{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:32:11Z","timestamp":1793140331547,"version":"4.5.0"},"reference-count":80,"publisher":"Elsevier BV","issue":"20","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.cub.2026.08.072","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:09:19Z","timestamp":1790867359000},"page":"5141-5155.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mitochondrial proteome of the apicomplexan Babesia divergens"],"prefix":"10.1016","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9263-3873","authenticated-orcid":false,"given":"Cora N.","family":"Betsinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6449-6058","authenticated-orcid":false,"given":"Sarah E.","family":"Calvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2344-1402","authenticated-orcid":false,"given":"Syed Yusuf","family":"Mian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4794-5035","authenticated-orcid":false,"given":"Niel C.","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4123-7410","authenticated-orcid":false,"given":"Aditya S.","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donovan L.","family":"Batzli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1370-2043","authenticated-orcid":false,"given":"Cameron Genxuan","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0097-3679","authenticated-orcid":false,"given":"Brian W.","family":"Boyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith D.","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8891-3714","authenticated-orcid":false,"given":"Sreelakshmi K.","family":"Sreenivasamurthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason G.","family":"McCoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2998-9014","authenticated-orcid":false,"given":"Michael Z.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7273-1809","authenticated-orcid":false,"given":"Tiana M.","family":"Issa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3235-1107","authenticated-orcid":false,"given":"Jonathan A.","family":"Stefely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruslan","family":"Aphasizhev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna","family":"Aphasizheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Carr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke H.","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia G.","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle Y.","family":"Fry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Goyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minsoo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ting","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget E.","family":"Luce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khanh","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Samuelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md","family":"Solayman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres F.","family":"Vacas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5883-7271","authenticated-orcid":false,"given":"Jeffrey D.","family":"Dvorin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namrata D.","family":"Udeshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj T.","family":"Duraisingh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9924-642X","authenticated-orcid":false,"given":"Vamsi K.","family":"Mootha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cub.2026.08.072_bib5","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a016139","article-title":"On the age of eukaryotes: evaluating evidence from fossils and molecular clocks","volume":"6","author":"Eme","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.cub.2026.08.072_bib2","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1101\/gr.083386.108","article-title":"The origins of apicomplexan sequence innovation","volume":"19","author":"Wasmuth","year":"2009","journal-title":"Genome Res."},{"key":"10.1016\/j.cub.2026.08.072_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms9122592","article-title":"An Uninvited Seat at the Dinner Table: How Apicomplexan Parasites Scavenge Nutrients from the Host","volume":"9","author":"Piro","year":"2021","journal-title":"Microorganisms"},{"key":"10.1016\/j.cub.2026.08.072_bib7","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tree.2019.08.008","article-title":"The New Tree of Eukaryotes","volume":"35","author":"Burki","year":"2020","journal-title":"Trends Ecol. Evol."},{"key":"10.1016\/j.cub.2026.08.072_bib9","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.chom.2020.09.011","article-title":"A Comprehensive Subcellular Atlas of the Toxoplasma Proteome via hyperLOPIT Provides Spatial Context for Protein Functions","volume":"28","author":"Barylyuk","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cub.2026.08.072_bib1","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev-micro-032421-120540","article-title":"Unique Properties of Apicomplexan Mitochondria","volume":"77","author":"Lamb","year":"2023","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.cub.2026.08.072_bib3","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1016\/j.cub.2021.04.028","article-title":"Parallel functional reduction in the mitochondria of apicomplexan parasites","volume":"31","author":"Mathur","year":"2021","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2026.08.072_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.751775","article-title":"The Elusive Mitochondrial Genomes of Apicomplexa: Where Are We Now?","volume":"12","author":"Bern\u00e1","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.cub.2026.08.072_bib8","first-page":"1","article-title":"Extrachromosomal DNA in the Apicomplexa","volume":"61","author":"Wilson","year":"1997","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.cub.2026.08.072_bib10","doi-asserted-by":"crossref","DOI":"10.1186\/s12864-016-3343-5","article-title":"Evolution of mitosome metabolism and invasion-related proteins in Cryptosporidium","volume":"17","author":"Liu","year":"2016","journal-title":"BMC Genomics"},{"key":"10.1016\/j.cub.2026.08.072_bib11","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.chom.2023.03.001","article-title":"Cryptosporidium uses multiple distinct secretory organelles to interact with and modify its host cell","volume":"31","author":"Gu\u00e9rin","year":"2023","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cub.2026.08.072_bib12","article-title":"Dissecting apicoplast functions through continuous cultivation of Toxoplasma gondii devoid of the organelle","volume":"16","author":"Chen","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2026.08.072_bib13","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1574-6968.1996.tb08090.x","article-title":"Enzymes of energy metabolism in the bradyzoites and tachyzoites of Toxoplasma gondii","volume":"137","author":"Denton","year":"1996","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.cub.2026.08.072_bib14","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.micinf.2009.12.010","article-title":"Apicoplast: keep it or leave it","volume":"12","author":"Fleige","year":"2010","journal-title":"Microbes Infect."},{"key":"10.1016\/j.cub.2026.08.072_bib15","doi-asserted-by":"crossref","DOI":"10.1186\/s13071-024-06213-9","article-title":"Lipid metabolism: the potential targets for toxoplasmosis treatment","volume":"17","author":"He","year":"2024","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.cub.2026.08.072_bib16","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.02864-23","article-title":"Cryogenic electron tomography reveals novel structures in the apical complex of Plasmodium falciparum","volume":"15","author":"Sun","year":"2024","journal-title":"mBio"},{"key":"10.1016\/j.cub.2026.08.072_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-66393-5","article-title":"An essential adaptor for apicoplast fission and inheritance in malaria parasites","volume":"16","author":"Blauwkamp","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2026.08.072_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-026-73664-2","article-title":"The spatial proteome of the Plasmodium falciparum schizont illuminates the composition and evolutionary trajectories of its organelles","volume":"17","author":"Chisholm","year":"2026","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2026.08.072_bib19","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00614-21","article-title":"A Prioritized and Validated Resource of Mitochondrial Proteins in Plasmodium Identifies Unique Biology","volume":"6","author":"van Esveld","year":"2021","journal-title":"mSphere"},{"key":"10.1016\/j.cub.2026.08.072_bib20","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.38131","article-title":"Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presence of a divergent cytochrome c oxidase","volume":"7","author":"Seidi","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.cub.2026.08.072_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0273357","article-title":"Mitochondrially targeted proximity biotinylation and proteomic analysis in Plasmodium falciparum","volume":"17","author":"Lamb","year":"2022","journal-title":"PLOS One"},{"key":"10.1016\/j.cub.2026.08.072_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-23919-x","article-title":"Composition and stage dynamics of mitochondrial complexes in Plasmodium falciparum","volume":"12","author":"Evers","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2026.08.072_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009301","article-title":"Complexome profile of Toxoplasma gondii mitochondria identifies divergent subunits of respiratory chain complexes including new subunits of cytochrome bc1 complex","volume":"17","author":"Maclean","year":"2021","journal-title":"PLOS Pathog."},{"key":"10.1016\/j.cub.2026.08.072_bib24","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1128\/CMR.13.3.451","article-title":"Babesiosis","volume":"13","author":"Homer","year":"2000","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.cub.2026.08.072_bib25","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.ijpara.2008.03.001","article-title":"Babesiosis: recent insights into an ancient disease","volume":"38","author":"Hunfeld","year":"2008","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.cub.2026.08.072_bib26","doi-asserted-by":"crossref","first-page":"94","DOI":"10.4103\/2229-5070.162490","article-title":"Morphology, epidemiology, and phylogeny of Babesia: An overview","volume":"5","author":"Laha","year":"2015","journal-title":"Trop. Parasitol."},{"key":"10.1016\/j.cub.2026.08.072_bib27","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.idc.2008.03.010","article-title":"Human babesiosis","volume":"22","author":"Vannier","year":"2008","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"10.1016\/j.cub.2026.08.072_bib28","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.pt.2019.01.007","article-title":"Babesia Life Cycle - When Phylogeny Meets Biology","volume":"35","author":"Jalovecka","year":"2019","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.cub.2026.08.072_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetpar.2020.109136","article-title":"Bovine babesiosis: An insight into the global perspective on the disease distribution by systematic review and meta-analysis","volume":"283","author":"Jacob","year":"2020","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.cub.2026.08.072_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens10111447","article-title":"The Global Emergence of Human Babesiosis","volume":"10","author":"Kumar","year":"2021","journal-title":"Pathogens"},{"key":"10.1016\/j.cub.2026.08.072_bib31","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1056\/NEJM200011163432004","article-title":"Atovaquone and azithromycin for the treatment of babesiosis","volume":"343","author":"Krause","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cub.2026.08.072_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens10091120","article-title":"Treatment of Human Babesiosis: Then and Now","volume":"10","author":"Renard","year":"2021","journal-title":"Pathogens"},{"key":"10.1016\/j.cub.2026.08.072_bib33","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/molbev\/msp320","article-title":"Divergence of the mitochondrial genome structure in the apicomplexan parasites, Babesia and Theileria","volume":"27","author":"Hikosaka","year":"2010","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.cub.2026.08.072_bib34","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1371\/journal.ppat.0030148","article-title":"Genome sequence of Babesia bovis and comparative analysis of apicomplexan hemoprotozoa","volume":"3","author":"Brayton","year":"2007","journal-title":"PLOS Pathog."},{"key":"10.1016\/j.cub.2026.08.072_bib35","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00721-23","article-title":"Babesia gibsoni Whole-Genome Sequencing, Assembling, Annotation, and Comparative Analysis","volume":"11","author":"Liu","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.cub.2026.08.072_bib36","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1093\/molbev\/msh166","article-title":"Tom22', an 8-kDa trans-site receptor in plants and protozoans, is a conserved feature of the TOM complex that appeared early in the evolution of eukaryotes","volume":"21","author":"Ma\u0107asev","year":"2004","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.cub.2026.08.072_bib37","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2200158119","article-title":"Structural basis of Tom20 and Tom22 cytosolic domains as the human TOM complex receptors","volume":"119","author":"Su","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2026.08.072_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ab.2009.02.040","article-title":"Isolation of functional pure mitochondria by superparamagnetic microbeads","volume":"389","author":"Hornig-Do","year":"2009","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cub.2026.08.072_bib39","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1038\/s41587-023-02099-7","article-title":"Ultra-fast label-free quantification and comprehensive proteome coverage with narrow-window data-independent acquisition","volume":"42","author":"Guzman","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cub.2026.08.072_bib40","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1021\/acs.jproteome.6b00947","article-title":"Analysis of Stage-Specific Protein Expression during Babesia Bovis Development within Female Rhipicephalus Microplus","volume":"16","author":"Johnson","year":"2017","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.cub.2026.08.072_bib41","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.cell.2006.03.022","article-title":"A mammalian organelle map by protein correlation profiling","volume":"125","author":"Foster","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.cub.2026.08.072_bib42","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1093\/molbev\/msx096","article-title":"Origin and Evolutionary Alteration of the Mitochondrial Import System in Eukaryotic Lineages","volume":"34","author":"Fukasawa","year":"2017","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.cub.2026.08.072_bib43","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1038\/s41559-022-01857-1","article-title":"An early origin of iron-sulfur cluster biosynthesis machineries before Earth oxygenation","volume":"6","author":"Garcia","year":"2022","journal-title":"Nat. Ecol. Evol."},{"key":"10.1016\/j.cub.2026.08.072_bib44","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2020885118","article-title":"On the evolution of chaperones and cochaperones and the expansion of proteomes across the Tree of Life","volume":"118","author":"Rebeaud","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2026.08.072_bib45","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.71636","article-title":"Divergent acyl carrier protein decouples mitochondrial Fe-S cluster biogenesis from fatty acid synthesis in malaria parasites","volume":"10","author":"Falekun","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.cub.2026.08.072_bib46","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1365-2958.2004.04112.x","article-title":"The human malaria parasite Plasmodium falciparum has distinct organelle-specific lipoylation pathways","volume":"53","author":"Wrenger","year":"2004","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.cub.2026.08.072_bib47","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1017\/S0031182018000501","article-title":"Characterization of mitochondrion-targeted GTPases in Plasmodium falciparum","volume":"145","author":"Gupta","year":"2018","journal-title":"Parasitology"},{"key":"10.1016\/j.cub.2026.08.072_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0074408","article-title":"An FtsH protease is recruited to the mitochondrion of Plasmodium falciparum","volume":"8","author":"Tanveer","year":"2013","journal-title":"PLOS One"},{"key":"10.1016\/j.cub.2026.08.072_bib49","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.molbiopara.2018.06.001","article-title":"Characterization of a Plasmodium falciparum rRNA methyltransferase","volume":"223","author":"Gupta","year":"2018","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.cub.2026.08.072_bib50","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.1042\/BCJ20200318","article-title":"Elucidation of an essential function of the unique charged domain of Plasmodium topoisomerase III","volume":"477","author":"Bansod","year":"2020","journal-title":"Biochem. J."},{"key":"10.1016\/j.cub.2026.08.072_bib75","first-page":"189","article-title":"Comparative analysis of mitochondrial proteomes across the tree of life","author":"Chen","year":"2026","journal-title":"Cell"},{"key":"10.1016\/j.cub.2026.08.072_bib51","doi-asserted-by":"crossref","DOI":"10.1126\/science.adq6241","article-title":"The essential genome of Plasmodium knowlesi reveals determinants of antimalarial susceptibility","volume":"387","author":"Elsworth","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.cub.2026.08.072_bib52","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.pt.2022.09.008","article-title":"The mystery of massive mitochondrial complexes: the apicomplexan respiratory chain","volume":"38","author":"Maclean","year":"2022","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.cub.2026.08.072_bib53","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.mito.2009.08.004","article-title":"Identification of mitochondrial Complex II subunits SDH3 and SDH4 and ATP synthase subunits a and b in Plasmodium spp","volume":"9","author":"Mogi","year":"2009","journal-title":"Mitochondrion"},{"key":"10.1016\/j.cub.2026.08.072_bib54","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-20381-z","article-title":"ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria","volume":"12","author":"M\u00fchleip","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2026.08.072_bib55","doi-asserted-by":"crossref","first-page":"D1541","DOI":"10.1093\/nar\/gkaa1011","article-title":"MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations","volume":"49","author":"Rath","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cub.2026.08.072_bib56","doi-asserted-by":"crossref","first-page":"42363","DOI":"10.1074\/jbc.M404519200","article-title":"Mitochondrial tRNA import in Toxoplasma gondii","volume":"279","author":"Esseiva","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cub.2026.08.072_bib58","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004263","article-title":"BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei","volume":"10","author":"Oppenheim","year":"2014","journal-title":"PLOS Pathog."},{"key":"10.1016\/j.cub.2026.08.072_bib57","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"630","author":"Abramson","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.cub.2026.08.072_bib69","doi-asserted-by":"crossref","first-page":"W215","DOI":"10.1093\/nar\/gkae237","article-title":"DeepLoc 2.1: multi-label membrane protein type prediction using protein language models","volume":"52","author":"\u00d8dum","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cub.2026.08.072_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2025.1542122","article-title":"The apicoplast localized isocitrate dehydrogenase is needed for de novo fatty acid synthesis in the apicoplast of Toxoplasma gondii","volume":"15","author":"Pan","year":"2025","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.cub.2026.08.072_bib60","doi-asserted-by":"crossref","DOI":"10.1038\/s41421-020-00220-7","article-title":"Structure and allosteric regulation of human NAD-dependent isocitrate dehydrogenase","volume":"6","author":"Sun","year":"2020","journal-title":"Cell Discov."},{"key":"10.1016\/j.cub.2026.08.072_bib61","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011430","article-title":"An essential role for an Fe-S cluster protein in the cytochrome c oxidase complex of Toxoplasma parasites","volume":"19","author":"Leonard","year":"2023","journal-title":"PLOS Pathog."},{"key":"10.1016\/j.cub.2026.08.072_bib62","article-title":"Numerous rRNA molecules form the apicomplexan mitoribosome via repurposed protein and RNA elements","volume":"16","author":"Shikha","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2026.08.072_bib63","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-55033-z","article-title":"Apicomplexan mitoribosome from highly fragmented rRNAs to a functional machine","volume":"15","author":"Wang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2026.08.072_bib65","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cub.2026.08.072_bib68","doi-asserted-by":"crossref","first-page":"W200","DOI":"10.1093\/nar\/gky448","article-title":"HMMER web server: 2018 update","volume":"46","author":"Potter","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cub.2026.08.072_bib71","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-019-1832-y","article-title":"OrthoFinder: phylogenetic orthology inference for comparative genomics","volume":"20","author":"Emms","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.cub.2026.08.072_bib72","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-34630-w","article-title":"Muscle5: High-accuracy alignment ensembles enable unbiased assessments of sequence homology and phylogeny","volume":"13","author":"Edgar","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2026.08.072_bib73","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001007","article-title":"ClipKIT: A multiple sequence alignment trimming software for accurate phylogenomic inference","volume":"18","author":"Steenwyk","year":"2020","journal-title":"PLOS Biol."},{"key":"10.1016\/j.cub.2026.08.072_bib74","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1093\/molbev\/msaa015","article-title":"IQ-TREE 2: New Models and Efficient Methods for Phylogenetic Inference in the Genomic Era","volume":"37","author":"Minh","year":"2020","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.cub.2026.08.072_bib67","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-10-421","article-title":"BLAST+: architecture and applications","volume":"10","author":"Camacho","year":"2009","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.cub.2026.08.072_bib64","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-025-07619-6","article-title":"PfFBXO1 is essential for inner membrane complex formation in Plasmodium falciparum during both asexual and transmission stages","volume":"8","author":"Sreenivasamurthy","year":"2025","journal-title":"Commun. Biol."},{"key":"10.1016\/j.cub.2026.08.072_bib66","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2024.2386136","article-title":"Insights into the evolution, virulence and speciation of Babesia MO1 and Babesia divergens through multiomics analyses","volume":"13","author":"Singh","year":"2024","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.cub.2026.08.072_bib70","doi-asserted-by":"crossref","first-page":"D1251","DOI":"10.1093\/nar\/gkv1003","article-title":"MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins","volume":"44","author":"Calvo","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cub.2026.08.072_bib76","first-page":"189","article-title":"Mitochondrial proteome of Acanthamoeba delineates aerobic and anaerobic pathways dynamically regulated by oxygen","author":"Stefely","year":"2026","journal-title":"Cell"},{"key":"10.1016\/j.cub.2026.08.072_bib77","first-page":"1","article-title":"Acanthamoeba castellanii genome reannotation and multi-omic encystation profiling reveals cyst wall proteins and carbohydrate-active enzymes","author":"Stefely","year":"2026","journal-title":"Cell Press Blue"},{"key":"10.1016\/j.cub.2026.08.072_bib78","first-page":"86","article-title":"Lineage-specific innovations expand mitochondrial proteomes in kinetoplastids","author":"Vacas","year":"2026","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cub.2026.08.072_bib79","first-page":"189","article-title":"A high-confidence plant mitochondrial proteome via protein correlation profiling","author":"Kim","year":"2026","journal-title":"Cell"},{"key":"10.1016\/j.cub.2026.08.072_bib80","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s12859-020-3513-y","article-title":"ICEKAT: an interactive online tool for calculating initial rates from continuous enzyme kinetic traces","volume":"1","author":"Olp","year":"2020","journal-title":"BMC Bioinformatics"}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982226011231?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982226011231?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:34:30Z","timestamp":1793136870000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982226011231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":80,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0960982226011231"],"URL":"https:\/\/doi.org\/10.1016\/j.cub.2026.08.072","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial proteome of the apicomplexan Babesia divergens","name":"articletitle","label":"Article Title"},{"value":"Current Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cub.2026.08.072","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}