{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T04:10:49Z","timestamp":1760069449699,"version":"build-2065373602"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinics of North America: Food Animal Practice"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.cvfa.2021.03.008","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T11:33:45Z","timestamp":1621942425000},"page":"329-339","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evidence Base for Treatment of Infectious Bovine Keratoconjunctivitis"],"prefix":"10.1016","volume":"37","author":[{"given":"Annette M.","family":"O'Connor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mac","family":"Kneipp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cvfa.2021.03.008_bib1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1017\/S1466252316000050","article-title":"A\u00a0systematic review and meta-analysis of the antibiotic treatment for infectious bovine keratoconjunctivitis: an update","volume":"17","author":"Cullen","year":"2016","journal-title":"Anim Health Res Rev"},{"key":"10.1016\/j.cvfa.2021.03.008_bib2","doi-asserted-by":"crossref","first-page":"105232","DOI":"10.1016\/j.prevetmed.2020.105232","article-title":"Current incidence, treatment costs and seasonality of pinkeye in Australian cattle estimated from sales of three popular medications","volume":"187","author":"Kneipp","year":"2020","journal-title":"Prev Vet Med"},{"key":"10.1016\/j.cvfa.2021.03.008_bib3","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.2527\/jas.2013-7264","article-title":"Evaluating approaches to measuring ocular pain in bovine calves with corneal scarification and infectious bovine keratoconjunctivitis\u2013associated corneal ulcerations","volume":"92","author":"Dewell","year":"2014","journal-title":"J\u00a0Anim Sci"},{"key":"10.1016\/j.cvfa.2021.03.008_bib4","series-title":"Slatter\u2019s fundamentals of veterinary ophthalmology","first-page":"213","article-title":"Diseases cornea and sclera","author":"Maggs","year":"2018"},{"key":"10.1016\/j.cvfa.2021.03.008_bib5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cvfa.2014.11.006","article-title":"Infectious bovine keratoconjunctivitis (pinkeye)","volume":"31","author":"Angelos","year":"2015","journal-title":"Vet Clin North Am Food Anim Pract"},{"issue":"4","key":"10.1016\/j.cvfa.2021.03.008_bib6","doi-asserted-by":"crossref","first-page":"840","DOI":"10.2460\/ajvr.1985.46.04.804","article-title":"Treatment of acute ocular Moraxella bovis infections in calves with parenterally administered long-acting oxytetracyline formulation","volume":"46","author":"Smith","year":"1985","journal-title":"Am J Vet Res"},{"issue":"12","key":"10.1016\/j.cvfa.2021.03.008_bib7","first-page":"712","article-title":"Clinical infectious Bovine Keraotconjunctivitis","volume":"6","author":"George","year":"1984","journal-title":"Compend Contin Educ Dent"},{"issue":"1\/2","key":"10.1016\/j.cvfa.2021.03.008_bib8","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1017\/S146625230700120X","article-title":"A\u00a0review of randomized clinical trials reporting antibiotic treatment of infectious bovine keratoconjunctivitis in cattle","volume":"7","author":"O'Connor","year":"2006","journal-title":"Anim Health Res Rev"},{"key":"10.1016\/j.cvfa.2021.03.008_bib9","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1136\/vr.84.21.526","article-title":"Large-animal ophthalmology","volume":"84","author":"Cox","year":"1969","journal-title":"Vet Rec"},{"issue":"3","key":"10.1016\/j.cvfa.2021.03.008_bib10","first-page":"487","article-title":"Infectious Bovine Keratoconjunctivitis: a review of cases in clinical practice","volume":"26","author":"Alexander","year":"2010","journal-title":"Vet Clin North Am"},{"issue":"2","key":"10.1016\/j.cvfa.2021.03.008_bib11","doi-asserted-by":"crossref","first-page":"180","DOI":"10.21423\/bovine-vol50no2p180-189","article-title":"Preliminary evaluation of hypochlorous acid spray for treatment of experimentally induced infectious bovine keratoconjunctivitis","volume":"50","author":"Gard","year":"2016","journal-title":"The Bovine Practitioner"},{"issue":"10","key":"10.1016\/j.cvfa.2021.03.008_bib12","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.2460\/javma.1988.192.10.1415","article-title":"Topically applied furazolidone or parenterally administered oxytetracycline for the treatment of infectious bovine keratoconjunctivitis","volume":"192","author":"George","year":"1988","journal-title":"J\u00a0Am Vet Med Assoc"},{"issue":"1","key":"10.1016\/j.cvfa.2021.03.008_bib13","doi-asserted-by":"crossref","first-page":"62","DOI":"10.2460\/javma.2000.216.62","article-title":"Efficacy of florfenicol for treatment of naturally occurring infectious bovine keratoconjunctivitis","volume":"216","author":"Angelos","year":"2000","journal-title":"J\u00a0Am Vet Med Assoc"},{"issue":"11","key":"10.1016\/j.cvfa.2021.03.008_bib14","first-page":"573","article-title":"A\u00a0comparison of the efficacy of florfenicol and oxytetracycline in the treatment of naturally occurring infectious bovine keratoconjunctivitis","volume":"55","author":"Gokce","year":"2002","journal-title":"Ir Vet J"},{"issue":"1","key":"10.1016\/j.cvfa.2021.03.008_bib15","first-page":"Pe97","article-title":"Povidone iodine spray for treatment of infectious bovine keratoconjunctivitis","volume":"56","author":"Seifi","year":"2001","journal-title":"Journal of the Faculty of Veterinary Medicine"},{"issue":"9","key":"10.1016\/j.cvfa.2021.03.008_bib16","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.2460\/ajvr.77.9.1017","article-title":"Efficacy of Bdellovibrio bacteriovorus 109J for the treatment of dairy calves with experimentally induced infectious bovine keratoconjunctivitis","volume":"77","author":"Boileau","year":"2016","journal-title":"Am J Vet Res"},{"issue":"3","key":"10.1016\/j.cvfa.2021.03.008_bib17","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/bioe.12467","article-title":"Social value, clinical equipoise, and research in a public health emergency","volume":"33","author":"London","year":"2019","journal-title":"Bioethics"},{"issue":"7","key":"10.1016\/j.cvfa.2021.03.008_bib18","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1161\/CIRCRESAHA.116.309594","article-title":"Equipoise in clinical trials: angst and progress","volume":"119","author":"Rabinstein","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.cvfa.2021.03.008_bib19","first-page":"k1065","article-title":"Is the concept of clinical equipoise still relevant to research?","volume":"360","year":"2018","journal-title":"BMJ"},{"issue":"5","key":"10.1016\/j.cvfa.2021.03.008_bib20","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1177\/1740774512450952","article-title":"Clinical equipoise and risk-benefit assessment","volume":"9","author":"Miller","year":"2012","journal-title":"Clin Trials"},{"issue":"4","key":"10.1016\/j.cvfa.2021.03.008_bib21","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1080\/15265160600755672","article-title":"Equipoise and the ethics of clinical research revisited","volume":"6","author":"Miller","year":"2006","journal-title":"Am J Bioeth"},{"issue":"3","key":"10.1016\/j.cvfa.2021.03.008_bib22","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1056\/NEJM198707163170304","article-title":"Equipoise and the ethics of clinical research","volume":"317","author":"Freedman","year":"1987","journal-title":"N\u00a0Engl J Med"},{"issue":"2","key":"10.1016\/j.cvfa.2021.03.008_bib23","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1353\/ken.2005.0010","article-title":"Principles of early stopping of randomized trials for efficacy: a critique of equipoise and an alternative nonexploitation ethical framework","volume":"15","author":"Buchanan","year":"2005","journal-title":"Kennedy Inst Ethics J"},{"issue":"2","key":"10.1016\/j.cvfa.2021.03.008_bib24","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1353\/ken.2011.0007","article-title":"A\u00a0framework for risk-benefit evaluations in biomedical research","volume":"21","author":"Rid","year":"2011","journal-title":"Kennedy Inst Ethics J"},{"issue":"2","key":"10.1016\/j.cvfa.2021.03.008_bib25","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1164\/ajrccm.170.2.958","article-title":"Ethics and standard of care in clinical trials","volume":"170","author":"Brower","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"10.1016\/j.cvfa.2021.03.008_bib26","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1002\/bimj.201300216","article-title":"Using conditional power of network meta-analysis (NMA) to inform the design of future clinical trials","volume":"56","author":"Nikolakopoulou","year":"2014","journal-title":"Biom J"},{"issue":"1","key":"10.1016\/j.cvfa.2021.03.008_bib27","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1186\/s13063-018-2885-z","article-title":"Superiority and non-inferiority: two sides of the same coin?","volume":"19","author":"Dunn","year":"2018","journal-title":"Trials"},{"issue":"4","key":"10.1016\/j.cvfa.2021.03.008_bib28","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0197-2456(82)90024-1","article-title":"\"Proving the null hypothesis\" in clinical trials","volume":"3","author":"Blackwelder","year":"1982","journal-title":"Control Clin Trials"},{"issue":"4","key":"10.1016\/j.cvfa.2021.03.008_bib29","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.2042-3306.2011.00414.x","article-title":"Clinical studies utilising ordinal data: pitfalls in the analysis and interpretation of clinical grading systems","volume":"43","author":"Boden","year":"2011","journal-title":"Equine Vet J"},{"issue":"10","key":"10.1016\/j.cvfa.2021.03.008_bib30","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.2527\/jas.2009-2772","article-title":"Technical note: analysis of ordinal outcomes from carcass data in beef cattle research","volume":"88","author":"Osterstock","year":"2010","journal-title":"J\u00a0Anim Sci"},{"issue":"4","key":"10.1016\/j.cvfa.2021.03.008_bib31","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.1365-3164.2007.00605.x","article-title":"Frequency of appropriate and inappropriate presentation and analysis methods of ordered categorical data in the veterinary dermatology literature from January 2003 to June 2006","volume":"18","author":"Plant","year":"2007","journal-title":"Vet Dermatol"}],"container-title":["Veterinary Clinics of North America: Food Animal Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S074907202100027X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S074907202100027X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T03:50:30Z","timestamp":1760068230000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S074907202100027X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S074907202100027X"],"URL":"https:\/\/doi.org\/10.1016\/j.cvfa.2021.03.008","relation":{},"ISSN":["0749-0720"],"issn-type":[{"type":"print","value":"0749-0720"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evidence Base for Treatment of Infectious Bovine Keratoconjunctivitis","name":"articletitle","label":"Article Title"},{"value":"Veterinary Clinics of North America: Food Animal Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cvfa.2021.03.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}