{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:32:39Z","timestamp":1793140359666,"version":"4.5.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"20","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["1ZIAHD008760-20"],"award-info":[{"award-number":["1ZIAHD008760-20"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.cub.2026.08.070","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:00:48Z","timestamp":1790175648000},"page":"5285-5299.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["A peripheral feedforward circuit amplifies taste signals, ensuring behavioral reliability"],"prefix":"10.1016","volume":"36","author":[{"given":"Bo-Mi","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bong-Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9200-1884","authenticated-orcid":false,"given":"Mark","family":"Stopfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cub.2026.08.070_bib1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nrn1949","article-title":"Variability, compensation and homeostasis in neuron and network function","volume":"7","author":"Marder","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.cub.2026.08.070_bib2","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nrn2258","article-title":"Noise in the nervous system","volume":"9","author":"Faisal","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.cub.2026.08.070_bib3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nrn3136","article-title":"Normalization as a canonical neural computation","volume":"13","author":"Carandini","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.cub.2026.08.070_bib4","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/s41583-022-00606-4","article-title":"The structures and functions of correlations in neural population codes","volume":"23","author":"Panzeri","year":"2022","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.cub.2026.08.070_bib5","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev-neuro-060909-153238","article-title":"Too many cooks? Intrinsic and synaptic homeostatic mechanisms in cortical circuit refinement","volume":"34","author":"Turrigiano","year":"2011","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.cub.2026.08.070_bib6","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0092-8674(00)80658-3","article-title":"Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity","volume":"96","author":"Hoon","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.cub.2026.08.070_bib7","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0092-8674(00)80705-9","article-title":"A novel family of mammalian taste receptors","volume":"100","author":"Adler","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.cub.2026.08.070_bib8","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0092-8674(01)00451-2","article-title":"Mammalian sweet taste receptors","volume":"106","author":"Nelson","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.cub.2026.08.070_bib9","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/164_2021_559","article-title":"Encoding taste: from receptors to perception","volume":"275","author":"Roper","year":"2022","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.cub.2026.08.070_bib10","doi-asserted-by":"crossref","first-page":"5533","DOI":"10.1016\/j.cub.2021.10.020","article-title":"Individual bitter-sensing neurons in Drosophila exhibit both ON and OFF responses that influence synaptic plasticity","volume":"31","author":"Devineni","year":"2021","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2026.08.070_bib11","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adj7032","article-title":"Diverse mechanisms of taste coding in Drosophila","volume":"9","author":"Dweck","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cub.2026.08.070_bib12","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.neuron.2013.06.025","article-title":"An odorant-binding protein required for suppression of sweet taste by bitter chemicals","volume":"79","author":"Jeong","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2026.08.070_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0198362","article-title":"A subset of octopaminergic neurons that promotes feeding initiation in Drosophila melanogaster","volume":"13","author":"Youn","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.cub.2026.08.070_bib14","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1016\/j.cub.2020.03.066","article-title":"Temperature and sweet taste integration in Drosophila","volume":"30","author":"Li","year":"2020","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2026.08.070_bib15","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.cophys.2020.12.004","article-title":"Chemical and electrical synaptic interactions among taste bud cells","volume":"20","author":"Roper","year":"2021","journal-title":"Curr. Opin. Physiol."},{"key":"10.1016\/j.cub.2026.08.070_bib16","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1016\/j.cub.2014.07.020","article-title":"Presynaptic gain control drives sweet and bitter taste integration in Drosophila","volume":"24","author":"Chu","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2026.08.070_bib17","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.cub.2018.01.084","article-title":"Identification of a single pair of interneurons for bitter taste processing in the Drosophila brain","volume":"28","author":"Bohra","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2026.08.070_bib18","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.96602.3","article-title":"Drosophila HCN mediates gustatory homeostasis by preserving sensillar transepithelial potential in sweet environments","volume":"13","author":"Lee","year":"2024","journal-title":"eLife"},{"key":"10.1016\/j.cub.2026.08.070_bib19","article-title":"An evolutionarily conserved cation channel tunes the sensitivity of gustatory neurons to ephaptic inhibition in Drosophila","volume":"122","author":"Lee","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.cub.2026.08.070_bib20","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.neuron.2011.01.001","article-title":"The molecular and cellular basis of bitter taste in Drosophila","volume":"69","author":"Weiss","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2026.08.070_bib21","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cub.2019.11.005","article-title":"Molecular logic and evolution of bitter taste in Drosophila","volume":"30","author":"Dweck","year":"2020","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2026.08.070_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/srep43754","article-title":"The taste response to ammonia in Drosophila","volume":"7","author":"Delventhal","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cub.2026.08.070_bib23","doi-asserted-by":"crossref","first-page":"10840","DOI":"10.1523\/JNEUROSCI.1863-07.2007","article-title":"Breadth of tuning and taste coding in mammalian taste buds","volume":"27","author":"Tomchik","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cub.2026.08.070_bib24","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.37167","article-title":"A complex peripheral code for salt taste in Drosophila","volume":"7","author":"Jaeger","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.cub.2026.08.070_bib25","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.78110","article-title":"Drosophila gustatory projections are segregated by taste modality and connectivity","volume":"11","author":"Engert","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.cub.2026.08.070_bib26","article-title":"Electrophysiological recording from Drosophila labellar taste sensilla","volume":"84","author":"Delventhal","year":"2014","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.cub.2026.08.070_bib27","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.neuron.2017.10.011","article-title":"Transsynaptic mapping of second-order taste neurons in flies by trans-Tango","volume":"96","author":"Talay","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2026.08.070_bib28","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.2108\/zsj.19.1009","article-title":"Differentiated response to sugars among labellar chemosensilla in Drosophila","volume":"19","author":"Hiroi","year":"2002","journal-title":"Zoolog. Sci."},{"key":"10.1016\/j.cub.2026.08.070_bib29","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/BF00616754","article-title":"The labellar sugar receptor of Drosophila","volume":"164","author":"Wieczorek","year":"1989","journal-title":"J. Comp. Physiol."},{"key":"10.1016\/j.cub.2026.08.070_bib30","doi-asserted-by":"crossref","first-page":"12309","DOI":"10.1523\/JNEUROSCI.3802-14.2015","article-title":"Spatiotemporal coding of individual chemicals by the gustatory system","volume":"35","author":"Reiter","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cub.2026.08.070_bib31","doi-asserted-by":"crossref","first-page":"4495","DOI":"10.1073\/pnas.0811744106","article-title":"Multiple gustatory receptors required for the caffeine response in Drosophila","volume":"106","author":"Lee","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.cub.2026.08.070_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12872","article-title":"Mechanosensory neurons control sweet sensing in Drosophila","volume":"7","author":"Jeong","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2026.08.070_bib33","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0962-8924(94)90203-8","article-title":"Clostridial neurotoxins: new tools for dissecting exocytosis","volume":"4","author":"Niemann","year":"1994","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.cub.2026.08.070_bib34","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nmeth.2836","article-title":"Independent optical excitation of distinct neural populations","volume":"11","author":"Klapoetke","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cub.2026.08.070_bib35","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.neuron.2019.01.045","article-title":"Chemoconnectomics: mapping chemical transmission in Drosophila","volume":"101","author":"Deng","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2026.08.070_bib36","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.35574","article-title":"A gene-specific T2A-GAL4 library for Drosophila","volume":"7","author":"Lee","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.cub.2026.08.070_bib37","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2202-13-73","article-title":"The Drosophila nicotinic acetylcholine receptor subunits D\u03b15 and D\u03b17 form functional homomeric and heteromeric ion channels","volume":"13","author":"Lansdell","year":"2012","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.cub.2026.08.070_bib38","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1016\/j.celrep.2019.01.042","article-title":"Mechanism of acetic acid gustatory repulsion in Drosophila","volume":"26","author":"Rimal","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.cub.2026.08.070_bib39","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.84856","article-title":"Selective integration of diverse taste inputs within a single taste modality","volume":"12","author":"Deere","year":"2023","journal-title":"eLife"},{"key":"10.1016\/j.cub.2026.08.070_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0101107","article-title":"FLIC: high-throughput, continuous analysis of feeding behaviors in Drosophila","volume":"9","author":"Ro","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cub.2026.08.070_bib41","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.84537.3","article-title":"Behavioral dissection of hunger states in Drosophila","volume":"12","author":"Weaver","year":"2023","journal-title":"eLife"},{"key":"10.1016\/j.cub.2026.08.070_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114625","article-title":"Taste cells expressing Ionotropic Receptor 94e reciprocally impact feeding and egg laying in Drosophila","volume":"43","author":"Guillemin","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.cub.2026.08.070_bib43","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.semcdb.2006.04.012","article-title":"Information processing in the olfactory systems of insects and vertebrates","volume":"17","author":"Kay","year":"2006","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.cub.2026.08.070_bib44","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41586-018-0244-6","article-title":"A synaptic threshold mechanism for computing escape decisions","volume":"558","author":"Evans","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cub.2026.08.070_bib45","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0324-17.2017","article-title":"The role of the gustatory system in the coordination of feeding","volume":"4","author":"Thoma","year":"2017","journal-title":"eNeuro"},{"key":"10.1016\/j.cub.2026.08.070_bib46","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.54978","article-title":"Controlling motor neurons of every muscle for fly proboscis reaching","volume":"9","author":"McKellar","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.cub.2026.08.070_bib47","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaw5141","article-title":"Mechanosensory circuits coordinate two opposing motor actions in Drosophila feeding","volume":"5","author":"Zhou","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cub.2026.08.070_bib48","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-89088-9","article-title":"Connectomic analysis of taste circuits in Drosophila","volume":"15","author":"Walker","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cub.2026.08.070_bib49","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF02289138","article-title":"Rank-biserial correlation","volume":"21","author":"Cureton","year":"1956","journal-title":"Psychometrika"},{"key":"10.1016\/j.cub.2026.08.070_bib50","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1177\/001316446602600307","article-title":"Note on rank biserial correlation","volume":"26","author":"Glass","year":"1966","journal-title":"Educ. Psychol. Meas."},{"key":"10.1016\/j.cub.2026.08.070_bib51","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1214\/aoms\/1177704575","article-title":"Rank methods for combination of independent experiments in analysis of variance","volume":"33","author":"Hodges","year":"1962","journal-title":"Ann. Math. Statist."},{"key":"10.1016\/j.cub.2026.08.070_bib52","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1081\/STA-120017231","article-title":"A nonparametric test for the equality of dependent correlation coefficients under normality","volume":"31","author":"Sakaori","year":"2002","journal-title":"Commun. Stat. Theory Methods"},{"key":"10.1016\/j.cub.2026.08.070_bib53","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1016\/j.jspi.2011.12.018","article-title":"Testing equality of correlation coefficients in two populations via permutation methods","volume":"142","author":"Omelka","year":"2012","journal-title":"J. Stat. Plan. Inference"},{"key":"10.1016\/j.cub.2026.08.070_bib54","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1214\/088342304000000396","article-title":"Permutation methods: a basis for exact inference","volume":"19","author":"Ernst","year":"2004","journal-title":"Stat. Sci."},{"key":"10.1016\/j.cub.2026.08.070_bib55","doi-asserted-by":"crossref","DOI":"10.2202\/1544-6115.1585","article-title":"Permutation p-values should never be zero: calculating exact p-values when permutations are randomly drawn","volume":"9","author":"Phipson","year":"2010","journal-title":"Stat. Appl. Genet. Mol. Biol."}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982226011218?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982226011218?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:36:05Z","timestamp":1793136965000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982226011218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":55,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0960982226011218"],"URL":"https:\/\/doi.org\/10.1016\/j.cub.2026.08.070","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A peripheral feedforward circuit amplifies taste signals, ensuring behavioral reliability","name":"articletitle","label":"Article Title"},{"value":"Current Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cub.2026.08.070","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}