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Commun."},{"key":"10.1016\/j.cub.2026.07.048_bib64","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1067\/S1526-5900(03)00781-8","article-title":"Spared nerve injury model of neuropathic pain in the mouse: a behavioral and anatomic analysis","volume":"4","author":"Shields","year":"2003","journal-title":"J. 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Res."},{"key":"10.1016\/j.cub.2026.07.048_bib68","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1523\/JNEUROSCI.1137-21.2022","article-title":"A female-specific role for calcitonin gene-related peptide (CGRP) in rodent pain models","volume":"42","author":"Paige","year":"2022","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cub.2026.07.048_bib69","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1097\/ALN.0b013e318238c051","article-title":"Metabotropic glutamate receptor 5 antagonism with fenobam: examination of analgesic tolerance and side effect profile in mice","volume":"115","author":"Montana","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1016\/j.cub.2026.07.048_bib70","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neuropharm.2017.11.036","article-title":"Pharmacological validation of voluntary gait and mechanical sensitivity assays associated with inflammatory and neuropathic pain in mice","volume":"130","author":"Shepherd","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.cub.2026.07.048_bib71","article-title":"The influence of aging and duration of nerve injury on the antiallodynic efficacy of analgesics in laboratory mice","volume":"5","author":"Muralidharan","year":"2020","journal-title":"PAIN Rep."},{"key":"10.1016\/j.cub.2026.07.048_bib72","article-title":"Spared nerve injury causes motor phenotypes unrelated to pain in mice","author":"Norris","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.cub.2026.07.048_bib73","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.pain.2013.05.010","article-title":"Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury","volume":"154","author":"Hughes","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.cub.2026.07.048_bib74","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2204515119","article-title":"Spinal neuropeptide Y Y1 receptor-expressing neurons are a pharmacotherapeutic target for the alleviation of neuropathic pain","volume":"119","author":"Nelson","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.cub.2026.07.048_bib75","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1038\/nn.2407","article-title":"Unmasking the tonic-aversive state in neuropathic pain","volume":"12","author":"King","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cub.2026.07.048_bib76","doi-asserted-by":"crossref","DOI":"10.1186\/1744-8069-7-4","article-title":"Transient inflammation-induced ongoing pain is driven by TRPV1 sensitive afferents","volume":"7","author":"Okun","year":"2011","journal-title":"Mol. Pain"},{"key":"10.1016\/j.cub.2026.07.048_bib77","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/jnr.24680","article-title":"Delta opioid receptor activation modulates affective pain and modality-specific pain hypersensitivity associated with chronic neuropathic pain","volume":"100","author":"Cahill","year":"2022","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.cub.2026.07.048_bib78","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0103524","article-title":"The mGluR5 antagonist fenobam induces analgesic conditioned place preference in mice with spared nerve injury","volume":"9","author":"Lax","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cub.2026.07.048_bib79","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/npp.2016.252","article-title":"Sex differences in \u03bc-opioid receptor regulation of the rat locus coeruleus and their cognitive consequences","volume":"42","author":"Guajardo","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.cub.2026.07.048_bib80","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1038\/s41386-025-02201-4","article-title":"Maternal separation disrupts noradrenergic control of adult coping behaviors","volume":"50","author":"Vazquez","year":"2025","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.cub.2026.07.048_bib81","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.brainres.2016.02.023","article-title":"Retrograde optogenetic characterization of the pontospinal module of the locus coeruleus with a canine adenoviral vector","volume":"1641","author":"Li","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.cub.2026.07.048_bib82","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1096\/fj.01-0321fje","article-title":"Preferential transduction of neurons by canine adenovirus vectors and their efficient retrograde transport in vivo","volume":"15","author":"Soudais","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.cub.2026.07.048_bib83","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1089\/104303401750476230","article-title":"A high-efficiency synthetic promoter that drives transgene expression selectively in noradrenergic neurons","volume":"12","author":"Hwang","year":"2001","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.cub.2026.07.048_bib84","doi-asserted-by":"crossref","first-page":"10515","DOI":"10.1523\/JNEUROSCI.23-33-10515.2003","article-title":"\u03bc-opioid receptor desensitization in mature rat neurons: lack of interaction between DAMGO and morphine","volume":"23","author":"Bailey","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cub.2026.07.048_bib85","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/299074a0","article-title":"Enkephalin opens potassium channels on mammalian central neurones","volume":"299","author":"Williams","year":"1982","journal-title":"Nature"},{"key":"10.1016\/j.cub.2026.07.048_bib86","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.neuron.2011.11.016","article-title":"Photoactivatable neuropeptides for spatiotemporally precise delivery of opioids in neural tissue","volume":"73","author":"Banghart","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2026.07.048_bib87","doi-asserted-by":"crossref","first-page":"5037","DOI":"10.1523\/JNEUROSCI.16-16-05037.1996","article-title":"Ultrastructural evidence for prominent distribution of the \u03bc-opioid receptor at extrasynaptic sites on noradrenergic dendrites in the rat nucleus locus coeruleus","volume":"16","author":"Van Bockstaele","year":"1996","journal-title":"J. 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Neurobiol."},{"key":"10.1016\/j.cub.2026.07.048_bib89","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0074706","article-title":"Mu opioid receptors on primary afferent Nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice","volume":"8","author":"Weibel","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cub.2026.07.048_bib90","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/383819a0","article-title":"Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the \u03bc-opioid-receptor gene","volume":"383","author":"Matthes","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.cub.2026.07.048_bib91","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1046\/j.1460-9568.2003.02482.x","article-title":"Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones","volume":"17","author":"Martin","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.cub.2026.07.048_bib92","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/0006-8993(83)90589-9","article-title":"Microinjection of morphine into nucleus reticularis paragigantocellularis of the rat suppresses spontaneous activity of nucleus raphe magnus neurons","volume":"272","author":"Heinricher","year":"1983","journal-title":"Brain Res."},{"key":"10.1016\/j.cub.2026.07.048_bib93","doi-asserted-by":"crossref","first-page":"4685","DOI":"10.1073\/pnas.73.12.4685","article-title":"Opiate and stimulus-produced analgesia: functional anatomy of a medullospinal pathway","volume":"73","author":"Basbaum","year":"1976","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.cub.2026.07.048_bib94","first-page":"208","article-title":"Nucleus raphe magnus: a common mediator of opiate- and stimulus-produced analgesia","volume":"101","author":"Fields","year":"1976","journal-title":"Trans. Am. Neurol. Assoc."},{"key":"10.1016\/j.cub.2026.07.048_bib95","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0006-8993(86)90958-3","article-title":"Morphine microinjected into the periaqueductal gray has differential effects on 3 classes of medullary neurons","volume":"375","author":"Cheng","year":"1986","journal-title":"Brain Res."},{"key":"10.1016\/j.cub.2026.07.048_bib96","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev.ph.40.030178.001245","article-title":"Brainstem control of spinal pain-transmission neurons","volume":"40","author":"Fields","year":"1978","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.cub.2026.07.048_bib97","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0014-2999(72)90129-X","article-title":"The effect of adrenalectomy on morphine analgesia and tolerance development in rats","volume":"18","author":"Gebhart","year":"1972","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cub.2026.07.048_bib98","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1152\/jn.00016.2023","article-title":"Persistent inflammation selectively activates opioid-sensitive phasic-firing neurons within the vlPAG","volume":"129","author":"McPherson","year":"2023","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.cub.2026.07.048_bib99","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.cell.2009.04.019","article-title":"Dissociation of the opioid receptor mechanisms that control mechanical and heat pain","volume":"137","author":"Scherrer","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.cub.2026.07.048_bib100","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev-neuro-080317-061522","article-title":"Endogenous and exogenous opioids in pain","volume":"41","author":"Corder","year":"2018","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.cub.2026.07.048_bib101","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0022-3565(25)21481-1","article-title":"Roles of mu, delta and kappa opioid receptors in spinal and supraspinal mediation of gastrointestinal transit effects and hot-plate analgesia in the mouse","volume":"230","author":"Porreca","year":"1984","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.cub.2026.07.048_bib102","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.biopsych.2012.06.033","article-title":"Chronic pain leads to concomitant noradrenergic impairment and mood disorders","volume":"73","author":"Alba-Delgado","year":"2013","journal-title":"Biol. 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USA"},{"key":"10.1016\/j.cub.2026.07.048_bib106","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1097\/ALN.0b013e31818dac9c","article-title":"Gabapentin acts within the locus coeruleus to alleviate neuropathic pain","volume":"109","author":"Hayashida","year":"2008","journal-title":"Anesthesiology"},{"key":"10.1016\/j.cub.2026.07.048_bib107","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neulet.2015.09.036","article-title":"Down-regulation of astroglial glutamate transporter-1 in the locus coeruleus impairs pain-evoked endogenous analgesia in rats","volume":"608","author":"Kimura","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.cub.2026.07.048_bib108","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1097\/j.pain.0000000000000608","article-title":"Gabapentin loses efficacy over time after nerve injury in rats: role of glutamate transporter-1 in the locus coeruleus","volume":"157","author":"Kimura","year":"2016","journal-title":"Pain"},{"key":"10.1016\/j.cub.2026.07.048_bib109","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41586-025-08952-w","article-title":"Heterogeneous pericoerulear neurons tune arousal and exploratory behaviours","volume":"643","author":"Luskin","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.cub.2026.07.048_bib110","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.104453.3","article-title":"Descending locus coeruleus noradrenergic signaling to spinal astrocyte subset is required for stress-induced mechanical pain hypersensitivity","volume":"14","author":"Kawanabe-Kobayashi","year":"2026","journal-title":"eLife"},{"key":"10.1016\/j.cub.2026.07.048_bib111","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1097\/j.pain.0000000000002802","article-title":"Pro-opiomelanocortin neurons in the nucleus of the solitary tract mediate endorphinergic endogenous analgesia in mice","volume":"164","author":"Patra","year":"2023","journal-title":"Pain"},{"key":"10.1016\/j.cub.2026.07.048_bib112","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-42623-6","article-title":"Lateral hypothalamic proenkephalin neurons drive threat-induced overeating associated with a negative emotional state","volume":"14","author":"You","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2026.07.048_bib113","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1523\/JNEUROSCI.12-08-03162.1992","article-title":"Robust enkephalin innervation of the locus coeruleus from the rostral medulla","volume":"12","author":"Drolet","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cub.2026.07.048_bib114","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0006-8993(02)03367-X","article-title":"Opioid circuits originating from the nucleus paragigantocellularis and their potential role in opiate withdrawal","volume":"955","author":"Johnson","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.cub.2026.07.048_bib115","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchemneu.2022.102167","article-title":"Organisation of enkephalin inputs and outputs of the central nucleus of the amygdala in mice","volume":"125","author":"Viden","year":"2022","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.cub.2026.07.048_bib116","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1111\/j.1460-9568.2006.04744.x","article-title":"Pro-opiomelanocortin colocalizes with corticotropin- releasing factor in axon terminals of the noradrenergic nucleus locus coeruleus","volume":"23","author":"Reyes","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.cub.2026.07.048_bib117","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0306-4522(95)00432-7","article-title":"Enkephalin terminals form inhibitory-type synapses on neurons in the rat nucleus locus coeruleus that project to the medial prefrontal cortex","volume":"71","author":"van Bockstaele","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.cub.2026.07.048_bib118","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1523\/JNEUROSCI.5339-03.2004","article-title":"Numerous GABAergic afferents to locus ceruleus in the pericerulear dendritic zone: possible interneuronal pool","volume":"24","author":"Aston-Jones","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cub.2026.07.048_bib119","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1111\/j.1476-5381.1996.tb16080.x","article-title":"Nociceptin receptor coupling to a potassium conductance in rat locus coeruleus neurones in vitro","volume":"119","author":"Connor","year":"1996","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cub.2026.07.048_bib120","first-page":"153","article-title":"Inhibition of locus coeruleus neurons by serotonin at high doses","volume":"38","author":"Chiu","year":"1995","journal-title":"Chin. J. Physiol."},{"key":"10.1016\/j.cub.2026.07.048_bib121","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1126\/science.6278591","article-title":"alpha 2-adrenoceptor-mediated hyperpolarization of locus coeruleus neurons: intracellular studies in vivo","volume":"215","author":"Aghajanian","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.cub.2026.07.048_bib122","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/0006-8993(77)90083-X","article-title":"Evidence for norepinephrine-mediated collateral inhibition of locus coeruleus neurons","volume":"136","author":"Aghajanian","year":"1977","journal-title":"Brain Res."},{"key":"10.1016\/j.cub.2026.07.048_bib123","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.1113\/JP279557","article-title":"Inhibitory interneurons regulate phasic activity of noradrenergic neurons in the mouse locus coeruleus and functional implications","volume":"598","author":"Kuo","year":"2020","journal-title":"J. Physiol."},{"key":"10.1016\/j.cub.2026.07.048_bib124","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci12070860","article-title":"Delta opioid receptors and enkephalinergic signaling within locus coeruleus promote stress resilience","volume":"12","author":"Tkaczynski","year":"2022","journal-title":"Brain Sci."},{"key":"10.1016\/j.cub.2026.07.048_bib125","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/ejn.15866","article-title":"Carbachol increases locus coeruleus activation by targeting noradrenergic neurons, inhibitory interneurons and inhibitory synaptic transmission","volume":"57","author":"Kuo","year":"2023","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.cub.2026.07.048_bib126","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1113\/jphysiol.2014.281378","article-title":"GABAB receptor-mediated tonic inhibition regulates the spontaneous firing of locus coeruleus neurons in developing rats and in citalopram-treated rats","volume":"593","author":"Wang","year":"2015","journal-title":"J. Physiol."},{"key":"10.1016\/j.cub.2026.07.048_bib127","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adq0011","article-title":"Neuropeptide Y neurons surrounding the locus coeruleus inhibit noradrenergic system activity to reduce anxiety","volume":"11","author":"Riga","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cub.2026.07.048_bib128","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0010-20.2020","article-title":"An intersectional viral-genetic method for fluorescent tracing of axon collaterals reveals details of noradrenergic locus coeruleus structure","volume":"7","author":"Plummer","year":"2020","journal-title":"eNeuro"},{"key":"10.1016\/j.cub.2026.07.048_bib129","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1038\/s41593-024-01659-7","article-title":"A single-vector intersectional AAV strategy for interrogating cellular diversity and brain function","volume":"27","author":"Hughes","year":"2024","journal-title":"Nat. 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