{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:19:18Z","timestamp":1760782758203},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,21]],"date-time":"2013-07-21T00:00:00Z","timestamp":1374364800000},"content-version":"vor","delay-in-days":3064,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Therapeutic Research"],"published-print":{"date-parts":[[2005,3]]},"DOI":"10.1016\/j.curtheres.2005.04.002","type":"journal-article","created":{"date-parts":[[2005,6,5]],"date-time":"2005-06-05T11:14:55Z","timestamp":1117970095000},"page":"117-129","source":"Crossref","is-referenced-by-count":11,"title":["Treatment-limiting toxicities associated withnucleoside analogue reverse transcriptase inhibitor therapy: A prospective, observational study"],"prefix":"10.1016","volume":"66","author":[{"given":"Rosario","family":"Palacios","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Camino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piedad","family":"Arazo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Torres Perea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Echevarrfa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esteban","family":"Ribera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainel","family":"S\u00e1nchez de la Rosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Moreno Guillen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.curtheres.2005.04.002_bib1_1","first-page":"176","article-title":"Long-term complications of nucleoside reverse transcriptase inhibitor therapy","volume":"13","author":"Dieterich","year":"2003","journal-title":"AIDS Read"},{"key":"10.1016\/j.curtheres.2005.04.002_bib1_2","first-page":"187","article-title":"Long-term complications of nucleoside reverse transcriptase inhibitor therapy","volume":"13","author":"Dieterich","year":"2003","journal-title":"AIDS Read"},{"key":"10.1016\/j.curtheres.2005.04.002_bib2","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1056\/NEJM199803263381301","article-title":"Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection","volume":"338","author":"Palella","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.curtheres.2005.04.002_bib3","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/S0140-6736(00)02854-3","article-title":"Adverse effects of antiretroviral therapy","volume":"356","author":"Carr","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.curtheres.2005.04.002_bib4","doi-asserted-by":"crossref","first-page":"F51","DOI":"10.1097\/00002030-199807000-00003","article-title":"A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors","volume":"12","author":"Carr","year":"1998","journal-title":"AIDS"},{"key":"10.1016\/j.curtheres.2005.04.002_bib5","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1097\/00002030-199912240-00002","article-title":"Fat distribution and metabolic changes in patients with HIV infection","volume":"13","author":"Safrin","year":"1999","journal-title":"AIDS"},{"issue":"Suppl 3","key":"10.1016\/j.curtheres.2005.04.002_bib6","doi-asserted-by":"crossref","first-page":"S140","DOI":"10.1097\/00126334-200212153-00011","article-title":"Relationship between HAART adherence and adipose tissue alterations","volume":"31","author":"Ammassari","year":"2002","journal-title":"J Acquir Inmune Defic Syndr"},{"key":"10.1016\/j.curtheres.2005.04.002_bib7","doi-asserted-by":"crossref","first-page":"F37","DOI":"10.1097\/00002030-199806000-00001","article-title":"Indinavir-associated lipodystrophy","volume":"12","author":"Viraben","year":"1998","journal-title":"AIDS"},{"key":"10.1016\/j.curtheres.2005.04.002_bib8","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/S0140-6736(98)03391-1","article-title":"Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance","volume":"351","author":"Carr","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.curtheres.2005.04.002_bib9","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1097\/00002030-199909100-00009","article-title":"A syndrome of peripheral fat wasting (lipodystrophy) in patients receiving long-term nucleoside analogue therapy","volume":"13","author":"Saint-Marc","year":"1999","journal-title":"AIDS"},{"key":"10.1016\/j.curtheres.2005.04.002_bib10","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1097\/00002030-200007070-00002","article-title":"Contribution of nucleoside analogue reverse transcriptase inhibitors to subcutaneous fat wasting in patients with HIV infection","volume":"14","author":"Mallal","year":"2000","journal-title":"AIDS"},{"key":"10.1016\/j.curtheres.2005.04.002_bib11","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/S0140-6736(99)06102-4","article-title":"Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis ofantiretroviral-therapy-related lipodystrophy","volume":"354","author":"Brinkman","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.curtheres.2005.04.002_bib12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1086\/313921","article-title":"Editorial response: Hyperlactatemia and hepatic steatosis as features of mitochondrial toxicity of nucleoside analogue reverse transcriptase inhibitors","volume":"31","author":"Brinkman","year":"2000","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.curtheres.2005.04.002_bib13","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1097\/00002030-200211080-00009","article-title":"Increased long-term mitochondrial toxicity in combinations of nucleoside analogue reverse-transcriptase inhibitors","volume":"16","author":"Walker","year":"2002","journal-title":"AIDS"},{"key":"10.1016\/j.curtheres.2005.04.002_bib14","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1086\/343050","article-title":"Switching effective antiretroviral therapy: A review","volume":"35","author":"Drechsler","year":"2002","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.curtheres.2005.04.002_bib15","first-page":"RR","article-title":"Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults","volume":"18","author":"Castro","year":"1993","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.curtheres.2005.04.002_bib16","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1177\/135965350300800401","article-title":"Mitochondria and lipodystrophy: Where are we now?","volume":"8","author":"Gerschenson","year":"2003","journal-title":"Antivir Ther"},{"key":"10.1016\/j.curtheres.2005.04.002_bib17","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1001\/jama.288.2.207","article-title":"Abacavir substitution for nucleoside analogs in patients with HIV lipoatrophy: A randomized trial","volume":"288","author":"Carr","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.curtheres.2005.04.002_bib18","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1016\/S0140-6736(98)08468-2","article-title":"Diagnosis, prediction, and natural course of HIV-1 protease-inhibitor-associated lipodystrophy, hyperlipidaemia, and diabetes mellitus: A cohort study","volume":"353","author":"Carr","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.curtheres.2005.04.002_bib19","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0166-3542(03)00069-X","article-title":"Mitochondrial dysfunction and nucleoside reverse transcriptase inhibitor therapy: Experimental clarifications and persistent clinical questions","volume":"58","author":"Lewis","year":"2003","journal-title":"Antiviral Res"},{"key":"10.1016\/j.curtheres.2005.04.002_bib20","first-page":"89","article-title":"HIV-associated lipodystrophy, metabolic complications, and antiretroviral toxicities","volume":"3","author":"Moyle","year":"2002","journal-title":"HIV Clin Trials"},{"key":"10.1016\/j.curtheres.2005.04.002_bib21","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1056\/NEJMoa021589","article-title":"Substitution of nevirapine, efavirenz, or abacavir for protease inhibitors in patients with human immunodeficiency virus infection","volume":"349","author":"Martinez","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.curtheres.2005.04.002_bib22","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1097\/00002030-200404300-00011","article-title":"Reversibility of lipoatrophy in HIV-infected patients 2 years after switching from a thymidine analogue to abacavir: The MITOX Extension Study","volume":"18","author":"Martin","year":"2004","journal-title":"AIDS"},{"key":"10.1016\/j.curtheres.2005.04.002_bib23","series-title":"12th Conference on Retroviruses and Opportunistic Infections","article-title":"A 48-week, randomized, open-label comparative study of tenofovir DF vs. abacavir as substitutes for a thymidine analog in persons with lipoatrophy and sustained virological suppression on HAART","author":"Moyle","year":"2005"},{"key":"10.1016\/j.curtheres.2005.04.002_bib24","series-title":"12th Conference on Retroviruses and Opportunistic Infections","article-title":"Improvement of subcutaneous fat, lipid profile and parameters of mitochondrial toxicity in patients with peripheral lipoatrophy when stavudine isswitched to tenofovir: The Lipotest Study","author":"Ribera","year":"2005"},{"key":"10.1016\/j.curtheres.2005.04.002_bib25","series-title":"12th Conference on Retroviruses and Opportunistic Infections","article-title":"A randomized open study comparing the impact of reducing stavudine dose vs switching to tenofovir on mitochondrial function, metabolic parameters, and subcutaneous fat in HIV-infected patients receiving anti retroviral therapy containing stavudine","author":"Milinkovic","year":"2005"},{"key":"10.1016\/j.curtheres.2005.04.002_bib26","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1097\/01.aids.0000131343.53419.04","article-title":"Improvement of dyslipidemia in patients switching from stavudine to tenofovir: Preliminary results","volume":"18","author":"Domingo","year":"2004","journal-title":"AIDS"}],"container-title":["Current Therapeutic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0011393X05000408?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0011393X05000408?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T12:21:03Z","timestamp":1706271663000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0011393X05000408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["S0011393X05000408"],"URL":"https:\/\/doi.org\/10.1016\/j.curtheres.2005.04.002","relation":{},"ISSN":["0011-393X"],"issn-type":[{"value":"0011-393X","type":"print"}],"subject":[],"published":{"date-parts":[[2005,3]]}}}