{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T21:17:37Z","timestamp":1788643057370,"version":"build-2803163510"},"reference-count":57,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinics of North America: Small Animal Practice"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.cvsm.2019.02.010","type":"journal-article","created":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T12:40:22Z","timestamp":1554468022000},"page":"745-762","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cutaneous and Renal Glomerular Vasculopathy"],"prefix":"10.1016","volume":"49","author":[{"given":"Rosanne E.","family":"Jepson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline M.","family":"Cardwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Cortellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Holm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.cvsm.2019.02.010_bib1","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1177\/030098588802500601","article-title":"Idiopathic cutaneous and renal glomerular vasculopathy of greyhounds","volume":"25","author":"Carpenter","year":"1988","journal-title":"Vet Pathol"},{"key":"10.1016\/j.cvsm.2019.02.010_bib2","unstructured":"Hendricks A. Akute ulzerative dermatitis bei einem Greyhound. Proceedings of the 46th Annual Congress of the Small Animal division of the German Veterinary Association, Dusseldorf, Germany, November 9-12, 2000. p. 62\u20133."},{"issue":"17","key":"10.1016\/j.cvsm.2019.02.010_bib3","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1136\/vr.151.17.510","article-title":"Cutaneous and renal glomerular vasculopathy in a great dane resembling \u2018Alabama rot\u2019 of greyhounds","volume":"151","author":"Rotermund","year":"2002","journal-title":"Vet Rec"},{"issue":"15","key":"10.1016\/j.cvsm.2019.02.010_bib4","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1136\/vr.102892","article-title":"Cutaneous and renal glomerular vasculopathy as a cause of acute kidney injury in dogs in the UK","volume":"176","author":"Holm","year":"2015","journal-title":"Vet Rec"},{"issue":"4","key":"10.1016\/j.cvsm.2019.02.010_bib5","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1939-1676.1993.tb01011.x","article-title":"Hemolytic uremic syndrome in dogs","volume":"7","author":"Holloway","year":"1993","journal-title":"J\u00a0Vet Intern Med"},{"issue":"3","key":"10.1016\/j.cvsm.2019.02.010_bib6","first-page":"264","article-title":"Hemolytic-uremic syndrome in a dog","volume":"34","author":"Marta","year":"2008","journal-title":"Vet Clin Pathol"},{"issue":"7","key":"10.1016\/j.cvsm.2019.02.010_bib7","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1093\/ndt\/gfs279","article-title":"Thrombotic microangiopathy and associated renal disorders","volume":"27","author":"Barbour","year":"2012","journal-title":"Nephrol Dial Transplant"},{"issue":"4\u20135","key":"10.1016\/j.cvsm.2019.02.010_bib8","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.autrev.2014.01.004","article-title":"Thrombotic thrombocytopenic purpura and other thrombotic microangiopathic hemolytic anemias: diagnosis and classification","volume":"13","author":"Shenkman","year":"2014","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.cvsm.2019.02.010_bib9","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1515\/cclm-2015-0024","article-title":"Atypical hemolytic uremic syndrome: from diagnosis to treatment","volume":"53","author":"Franchini","year":"2015","journal-title":"Clin Chem Lab Med"},{"issue":"6","key":"10.1016\/j.cvsm.2019.02.010_bib10","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1055\/s-0030-1262879","article-title":"Pathophysiology of typical hemolytic uremic syndrome","volume":"36","author":"Karpman","year":"2010","journal-title":"Semin Thromb Hemost"},{"issue":"6","key":"10.1016\/j.cvsm.2019.02.010_bib11","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1111\/bjh.12718","article-title":"How I treat thrombotic thrombocytopenic purpura and atypical haemolytic uraemic syndrome","volume":"164","author":"Scully","year":"2014","journal-title":"Br J Haematol"},{"issue":"8","key":"10.1016\/j.cvsm.2019.02.010_bib12","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1681\/ASN.2006080811","article-title":"Differential impact of complement mutations on clinical characteristics in atypical hemolytic uremic syndrome","volume":"18","author":"Sellier-Leclerc","year":"2007","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"3","key":"10.1016\/j.cvsm.2019.02.010_bib13","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1053\/j.ajkd.2007.08.030","article-title":"Association of a factor H mutation with hemolytic uremic syndrome following a diarrheal illness","volume":"51","author":"Edey","year":"2008","journal-title":"Am J Kidney Dis"},{"issue":"5","key":"10.1016\/j.cvsm.2019.02.010_bib14","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1177\/030098589503200501","article-title":"Glomerular ultrastructural lesions of idiopathic cutaneous and renal glomerular vasculopathy of greyhounds","volume":"32","author":"Hertzke","year":"1995","journal-title":"Vet Pathol"},{"issue":"14","key":"10.1016\/j.cvsm.2019.02.010_bib15","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1136\/vr.104891","article-title":"Signalment risk factors for cutaneous and renal glomerular vasculopathy (Alabama Rot) in dogs in the UK","volume":"183","author":"Stevens","year":"2018","journal-title":"Vet Rec"},{"issue":"6","key":"10.1016\/j.cvsm.2019.02.010_bib16","doi-asserted-by":"crossref","first-page":"789","DOI":"10.2460\/javma.1997.210.06.789","article-title":"Clinical and clinicopathologic abnormalities in Greyhounds with cutaneous and renal glomerular vasculopathy: 18 cases (1992-1994)","volume":"210","author":"Cowan","year":"1997","journal-title":"J\u00a0Am Vet Med Assoc"},{"issue":"10","key":"10.1016\/j.cvsm.2019.02.010_bib17","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1136\/inp.k4368","article-title":"Dealing with cutaneous and renal glomerular vasculopathy in dogs","volume":"40","author":"Holm","year":"2018","journal-title":"In Practice"},{"key":"10.1016\/j.cvsm.2019.02.010_bib18","series-title":"Escherichia Coli 0157:H7 and other shiga toxin\u00a0producing E.coli strains. Chapter 26","first-page":"268","article-title":"Canine Model of hemolytic-uremic syndrome","author":"Fenwick","year":"1998"},{"issue":"2","key":"10.1016\/j.cvsm.2019.02.010_bib19","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1177\/104063870802000218","article-title":"Hemolytic-uremic syndrome in a postpartum mare concurrent with encephalopathy in the neonatal foal","volume":"20","author":"Dickinson","year":"2008","journal-title":"J\u00a0Vet Diagn Invest"},{"key":"10.1016\/j.cvsm.2019.02.010_bib20","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1046\/j.1439-0442.2002.00479.x","article-title":"Haemolytic uraemic syndrome in a dog","volume":"49","author":"Chantey","year":"2002","journal-title":"J\u00a0Vet Med A Physiol Pathol Clin Med"},{"issue":"9464","key":"10.1016\/j.cvsm.2019.02.010_bib21","first-page":"1073","article-title":"Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome","volume":"365","author":"Tarr","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.cvsm.2019.02.010_bib22","series-title":"WSAVA Standards for Clinical and Histological Diagnosis of Canine and Feline Liver Diseases","first-page":"93","article-title":"Morphological classification of parenchymal disorders of the canine and feline liver","author":"Van Den Ingh","year":"2006"},{"issue":"1","key":"10.1016\/j.cvsm.2019.02.010_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1939-1676.2010.0654.x","article-title":"2010 ACVIM small animal consensus statement on leptospirosis: diagnosis, epidemiology, treatment, and prevention","volume":"25","author":"Sykes","year":"2010","journal-title":"J\u00a0Vet Intern Med"},{"issue":"9","key":"10.1016\/j.cvsm.2019.02.010_bib24","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.2460\/javma.243.9.1316","article-title":"Clinicopathologic and atypical features of naturally occurring leptospirosis in dogs: 51 cases (2000\u20132010)","volume":"243","author":"Tangeman","year":"2013","journal-title":"J\u00a0Am Vet Med Assoc"},{"issue":"5","key":"10.1016\/j.cvsm.2019.02.010_bib25","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1354\/vp.08-VP-0265-N-REV","article-title":"Review paper: host-pathogen interactions in the kidney during chronic leptospirosis","volume":"46","author":"Monahan","year":"2009","journal-title":"Vet Pathol"},{"issue":"4","key":"10.1016\/j.cvsm.2019.02.010_bib26","doi-asserted-by":"crossref","first-page":"534","DOI":"10.3201\/eid1904.121390","article-title":"Circovirus in tissues of dogs with vasculitis and hemorrhage","volume":"19","author":"Li","year":"2013","journal-title":"Emerg Infect Dis"},{"issue":"3","key":"10.1016\/j.cvsm.2019.02.010_bib27","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1097\/00000372-200006000-00006","article-title":"Histological Findings After Brown Recluse Spider Envenomation","volume":"22","author":"Elston","year":"2000","journal-title":"Am J Dermatopathol"},{"issue":"6","key":"10.1016\/j.cvsm.2019.02.010_bib28","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1093\/ckj\/sft111","article-title":"Clinicopathological course of acute kidney injury following brown recluse (Loxoscles reclusa) envenomation","volume":"6","author":"Anwar","year":"2013","journal-title":"Clin Kidney J"},{"key":"10.1016\/j.cvsm.2019.02.010_bib29","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nature02759","article-title":"The challenge of emerging and re-emerging infectious diseases","volume":"430","author":"Morens","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.cvsm.2019.02.010_bib30","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1136\/vr.104892","article-title":"Spatio-temporal patterns and agro-ecological risk factors for cutaneous and renal glomerular vasculopathy (Alabama Rot) in dogs in the UK","volume":"183","author":"Stevens","year":"2018","journal-title":"Vet Rec"},{"issue":"7\u20138","key":"10.1016\/j.cvsm.2019.02.010_bib31","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1345\/aph.1A339","article-title":"Acute renal failure in hospitalized patients: part I","volume":"36","author":"Pruchnicki","year":"2002","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.cvsm.2019.02.010_bib32","series-title":"Textbook of veterinary internal medicine","first-page":"1926","article-title":"Acute kidney injury","author":"Langston","year":"2017"},{"issue":"6","key":"10.1016\/j.cvsm.2019.02.010_bib33","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/S0195-5616(01)50103-5","article-title":"Strategies for management of acute renal failure","volume":"31","author":"Labato","year":"2001","journal-title":"Vet Clin North Am Small Anim Pract"},{"issue":"7","key":"10.1016\/j.cvsm.2019.02.010_bib34","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1748-5827.2011.01067.x","article-title":"Occurrence of systemic hypertension in dogs with acute kidney injury and treatment with amlodipine besylate","volume":"52","author":"Geigy","year":"2011","journal-title":"J\u00a0Small Anim Pract"},{"issue":"6","key":"10.1016\/j.cvsm.2019.02.010_bib35","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1111\/jvim.15331","article-title":"Guidelines for the identification, evaluation and management of systemic hypertension in dogs and cats","volume":"32","author":"Acierno","year":"2018","journal-title":"J\u00a0Vet Intern Med"},{"issue":"6","key":"10.1016\/j.cvsm.2019.02.010_bib36","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.semnephrol.2013.08.003","article-title":"Atypical hemolytic uremic syndrome","volume":"33","author":"Kavanagh","year":"2013","journal-title":"Semin Nephrol"},{"issue":"3","key":"10.1016\/j.cvsm.2019.02.010_bib37","doi-asserted-by":"crossref","first-page":"56","DOI":"10.5527\/wjn.v2.i3.56","article-title":"Update on hemolytic uremic syndrome: diagnostic and therapeutic recommendations","volume":"2","author":"Salvadori","year":"2013","journal-title":"World J Nephrol"},{"key":"10.1016\/j.cvsm.2019.02.010_bib38","first-page":"15","article-title":"Management of thrombotic thrombocytopenic purpura: current perspectives","volume":"5","author":"Blombery","year":"2014","journal-title":"J\u00a0Blood Med"},{"issue":"6","key":"10.1016\/j.cvsm.2019.02.010_bib39","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1056\/NEJM199108083250605","article-title":"Improved survival in thrombotic thrombocytopenic purpura\u2013hemolytic uremic syndrome","volume":"325","author":"Bell","year":"1991","journal-title":"N\u00a0Engl J Med"},{"issue":"6","key":"10.1016\/j.cvsm.2019.02.010_bib40","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1056\/NEJM199108083250604","article-title":"Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura","volume":"325","author":"Rock","year":"1991","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cvsm.2019.02.010_bib41","first-page":"194","article-title":"Deleterious effects of platelet transfusions and recovery thrombocytosis in patients with thrombotic microangiopathy","volume":"24","author":"Gordon","year":"1987","journal-title":"Semin Hematol"},{"issue":"4","key":"10.1016\/j.cvsm.2019.02.010_bib42","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1046\/j.1365-2141.2003.04049.x","article-title":"Guidelines on the diagnosis and management of the thrombotic microangiopathic haemolytic anaemias","volume":"120","author":"Allford","year":"2003","journal-title":"Br J Haematol"},{"issue":"24","key":"10.1016\/j.cvsm.2019.02.010_bib43","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1056\/NEJM200006153422402","article-title":"Thrombotic thrombocytopenic purpura associated with clopidogrel","volume":"342","author":"Bennett","year":"2000","journal-title":"N\u00a0Engl J Med"},{"issue":"12","key":"10.1016\/j.cvsm.2019.02.010_bib44","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/S0196-0644(88)80354-8","article-title":"Principles of emergency wound management","volume":"17","author":"Edlich","year":"1988","journal-title":"Ann Emerg Med"},{"issue":"14","key":"10.1016\/j.cvsm.2019.02.010_bib45","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1136\/vr.136.14.362","article-title":"Management of veterinary wounds","volume":"136","author":"Cockbill","year":"1995","journal-title":"Vet Rec"},{"issue":"Sup1","key":"10.1016\/j.cvsm.2019.02.010_bib46","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.12968\/jowc.2013.22.Sup1.S1","article-title":"EWMA Document: Debridement: An updated overview and clarification of the principle role of debridement","volume":"22","author":"Strohal","year":"2013","journal-title":"J\u00a0Wound Care"},{"issue":"3","key":"10.1016\/j.cvsm.2019.02.010_bib47","doi-asserted-by":"crossref","first-page":"590","DOI":"10.4103\/0970-0358.105996","article-title":"Syringe-based wound irrigating device","volume":"45","author":"Shetty","year":"2012","journal-title":"Indian J Plast Surg"},{"issue":"6","key":"10.1016\/j.cvsm.2019.02.010_bib48","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/0002-9610(71)90042-0","article-title":"Studies in the management of the contaminated wound: VI. The therapeutic value of gentle scrubbing in prolonging the limited period of effectiveness of antibiotics in contaminated wounds","volume":"121","author":"Edlich","year":"1971","journal-title":"Am J Surg"},{"issue":"6","key":"10.1016\/j.cvsm.2019.02.010_bib49","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.cvsm.2017.06.001","article-title":"Initial management of traumatic wounds","volume":"47","author":"Devriendt","year":"2017","journal-title":"Vet Clin North Am Small Anim Pract"},{"issue":"4","key":"10.1016\/j.cvsm.2019.02.010_bib50","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.cvsm.2006.04.003","article-title":"Initial wound management","volume":"36","author":"Dernell","year":"2006","journal-title":"Vet Clin North Am Small Anim Pract"},{"issue":"2","key":"10.1016\/j.cvsm.2019.02.010_bib51","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1128\/CMR.14.2.244-269.2001","article-title":"Wound microbiology and associated approaches to wound management","volume":"14","author":"Bowler","year":"2001","journal-title":"Clin Microbiol Rev"},{"issue":"1\u20132","key":"10.1016\/j.cvsm.2019.02.010_bib52","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.vetmic.2009.12.042","article-title":"Clinical and bacteriological assessment of dog-to-dog bite wounds","volume":"144","author":"Mouro","year":"2010","journal-title":"Vet Microbiol"},{"issue":"3","key":"10.1016\/j.cvsm.2019.02.010_bib53","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1128\/MMBR.00016-10","article-title":"Origins and evolution of antibiotic resistance","volume":"74","author":"Davies","year":"2010","journal-title":"Microbiol Mol Biol Rev"},{"issue":"5","key":"10.1016\/j.cvsm.2019.02.010_bib54","first-page":"114","article-title":"Classification of wounds and their management","volume":"20","author":"Percival","year":"2001","journal-title":"Surgery"},{"issue":"19","key":"10.1016\/j.cvsm.2019.02.010_bib55","first-page":"327","article-title":"The differential diagnosis and treatment of thrombotic microangiopathies","volume":"115","author":"Bommer","year":"2018","journal-title":"Dtsch Arztebl Int"},{"issue":"3","key":"10.1016\/j.cvsm.2019.02.010_bib56","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/jca.21470","article-title":"Guidelines on the use of therapeutic apheresis in clinical practice\u2013evidence-based approach from the writing committee of the American Society for Apheresis: the seventh special issue","volume":"31","author":"Joseph","year":"2016","journal-title":"J\u00a0Clin Apher"},{"key":"10.1016\/j.cvsm.2019.02.010_bib57","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3389\/fvets.2018.00161","article-title":"Description of the use of plasma exchange in dogs with cutaneous and renal glomerular vasculopathy","volume":"5","author":"Skulberg","year":"2018","journal-title":"Front Vet Sci"}],"container-title":["Veterinary Clinics of North America: Small Animal Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0195561619300403?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0195561619300403?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T01:43:54Z","timestamp":1759283034000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0195561619300403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S0195561619300403"],"URL":"https:\/\/doi.org\/10.1016\/j.cvsm.2019.02.010","relation":{},"ISSN":["0195-5616"],"issn-type":[{"value":"0195-5616","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cutaneous and Renal Glomerular Vasculopathy","name":"articletitle","label":"Article Title"},{"value":"Veterinary Clinics of North America: Small Animal Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cvsm.2019.02.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}