{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:51:33Z","timestamp":1791589893585,"version":"4.3.4"},"reference-count":41,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["vetsmall.theclinics.com","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinics of North America: Small Animal Practice"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.cvsm.2016.06.001","type":"journal-article","created":{"date-parts":[[2016,9,3]],"date-time":"2016-09-03T01:38:35Z","timestamp":1472866715000},"page":"995-1013","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"title":["Is Progressive Chronic Kidney Disease a Slow Acute Kidney Injury?"],"prefix":"10.1016","volume":"46","author":[{"given":"Larry D.","family":"Cowgill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Polzin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary B.","family":"Nabity","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilad","family":"Segev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory F.","family":"Grauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Langston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid M.","family":"van Dongen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cvsm.2016.06.001_bib1","unstructured":"Available at: www.iris-kidney.com. Accessed August 1, 2016."},{"key":"10.1016\/j.cvsm.2016.06.001_bib2","unstructured":"Elliott J, Cowgill L. Diagnostic algorithms for grading of acute kidney injury and staging the chronic kidney disease patient. In: Elliott J, Grauer GF, editors: BSAVA manual of canine and feline nephrology and urology. 3rd edition, in press."},{"key":"10.1016\/j.cvsm.2016.06.001_bib3","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1939-165X.2003.tb00332.x","article-title":"Creatinine in the dog: a review","volume":"32","author":"Braun","year":"2003","journal-title":"Vet Clin Pathol"},{"issue":"3","key":"10.1016\/j.cvsm.2016.06.001_bib4","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1681\/ASN.2015030309","article-title":"Progression after AKI: understanding maladaptive repair processes to predict and identify therapeutic treatments","volume":"27","author":"Basile","year":"2016","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"6","key":"10.1016\/j.cvsm.2016.06.001_bib5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1748-5827.2003.tb00153.x","article-title":"Acid-base balance of cats with chronic renal failure: effect of deterioration in renal function","volume":"44","author":"Elliott","year":"2003","journal-title":"J\u00a0Small Anim Pract"},{"key":"10.1016\/j.cvsm.2016.06.001_bib6","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1939-1676.2011.00874.x","article-title":"Clinicopathological variables predicting progression of azotemia in cats with chronic kidney disease","volume":"26","author":"Chakrabarti","year":"2012","journal-title":"J\u00a0Vet Intern Med"},{"key":"10.1016\/j.cvsm.2016.06.001_bib7","series-title":"Textbook of veterinary internal medicine","first-page":"2036","article-title":"Chronic kidney disease","author":"Polzin","year":"2010"},{"key":"10.1016\/j.cvsm.2016.06.001_bib8","series-title":"Nephrology and urology of small animals","article-title":"Acute kidney disease","author":"Cowgill","year":"2011"},{"key":"10.1016\/j.cvsm.2016.06.001_bib9","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1056\/NEJMra1214243","article-title":"Acute kidney injury and chronic kidney disease as interconnected syndromes","volume":"371","author":"Chawla","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cvsm.2016.06.001_bib10","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/ki.2012.208","article-title":"Acute kidney injury and chronic kidney disease: an integrated clinical syndrome","volume":"82","author":"Chawla","year":"2012","journal-title":"Kidney Int"},{"key":"10.1016\/j.cvsm.2016.06.001_bib11","doi-asserted-by":"crossref","first-page":"57","DOI":"10.5527\/wjn.v4.i1.57","article-title":"Biomarkers in chronic kidney disease, from kidney function to kidney damage","volume":"4","author":"Lopez-Giacoman","year":"2015","journal-title":"World J Nephrol"},{"key":"10.1016\/j.cvsm.2016.06.001_bib12","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/j.1939-1676.2006.tb02892.x","article-title":"Survival of cats with naturally occurring chronic renal failure is related to severity of proteinuria","volume":"20","author":"Syme","year":"2008","journal-title":"J\u00a0Vet Intern Med"},{"key":"10.1016\/j.cvsm.2016.06.001_bib13","doi-asserted-by":"crossref","first-page":"31","DOI":"10.5527\/wjn.v3.i3.31","article-title":"Chronic kidney disease prediction is an inexact science: the concept of \u201cprogressors\u201d and \u201cnonprogressors\u201d","volume":"3","author":"Onuigbo","year":"2014","journal-title":"World J Nephrol"},{"key":"10.1016\/j.cvsm.2016.06.001_bib14","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.bbadis.2013.02.010","article-title":"Renal epithelial injury and fibrosis","volume":"1832","author":"Kaissling","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.cvsm.2016.06.001_bib15","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/ki.2011.379","article-title":"Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis","volume":"81","author":"Coca","year":"2012","journal-title":"Kidney Int"},{"key":"10.1016\/j.cvsm.2016.06.001_bib16","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1159\/000363675","article-title":"Acute kidney injury: gateway to chronic kidney disease","volume":"127","author":"Heung","year":"2014","journal-title":"Nephron Clin Pract"},{"key":"10.1016\/j.cvsm.2016.06.001_bib17","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nrneph.2015.3","article-title":"Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD","volume":"11","author":"Ferenbach","year":"2015","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.cvsm.2016.06.001_bib18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/kisup.2014.8","article-title":"Primary proximal tubule injury leads to epithelial cell cycle arrest, fibrosis, vascular rarefaction, and glomerulosclerosis","volume":"4","author":"Bonventre","year":"2014","journal-title":"Kidney Int Suppl"},{"key":"10.1016\/j.cvsm.2016.06.001_bib19","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1146\/annurev-med-050214-013407","article-title":"Acute Kidney Injury","volume":"67","author":"Zuk","year":"2016","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.cvsm.2016.06.001_bib20","doi-asserted-by":"crossref","DOI":"10.1007\/s00467-015-3298-9","article-title":"The path to chronic kidney disease following acute kidney injury: a neonatal perspective","author":"Chaturvedi","year":"2016","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.cvsm.2016.06.001_bib21","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1159\/000363726","article-title":"Progression from acute kidney injury to chronic kidney disease: clinical and experimental insights and queries","volume":"127","author":"Zager","year":"2014","journal-title":"Nephron Clin Pract"},{"key":"10.1016\/j.cvsm.2016.06.001_bib22","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000441269","article-title":"Acute kidney injury: tubular markers and risk for chronic kidney disease and end-stage kidney failure","volume":"41","author":"Tan","year":"2016","journal-title":"Blood Purif"},{"key":"10.1016\/j.cvsm.2016.06.001_bib23","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1093\/ndt\/gfu261","article-title":"Progression of renal injury toward interstitial inflammation and glomerular sclerosis is dependent on abnormal protein filtration","volume":"30","author":"Zoja","year":"2015","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.cvsm.2016.06.001_bib24","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ndt\/gfv130","article-title":"Cell-cycle arrest and acute kidney injury: the light and the dark sides","volume":"31","author":"Kellum","year":"2016","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.cvsm.2016.06.001_bib25","first-page":"428508","article-title":"Crosstalk between the unfolded protein response and NF-\u03baB-mediated inflammation in the progression of chronic kidney disease","volume":"2015","author":"Mohammed-Ali","year":"2015","journal-title":"J\u00a0Immunol Res"},{"key":"10.1016\/j.cvsm.2016.06.001_bib26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1159\/000442364","article-title":"Biomarkers for diagnosis, prognosis and intervention in acute kidney injury","volume":"187","author":"Fuhrman","year":"2016","journal-title":"Contrib Nephrol"},{"key":"10.1016\/j.cvsm.2016.06.001_bib27","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2215\/CJN.12191213","article-title":"Biomarkers of AKI: a review of mechanistic relevance and potential therapeutic implications","volume":"10","author":"Alge","year":"2015","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.cvsm.2016.06.001_bib28","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1681\/ASN.2011090907","article-title":"Biomarkers predict progression of acute kidney injury after cardiac surgery","volume":"23","author":"Koyner","year":"2012","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.cvsm.2016.06.001_bib29","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/MNH.0000000000000090","article-title":"Novel biomarkers indicating repair or progression after acute kidney injury","volume":"24","author":"Kashani","year":"2015","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.cvsm.2016.06.001_bib30","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1111\/jvim.12155","article-title":"Urinary biomarkers for acute kidney injury in dogs","volume":"27","author":"De Loor","year":"2013","journal-title":"J\u00a0Vet Intern Med"},{"key":"10.1016\/j.cvsm.2016.06.001_bib31","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.tvjl.2015.07.004","article-title":"Characterization of kidney damage using several renal biomarkers in dogs with naturally occurring heatstroke","volume":"206","author":"Segev","year":"2015","journal-title":"Vet J"},{"key":"10.1016\/j.cvsm.2016.06.001_bib32","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1111\/jvim.12180","article-title":"Evaluation of neutrophil gelatinase-associated lipocalin as a marker of kidney injury in dogs","volume":"27","author":"Segev","year":"2013","journal-title":"J\u00a0Vet Intern Med"},{"key":"10.1016\/j.cvsm.2016.06.001_bib33","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/jvim.13819","article-title":"Urinary neutrophil gelatinase-associated lipocalin as a marker for identification of acute kidney injury and recovery in dogs with gentamicin-induced nephrotoxicity","volume":"30","author":"Palm","year":"2016","journal-title":"J\u00a0Vet Intern Med"},{"key":"10.1016\/j.cvsm.2016.06.001_bib34","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1136\/vr.101829","article-title":"Evaluation of serum neutrophil gelatinase-associated lipocalin (NGAL) activity in dogs with chronic kidney disease","volume":"173","author":"Ahn","year":"2013","journal-title":"Vet Rec"},{"key":"10.1016\/j.cvsm.2016.06.001_bib35","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3109\/15563650.2015.1118487","article-title":"Plasma neutrophil gelatinase-associated lipocalin as a predictive biomarker for the detection of acute kidney injury in adult poisoning","volume":"54","author":"Ahn","year":"2016","journal-title":"Clin Toxicol"},{"key":"10.1016\/j.cvsm.2016.06.001_bib36","first-page":"248","article-title":"Urine neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute canine kidney injury","volume":"8","author":"Lee","year":"2012","journal-title":"Vet Res"},{"key":"10.1016\/j.cvsm.2016.06.001_bib37","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/jvim.12288","article-title":"Neutrophil gelatinase-associated lipocalin in dogs with naturally occurring renal diseases","volume":"28","author":"Hsu","year":"2014","journal-title":"J\u00a0Vet Intern Med"},{"key":"10.1016\/j.cvsm.2016.06.001_bib38","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/vcp.12333","article-title":"Renal biomarkers in domestic species","volume":"45","author":"Hokamp","year":"2016","journal-title":"Vet Clin Pathol"},{"key":"10.1016\/j.cvsm.2016.06.001_bib39","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.2460\/ajvr.71.11.1387","article-title":"Influence of kidney function on urinary excretion of albumin and retinol-binding protein in dogs with naturally occurring renal disease","volume":"71","author":"Raila","year":"2010","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.cvsm.2016.06.001_bib40","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1939-1676.2012.00891.x","article-title":"Urinary biomarkers of renal disease in dogs with X-linked hereditary nephropathy","volume":"26","author":"Nabity","year":"2012","journal-title":"J\u00a0Vet Intern Med"},{"key":"10.1016\/j.cvsm.2016.06.001_bib41","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1515\/CCLM.2011.156","article-title":"Increased urinary neutrophil gelatinase associated lipocalin in urinary tract infections and leukocyturia","volume":"49","author":"Decavele","year":"2011","journal-title":"Clin Chem Lab Med"}],"container-title":["Veterinary Clinics of North America: Small Animal Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0195561616300377?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0195561616300377?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T14:16:56Z","timestamp":1657203416000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0195561616300377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S0195561616300377"],"URL":"https:\/\/doi.org\/10.1016\/j.cvsm.2016.06.001","relation":{},"ISSN":["0195-5616"],"issn-type":[{"value":"0195-5616","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is Progressive Chronic Kidney Disease a Slow Acute Kidney Injury?","name":"articletitle","label":"Article Title"},{"value":"Veterinary Clinics of North America: Small Animal Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cvsm.2016.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}