{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:52:10Z","timestamp":1777873930770,"version":"3.51.4"},"reference-count":18,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"am","delay-in-days":335,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DP2OD007216"],"award-info":[{"award-number":["DP2OD007216"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K12AR084226"],"award-info":[{"award-number":["K12AR084226"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinics of North America: Equine Practice"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.cveq.2024.04.005","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T15:54:26Z","timestamp":1716479666000},"page":"179-188","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Horse with Recurrent Fevers and Infections: Approach to Common Variable Immunodeficiency"],"prefix":"10.1016","volume":"40","author":[{"given":"Kathleen Rory","family":"Mullen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Julia Bevilaqua","family":"Felippe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.cveq.2024.04.005_bib1","doi-asserted-by":"crossref","first-page":"e0247941","DOI":"10.1371\/journal.pone.0247941","article-title":"Immunoglobulin replacement therapy is critical and cost-effective in increasing life expectancy and quality of life in patients suffering from common variable immunodeficiency disorders (CVID): a health-economic assessment","volume":"16","author":"van Wilder","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.cveq.2024.04.005_bib2","doi-asserted-by":"crossref","first-page":"620709","DOI":"10.3389\/fimmu.2021.620709","article-title":"Lessons learned from the clinical presentation of common variable immunodeficiency disorders: a systematic review and meta-analysis","volume":"12","author":"Janssen","year":"2021","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.cveq.2024.04.005_bib3","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s10875-008-9221-4","article-title":"Common variable immunodeficiency in horses is characterized by B cell depletion in primary and secondary lymphoid tissues","volume":"29","author":"Flaminio","year":"2009","journal-title":"J\u00a0Clin Immunol"},{"issue":"9","key":"10.1016\/j.cveq.2024.04.005_bib4","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.2460\/javma.2002.221.1296","article-title":"Common variable immunodeficiency in a horse","volume":"221","author":"Flaminio","year":"2002","journal-title":"J\u00a0Am Vet Med Assoc"},{"key":"10.1016\/j.cveq.2024.04.005_bib5","doi-asserted-by":"crossref","DOI":"10.1111\/eve.13948","article-title":"Equine common variable immunodeficiency: lessons from 100 clinical cases","author":"Felippe","year":"2024","journal-title":"Equine Vet Educ"},{"issue":"1","key":"10.1016\/j.cveq.2024.04.005_bib6","doi-asserted-by":"crossref","first-page":"114","DOI":"10.2460\/javma.2005.227.114","article-title":"Common variable immunodeficiency in three horses with presumptive bacterial meningitis","volume":"227","author":"Pellegrini-Masini","year":"2005","journal-title":"J\u00a0Am Vet Med Assoc"},{"issue":"2","key":"10.1016\/j.cveq.2024.04.005_bib7","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1177\/1040638718824146","article-title":"Neuroborreliosis in a horse with common variable immunodeficiency","volume":"31","author":"Pecoraro","year":"2019","journal-title":"J\u00a0Vet Diagn Invest"},{"issue":"3","key":"10.1016\/j.cveq.2024.04.005_bib8","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S1081-1206(10)60665-5","article-title":"Assessment and clinical interpretation of reduced IgG values","volume":"99","author":"Agarwal","year":"2007","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"6","key":"10.1016\/j.cveq.2024.04.005_bib9","doi-asserted-by":"crossref","first-page":"808","DOI":"10.2460\/javma.1999.214.06.808","article-title":"Pulmonary aspergillosis in horses: 29 cases (1974-1997)","volume":"214","author":"Sweeney","year":"1999","journal-title":"J\u00a0Am Vet Med Assoc"},{"key":"10.1016\/j.cveq.2024.04.005_bib10","doi-asserted-by":"crossref","first-page":"106531","DOI":"10.1016\/j.domaniend.2020.106531","article-title":"Effects of pituitary pars intermedia dysfunction and Prascend (pergolide tablets) treatment on endocrine and immune function in horses","volume":"74","author":"Miller","year":"2021","journal-title":"Domest Anim Endocrinol"},{"issue":"10","key":"10.1016\/j.cveq.2024.04.005_bib11","article-title":"Pituitary pars intermedia dysfunction (PPID) in horses","volume":"9","author":"Kirkwood","year":"2022","journal-title":"Vet Sci China"},{"issue":"4","key":"10.1016\/j.cveq.2024.04.005_bib12","doi-asserted-by":"crossref","first-page":"233","DOI":"10.18176\/jiaci.0069","article-title":"T-cell abnormalities in common variable immunodeficiency","volume":"26","author":"Azizi","year":"2016","journal-title":"J\u00a0Investig Allergol Clin Immunol"},{"issue":"1","key":"10.1016\/j.cveq.2024.04.005_bib13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.18176\/jiaci.0388","article-title":"Common variable immunodeficiency: epidemiology, pathogenesis, clinical manifestations, diagnosis, classification, and management","volume":"30","author":"Yazdani","year":"2020","journal-title":"J\u00a0Investig Allergol Clin Immunol"},{"key":"10.1016\/j.cveq.2024.04.005_bib14","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.clim.2015.11.003","article-title":"Altered fraction of regulatory B and T\u00a0cells is correlated with autoimmune phenomena and splenomegaly in patients with CVID","volume":"162","author":"Kofod-Olsen","year":"2016","journal-title":"Clin Immunol"},{"issue":"8","key":"10.1016\/j.cveq.2024.04.005_bib15","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.2042-3292.2010.00083.x","article-title":"Common variable immunodeficiency in a horse with chronic peritonitis","volume":"22","author":"Tennent-Brown","year":"2010","journal-title":"Equine Vet Educ"},{"issue":"5","key":"10.1016\/j.cveq.2024.04.005_bib16","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.anai.2019.07.014","article-title":"Autoimmunity in common variable immunodeficiency","volume":"123","author":"Agarwal","year":"2019","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"2","key":"10.1016\/j.cveq.2024.04.005_bib17","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.clim.2015.05.005","article-title":"Bone marrow transcriptome and epigenome profiles of equine common variable immunodeficiency patients unveil block of B lymphocyte differentiation","volume":"160","author":"Tallmadge","year":"2015","journal-title":"Clin Immunol"},{"issue":"1","key":"10.1016\/j.cveq.2024.04.005_bib18","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1038\/s41467-022-29450-x","article-title":"Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses","volume":"13","author":"Rodr\u00edguez-Ubreva","year":"2022","journal-title":"Nat Commun"}],"container-title":["Veterinary Clinics of North America: Equine Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749073924000312?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749073924000312?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:33:59Z","timestamp":1777574039000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0749073924000312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S0749073924000312"],"URL":"https:\/\/doi.org\/10.1016\/j.cveq.2024.04.005","relation":{},"ISSN":["0749-0739"],"issn-type":[{"value":"0749-0739","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Horse with Recurrent Fevers and Infections: Approach to Common Variable Immunodeficiency","name":"articletitle","label":"Article Title"},{"value":"Veterinary Clinics of North America: Equine Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cveq.2024.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}