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USA"},{"key":"10.1016\/j.cub.2026.09.062_bib57","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1016\/j.cub.2021.07.069","article-title":"Sex-specific, pdfr-1-dependent modulation of pheromone avoidance by food abundance enables flexibility in C. elegans foraging behavior","volume":"31","author":"Luo","year":"2021","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2026.09.062_bib58","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1101\/gad.1117903","article-title":"A transcriptional regulatory cascade that controls left\/right asymmetry in chemosensory neurons of C. elegans","volume":"17","author":"Chang","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.cub.2026.09.062_bib59","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0896-6273(01)00431-7","article-title":"Specification of thermosensory neuron fate in C. elegans requires ttx-1, a homolog of otd\/Otx","volume":"31","author":"Satterlee","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2026.09.062_bib60","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/349588a0","article-title":"The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration","volume":"349","author":"Driscoll","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.cub.2026.09.062_bib61","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1242\/dev.120.5.1035","article-title":"The Caenorhabditis elegans gene lin-44 controls the polarity of asymmetric cell divisions","volume":"120","author":"Herman","year":"1994","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.062_bib62","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1242\/jcs.052373","article-title":"The nuclear receptor NHR-25 cooperates with the Wnt\/beta-catenin asymmetry pathway to control differentiation of the T seam cell in C. elegans","volume":"122","author":"Hajduskova","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.cub.2026.09.062_bib63","doi-asserted-by":"crossref","first-page":"3900","DOI":"10.1073\/pnas.1720063115","article-title":"Split cGAL, an intersectional strategy using a split intein for refined spatiotemporal transgene control in Caenorhabditis elegans","volume":"115","author":"Wang","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2026.09.062_bib64","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/nn.2157","article-title":"Bidirectional temperature-sensing by a single thermosensory neuron in C. elegans","volume":"11","author":"Ramot","year":"2008","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cub.2026.09.062_bib65","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.neuron.2018.12.030","article-title":"Structured Odorant Response Patterns across a Complete Olfactory Receptor Neuron Population","volume":"101","author":"Si","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2026.09.062_bib66","doi-asserted-by":"crossref","first-page":"4803","DOI":"10.1016\/j.cub.2026.08.040","article-title":"Whole-brain chemosensory responses of both C. elegans sexes","volume":"36","author":"Seyedolmohadesin","year":"2026","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2026.09.062_bib67","doi-asserted-by":"crossref","DOI":"10.1093\/genetics\/iyae056","article-title":"Dendrite morphogenesis in Caenorhabditis elegans","volume":"227","author":"Heiman","year":"2024","journal-title":"Genetics"},{"key":"10.1016\/j.cub.2026.09.062_bib68","doi-asserted-by":"crossref","first-page":"7444","DOI":"10.1523\/JNEUROSCI.1137-06.2006","article-title":"The AFD sensory neurons encode multiple functions underlying thermotactic behavior in Caenorhabditis elegans","volume":"26","author":"Clark","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cub.2026.09.062_bib69","doi-asserted-by":"crossref","first-page":"19839","DOI":"10.1073\/pnas.0805507105","article-title":"A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance","volume":"105","author":"Ol\u00e1hov\u00e1","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2026.09.062_bib70","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.jmb.2004.03.021","article-title":"A peroxiredoxin specifically expressed in two types of pharyngeal neurons is required for normal growth and egg production in Caenorhabditis elegans","volume":"338","author":"Isermann","year":"2004","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.cub.2026.09.062_bib71","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.97503","article-title":"Endogenous hydrogen peroxide positively regulates secretion of a gut-derived peptide in neuroendocrine potentiation of the oxidative stress response in Caenorhabditis elegans","volume":"13","author":"Jia","year":"2024","journal-title":"eLife"},{"key":"10.1016\/j.cub.2026.09.062_bib72","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.str.2021.04.007","article-title":"Structural determinants of multimerization and dissociation in 2-Cys peroxiredoxin chaperone function","volume":"29","author":"Troussicot","year":"2021","journal-title":"Structure"},{"key":"10.1016\/j.cub.2026.09.062_bib73","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1016\/j.bbagen.2012.09.018","article-title":"Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes","volume":"1830","author":"Deponte","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cub.2026.09.062_bib74","doi-asserted-by":"crossref","DOI":"10.1002\/pro.4290","article-title":"Characterization of the glutathione-dependent reduction of the peroxiredoxin 5 homolog PfAOP from Plasmodium falciparum","volume":"31","author":"Schumann","year":"2022","journal-title":"Protein Sci."},{"key":"10.1016\/j.cub.2026.09.062_bib75","doi-asserted-by":"crossref","first-page":"13963","DOI":"10.1016\/S0021-9258(18)71625-6","article-title":"Thioredoxin and glutaredoxin systems","volume":"264","author":"Holmgren","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cub.2026.09.062_bib76","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009257","article-title":"Regulation of photosensation by hydrogen peroxide and antioxidants in C. elegans","volume":"16","author":"Zhang","year":"2020","journal-title":"PLOS Genet."},{"key":"10.1016\/j.cub.2026.09.062_bib77","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0060731","article-title":"The glutathione reductase GSR-1 determines stress tolerance and longevity in Caenorhabditis elegans","volume":"8","author":"L\u00fcersen","year":"2013","journal-title":"PLOS One"},{"key":"10.1016\/j.cub.2026.09.062_bib78","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.freeradbiomed.2016.04.017","article-title":"Glutathione reductase gsr-1 is an essential gene required for Caenorhabditis elegans early embryonic development","volume":"96","author":"Mora-Lorca","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cub.2026.09.062_bib79","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.jmb.2009.08.040","article-title":"Structural changes common to catalysis in the Tpx peroxiredoxin subfamily","volume":"393","author":"Hall","year":"2009","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.cub.2026.09.062_bib80","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10059-012-0155-6","article-title":"Two thioredoxin reductases, trxr-1 and trxr-2, have differential physiological roles in Caenorhabditis elegans","volume":"34","author":"Li","year":"2012","journal-title":"Mol. 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Redox Signal."},{"key":"10.1016\/j.cub.2026.09.062_bib82","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.febslet.2005.12.046","article-title":"Lifespan decrease in a Caenorhabditis elegans mutant lacking TRX-1, a thioredoxin expressed in ASJ sensory neurons","volume":"580","author":"Miranda-Vizuete","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cub.2026.09.062_bib83","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.36833","article-title":"Thioredoxin shapes the C. elegans sensory response to Pseudomonas produced nitric oxide","volume":"7","author":"Hao","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.cub.2026.09.062_bib84","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0969-2126(96)00079-2","article-title":"Crystal structures of reduced, oxidized, and mutated human thioredoxins: evidence for a regulatory homodimer","volume":"4","author":"Weichsel","year":"1996","journal-title":"Structure"},{"key":"10.1016\/j.cub.2026.09.062_bib85","doi-asserted-by":"crossref","first-page":"32241","DOI":"10.1074\/jbc.M113.495150","article-title":"Thioredoxin 1 is inactivated due to oxidation induced by peroxiredoxin under oxidative stress and reactivated by the glutaredoxin system","volume":"288","author":"Du","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cub.2026.09.062_bib86","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1089\/ars.2010.3203","article-title":"Effects of oxidative stress on behavior, physiology, and the redox thiol proteome of Caenorhabditis elegans","volume":"14","author":"Kumsta","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.cub.2026.09.062_bib87","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1016\/j.cell.2021.06.023","article-title":"Molecular topography of an entire nervous system","volume":"184","author":"Taylor","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.cub.2026.09.062_bib88","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/nn.2155","article-title":"Light-sensitive neurons and channels mediate phototaxis in C. elegans","volume":"11","author":"Ward","year":"2008","journal-title":"Nat. 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Neurosci."},{"key":"10.1016\/j.cub.2026.09.062_bib92","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1523\/JNEUROSCI.19-01-00159.1999","article-title":"EAT-4, a homolog of a mammalian sodium-dependent inorganic phosphate cotransporter, is necessary for glutamatergic neurotransmission in caenorhabditis elegans","volume":"19","author":"Lee","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cub.2026.09.062_bib93","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/35000609","article-title":"Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant","volume":"403","author":"Sze","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.cub.2026.09.062_bib94","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.chom.2009.09.001","article-title":"Tissue-specific activities of an immune signaling module regulate physiological responses to pathogenic and nutritional bacteria in C. elegans","volume":"6","author":"Shivers","year":"2009","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cub.2026.09.062_bib95","doi-asserted-by":"crossref","first-page":"5819","DOI":"10.1242\/dev.126.24.5819","article-title":"Patterning of dopaminergic neurotransmitter identity among Caenorhabditis elegans ray sensory neurons by a TGFbeta family signaling pathway and a Hox gene","volume":"126","author":"Lints","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.062_bib96","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.neuron.2005.02.024","article-title":"Tyramine Functions independently of octopamine in the Caenorhabditis elegans nervous system","volume":"46","author":"Alkema","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2026.09.062_bib97","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/364334a0","article-title":"Genes required for GABA function in Caenorhabditis elegans","volume":"364","author":"McIntire","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.cub.2026.09.062_bib98","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/39908","article-title":"Identification and characterization of the vesicular GABA transporter","volume":"389","author":"McIntire","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.cub.2026.09.062_bib99","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1523\/JNEUROSCI.23-06-02122.2003","article-title":"The EGL-21 carboxypeptidase E facilitates acetylcholine release at Caenorhabditis elegans neuromuscular junctions","volume":"23","author":"Jacob","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cub.2026.09.062_bib100","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1471-4159.2007.04474.x","article-title":"Impaired processing of FLP and NLP peptides in carboxypeptidase E (EGL-21)-deficient Caenorhabditis elegans as analyzed by mass spectrometry","volume":"102","author":"Husson","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.cub.2026.09.062_bib101","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.neuron.2019.01.053","article-title":"Parallel Multimodal Circuits Control an Innate Foraging Behavior","volume":"102","author":"L\u00f3pez-Cruz","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2026.09.062_bib102","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nmeth.4109","article-title":"cGAL, a temperature-robust GAL4-UAS system for Caenorhabditis elegans","volume":"14","author":"Wang","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cub.2026.09.062_bib103","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1098\/rstb.1976.0085","article-title":"The pharynx of Caenorhabditis elegans","volume":"275","author":"Albertson","year":"1976","journal-title":"Philos. Trans. R. Soc. Lond., B Biol. Sci."},{"key":"10.1016\/j.cub.2026.09.062_bib104","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nature06292","article-title":"Dissecting a circuit for olfactory behaviour in Caenorhabditis elegans","volume":"450","author":"Chalasani","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.cub.2026.09.062_bib105","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.50566","article-title":"Reliability of an interneuron response depends on an integrated sensory state","volume":"8","author":"Dobosiewicz","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.cub.2026.09.062_bib106","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1523\/JNEUROSCI.4691-10.2011","article-title":"Behavioral choice between conflicting alternatives is regulated by a receptor guanylyl cyclase, GCY-28, and a receptor tyrosine kinase, SCD-2, in AIA interneurons of Caenorhabditis elegans","volume":"31","author":"Shinkai","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cub.2026.09.062_bib107","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/nn.2526","article-title":"Neuropeptide feedback modifies odor-evoked dynamics in Caenorhabditis elegans olfactory neurons","volume":"13","author":"Chalasani","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cub.2026.09.062_bib108","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature11081","article-title":"Compartmentalized calcium dynamics in a C. elegans interneuron encode head movement","volume":"487","author":"Hendricks","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.cub.2026.09.062_bib109","doi-asserted-by":"crossref","first-page":"E4266","DOI":"10.1073\/pnas.1318325110","article-title":"High-throughput imaging of neuronal activity in Caenorhabditis elegans","volume":"110","author":"Larsch","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2026.09.062_bib110","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1534\/genetics.107.072587","article-title":"Oxidative stress enzymes are required for DAF-16-mediated immunity due to generation of reactive oxygen species by Caenorhabditis elegans","volume":"176","author":"Ch\u00e1vez","year":"2007","journal-title":"Genetics"},{"key":"10.1016\/j.cub.2026.09.062_bib111","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1534\/genetics.116.195172","article-title":"H2O2-Sensitive Isoforms of Drosophila melanogaster TRPA1 Act in Bitter-Sensing Gustatory Neurons to Promote Avoidance of UV During Egg-Laying","volume":"205","author":"Guntur","year":"2017","journal-title":"Genetics"},{"key":"10.1016\/j.cub.2026.09.062_bib112","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-09581-4","article-title":"Glutamate spillover in C. elegans triggers repetitive behavior through presynaptic activation of MGL-2\/mGluR5","volume":"10","author":"Katz","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2026.09.062_bib113","article-title":"The role of glutamate transporters in the pathophysiology of neuropsychiatric disorders","volume":"3","author":"O'Donovan","year":"2017","journal-title":"NPJ Schizophr."},{"key":"10.1016\/j.cub.2026.09.062_bib114","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.neuron.2012.08.039","article-title":"Proprioceptive coupling within motor neurons drives C. elegans forward locomotion","volume":"76","author":"Wen","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2026.09.062_bib115","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-40286-x","article-title":"Locomotion modulates olfactory learning through proprioception in C. elegans","volume":"14","author":"Zhan","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2026.09.062_bib116","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.115224","article-title":"Redox proteomics reveal a role for peroxiredoxinylation in stress protection","volume":"44","author":"Seisenbacher","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.cub.2026.09.062_bib117","article-title":"The Human 2-Cys Peroxiredoxins form Widespread, Cysteine-Dependent- and Isoform-Specific Protein-Protein Interactions","volume":"10","author":"van Dam","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.cub.2026.09.062_bib118","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ade1249","article-title":"Functional imaging and quantification of multineuronal olfactory responses in C. elegans","volume":"9","author":"Lin","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cub.2026.09.062_bib119","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.neuron.2009.02.013","article-title":"Neurons detect increases and decreases in oxygen levels using distinct guanylate cyclases","volume":"61","author":"Zimmer","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2026.09.062_bib120","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.redox.2016.12.035","article-title":"Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress","volume":"11","author":"Sies","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.cub.2026.09.062_bib121","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1089\/ars.2010.3624","article-title":"Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins","volume":"15","author":"Hall","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.cub.2026.09.062_bib122","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/B978-0-12-405881-1.00001-X","article-title":"The biological chemistry of hydrogen peroxide","volume":"528","author":"Winterbourn","year":"2013","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.cub.2026.09.062_bib123","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S0022-2143(97)90081-0","article-title":"Dimethylthiourea protects rats against gram-negative sepsis and decreases tumor necrosis factor and nuclear factor kappaB activity","volume":"129","author":"Sprong","year":"1997","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.cub.2026.09.062_bib124","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.coph.2007.12.012","article-title":"Hydrogen peroxide as an endogenous mediator and exogenous tool in cardiovascular research: issues and considerations","volume":"8","author":"Schr\u00f6der","year":"2008","journal-title":"Curr. Opin. 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