{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:41:35Z","timestamp":1792788095475,"version":"4.5.0"},"reference-count":119,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R00HD091386"],"award-info":[{"award-number":["R00HD091386"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD104784"],"award-info":[{"award-number":["R01HD104784"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.cub.2026.09.072","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:48:49Z","timestamp":1792680529000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dorsal forerunner cells couple epiboly movements to zebrafish notochord extension"],"prefix":"10.1016","author":[{"given":"Christopher","family":"Small","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9704-6301","authenticated-orcid":false,"given":"Margot Kossmann","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cub.2026.09.072_bib1","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1242\/dev.128.13.2581","article-title":"Xenopus Dishevelled signaling regulates both neural and mesodermal convergent extension: parallel forces elongating the body axis","volume":"128","author":"Wallingford","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib2","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1126\/science.1079478","article-title":"Shaping the vertebrate body plan by polarized embryonic cell movements","volume":"298","author":"Keller","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.cub.2026.09.072_bib3","doi-asserted-by":"crossref","first-page":"5815","DOI":"10.1242\/dev.00123","article-title":"Neural tube closure requires Dishevelled-dependent convergent extension of the midline","volume":"129","author":"Wallingford","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib4","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1242\/dev.000380","article-title":"Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure","volume":"134","author":"Ybot-Gonzalez","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib5","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0962-8924(03)00173-9","article-title":"Cell polarity pathways converge and extend to regulate neural tube closure","volume":"13","author":"Zohn","year":"2003","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.cub.2026.09.072_bib6","doi-asserted-by":"crossref","first-page":"4547","DOI":"10.1242\/dev.126.20.4547","article-title":"Neural tube closure in Xenopus laevis involves medial migration, directed protrusive activity, cell intercalation and convergent extension","volume":"126","author":"Davidson","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib7","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1098\/rstb.2000.0626","article-title":"Mechanisms of convergence and extension by cell intercalation","volume":"355","author":"Keller","year":"2000","journal-title":"Philos. Trans. R. Soc. Lond., B Biol. Sci."},{"key":"10.1016\/j.cub.2026.09.072_bib8","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.devcel.2011.06.011","article-title":"Planar cell polarity: coordinating morphogenetic cell behaviors with embryonic polarity","volume":"21","author":"Gray","year":"2011","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2026.09.072_bib9","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/ncb828","article-title":"Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements","volume":"4","author":"Jessen","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cub.2026.09.072_bib10","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/35011077","article-title":"Dishevelled controls cell polarity during Xenopus gastrulation","volume":"405","author":"Wallingford","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.cub.2026.09.072_bib11","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/nature06211","article-title":"The amniote primitive streak is defined by epithelial cell intercalation before gastrulation","volume":"449","author":"Voiculescu","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.cub.2026.09.072_bib12","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1242\/dev.030601","article-title":"PTK7 is essential for polarized cell motility and convergent extension during mouse gastrulation","volume":"136","author":"Yen","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib13","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/ncb1894","article-title":"Cell shape changes indicate a role for extrinsic tensile forces in Drosophila germ-band extension","volume":"11","author":"Butler","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cub.2026.09.072_bib14","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00418-020-01887-5","article-title":"Pcdh18a regulates endocytosis of E-cadherin during axial mesoderm development in zebrafish","volume":"154","author":"Bosze","year":"2020","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.cub.2026.09.072_bib15","doi-asserted-by":"crossref","first-page":"5375","DOI":"10.1242\/dev.00758","article-title":"Slb\/Wnt11 controls hypoblast cell migration and morphogenesis at the onset of zebrafish gastrulation","volume":"130","author":"Ulrich","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib16","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1242\/dev.100.1.147","article-title":"Experimental analysis of the extension of the dorsal marginal zone in Pleurodeles waltl gastrulae","volume":"100","author":"Shi","year":"1987","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib17","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.ydbio.2013.07.023","article-title":"Directional migration of leading-edge mesoderm generates physical forces: Implication in Xenopus notochord formation during gastrulation","volume":"382","author":"Hara","year":"2013","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cub.2026.09.072_bib18","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1242\/dev.116.4.915","article-title":"Patterns of cell motility in the organizer and dorsal mesoderm of Xenopus laevis","volume":"116","author":"Shih","year":"1992","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib19","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.devcel.2013.09.004","article-title":"A molecular base for cell sorting at embryonic boundaries: contact inhibition of cadherin adhesion by ephrin \/ Eph-dependent contractility","volume":"27","author":"Fagotto","year":"2013","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2026.09.072_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001600","article-title":"Coordination of cell polarity during Xenopus gastrulation","volume":"3","author":"Shindo","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.cub.2026.09.072_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-03715-w","article-title":"Gon4l regulates notochord boundary formation and cell polarity underlying axis extension by repressing adhesion genes","volume":"9","author":"Williams","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2026.09.072_bib22","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1242\/dev.010892","article-title":"Chongmague reveals an essential role for laminin-mediated boundary formation in chordate convergence and extension movements","volume":"135","author":"Veeman","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib23","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1242\/dev.00202","article-title":"Localized JAK\/STAT signaling is required for oriented cell rearrangement in a tubular epithelium","volume":"130","author":"Johansen","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib24","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1242\/dev.039735","article-title":"Distinct Xenopus Nodal ligands sequentially induce mesendoderm and control gastrulation movements in parallel to the Wnt\/PCP pathway","volume":"137","author":"Luxardi","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib25","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/nature02620","article-title":"Antero-posterior tissue polarity links mesoderm convergent extension to axial patterning","volume":"430","author":"Ninomiya","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.cub.2026.09.072_bib26","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.54445","article-title":"Nodal and Planar Cell Polarity signaling cooperate to regulate zebrafish convergence and extension gastrulation movements","volume":"9","author":"Williams","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.cub.2026.09.072_bib27","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1242\/dev.101.2.339","article-title":"Gastrulation movements provide an early marker of mesoderm induction in Xenopus laevis","volume":"101","author":"Symes","year":"1987","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib28","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1242\/dev.120.7.1919","article-title":"A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse","volume":"120","author":"Conlon","year":"1994","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib29","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/26013","article-title":"Zebrafish organizer development and germ-layer formation require nodal-related signals","volume":"395","author":"Feldman","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.cub.2026.09.072_bib30","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0092-8674(00)80720-5","article-title":"The EGF-CFC protein one-eyed pinhead is essential for nodal signaling","volume":"97","author":"Gritsman","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.cub.2026.09.072_bib31","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/371487a0","article-title":"Activin signalling and response to a morphogen gradient","volume":"371","author":"Gurdon","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.cub.2026.09.072_bib32","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1083\/jcb.201203012","article-title":"Nodal signaling regulates endodermal cell motility and actin dynamics via Rac1 and Prex1","volume":"198","author":"Woo","year":"2012","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cub.2026.09.072_bib33","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.259972","article-title":"A network of transcription factors governs the dynamics of NODAL\/Activin transcriptional responses","volume":"135","author":"Coda","year":"2022","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.cub.2026.09.072_bib34","doi-asserted-by":"crossref","DOI":"10.1242\/dev.202931","article-title":"Temporal dynamics of BMP\/Nodal ratio drive tissue-specific gastrulation morphogenesis","volume":"152","author":"Emig","year":"2025","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib35","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.cub.2006.03.058","article-title":"oko meduzy and related crumbs genes are determinants of apical cell features in the vertebrate embryo","volume":"16","author":"Omori","year":"2006","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2026.09.072_bib36","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1534\/genetics.117.300260","article-title":"Apico-basal Polarity Determinants Encoded by Crumbs Genes Affect Ciliary Shaft Protein Composition, IFT Movement Dynamics, and Cilia Length","volume":"207","author":"Hazime","year":"2017","journal-title":"Genetics"},{"key":"10.1016\/j.cub.2026.09.072_bib37","doi-asserted-by":"crossref","DOI":"10.1242\/dev.171207","article-title":"The transmembrane protein Crb2a regulates cardiomyocyte apicobasal polarity and adhesion in zebrafish","volume":"146","author":"Jim\u00e9nez-Amilburu","year":"2019","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib38","doi-asserted-by":"crossref","DOI":"10.1242\/dev.175497","article-title":"Cdc42 defines apical identity and regulates epithelial morphogenesis by promoting apical recruitment of Par6-aPKC and Crumbs","volume":"146","author":"Nunes de Almeida","year":"2019","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib39","doi-asserted-by":"crossref","first-page":"R289","DOI":"10.1016\/j.cub.2013.03.001","article-title":"Complexities of Crumbs function and regulation in tissue morphogenesis","volume":"23","author":"Pocha","year":"2013","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2026.09.072_bib40","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.semcdb.2017.10.018","article-title":"Role of the Crumbs proteins in ciliogenesis, cell migration and actin organization","volume":"81","author":"Bazelli\u00e8res","year":"2018","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.cub.2026.09.072_bib41","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1021\/acs.biochem.5b01342","article-title":"Binding of Crumbs to the Par-6 CRIB-PDZ Module Is Regulated by Cdc42","volume":"55","author":"Whitney","year":"2016","journal-title":"Biochemistry"},{"key":"10.1016\/j.cub.2026.09.072_bib42","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202108076","article-title":"Crumbs complex-directed apical membrane dynamics in epithelial cell ingression","volume":"221","author":"Sim\u00f5es","year":"2022","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cub.2026.09.072_bib43","doi-asserted-by":"crossref","first-page":"10532","DOI":"10.1073\/pnas.1004279107","article-title":"The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded","volume":"107","author":"Ling","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2026.09.072_bib44","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.261691","article-title":"The polarity protein Yurt associates with the plasma membrane via basic and hydrophobic motifs embedded in its FERM domain","volume":"137","author":"Gamblin","year":"2024","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.cub.2026.09.072_bib45","doi-asserted-by":"crossref","first-page":"15810","DOI":"10.1073\/pnas.1004060107","article-title":"The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila","volume":"107","author":"Chen","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2026.09.072_bib46","doi-asserted-by":"crossref","first-page":"E1980","DOI":"10.1073\/pnas.1315508111","article-title":"Crumbs promotes expanded recognition and degradation by the SCF(Slimb\/\u03b2-TrCP) ubiquitin ligase","volume":"111","author":"Ribeiro","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2026.09.072_bib47","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.devcel.2019.12.003","article-title":"Rho-Kinase Planar Polarization at Tissue Boundaries Depends on Phospho-regulation of Membrane Residence Time","volume":"52","author":"Sidor","year":"2020","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2026.09.072_bib48","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.devcel.2012.09.013","article-title":"Anisotropy of Crumbs and aPKC drives myosin cable assembly during tube formation","volume":"23","author":"R\u00f6per","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2026.09.072_bib49","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1038\/ncb3442","article-title":"Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation","volume":"18","author":"Ramkumar","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cub.2026.09.072_bib50","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nature02590","article-title":"Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation","volume":"429","author":"Bertet","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.cub.2026.09.072_bib51","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.semcdb.2008.01.005","article-title":"Multicellular dynamics during epithelial elongation","volume":"19","author":"Zallen","year":"2008","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.cub.2026.09.072_bib52","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1242\/dev.123.1.263","article-title":"Mutations affecting development of the zebrafish retina","volume":"123","author":"Malicki","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib53","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1242\/dev.126.6.1235","article-title":"oko meduzy mutations affect neuronal patterning in the zebrafish retina and reveal cell-cell interactions of the retinal neuroepithelial sheet","volume":"126","author":"Malicki","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib54","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1242\/dev.123.1.165","article-title":"Mutations affecting the development of the embryonic zebrafish brain","volume":"123","author":"Schier","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib55","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.66483","article-title":"Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism","volume":"10","author":"Pulgar","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.cub.2026.09.072_bib56","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1006\/dbio.1996.0294","article-title":"A cluster of noninvoluting endocytic cells at the margin of the zebrafish blastoderm marks the site of embryonic shield formation","volume":"180","author":"Cooper","year":"1996","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cub.2026.09.072_bib57","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1242\/dev.022228","article-title":"Origin and shaping of the laterality organ in zebrafish","volume":"135","author":"Ote\u00edza","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib58","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1242\/dev.122.7.2225","article-title":"Specification of cell fates at the dorsal margin of the zebrafish gastrula","volume":"122","author":"Melby","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib59","first-page":"2025","article-title":"Maximizing mutagenesis with solubilized CRISPR-Cas9 ribonucleoprotein complexes","volume":"143","author":"Burger","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib60","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1242\/dev.123.1.67","article-title":"Mutations affecting cell fates and cellular rearrangements during gastrulation in zebrafish","volume":"123","author":"Solnica-Krezel","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib61","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0960-9822(00)80016-0","article-title":"A molecular pathway leading to endoderm formation in zebrafish","volume":"9","author":"Alexander","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2026.09.072_bib62","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1002\/dvdy.24657","article-title":"Wilson cell origin for kupffer's vesicle in the zebrafish","volume":"247","author":"Warga","year":"2018","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.cub.2026.09.072_bib63","doi-asserted-by":"crossref","first-page":"9881","DOI":"10.1073\/pnas.1017248108","article-title":"Canopy1, a positive feedback regulator of FGF signaling, controls progenitor cell clustering during Kupffer's vesicle organogenesis","volume":"108","author":"Matsui","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2026.09.072_bib64","first-page":"2603","article-title":"Eph\/ephrin signaling maintains the boundary of dorsal forerunner cell cluster during morphogenesis of the zebrafish embryonic left-right organizer","volume":"143","author":"Zhang","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib65","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ydbio.2012.07.019","article-title":"Regional cell shape changes control form and function of Kupffer's vesicle in the zebrafish embryo","volume":"370","author":"Wang","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cub.2026.09.072_bib66","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.cub.2010.01.055","article-title":"Lgl, aPKC, and Crumbs regulate the Salvador\/Warts\/Hippo pathway through two distinct mechanisms","volume":"20","author":"Grzeschik","year":"2010","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2026.09.072_bib67","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.devcel.2008.02.012","article-title":"Intra-endodermal interactions are required for pancreatic beta cell induction","volume":"14","author":"Chung","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2026.09.072_bib68","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.952844","article-title":"Mild cold stress specifically disturbs clustering movement of DFCs and sequential organ left-right patterning in zebrafish","volume":"10","author":"Liu","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cub.2026.09.072_bib69","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1242\/dev.045310","article-title":"Integrin alphaV is necessary for gastrulation movements that regulate vertebrate body asymmetry","volume":"137","author":"Ablooglu","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib70","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1429782","article-title":"Cdon is essential for organ left-right patterning by regulating dorsal forerunner cells clustering and Kupffer's vesicle morphogenesis","volume":"12","author":"Deng","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cub.2026.09.072_bib71","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1006\/dbio.1999.9441","article-title":"casanova plays an early and essential role in endoderm formation in zebrafish","volume":"215","author":"Alexander","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cub.2026.09.072_bib72","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1242\/dev.049981","article-title":"Planar cell polarity signalling regulates cell adhesion properties in progenitors of the zebrafish laterality organ","volume":"137","author":"Oteiza","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib73","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.devcel.2014.11.003","article-title":"The notochord breaks bilateral symmetry by controlling cell shapes in the zebrafish laterality organ","volume":"31","author":"Compagnon","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2026.09.072_bib74","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1038\/s41592-022-01663-4","article-title":"Cellpose 2.0: how to train your own model","volume":"19","author":"Pachitariu","year":"2022","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cub.2026.09.072_bib75","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cub.2026.09.072_bib76","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1242\/dev.125.6.983","article-title":"Oriented cell divisions and cellular morphogenesis in the zebrafish gastrula and neurula: a time-lapse analysis","volume":"125","author":"Concha","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib77","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/dvdy.20507","article-title":"Initiation of convergence and extension movements of lateral mesoderm during zebrafish gastrulation","volume":"234","author":"Sepich","year":"2005","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.cub.2026.09.072_bib78","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1126\/science.1248252","article-title":"Construction of a vertebrate embryo from two opposing morphogen gradients","volume":"344","author":"Xu","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.cub.2026.09.072_bib79","doi-asserted-by":"crossref","DOI":"10.3791\/62797","article-title":"Generation of Na\u00efve Blastoderm Explants from Zebrafish Embryos","author":"Alaniz Emig","year":"2021","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.cub.2026.09.072_bib80","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.devcel.2018.08.003","article-title":"Coming to Consensus: A Unifying Model Emerges for Convergent Extension","volume":"46","author":"Huebner","year":"2018","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2026.09.072_bib81","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/aja.1001950303","article-title":"Xenopus Gastrulation without a blastocoel roof","volume":"195","author":"Keller","year":"1992","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.cub.2026.09.072_bib82","first-page":"185","article-title":"The function and mechanism of convergent extension during gastrulation of Xenopus laevis","volume":"89","author":"Keller","year":"1985","journal-title":"J. Embryol. Exp. Morphol."},{"key":"10.1016\/j.cub.2026.09.072_bib83","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/0012-1606(91)90275-8","article-title":"Directional mesoderm cell migration in the Xenopus gastrula","volume":"148","author":"Winklbauer","year":"1991","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cub.2026.09.072_bib84","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.devcel.2011.10.013","article-title":"A mechanoresponsive cadherin-keratin complex directs polarized protrusive behavior and collective cell migration","volume":"22","author":"Weber","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2026.09.072_bib85","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/j.devcel.2022.05.001","article-title":"Guidance by followers ensures long-range coordination of cell migration through \u03b1-catenin mechanoperception","volume":"57","author":"Boutillon","year":"2022","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2026.09.072_bib86","doi-asserted-by":"crossref","first-page":"16945","DOI":"10.1073\/pnas.1205870109","article-title":"Collective mesendoderm migration relies on an intrinsic directionality signal transmitted through cell contacts","volume":"109","author":"Dumortier","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2026.09.072_bib87","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/aja.1001950407","article-title":"Cell interaction and its role in mesoderm cell migration during Xenopus gastrulation","volume":"195","author":"Winklbauer","year":"1992","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.cub.2026.09.072_bib88","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41556-018-0247-4","article-title":"Fluidization-mediated tissue spreading by mitotic cell rounding and non-canonical Wnt signalling","volume":"21","author":"Petridou","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cub.2026.09.072_bib89","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1016\/j.cell.2021.02.017","article-title":"Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions","volume":"184","author":"Petridou","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.cub.2026.09.072_bib90","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/dvdy.24353","article-title":"Zebrafish epiboly: Spreading thin over the yolk","volume":"245","author":"Bruce","year":"2016","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.cub.2026.09.072_bib91","doi-asserted-by":"crossref","first-page":"25","DOI":"10.15252\/embj.201694264","article-title":"Polarized cortical tension drives zebrafish epiboly movements","volume":"36","author":"Hern\u00e1ndez-Vega","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.cub.2026.09.072_bib92","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/jez.1401180204","article-title":"A STUDY OF THE MECHANISM OF EPIBOLY IN THE EGG OF FUNDULUS HETEROCLITUS","volume":"118","author":"Trinkaus","year":"1951","journal-title":"J. Exp. Zool."},{"key":"10.1016\/j.cub.2026.09.072_bib93","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1242\/dev.123.1.47","article-title":"The zebrafish epiboly mutants","volume":"123","author":"Kane","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib94","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000563","article-title":"The epithelial cell adhesion molecule EpCAM is required for epithelial morphogenesis and integrity during zebrafish epiboly and skin development","volume":"5","author":"Slanchev","year":"2009","journal-title":"PLoS Genet"},{"key":"10.1016\/j.cub.2026.09.072_bib95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cub.2024.10.070","article-title":"Planar polarized force propagation integrates cell behavior with tissue shaping during convergent extension","volume":"35","author":"Weng","year":"2025","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2026.09.072_bib96","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.devcel.2012.03.007","article-title":"Crb apical polarity proteins maintain zebrafish retinal cone mosaics via intercellular binding of their extracellular domains","volume":"22","author":"Zou","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cub.2026.09.072_bib97","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nrm3568","article-title":"Sticking together the Crumbs - an unexpected function for an old friend","volume":"14","author":"Thompson","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cub.2026.09.072_bib98","doi-asserted-by":"crossref","first-page":"E4621","DOI":"10.1073\/pnas.1617004114","article-title":"The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier","volume":"114","author":"Schell","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2026.09.072_bib99","article-title":"A binding protein regulates myosin-7a dimerization and actin bundle assembly","volume":"12","author":"Liu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cub.2026.09.072_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108606","article-title":"Variability of an Early Developmental Cell Population Underlies Stochastic Laterality Defects","volume":"34","author":"Moreno-Ayala","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.cub.2026.09.072_bib101","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1534\/genetics.118.301692","article-title":"Probing Cadherin Interactions in Zebrafish with E- and N-Cadherin Missense Mutants","volume":"210","author":"Warga","year":"2018","journal-title":"Genetics"},{"key":"10.1016\/j.cub.2026.09.072_bib102","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1242\/dev.083709","article-title":"Fgf signaling governs cell fate in the zebrafish pineal complex","volume":"140","author":"Clanton","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib103","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1387\/ijdb.092969ls","article-title":"Characterization of an lhx1a transgenic reporter in zebrafish","volume":"54","author":"Swanhart","year":"2010","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.cub.2026.09.072_bib104","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0925-4773(01)00453-1","article-title":"A novel sox gene, 226D7, acts downstream of Nodal signaling to specify endoderm precursors in zebrafish","volume":"107","author":"Sakaguchi","year":"2001","journal-title":"Mech. Dev."},{"key":"10.1016\/j.cub.2026.09.072_bib105","doi-asserted-by":"crossref","DOI":"10.1093\/genetics\/iyab196","article-title":"Orthogonal CRISPR-Cas tools for genome editing, inhibition, and CRISPR recording in zebrafish embryos","volume":"220","author":"Takasugi","year":"2022","journal-title":"Genetics"},{"key":"10.1016\/j.cub.2026.09.072_bib106","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nmeth.4074","article-title":"mScarlet: a bright monomeric red fluorescent protein for cellular imaging","volume":"14","author":"Bindels","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cub.2026.09.072_bib107","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/nmeth.3543","article-title":"CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo","volume":"12","author":"Moreno-Mateos","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cub.2026.09.072_bib108","doi-asserted-by":"crossref","first-page":"W171","DOI":"10.1093\/nar\/gkz365","article-title":"CHOPCHOP v3: expanding the CRISPR web toolbox beyond genome editing","volume":"47","author":"Labun","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cub.2026.09.072_bib109","doi-asserted-by":"crossref","DOI":"10.3389\/fbinf.2022.818619","article-title":"ApE, A Plasmid Editor: A Freely Available DNA Manipulation and Visualization Program","volume":"2","author":"Davis","year":"2022","journal-title":"Front. Bioinform."},{"key":"10.1016\/j.cub.2026.09.072_bib110","first-page":"31","article-title":"The 'MTB Cell Counter' a versatile tool for the semi-automated quantification of sub-cellular phenotypes in fluorescence microscopy images. A case study on plastids, nuclei and peroxisomes","volume":"26","author":"Franke","year":"2015","journal-title":"Endocytobiosis Cell Res."},{"key":"10.1016\/j.cub.2026.09.072_bib111","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.712503","article-title":"Tools to Image Germplasm Dynamics During Early Zebrafish Development","volume":"9","author":"Zaucker","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cub.2026.09.072_bib112","series-title":"The Zebrafish Book; A Guide for the Laboratory Use of Zebrafish (Brachydanio rerio)","author":"Westerfield","year":"1993"},{"key":"10.1016\/j.cub.2026.09.072_bib113","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.cub.2026.09.072_bib114","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.1242\/dev.122.12.3735","article-title":"An activated form of type I serine\/threonine kinase receptor TARAM-A reveals a specific signalling pathway involved in fish head organiser formation","volume":"122","author":"Renucci","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.cub.2026.09.072_bib115","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.celrep.2013.06.020","article-title":"Highly efficient targeted mutagenesis of Drosophila with the CRISPR\/Cas9 system","volume":"4","author":"Bassett","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.cub.2026.09.072_bib116","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098186","article-title":"Efficient mutagenesis by Cas9 protein-mediated oligonucleotide insertion and large-scale assessment of single-guide RNAs","volume":"9","author":"Gagnon","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cub.2026.09.072_bib117","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.cub.2004.04.002","article-title":"The T box transcription factor no tail in ciliated cells controls zebrafish left-right asymmetry","volume":"14","author":"Amack","year":"2004","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2026.09.072_bib118","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nprot.2007.514","article-title":"High-resolution in situ hybridization to whole-mount zebrafish embryos","volume":"3","author":"Thisse","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cub.2026.09.072_bib119","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ydbio.2025.08.021","article-title":"Rbm8a deficiency causes hematopoietic defects by modulating Wnt\/PCP signaling","volume":"528","author":"Kocere","year":"2025","journal-title":"Dev. Biol."}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982226012819?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982226012819?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:25:05Z","timestamp":1792787105000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982226012819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":119,"alternative-id":["S0960982226012819"],"URL":"https:\/\/doi.org\/10.1016\/j.cub.2026.09.072","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dorsal forerunner cells couple epiboly movements to zebrafish notochord extension","name":"articletitle","label":"Article Title"},{"value":"Current Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cub.2026.09.072","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}