{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:59:55Z","timestamp":1790398795081,"version":"4.1.0"},"reference-count":70,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,9,21]],"date-time":"2027-09-21T00:00:00Z","timestamp":1821484800000},"content-version":"am","delay-in-days":385,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["F31 HL167553"],"award-info":[{"award-number":["F31 HL167553"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["R01HL104101"],"award-info":[{"award-number":["R01HL104101"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["R01HL137094"],"award-info":[{"award-number":["R01HL137094"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R21NS134132"],"award-info":[{"award-number":["R21NS134132"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.cub.2026.08.015","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:46:21Z","timestamp":1788273981000},"page":"4733-4748.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Carotid body dysfunction contributes to respiratory instability in Rett syndrome"],"prefix":"10.1016","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5276-315X","authenticated-orcid":false,"given":"Monica L.","family":"Strain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliandra N.","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle L.","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7040-3927","authenticated-orcid":false,"given":"Daniel K.","family":"Mulkey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cub.2026.08.015_bib1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/13810","article-title":"Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2","volume":"23","author":"Amir","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cub.2026.08.015_bib2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1212\/01.wnl.0000223318.28938.45","article-title":"Early progressive encephalopathy in boys and MECP2 mutations","volume":"67","author":"Kankirawatana","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.cub.2026.08.015_bib3","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/ajmg.b.32707","article-title":"The array of clinical phenotypes of males with mutations in Methyl-CpG binding protein 2","volume":"180","author":"Neul","year":"2019","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.cub.2026.08.015_bib4","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1126\/science.1153252","article-title":"MeCP2, a key contributor to neurological disease, activates and represses transcription","volume":"320","author":"Chahrour","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.cub.2026.08.015_bib5","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1086\/382228","article-title":"X-chromosome inactivation patterns are unbalanced and affect the phenotypic outcome in a mouse model of rett syndrome","volume":"74","author":"Young","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.cub.2026.08.015_bib6","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1212\/01.wnl.0000291011.54508.aa","article-title":"Specific mutations in methyl-CpG-binding protein 2 confer different severity in Rett syndrome","volume":"70","author":"Neul","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.cub.2026.08.015_bib7","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1136\/adc.63.9.1039","article-title":"Hyperventilation in the awake state: potentially treatable component of Rett syndrome","volume":"63","author":"Southall","year":"1988","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.cub.2026.08.015_bib8","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1136\/adc.85.1.29","article-title":"Characterisation of breathing and associated central autonomic dysfunction in the Rett disorder","volume":"85","author":"Julu","year":"2001","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.cub.2026.08.015_bib9","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1203\/01.pdr.0000238302.84552.d0","article-title":"Autonomic nervous system dysregulation: breathing and heart rate perturbation during wakefulness in young girls with Rett syndrome","volume":"60","author":"Weese-Mayer","year":"2006","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.cub.2026.08.015_bib10","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.pediatrneurol.2007.06.009","article-title":"Disturbances in cardiorespiratory function during day and night in Rett syndrome","volume":"37","author":"Rohdin","year":"2007","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.cub.2026.08.015_bib11","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1002\/ppul.20866","article-title":"Autonomic dysregulation in young girls with Rett Syndrome during nighttime in-home recordings","volume":"43","author":"Weese-Mayer","year":"2008","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.cub.2026.08.015_bib12","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.braindev.2018.03.010","article-title":"The course of awake breathing disturbances across the lifespan in Rett syndrome","volume":"40","author":"Tarquinio","year":"2018","journal-title":"Brain Dev."},{"key":"10.1016\/j.cub.2026.08.015_bib13","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/B978-0-323-91532-8.00018-5","article-title":"Breathing disturbances in Rett syndrome","volume":"189","author":"Ramirez","year":"2022","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.cub.2026.08.015_bib14","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.resp.2013.06.022","article-title":"Breathing challenges in Rett syndrome: lessons learned from humans and animal models","volume":"189","author":"Ramirez","year":"2013","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.cub.2026.08.015_bib15","doi-asserted-by":"crossref","first-page":"10359","DOI":"10.1523\/JNEUROSCI.0057-11.2011","article-title":"MeCP2 is critical within HoxB1-derived tissues of mice for normal lifespan","volume":"31","author":"Ward","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cub.2026.08.015_bib16","doi-asserted-by":"crossref","first-page":"5572","DOI":"10.1523\/JNEUROSCI.2330-15.2016","article-title":"Progressive Changes in a Distributed Neural Circuit Underlie Breathing Abnormalities in Mice Lacking MeCP2","volume":"36","author":"Huang","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cub.2026.08.015_bib17","doi-asserted-by":"crossref","first-page":"C729","DOI":"10.1152\/ajpcell.00334.2010","article-title":"The disruption of central CO2 chemosensitivity in a mouse model of Rett syndrome","volume":"301","author":"Zhang","year":"2011","journal-title":"Am. J. Physiol., Cell Physiol."},{"key":"10.1016\/j.cub.2026.08.015_bib18","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1113\/expphysiol.2012.069872","article-title":"Increasing brain serotonin corrects CO2 chemosensitivity in methyl-CpG-binding protein 2 (Mecp2)-deficient mice","volume":"98","author":"Toward","year":"2013","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.cub.2026.08.015_bib19","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.neuroscience.2014.02.043","article-title":"Respiratory phenotypes are distinctly affected in mice with common Rett syndrome mutations MeCP2 T158A and R168X","volume":"267","author":"Bissonnette","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.cub.2026.08.015_bib20","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1203\/01.pdr.0000203157.31924.4a","article-title":"Separate respiratory phenotypes in methyl-CpG-binding protein 2 (Mecp2) deficient mice","volume":"59","author":"Bissonnette","year":"2006","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.cub.2026.08.015_bib21","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.resp.2009.05.013","article-title":"Early breathing defects after moderate hypoxia or hypercapnia in a mouse model of Rett syndrome","volume":"168","author":"Voituron","year":"2009","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.cub.2026.08.015_bib22","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.neulet.2008.09.045","article-title":"Tyrosine hydroxylase deficit in the chemoafferent and the sympathoadrenergic pathways of the Mecp2 deficient mouse","volume":"447","author":"Roux","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.cub.2026.08.015_bib23","doi-asserted-by":"crossref","first-page":"593554","DOI":"10.3389\/fneur.2020.593554","article-title":"Loss of MeCP2 Function Across Several Neuronal Populations Impairs Breathing Response to Acute Hypoxia","volume":"11","author":"Ward","year":"2020","journal-title":"Front. Neurol."},{"key":"10.1016\/j.cub.2026.08.015_bib24","doi-asserted-by":"crossref","first-page":"11521","DOI":"10.1523\/JNEUROSCI.4373-05.2005","article-title":"Mecp2 deficiency disrupts norepinephrine and respiratory systems in mice","volume":"25","author":"Viemari","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cub.2026.08.015_bib25","doi-asserted-by":"crossref","first-page":"17230","DOI":"10.1523\/JNEUROSCI.2951-12.2012","article-title":"Anxiety-related mechanisms of respiratory dysfunction in a mouse model of Rett syndrome","volume":"32","author":"Ren","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cub.2026.08.015_bib26","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1111\/j.1460-9568.2007.05466.x","article-title":"Treatment with desipramine improves breathing and survival in a mouse model for Rett syndrome","volume":"25","author":"Roux","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.cub.2026.08.015_bib27","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.resp.2007.08.009","article-title":"Oral treatment with desipramine improves breathing and life span in Rett syndrome mouse model","volume":"160","author":"Zanella","year":"2008","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.cub.2026.08.015_bib28","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1113\/EP091784","article-title":"Breathing patterns and associated cardiovascular changes in intermittently breathing animals: (Partially) correcting a semantic quagmire","volume":"109","author":"Burggren","year":"2024","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.cub.2026.08.015_bib29","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1152\/physrev.1962.42.3.335","article-title":"Chemoreflexes in breathing","volume":"42","author":"Dejours","year":"1962","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cub.2026.08.015_bib30","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/978-94-007-4584-1_19","article-title":"Shifting from hypoxia to hyperoxia to assess the peripheral chemosensory drive of ventilation","volume":"758","author":"Zapata","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.cub.2026.08.015_bib31","doi-asserted-by":"crossref","first-page":"e184231","DOI":"10.1172\/jci.insight.184231","article-title":"Developmental progression of respiratory dysfunction in a mouse model of Dravet syndrome","volume":"10","author":"Milla","year":"2025","journal-title":"JCI Insight"},{"key":"10.1016\/j.cub.2026.08.015_bib32","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.cub.2023.01.019","article-title":"A carotid body-brainstem neural circuit mediates sighing in hypoxia","volume":"33","author":"Yao","year":"2023","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2026.08.015_bib34","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/j.2040-4603.2012.tb00399.x","article-title":"Peripheral chemoreceptors: function and plasticity of the carotid body","volume":"2","author":"Kumar","year":"2012","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.cub.2026.08.015_bib35","doi-asserted-by":"crossref","first-page":"10460","DOI":"10.1523\/JNEUROSCI.0045-15.2015","article-title":"Functional Oxygen Sensitivity of Astrocytes","volume":"35","author":"Angelova","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cub.2026.08.015_bib36","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1152\/japplphysiol.00864.2002","article-title":"Hyperbaric oxygen and chemical oxidants stimulate CO2\/H+-sensitive neurons in rat brain stem slices","volume":"95","author":"Mulkey","year":"2003","journal-title":"J. Appl. Physiol. (1985)"},{"key":"10.1016\/j.cub.2026.08.015_bib37","doi-asserted-by":"crossref","DOI":"10.3791\/60298","article-title":"Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing","author":"Shin","year":"2019","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.cub.2026.08.015_bib38","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0092-8674(00)81887-5","article-title":"MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin","volume":"88","author":"Nan","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.cub.2026.08.015_bib39","doi-asserted-by":"crossref","DOI":"10.1186\/s13229-017-0174-4","article-title":"RNA sequencing and proteomics approaches reveal novel deficits in the cortex of Mecp2-deficient mice, a model for Rett syndrome","volume":"8","author":"Pacheco","year":"2017","journal-title":"Mol. Autism"},{"key":"10.1016\/j.cub.2026.08.015_bib40","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neuroscience.2019.06.013","article-title":"Transcriptomic Studies in Mouse Models of Rett Syndrome: A Review","volume":"413","author":"Sanfeliu","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.cub.2026.08.015_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24044218","article-title":"MeCP2 Is an Epigenetic Factor That Links DNA Methylation with Brain Metabolism","volume":"24","author":"Vuu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cub.2026.08.015_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/cells13242077","article-title":"Molecular Mechanisms of Rett Syndrome: Emphasizing the Roles of Monoamine, Immunity, and Mitochondrial Dysfunction","volume":"13","author":"Gon\u00e7alez","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.cub.2026.08.015_bib43","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.brainresrev.2004.05.007","article-title":"Neurotransmission in the carotid body: transmitters and modulators between glomus cells and petrosal ganglion nerve terminals","volume":"47","author":"Iturriaga","year":"2004","journal-title":"Brain Res., Brain Res. Rev."},{"key":"10.1016\/j.cub.2026.08.015_bib44","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1038\/npp.2014.136","article-title":"Improvement of the Rett syndrome phenotype in a MeCP2 mouse model upon treatment with levodopa and a dopa-decarboxylase inhibitor","volume":"39","author":"Szczesna","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.cub.2026.08.015_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2025.115193","article-title":"Role of substantia Nigra dopaminergic neurons in respiratory modulation and limitations of levodopa in Parkinson's disease","volume":"387","author":"Miranda","year":"2025","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.cub.2026.08.015_bib46","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/syn.21805","article-title":"Parkinson's disease treatment may cause impulse-control disorder via dopamine D3 receptors","volume":"69","author":"Seeman","year":"2015","journal-title":"Synapse"},{"key":"10.1016\/j.cub.2026.08.015_bib47","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrn.2015.8","article-title":"Neurobiology of rodent self-grooming and its value for translational neuroscience","volume":"17","author":"Kalueff","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.cub.2026.08.015_bib48","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.tins.2025.07.006","article-title":"Retrotrapezoid nucleus chemoreception: mechanisms of function and contributions to disordered breathing in disease","volume":"48","author":"Mulkey","year":"2025","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.cub.2026.08.015_bib49","series-title":"Disorders of Sleep and Control of Breathing","first-page":"1511","article-title":"Control of Breathing and Upper Airways During Sleep","author":"Horner","year":"2015"},{"key":"10.1016\/j.cub.2026.08.015_bib50","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.resp.2009.04.017","article-title":"Breathing disorders in Rett syndrome: progressive neurochemical dysfunction in the respiratory network after birth","volume":"168","author":"Katz","year":"2009","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.cub.2026.08.015_bib51","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.braindev.2006.04.010","article-title":"Management of a severe forceful breather with Rett syndrome using carbogen","volume":"28","author":"Smeets","year":"2006","journal-title":"Brain Dev."},{"key":"10.1016\/j.cub.2026.08.015_bib52","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.braindev.2012.04.004","article-title":"Treating hypoxia in a feeble breather with Rett syndrome","volume":"35","author":"Julu","year":"2013","journal-title":"Brain Dev."},{"key":"10.1016\/j.cub.2026.08.015_bib53","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1152\/japplphysiol.00843.2007","article-title":"Effect of inspired oxygen on periodic breathing in methy-CpG-binding protein 2 (Mecp2) deficient mice","volume":"104","author":"Bissonnette","year":"2008","journal-title":"J. Appl. Physiol. (1985)"},{"key":"10.1016\/j.cub.2026.08.015_bib54","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s11689-017-9196-7","article-title":"Autonomic breathing abnormalities in Rett syndrome: caregiver perspectives in an international database study","volume":"9","author":"Mackay","year":"2017","journal-title":"J. Neurodev. Disord."},{"key":"10.1016\/j.cub.2026.08.015_bib55","first-page":"4389","article-title":"Exclusive expression of MeCP2 in the nervous system distinguishes between brain and peripheral Rett syndrome-like phenotypes","volume":"25","author":"Ross","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cub.2026.08.015_bib56","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/5584_2015_189","article-title":"Coexpression of Galanin and Nestin in the Chemoreceptor Cells of the Human Carotid Body","volume":"885","author":"Mazzatenta","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.cub.2026.08.015_bib57","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.cell.2019.07.024","article-title":"Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models","volume":"178","author":"Orefice","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cub.2026.08.015_bib58","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/j.1460-9568.1990.tb00473.x","article-title":"Feedback Inhibition of Ca2+ Currents by Dopamine in Glomus Cells of the Carotid Body","volume":"2","author":"Benot","year":"1990","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.cub.2026.08.015_bib59","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.neulet.2005.05.056","article-title":"Defect in normal developmental increase of the brain biogenic amine concentrations in the mecp2-null mouse","volume":"386","author":"Ide","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.cub.2026.08.015_bib60","doi-asserted-by":"crossref","first-page":"21966","DOI":"10.1073\/pnas.0912257106","article-title":"Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities","volume":"106","author":"Samaco","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2026.08.015_bib61","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2202-12-47","article-title":"Biogenic amines and their metabolites are differentially affected in the Mecp2-deficient mouse brain","volume":"12","author":"Panayotis","year":"2011","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.cub.2026.08.015_bib62","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.nbd.2010.10.006","article-title":"Morphological and functional alterations in the substantia nigra pars compacta of the Mecp2-null mouse","volume":"41","author":"Panayotis","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.cub.2026.08.015_bib63","doi-asserted-by":"crossref","first-page":"7229","DOI":"10.1113\/JP272961","article-title":"Selective accumulation of biotin in arterial chemoreceptors: requirement for carotid body exocytotic dopamine secretion","volume":"594","author":"Ortega-S\u00e1enz","year":"2016","journal-title":"J. Physiol."},{"key":"10.1016\/j.cub.2026.08.015_bib64","doi-asserted-by":"crossref","DOI":"10.3390\/biom11040612","article-title":"Treatment Options for Motor and Non-Motor Symptoms of Parkinson's Disease","volume":"11","author":"Church","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.cub.2026.08.015_bib65","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00702-023-02623-8","article-title":"Clinical benefit of MAO-B and COMT inhibition in Parkinson's disease: practical considerations","volume":"130","author":"Regensburger","year":"2023","journal-title":"J. Neural Transm. (Vienna)"},{"key":"10.1016\/j.cub.2026.08.015_bib66","doi-asserted-by":"crossref","first-page":"18208","DOI":"10.1073\/pnas.1012104107","article-title":"Correction of respiratory disorders in a mouse model of Rett syndrome","volume":"107","author":"Abdala","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2026.08.015_bib67","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.14198","article-title":"Restoration of Mecp2 expression in GABAergic neurons is sufficient to rescue multiple disease features in a mouse model of Rett syndrome","volume":"5","author":"Ure","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.cub.2026.08.015_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.117989","article-title":"Rescue of respiratory and cognitive impairments in Rett syndrome mice using NLX-101, a selective 5-HT1A receptor biased agonist","volume":"186","author":"Monteiro-Fernandes","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cub.2026.08.015_bib69","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232214025","article-title":"5-HT1A Receptor Agonist Treatment Partially Ameliorates Rett Syndrome Phenotypes in mecp2-Null Mice by Rescuing Impairment of Neuron Transmission and the CREB\/BDNF Signaling Pathway","volume":"23","author":"Dai","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cub.2026.08.015_bib70","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1165\/rcmb.2013-0372OC","article-title":"Effect of Sarizotan, a 5-HT1a and D2-like receptor agonist, on respiration in three mouse models of Rett syndrome","volume":"50","author":"Abdala","year":"2014","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.cub.2026.08.015_bib71","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982226010250?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982226010250?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:29:57Z","timestamp":1790396997000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982226010250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":70,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0960982226010250"],"URL":"https:\/\/doi.org\/10.1016\/j.cub.2026.08.015","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carotid body dysfunction contributes to respiratory instability in Rett syndrome","name":"articletitle","label":"Article Title"},{"value":"Current Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cub.2026.08.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}