{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T18:12:11Z","timestamp":1782497531488,"version":"3.54.5"},"reference-count":23,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinics of North America: Equine Practice"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.cveq.2024.04.003","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T20:33:40Z","timestamp":1716842020000},"page":"275-286","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Approach to Immune-mediated Ocular Diseases"],"prefix":"10.1016","volume":"40","author":[{"given":"Kelly E.","family":"Knickelbein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Lassaline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.cveq.2024.04.003_bib1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1463-5224.2005.00393.x","article-title":"Immune-mediated keratitis in horses: 19 cases (1998-2004)","volume":"8","author":"Gilger","year":"2005","journal-title":"Vet Ophthalmol"},{"issue":"Suppl 1","key":"10.1016\/j.cveq.2024.04.003_bib2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1463-5224.2009.00740.x","article-title":"Equine immune-mediated keratopathies","volume":"12","author":"Matthews","year":"2009","journal-title":"Vet Ophthalmol"},{"issue":"7","key":"10.1016\/j.cveq.2024.04.003_bib3","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.2460\/ajvr.73.7.1067","article-title":"Immunohistochemical and immunopathologic characterization of superficial stromal immune-mediated keratitis in horses","volume":"73","author":"Pate","year":"2012","journal-title":"Am J Vet Res"},{"issue":"1","key":"10.1016\/j.cveq.2024.04.003_bib4","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/vop.12677","article-title":"Laser scanning in\u00a0vivo confocal microscopic characterization of equine immune-mediated keratitis","volume":"23","author":"Ledbetter","year":"2020","journal-title":"Vet Ophthalmol"},{"issue":"1","key":"10.1016\/j.cveq.2024.04.003_bib5","first-page":"75","article-title":"Detection of an antigenic protein of Leptospira interrogans which shares epitopes with the equine cornea and lens","volume":"153","author":"Parma","year":"1997","journal-title":"Vet J Lond Engl"},{"key":"10.1016\/j.cveq.2024.04.003_bib6","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.vetimm.2017.04.002","article-title":"Investigation of corneal autoantibodies in horses with immune mediated keratitis (IMMK)","volume":"187","author":"Braus","year":"2017","journal-title":"Vet Immunol Immunopathol"},{"issue":"Suppl 1","key":"10.1016\/j.cveq.2024.04.003_bib7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/vop.12087","article-title":"Treatment of immune-mediated keratitis in horses with episcleral silicone matrix cyclosporine delivery devices","volume":"17","author":"Gilger","year":"2014","journal-title":"Vet Ophthalmol"},{"issue":"5","key":"10.1016\/j.cveq.2024.04.003_bib8","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/vop.12641","article-title":"Subconjunctival bone marrow-derived mesenchymal stem cell therapy as a novel treatment alternative for equine immune-mediated keratitis: A case series","volume":"22","author":"Davis","year":"2019","journal-title":"Vet Ophthalmol"},{"issue":"11","key":"10.1016\/j.cveq.2024.04.003_bib9","doi-asserted-by":"crossref","DOI":"10.1111\/eve.13601","article-title":"Primary bilateral corneal T\u00a0cell lymphoma in a horse","volume":"34","author":"Opgenorth","year":"2022","journal-title":"Equine Vet Educ"},{"issue":"2","key":"10.1016\/j.cveq.2024.04.003_bib10","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/vop.12275","article-title":"Suspected malignant transformation of B lymphocytes in the equine cornea from immune-mediated keratitis","volume":"19","author":"Vallone","year":"2016","journal-title":"Vet Ophthalmol"},{"key":"10.1016\/j.cveq.2024.04.003_bib11","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/evj.12451","article-title":"Prognosis and impact of equine recurrent uveitis","volume":"48","author":"Gerding","year":"2016","journal-title":"Eq Vet J"},{"key":"10.1016\/j.cveq.2024.04.003_bib12","first-page":"717","article-title":"Equine re-current uveitis in western Canadian prairie provinces: A retrospec-tive study (2002-2015)","volume":"58","author":"Sandmeyer","year":"2017","journal-title":"Canad Vet J"},{"issue":"2","key":"10.1016\/j.cveq.2024.04.003_bib13","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/vop.13002","article-title":"A\u00a0review of investigated risk factors for developing equine recurrent uveitis","volume":"26","author":"Kingsley","year":"2023","journal-title":"Vet Ophthalmol"},{"issue":"6","key":"10.1016\/j.cveq.2024.04.003_bib14","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/vop.12234","article-title":"Clinical, histopathological and immunohistochemical characterization of a novel equine ocular disorder: heterochromic iridocyclitis with secondary keratitis in adult horses","volume":"18","author":"Pinto","year":"2015","journal-title":"Vet Ophthalmol"},{"issue":"3","key":"10.1016\/j.cveq.2024.04.003_bib15","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1177\/1040638720912698","article-title":"A\u00a0retrospective histologic study of 140 cases of clinically significant equine ocular disorders","volume":"32","author":"Flores","year":"2020","journal-title":"J\u00a0of Vet Diag Inv"},{"key":"10.1016\/j.cveq.2024.04.003_bib16","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/j.1365-2885.2008.00986.x","article-title":"Ocular toxicity and distribution of subconjunctival and intravitreal rapamycin in horses","volume":"31","author":"Douglas","year":"2008","journal-title":"J\u00a0Vet Pharmacol Ther"},{"key":"10.1016\/j.cveq.2024.04.003_bib17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1463-5224.2008.00636.x","article-title":"Ocular Distribution and Toxicity of Intravitreal Injection of Triamcinolone Acetonide in Normal Equine Eyes","volume":"11","author":"Yi","year":"2008","journal-title":"Vet Ophthalmol"},{"issue":"3","key":"10.1016\/j.cveq.2024.04.003_bib18","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/vop.12887","article-title":"Efficacy and safety of suprachoroidal triamcinolone injection in horses with poorly responsive equine recurrent uveitis","volume":"24","author":"Gagnon","year":"2021","journal-title":"Vet Ophthalmol"},{"issue":"1","key":"10.1016\/j.cveq.2024.04.003_bib19","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12917-018-1722-7","article-title":"Intravitreal injection of low-dose gentamicin for the treatment of recurrent or persistent uveitis in horses: preliminary results","volume":"15","author":"Fischer","year":"2019","journal-title":"BMC Vet Res"},{"issue":"5","key":"10.1016\/j.cveq.2024.04.003_bib20","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1463-5224.2010.00807.x","article-title":"Long-term outcome after implantation of a suprachoroidal cyclosporine drug delivery device in horses with recurrent uveitis","volume":"13","author":"Gilger","year":"2010","journal-title":"Vet Ophthalmol"},{"key":"10.1016\/j.cveq.2024.04.003_bib21","article-title":"Use of biologics and stem cells in equine ophthalmology","volume":"11","author":"Gilger","year":"2023","journal-title":"Vet Clin Equine Pract"},{"issue":"1","key":"10.1016\/j.cveq.2024.04.003_bib22","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/vop.12704","article-title":"Horses with equine recurrent uveitis have an activated CD4+ T-cell phenotype that can be modulated by mesenchymal stem cells in\u00a0vitro","volume":"23","author":"Saldinger","year":"2020","journal-title":"Vet Ophthalmol"},{"key":"10.1016\/j.cveq.2024.04.003_bib23","series-title":"Equine Ophthalmology","first-page":"798","article-title":"Management of blind horses","author":"Dwyer","year":"2022"}],"container-title":["Veterinary Clinics of North America: Equine Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749073924000294?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749073924000294?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T03:12:10Z","timestamp":1722654730000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0749073924000294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S0749073924000294"],"URL":"https:\/\/doi.org\/10.1016\/j.cveq.2024.04.003","relation":{},"ISSN":["0749-0739"],"issn-type":[{"value":"0749-0739","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Approach to Immune-mediated Ocular Diseases","name":"articletitle","label":"Article Title"},{"value":"Veterinary Clinics of North America: Equine Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cveq.2024.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}