{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T14:27:16Z","timestamp":1770215236761,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinics of North America: Small Animal Practice"],"published-print":{"date-parts":[[2004,11]]},"DOI":"10.1016\/j.cvsm.2004.05.017","type":"journal-article","created":{"date-parts":[[2005,4,18]],"date-time":"2005-04-18T10:53:20Z","timestamp":1113821600000},"page":"1403-1418","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Motor neuron disease: inherited and acquired"],"prefix":"10.1016","volume":"34","author":[{"given":"Natasha","family":"Olby","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cvsm.2004.05.017_bib1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1006\/nbdi.1994.0002","article-title":"Motor neurone disease and animal models","volume":"1","author":"Price","year":"1994","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.cvsm.2004.05.017_bib2","series-title":"Veterinary neuropathology","first-page":"307","article-title":"Degenerative diseases of the central nervous system","author":"Summers","year":"1995"},{"key":"10.1016\/j.cvsm.2004.05.017_bib3","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1056\/NEJM199105163242001","article-title":"Linkage of a gene causing familial amyotrophic lateral sclerosis to chromosome 21 and evidence of genetic-locus heterogeneity","volume":"324","author":"Siddique","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cvsm.2004.05.017_bib4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1586\/14737159.4.1.15","article-title":"Spinal muscular atrophy: molecular genetics and diagnostics","volume":"4","author":"Ogino","year":"2004","journal-title":"Expert Rev Mol Diagn"},{"key":"10.1016\/j.cvsm.2004.05.017_bib5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/352077a0","article-title":"Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy","volume":"352","author":"La Spada","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.cvsm.2004.05.017_bib6","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1086\/377157","article-title":"Two families with familial amyotrophic lateral sclerosis are linked to a novel locus on chromosome 16q","volume":"73","author":"Ruddy","year":"2003","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.cvsm.2004.05.017_bib7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.tins.2003.11.001","article-title":"Excitotoxic and oxidative cross-talk between motor neurons and glia in ALS pathogenesis","volume":"27","author":"Rao","year":"2004","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.cvsm.2004.05.017_bib8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/ana.410380114","article-title":"Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis","volume":"38","author":"Rothstein","year":"1995","journal-title":"Ann Neurol"},{"key":"10.1016\/j.cvsm.2004.05.017_bib9","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1056\/NEJM199403033300901","article-title":"A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS\/Riluzole Study Group","volume":"330","author":"Bensimon","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cvsm.2004.05.017_bib10","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/ana.10374","article-title":"Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS","volume":"52","author":"Drachman","year":"2002","journal-title":"Ann Neurol"},{"key":"10.1016\/j.cvsm.2004.05.017_bib11","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/mus.10191","article-title":"Inflammatory processes in amyotrophic lateral sclerosis","volume":"26","author":"McGeer","year":"2002","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.cvsm.2004.05.017_bib12","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.2042-3306.1994.tb04411.x","article-title":"Equine motor neuron disease: findings in 28 horses and proposal of a pathophysiological mechanism for the disease","volume":"26","author":"Divers","year":"1994","journal-title":"Equine Vet J"},{"key":"10.1016\/j.cvsm.2004.05.017_bib13","doi-asserted-by":"crossref","unstructured":"De la Rua-Domenech R, Mohammed HO, Cummings JF, Divers TJ, De Lahunta A, Summers BA. Association between plasma vitamin E concentration and the risk of equine motor neuron disease. Equine Vet J 1997a;154:203\u201313.","DOI":"10.1016\/S1090-0233(97)80021-4"},{"key":"10.1016\/j.cvsm.2004.05.017_bib14","doi-asserted-by":"crossref","unstructured":"De la Rua-Domenech R, Mohammed HO, Cummings JF, Divers TJ, de Lahunta A, Summers BA. Intrinsic, management, and nutritional factors associated with equine motor neuron disease. J Am Vet Med Assoc 1997b;211:1261\u20137.","DOI":"10.2460\/javma.1997.211.10.1261"},{"key":"10.1016\/j.cvsm.2004.05.017_bib15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0092-8674(93)90157-L","article-title":"Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease","volume":"73","author":"Xu","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.cvsm.2004.05.017_bib16","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/sj.ejhg.5201144","article-title":"Analysis of heavy neurofilament subunit gene polymorphism in Russian patients with sporadic motor neuron disease (MND)","volume":"12","author":"Skvortsova","year":"2004","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.cvsm.2004.05.017_bib17","first-page":"47","article-title":"Autoimmunity as an etiological factor in sporadic amyotrophic lateral sclerosis","volume":"68","author":"Appel","year":"1995","journal-title":"Adv Neurol"},{"issue":"4 Suppl 2","key":"10.1016\/j.cvsm.2004.05.017_bib18","first-page":"S40","article-title":"Autoimmunity and ALS","volume":"47","author":"Smith","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.cvsm.2004.05.017_bib19","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0361-9230(93)90268-G","article-title":"Experimental immune-mediated motor neuron diseases: models for human ALS","volume":"30","author":"Smith","year":"1993","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.cvsm.2004.05.017_bib20","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0165-5728(97)00082-9","article-title":"Immunization of guinea pigs with human choline acetyltransferase induces selective lower motoneuron destruction","volume":"78","author":"Engelhardt","year":"1997","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.cvsm.2004.05.017_bib21","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/ana.410150411","article-title":"Autosomal dominant inheritance of hereditary canine spinal muscular atrophy","volume":"15","author":"Sack","year":"1984","journal-title":"Ann Neurol"},{"key":"10.1016\/j.cvsm.2004.05.017_bib22","doi-asserted-by":"crossref","first-page":"833","DOI":"10.2460\/javma.1979.175.08.833","article-title":"Hereditary spinal muscular atrophy in Brittany spaniels: clinical manifestations","volume":"175","author":"Lorenz","year":"1979","journal-title":"J Am Vet Med Assoc"},{"key":"10.1016\/j.cvsm.2004.05.017_bib23","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/1531-8249(200005)47:5<596::AID-ANA7>3.0.CO;2-I","article-title":"Functional motor unit failure precedes neuromuscular degeneration in canine motor neuron disease","volume":"47","author":"Balice-Gordon","year":"2000","journal-title":"Ann Neurol"},{"key":"10.1016\/j.cvsm.2004.05.017_bib24","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1152\/jn.00270.2002","article-title":"Reduced endplate currents underlie motor unit dysfunction in canine motor neuron disease","volume":"88","author":"Rich","year":"2002","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.cvsm.2004.05.017_bib25","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/00005072-197905000-00002","article-title":"Hereditary canine spinal muscular atrophy","volume":"38","author":"Cork","year":"1979","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.cvsm.2004.05.017_bib26","first-page":"599","article-title":"Animal model of human disease: motor neuron disease: spinal muscular atrophy and amyotrophic lateral sclerosis","volume":"100","author":"Cork","year":"1980","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cvsm.2004.05.017_bib27","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/jhered\/89.6.531","article-title":"Hereditary canine spinal muscular atrophy is phenotypically similar but molecularly distinct from human spinal muscular atrophy","volume":"89","author":"Blazej","year":"1998","journal-title":"J Hered"},{"key":"10.1016\/j.cvsm.2004.05.017_bib28","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/jhered\/93.2.119","article-title":"Structure, chromosomal location, and analysis of the canine Cu\/Zn superoxide dismutase (SOD1) gene","volume":"93","author":"Green","year":"2002","journal-title":"J Hered"},{"key":"10.1016\/j.cvsm.2004.05.017_bib29","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1939-1676.2001.tb01241.x","article-title":"Canine motor neuron disease: clinicopathologic features and selected indicators of oxidative stress","volume":"15","author":"Green","year":"2001","journal-title":"Vet Intern Med"},{"key":"10.1016\/j.cvsm.2004.05.017_bib30","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1292\/jvms1939.40.539","article-title":"A clinical study on hereditary progressive neurogenic muscular atrophy in Pointer dogs","volume":"40","author":"Inada","year":"1978","journal-title":"Nippon Juigaku Zasshi"},{"key":"10.1016\/j.cvsm.2004.05.017_bib31","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF00308967","article-title":"Focal spinal muscular atrophy in two German shepherd pups","volume":"79","author":"Cummings","year":"1989","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.1016\/j.cvsm.2004.05.017_bib32","doi-asserted-by":"crossref","unstructured":"Shell LG, Jortner BS, Leib MS. Spinal muscular atrophy in two Rottweiler littermates. J Am Vet Med Assoc 1987a;190:878\u201380.","DOI":"10.2460\/javma.1987.190.07.878"},{"key":"10.1016\/j.cvsm.2004.05.017_bib33","first-page":"821","article-title":"Spinal muscular atrophy in Rottweilers","volume":"100","author":"Presthus","year":"1988","journal-title":"Norsk Vet"},{"key":"10.1016\/j.cvsm.2004.05.017_bib34","doi-asserted-by":"crossref","unstructured":"Shell LG, Jortner BS, Leib MS. Familial motor neuron disease in Rottweiler dogs: neuropathologic studies. Vet Pathol 1987b;24:135\u20139.","DOI":"10.1177\/030098588702400206"},{"key":"10.1016\/j.cvsm.2004.05.017_bib35","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1177\/030098589803500512","article-title":"Lower motor neuron disease in the Griffon Briquet Vendeen dog","volume":"35","author":"Mandara","year":"1998","journal-title":"Vet Pathol"},{"key":"10.1016\/j.cvsm.2004.05.017_bib36","doi-asserted-by":"crossref","first-page":"436","DOI":"10.5326\/15473317-35-5-436","article-title":"Motor neuron abiotrophy in a saluki","volume":"35","author":"Kent","year":"1999","journal-title":"J Am Anim Hosp Assoc"},{"key":"10.1016\/j.cvsm.2004.05.017_bib37","first-page":"240","article-title":"Neurofibrillary accumulation in a puppy","volume":"65","author":"de Lahunta","year":"1975","journal-title":"Cornell Vet"},{"key":"10.1016\/j.cvsm.2004.05.017_bib38","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/BF00685990","article-title":"Lower motor neurone disease in dogs","volume":"2","author":"Hartley","year":"1963","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.1016\/j.cvsm.2004.05.017_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/aja.1000590102","article-title":"An hereditary lethal factor for localized motor and preganglionic neurons with a resulting paralysis in the dog","volume":"59","author":"Stockard","year":"1936","journal-title":"Am J Anat"},{"key":"10.1016\/j.cvsm.2004.05.017_bib40","first-page":"649","article-title":"Animal model of human disease. Infantile spinal muscular atrophy, Werdnig-Hoffman disease. Animal model: hereditary neuronal abiotrophy in Swedish Lapland dogs","volume":"82","author":"Sandefeldt","year":"1976","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cvsm.2004.05.017_bib41","unstructured":"He Q, Lowrie C, Shelton GD, Menotti-Raymond M, Murphy W, Fyfe J. Inherited motor neuron disease in domestic cats: a model of spinal muscular atrophy. Pediatr Res (in press)."},{"key":"10.1016\/j.cvsm.2004.05.017_bib42","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1177\/030098587601300604","article-title":"Lower motor neuron disease with accumulation of neurofilaments in a cat","volume":"13","author":"Vandevelde","year":"1976","journal-title":"Vet Pathol"},{"key":"10.1016\/j.cvsm.2004.05.017_bib43","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.2460\/javma.1998.212.08.1271","article-title":"Adult-onset motor neuron disease in three cats","volume":"212","author":"Shelton","year":"1998","journal-title":"J Am Vet Med Assoc"}],"container-title":["Veterinary Clinics of North America: Small Animal Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0195561604000749?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0195561604000749?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T01:42:50Z","timestamp":1759282970000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0195561604000749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["S0195561604000749"],"URL":"https:\/\/doi.org\/10.1016\/j.cvsm.2004.05.017","relation":{},"ISSN":["0195-5616"],"issn-type":[{"value":"0195-5616","type":"print"}],"subject":[],"published":{"date-parts":[[2004,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Motor neuron disease: inherited and acquired","name":"articletitle","label":"Article Title"},{"value":"Veterinary Clinics of North America: Small Animal Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cvsm.2004.05.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}