c3np70064j","article-title":"UV-protectant metabolites from lichens and their symbiotic partners","volume":"30","author":"Nguyen","year":"2013","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.cub.2026.05.047_bib3","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.1080\/13693780400028967","article-title":"Aspergillus fumigatus conidial pigment and cAMP signal transduction: significance for virulence","volume":"43","author":"Brakhage","year":"2005","journal-title":"Med. Mycol."},{"key":"10.1016\/j.cub.2026.05.047_bib4","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/intimm\/dxh356","article-title":"Aspergillus fumigatus conidia inhibit tumour necrosis factor- or staurosporine-induced apoptosis in epithelial cells","volume":"18","author":"Berkova","year":"2006","journal-title":"Int. Immunol."},{"key":"10.1016\/j.cub.2026.05.047_bib5","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1099\/mic.0.27847-0","article-title":"The epipolythiodioxopiperazine (ETP) class of fungal toxins: distribution, mode of action, functions and biosynthesis","volume":"151","author":"Gardiner","year":"2005","journal-title":"Microbiology (Reading)"},{"key":"10.1016\/j.cub.2026.05.047_bib6","doi-asserted-by":"crossref","first-page":"6761","DOI":"10.1128\/IAI.00780-06","article-title":"GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence","volume":"74","author":"Bok","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cub.2026.05.047_bib7","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1083\/jcb.200604044","article-title":"The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice","volume":"174","author":"Pardo","year":"2006","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cub.2026.05.047_bib8","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1086\/525044","article-title":"Gliotoxin production in Aspergillus fumigatus contributes to host-specific differences in virulence","volume":"197","author":"Spikes","year":"2008","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.cub.2026.05.047_bib9","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/QCO.0b013e328348b159","article-title":"Immune responses against Aspergillus fumigatus: what have we learned?","volume":"24","author":"Cramer","year":"2011","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.cub.2026.05.047_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007606","article-title":"A call to arms: mustering secondary metabolites for success and survival of an opportunistic pathogen","volume":"15","author":"Raffa","year":"2019","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cub.2026.05.047_bib11","series-title":"Methods in Enzymology Natural Product Biosynthesis by Microorganisms and Plants","first-page":"303","article-title":"Chapter Fifteen \u2013 Toward awakening cryptic secondary metabolite gene clusters in filamentous fungi","author":"Lim","year":"2012"},{"key":"10.1016\/j.cub.2026.05.047_bib12","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.1128\/IAI.00192-11","article-title":"Targeted disruption of nonribosomal peptide synthetase pes3 augments the virulence of Aspergillus fumigatus","volume":"79","author":"O\u2019Hanlon","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cub.2026.05.047_bib13","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1021\/ja311145n","article-title":"A nonribosomal peptide synthetase-derived iron(III) complex from the pathogenic fungus Aspergillus fumigatus","volume":"135","author":"Yin","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.cub.2026.05.047_bib14","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/nchembio.1366","article-title":"Distinct mechanisms for spiro-carbon formation reveal biosynthetic pathway crosstalk","volume":"9","author":"Tsunematsu","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cub.2026.05.047_bib15","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1186\/1471-2164-15-894","article-title":"RNA-seq reveals the pan-transcriptomic impact of attenuating the gliotoxin self-protection mechanism in Aspergillus fumigatus","volume":"15","author":"O\u2019Keeffe","year":"2014","journal-title":"BMC Genomics"},{"key":"10.1016\/j.cub.2026.05.047_bib16","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev-cancerbio-042616-072231","article-title":"Aneuploidy in cancer: Seq-ing answers to old questions","volume":"1","author":"Knouse","year":"2017","journal-title":"Annu. Rev. Cancer Biol."},{"key":"10.1016\/j.cub.2026.05.047_bib17","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41576-019-0171-x","article-title":"Context is everything: aneuploidy in cancer","volume":"21","author":"Ben-David","year":"2020","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.cub.2026.05.047_bib18","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1534\/genetics.108.090878","article-title":"Aneuploidy: cells losing their balance","volume":"179","author":"Torres","year":"2008","journal-title":"Genetics"},{"key":"10.1016\/j.cub.2026.05.047_bib19","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/yea.3427","article-title":"Aneuploidy in yeast: segregation error or adaptation mechanism?","volume":"36","author":"Gilchrist","year":"2019","journal-title":"Yeast"},{"key":"10.1016\/j.cub.2026.05.047_bib20","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1126\/science.1206412","article-title":"Aneuploidy drives genomic instability in yeast","volume":"333","author":"Sheltzer","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.cub.2026.05.047_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1002155","article-title":"The fitness consequences of aneuploidy are driven by condition-dependent gene effects","volume":"13","author":"Sunshine","year":"2015","journal-title":"PLoS Biol."},{"key":"10.1016\/j.cub.2026.05.047_bib22","doi-asserted-by":"crossref","first-page":"21010","DOI":"10.1073\/pnas.1211150109","article-title":"Chromosomal duplication is a transient evolutionary solution to stress","volume":"109","author":"Yona","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2026.05.047_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000303","article-title":"The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments in yeast","volume":"4","author":"Gresham","year":"2008","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cub.2026.05.047_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3003224","article-title":"Rapid gain and loss of a chromosome drives key morphology and virulence phenotypes in the fungal pathogen Histoplasma","volume":"24","author":"Heater","year":"2026","journal-title":"PLoS Biol."},{"key":"10.1016\/j.cub.2026.05.047_bib25","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1126\/science.1128242","article-title":"Aneuploidy and isochromosome formation in drug-resistant Candida albicans","volume":"313","author":"Selmecki","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.cub.2026.05.047_bib26","article-title":"Aneuploidy mediates rapid adaptation to a subinhibitory amount of fluconazole in Candida albicans","volume":"11","author":"Sun","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.cub.2026.05.047_bib27","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.1128\/JB.181.13.4041-4049.1999","article-title":"Specific chromosome alterations in fluconazole-resistant mutants of Candida albicans","volume":"181","author":"Perepnikhatka","year":"1999","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.cub.2026.05.047_bib28","doi-asserted-by":"crossref","DOI":"10.1128\/Spectrum.00723-21","article-title":"Adaptation to fluconazole via aneuploidy enables cross-adaptation to amphotericin B and flucytosine in Cryptococcus neoformans","volume":"9","author":"Yang","year":"2021","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.cub.2026.05.047_bib29","article-title":"Aneuploidy underlies brefeldin A-induced antifungal drug resistance in Cryptococcus neoformans","volume":"14","author":"Zhang","year":"2024","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.cub.2026.05.047_bib30","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.04339-22","article-title":"Aneuploidy formation in the filamentous fungus Aspergillus flavus in response to azole stress","volume":"11","author":"Barda","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.cub.2026.05.047_bib31","doi-asserted-by":"crossref","DOI":"10.1128\/aac.01253-22","article-title":"Aneuploidy Is associated with azole resistance in Aspergillus fumigatus","volume":"67","author":"Khateb","year":"2023","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.cub.2026.05.047_bib32","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/nature13575","article-title":"Antifungal drug resistance evoked via RNAi-dependent epimutations","volume":"513","author":"Calo","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.cub.2026.05.047_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006686","article-title":"A non-canonical RNA degradation pathway suppresses RNAi-dependent epimutations in the human fungal pathogen Mucor circinelloides","volume":"13","author":"Calo","year":"2017","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cub.2026.05.047_bib34","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1038\/s41564-022-01183-z","article-title":"Uncontrolled transposition following RNAi loss causes hypermutation and antifungal drug resistance in clinical isolates of Cryptococcus neoformans","volume":"7","author":"Priest","year":"2022","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.cub.2026.05.047_bib35","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2503751122","article-title":"Calcineurin controls the cytokinesis machinery during thermal stress in Cryptococcus deneoformans","volume":"122","author":"Yadav","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2026.05.047_bib36","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2416656121","article-title":"Distinct evolutionary trajectories following loss of RNA interference in Cryptococcus neoformans","volume":"121","author":"Huang","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2026.05.047_bib37","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0092-8674(91)90124-H","article-title":"Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes","volume":"66","author":"Liu","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.cub.2026.05.047_bib38","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1006\/clin.1996.0140","article-title":"The mechanism of action of cyclosporin A and FK506","volume":"80","author":"Ho","year":"1996","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.cub.2026.05.047_bib39","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF02737887","article-title":"Calcineurin. Structure, function, and inhibition","volume":"30","author":"Hemenway","year":"1999","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.cub.2026.05.047_bib40","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1128\/EC.00200-08","article-title":"Calcineurin localizes to the hyphal septum in Aspergillus fumigatus: Implications for septum formation and conidiophore development","volume":"7","author":"Juvvadi","year":"2008","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.cub.2026.05.047_bib41","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1128\/EC.00139-06","article-title":"Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus","volume":"5","author":"Steinbach","year":"2006","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.cub.2026.05.047_bib42","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1128\/EC.00086-08","article-title":"Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus","volume":"7","author":"Cramer","year":"2008","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.cub.2026.05.047_bib43","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1111\/j.1365-2958.2011.07886.x","article-title":"Localization and activity of the calcineurin catalytic and regulatory subunit complex at the septum is essential for hyphal elongation and proper septation in Aspergillus fumigatus","volume":"82","author":"Juvvadi","year":"2011","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.cub.2026.05.047_bib44","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1128\/AAC.48.5.1664-1669.2004","article-title":"In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus","volume":"48","author":"Steinbach","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.cub.2026.05.047_bib45","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1111\/j.1365-2958.2008.06122.x","article-title":"Functional characterization of the Aspergillus fumigatus CRZ1 homologue, CrzA","volume":"67","author":"Soriani","year":"2008","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.cub.2026.05.047_bib46","doi-asserted-by":"crossref","first-page":"e00705-17","DOI":"10.1128\/mBio.00705-17","article-title":"The Aspergillus fumigatus CrzA transcription factor activates chitin synthase gene expression during the caspofungin paradoxical effect","volume":"8","author":"Ries","year":"2017","journal-title":"mBio"},{"key":"10.1016\/j.cub.2026.05.047_bib47","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.fgb.2006.08.004","article-title":"Functional characterization of the Aspergillus fumigatus calcineurin","volume":"44","author":"da Silva Ferreira","year":"2007","journal-title":"Fungal Genet. Biol."},{"key":"10.1016\/j.cub.2026.05.047_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006154","article-title":"Neutrophil interactions stimulate evasive hyphal branching by Aspergillus fumigatus","volume":"13","author":"Ellett","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cub.2026.05.047_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011152","article-title":"Aspergillus fumigatus transcription factor ZfpA regulates hyphal development and alters susceptibility to antifungals and neutrophil killing during infection","volume":"19","author":"Schoen","year":"2023","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cub.2026.05.047_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001890","article-title":"The pan-genome of Aspergillus fumigatus provides a high-resolution view of its population structure revealing high levels of lineage-specific diversity driven by recombination","volume":"20","author":"Lofgren","year":"2022","journal-title":"PLoS Biol."},{"key":"10.1016\/j.cub.2026.05.047_bib51","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02153-21","article-title":"Aspergillus fumigatus in-host HOG pathway mutation for cystic fibrosis lung microenvironment persistence","volume":"12","author":"Ross","year":"2021","journal-title":"mBio"},{"key":"10.1016\/j.cub.2026.05.047_bib52","article-title":"Genomic context of azole resistance mutations in Aspergillus fumigatus determined using whole-genome sequencing","volume":"6","author":"Abdolrasouli","year":"2015","journal-title":"mBio"},{"key":"10.1016\/j.cub.2026.05.047_bib53","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.3201\/eid1507.090043","article-title":"Frequency and evolution of Azole resistance in Aspergillus fumigatus associated with treatment failure","volume":"15","author":"Howard","year":"2009","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.cub.2026.05.047_bib54","doi-asserted-by":"crossref","first-page":"e01250-20","DOI":"10.1128\/mSphere.01250-20","article-title":"Aspergillus fumigatus strain-specific conidia lung persistence causes an allergic broncho-pulmonary aspergillosis-like disease phenotype","volume":"6","author":"Jones","year":"2021","journal-title":"mSphere"},{"key":"10.1016\/j.cub.2026.05.047_bib55","doi-asserted-by":"crossref","first-page":"12644","DOI":"10.1073\/pnas.1209227109","article-title":"Transcriptional consequences of aneuploidy","volume":"109","author":"Sheltzer","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2026.05.047_bib56","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1091\/mbc.E21-03-0104","article-title":"Cell adaptation to aneuploidy by the environmental stress response dampens induction of the cytosolic unfolded-protein response","volume":"32","author":"Kane","year":"2021","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.cub.2026.05.047_bib57","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2218163120","article-title":"Aneuploidy and gene dosage regulate filamentation and host colonization by Candida albicans","volume":"120","author":"Kakade","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2026.05.047_bib58","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1534\/genetics.115.185660","article-title":"Chromosome-specific and global effects of aneuploidy in Saccharomyces cerevisiae","volume":"202","author":"Dodgson","year":"2016","journal-title":"Genetics"},{"key":"10.1016\/j.cub.2026.05.047_bib59","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000046","article-title":"Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus","volume":"4","author":"Fedorova","year":"2008","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cub.2026.05.047_bib60","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1021\/ol303435y","article-title":"Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi","volume":"15","author":"Chooi","year":"2013","journal-title":"Org. Lett."},{"key":"10.1016\/j.cub.2026.05.047_bib61","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.fgb.2010.04.004","article-title":"Fungal secondary metabolites \u2013 Strategies to activate silent gene clusters","volume":"48","author":"Brakhage","year":"2011","journal-title":"Fungal Genet. Biol."},{"key":"10.1016\/j.cub.2026.05.047_bib62","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1128\/EC.4.9.1574-1582.2005","article-title":"LaeA, a regulator of morphogenetic fungal virulence factors","volume":"4","author":"Bok","year":"2005","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.cub.2026.05.047_bib63","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.901037","article-title":"Transcriptional activation of biosynthetic gene clusters in filamentous fungi","volume":"10","author":"M\u00f3zsik","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.cub.2026.05.047_bib64","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3390\/jof10040266","article-title":"A timeline of biosynthetic gene cluster discovery in Aspergillus fumigatus: From characterization to future perspectives","volume":"10","author":"Seo","year":"2024","journal-title":"J. Fungi"},{"key":"10.1016\/j.cub.2026.05.047_bib65","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1056\/NEJMc061720","article-title":"Multiple-triazole\u2013resistant aspergillosis","volume":"356","author":"Verweij","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cub.2026.05.047_bib66","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1093\/jac\/dkx168","article-title":"Isolation of azole-resistant Aspergillus fumigatus from the environment in the south-eastern USA","volume":"72","author":"Hurst","year":"2017","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.cub.2026.05.047_bib67","doi-asserted-by":"crossref","first-page":"4053","DOI":"10.1128\/AEM.00231-09","article-title":"Possible environmental origin of resistance of Aspergillus fumigatus to medical triazoles","volume":"75","author":"Snelders","year":"2009","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.cub.2026.05.047_bib68","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0050219","article-title":"Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism","volume":"5","author":"Snelders","year":"2008","journal-title":"PLoS Med."},{"key":"10.1016\/j.cub.2026.05.047_bib69","doi-asserted-by":"crossref","DOI":"10.1038\/srep45631","article-title":"Azole-resistant Aspergillus fumigatus harboring TR34\/L98H, TR46\/Y121F\/T289A and TR53 mutations related to flower fields in Colombia","volume":"7","author":"Alvarez-Moreno","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cub.2026.05.047_bib70","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1128\/AAC.01092-06","article-title":"A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations","volume":"51","author":"Mellado","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.cub.2026.05.047_bib71","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/jac\/dks451","article-title":"High-level expression of cyp51B in azole-resistant clinical Aspergillus fumigatus isolates","volume":"68","author":"Buied","year":"2013","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.cub.2026.05.047_bib72","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1111\/j.1365-2958.2008.06176.x","article-title":"An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1","volume":"68","author":"Selmecki","year":"2008","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.cub.2026.05.047_bib73","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: The next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.cub.2026.05.047_bib74","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.tibs.2015.12.001","article-title":"The Warburg Effect: How does it benefit cancer cells?","volume":"41","author":"Liberti","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.cub.2026.05.047_bib75","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s10863-007-9080-3","article-title":"Hypoxia, glucose metabolism and the Warburg\u2019s effect","volume":"39","author":"Bartrons","year":"2007","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.cub.2026.05.047_bib76","doi-asserted-by":"crossref","first-page":"914","DOI":"10.15252\/msb.20167159","article-title":"Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures","volume":"13","author":"Graham","year":"2017","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.cub.2026.05.047_bib77","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1126\/science.1160058","article-title":"Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells","volume":"322","author":"Williams","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.cub.2026.05.047_bib78","doi-asserted-by":"crossref","first-page":"e01620-17","DOI":"10.1128\/AEM.01620-17","article-title":"Chromosomal aneuploidy improves the brewing characteristics of sake yeast","volume":"83","author":"Kadowaki","year":"2017","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.cub.2026.05.047_bib79","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006340","article-title":"Filamentous fungal carbon catabolite repression supports metabolic plasticity and stress responses essential for disease progression","volume":"13","author":"Beattie","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cub.2026.05.047_bib80","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/j.1365-2958.2004.04015.x","article-title":"The Aspergillus fumigatus transcriptional activator CpcA contributes significantly to the virulence of this fungal pathogen","volume":"52","author":"Krappmann","year":"2004","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.cub.2026.05.047_bib81","doi-asserted-by":"crossref","first-page":"22473","DOI":"10.1073\/pnas.2003700117","article-title":"Fungal biofilm architecture produces hypoxic microenvironments that drive antifungal resistance","volume":"117","author":"Kowalski","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2026.05.047_bib82","doi-asserted-by":"crossref","DOI":"10.1128\/msphere.00752-25","article-title":"Transcriptional and metabolic modeling analyses of developing Aspergillus fumigatus biofilms reveal metabolic shifts required for biofilm maturation","volume":"10","author":"Puerner","year":"2025","journal-title":"mSphere"},{"key":"10.1016\/j.cub.2026.05.047_bib83","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1126\/science.1140818","article-title":"Noise in gene expression determines cell fate in Bacillus subtilis","volume":"317","author":"Maamar","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.cub.2026.05.047_bib84","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/ng1807","article-title":"Noise in protein expression scales with natural protein abundance","volume":"38","author":"Bar-Even","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cub.2026.05.047_bib85","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.cell.2017.03.021","article-title":"Aneuploidy causes non-genetic individuality","volume":"169","author":"Beach","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.cub.2026.05.047_bib86","doi-asserted-by":"crossref","DOI":"10.1093\/genetics\/iyab183","article-title":"Heterogeneity in the transcriptional response of the human pathogen Aspergillus fumigatus to the antifungal agent caspofungin","volume":"220","author":"Colabardini","year":"2022","journal-title":"Genetics"},{"key":"10.1016\/j.cub.2026.05.047_bib87","doi-asserted-by":"crossref","first-page":"8143","DOI":"10.1128\/AEM.00683-10","article-title":"Activation of a silent fungal polyketide biosynthesis pathway through regulatory cross talk with a cryptic nonribosomal peptide synthetase gene cluster","volume":"76","author":"Bergmann","year":"2010","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.cub.2026.05.047_bib88","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1111\/mpp.12734","article-title":"Fungal attack and host defence pathways unveiled in near-avirulent interactions of Penicillium expansum creA mutants on apples","volume":"19","author":"Tannous","year":"2018","journal-title":"Mol. Plant Pathol."},{"key":"10.1016\/j.cub.2026.05.047_bib89","doi-asserted-by":"crossref","first-page":"530","DOI":"10.3389\/fmicb.2014.00530","article-title":"Perturbations in small molecule synthesis uncovers an iron-responsive secondary metabolite network in Aspergillus fumigatus","volume":"5","author":"Wiemann","year":"2014","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.cub.2026.05.047_bib90","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01399-21","article-title":"Transcription factor repurposing offers insights into evolution of biosynthetic gene cluster regulation","volume":"12","author":"Wang","year":"2021","journal-title":"mBio"},{"key":"10.1016\/j.cub.2026.05.047_bib91","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/mmi.14575","article-title":"Activation of biosynthetic gene clusters by the global transcriptional regulator TRI6 in Fusarium graminearum","volume":"114","author":"Shostak","year":"2020","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.cub.2026.05.047_bib92","unstructured":"Seemann, T. (2024). Rapid haploid variant calling and core genome alignment. GitHub. https:\/\/github.com\/tseemann\/snippy."},{"key":"10.1016\/j.cub.2026.05.047_bib93","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4161\/fly.19695","article-title":"A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3","volume":"6","author":"Cingolani","year":"2012","journal-title":"Fly"},{"key":"10.1016\/j.cub.2026.05.047_bib94","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.1093\/bioinformatics\/bty191","article-title":"Minimap2: pairwise alignment for nucleotide sequences","volume":"34","author":"Li","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cub.2026.05.047_bib95","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cub.2026.05.047_bib96","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1093\/bioinformatics\/btx699","article-title":"Mosdepth: quick coverage calculation for genomes and exomes","volume":"34","author":"Pedersen","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cub.2026.05.047_bib97","series-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"key":"10.1016\/j.cub.2026.05.047_bib98","unstructured":"Pederson, T.L. (2025). patchwork: The composer of plots. R package version 1.3.2.9000. https:\/\/patchwork.data-imaginist.com."},{"key":"10.1016\/j.cub.2026.05.047_bib99","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet J."},{"key":"10.1016\/j.cub.2026.05.047_bib100","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cub.2026.05.047_bib101","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cub.2026.05.047_bib102","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.cub.2026.05.047_bib103","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/s41587-023-01690-2","article-title":"Integrative analysis of multimodal mass spectrometry data in MZmine 3","volume":"41","author":"Schmid","year":"2023","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cub.2026.05.047_bib104","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.cub.2026.05.047_bib105","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/978-1-4939-6747-6_23","article-title":"Data conversion with ProteoWizard msConvert","volume":"1550","author":"Adusumilli","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.cub.2026.05.047_bib106","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/s41592-020-0933-6","article-title":"Feature-based molecular networking in the GNPS analysis environment","volume":"17","author":"Nothias","year":"2020","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cub.2026.05.047_bib107","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3390\/jof8060642","article-title":"The antidepressant sertraline induces the formation of supersized lipid droplets in the human pathogen Cryptococcus neoformans","volume":"8","author":"Breuer","year":"2022","journal-title":"J. Fungi (Basel)"},{"key":"10.1016\/j.cub.2026.05.047_bib108","doi-asserted-by":"crossref","first-page":"20","DOI":"10.4148\/1941-4765.1173","article-title":"Improved protocols for Aspergillus minimal medium: trace element and minimal medium salt stock solutions","volume":"48","author":"Hill","year":"2001","journal-title":"Fungal Genet. Rep."},{"key":"10.1016\/j.cub.2026.05.047_bib109","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-32924-7","article-title":"Telomere-to-telomere genome sequence of the model mould pathogen Aspergillus fumigatus","volume":"13","author":"Bowyer","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2026.05.047_bib110","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.02933-21","article-title":"An alanine aminotransferase is required for biofilm-specific resistance of Aspergillus fumigatus to echinocandin treatment","volume":"13","author":"Kerkaert","year":"2022","journal-title":"mBio"},{"key":"10.1016\/j.cub.2026.05.047_bib111","doi-asserted-by":"crossref","DOI":"10.1002\/cpmc.88","article-title":"High-throughput gene replacement in Aspergillus fumigatus","volume":"54","author":"Zhao","year":"2019","journal-title":"Curr. Protoc. Microbiol."},{"key":"10.1016\/j.cub.2026.05.047_bib112","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.cub.2026.05.047_bib113","doi-asserted-by":"crossref","DOI":"10.1002\/rcm.8780","article-title":"Detection of ergosterol using liquid chromatography\/electrospray ionization mass spectrometry: Investigation of unusual in-source reactions","volume":"34","author":"Ory","year":"2020","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.cub.2026.05.047_bib114","series-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi, Approved Standard","first-page":"1","volume":"28","author":"Rex","year":"2008"}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982226006524?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982226006524?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:37:20Z","timestamp":1785886640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982226006524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":114,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0960982226006524"],"URL":"https:\/\/doi.org\/10.1016\/j.cub.2026.05.047","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aneuploidy promotes transient stress adaptation and metabolic flexibility in the human fungal pathogen Aspergillus fumigatus","name":"articletitle","label":"Article Title"},{"value":"Current Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cub.2026.05.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}