{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:01:53Z","timestamp":1792504913671,"version":"4.5.0"},"reference-count":85,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinics of North America: Small Animal Practice"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.cvsm.2022.07.010","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T03:30:24Z","timestamp":1666150224000},"page":"121-140","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Histiocytic Diseases"],"prefix":"10.1016","volume":"53","author":[{"given":"Peter F.","family":"Moore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cvsm.2022.07.010_bib1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1177\/0300985813510413","article-title":"A\u00a0review of histiocytic diseases of dogs and cats","volume":"51","author":"Moore","year":"2014","journal-title":"Vet Pathol"},{"issue":"9","key":"10.1016\/j.cvsm.2022.07.010_bib2","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1182\/blood.V84.9.2840.2840","article-title":"Histiocytes and histiocytosis","volume":"84","author":"Cline","year":"1994","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.cvsm.2022.07.010_bib3","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/(SICI)1096-911X(199709)29:3<157::AID-MPO1>3.0.CO;2-C","article-title":"Contemporary classification of histiocytic disorders. The WHO Committee On Histiocytic\/Reticulum Cell Proliferations. Reclassification Working Group of the Histiocyte Society","volume":"29","author":"Favara","year":"1997","journal-title":"Med Pediatr Oncol"},{"issue":"12","key":"10.1016\/j.cvsm.2022.07.010_bib4","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/nri2455","article-title":"Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells","volume":"8","author":"Merad","year":"2008","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"10.1016\/j.cvsm.2022.07.010_bib5","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s00401-012-1018-0","article-title":"Brain dendritic cells: biology and pathology","volume":"124","author":"D'Agostino","year":"2012","journal-title":"Acta Neuropathol"},{"issue":"1","key":"10.1016\/j.cvsm.2022.07.010_bib6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nri1996","article-title":"Steady-state and inflammatory dendritic-cell development","volume":"7","author":"Shortman","year":"2007","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"10.1016\/j.cvsm.2022.07.010_bib7","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s00251-008-0297-z","article-title":"Two canine CD1a proteins are differentially expressed in skin","volume":"60","author":"Looringh van Beeck","year":"2008","journal-title":"Immunogenetics"},{"key":"10.1016\/j.cvsm.2022.07.010_bib8","series-title":"Advances in Veterinary Dermatology","first-page":"77","article-title":"The use of immunological reagents in defining the pathogenesis of canine skin diseases involving proliferation of leukocytes","author":"Moore","year":"1998"},{"issue":"5","key":"10.1016\/j.cvsm.2022.07.010_bib9","first-page":"1699","article-title":"Canine cutaneous histiocytoma is an epidermotropic Langerhans cell histiocytosis that expresses CD1 and specific beta(2)-integrin molecules","volume":"148","author":"Moore","year":"1996","journal-title":"Am J Pathol"},{"issue":"1","key":"10.1016\/j.cvsm.2022.07.010_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-2427(97)00016-0","article-title":"Immunophenotypic characterization of feline Langerhans cells","volume":"58","author":"Saint-Andre Marchal","year":"1997","journal-title":"Vet Immunol Immunopathol"},{"issue":"3","key":"10.1016\/j.cvsm.2022.07.010_bib11","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00251-015-0889-3","article-title":"Refinement of the canine CD1 locus topology and investigation of antibody binding to recombinant canine CD1 isoforms","volume":"68","author":"Schjaerff","year":"2016","journal-title":"Immunogenetics"},{"issue":"3 Pt 1","key":"10.1016\/j.cvsm.2022.07.010_bib12","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1399-0039.1997.tb02745.x","article-title":"A\u00a0feline homologue of CD1 is defined using a feline-specific monoclonal antibody","volume":"49","author":"Woo","year":"1997","journal-title":"Tissue Antigens"},{"issue":"6673","key":"10.1016\/j.cvsm.2022.07.010_bib13","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity","volume":"392","author":"Banchereau","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.cvsm.2022.07.010_bib14","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1600-065X.2008.00639.x","article-title":"CTLA-4: a key regulatory point in the control of autoimmune disease","volume":"223","author":"Scalapino","year":"2008","journal-title":"Immunol Rev"},{"issue":"1","key":"10.1016\/j.cvsm.2022.07.010_bib15","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/COC.0000000000000239","article-title":"CTLA-4 and PD-1 pathways: similarities, differences, and implications of their inhibition","volume":"39","author":"Buchbinder","year":"2016","journal-title":"Am J Clin Oncol"},{"issue":"10","key":"10.1016\/j.cvsm.2022.07.010_bib16","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1002\/eji.200324228","article-title":"Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses","volume":"33","author":"Liang","year":"2003","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.cvsm.2022.07.010_bib17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1399-0039.1992.tb01952.x","article-title":"Canine leukocyte cell adhesion molecules (LeuCAMS): characterization of the CD11\/CD18 family","volume":"40","author":"Danilenko","year":"1992","journal-title":"Tissue Antigens"},{"issue":"1","key":"10.1016\/j.cvsm.2022.07.010_bib18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4049\/jimmunol.155.1.35","article-title":"A\u00a0novel canine leukointegrin, alpha d beta 2, is expressed by specific macrophage subpopulations in tissue and a minor CD8+ lymphocyte subpopulation in peripheral blood","volume":"155","author":"Danilenko","year":"1995","journal-title":"J\u00a0Immunol"},{"issue":"4","key":"10.1016\/j.cvsm.2022.07.010_bib19","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.4049\/jimmunol.163.4.1984","article-title":"The leukocyte integrin alpha D beta 2 binds VCAM-1: evidence for a binding interface between I domain and VCAM-1","volume":"163","author":"Van der Vieren","year":"1999","journal-title":"J\u00a0Immunol"},{"issue":"1","key":"10.1016\/j.cvsm.2022.07.010_bib20","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1177\/104063871102300123","article-title":"Pathological and immunohistochemical features of subdural histiocytic sarcomas in 15 dogs","volume":"23","author":"Ide","year":"2011","journal-title":"J\u00a0Vet Diagn Invest"},{"issue":"4","key":"10.1016\/j.cvsm.2022.07.010_bib21","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jcpa.2014.07.003","article-title":"Immunohistochemical expression of ionized calcium binding adapter molecule 1 in cutaneous histiocytic proliferative, neoplastic and inflammatory disorders of dogs and cats","volume":"151","author":"Pierezan","year":"2014","journal-title":"J\u00a0Comp Pathol"},{"issue":"2\u20133","key":"10.1016\/j.cvsm.2022.07.010_bib22","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jcpa.2012.06.009","article-title":"The class A macrophage scavenger receptor CD204 is a useful immunohistochemical marker of canine histiocytic sarcoma","volume":"148","author":"Kato","year":"2013","journal-title":"J\u00a0Comp Pathol"},{"issue":"1","key":"10.1016\/j.cvsm.2022.07.010_bib23","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0021-9150(01)00624-4","article-title":"Production, characterization, and interspecies reactivities of monoclonal antibodies against human class A macrophage scavenger receptors","volume":"161","author":"Tomokiyo","year":"2002","journal-title":"Atherosclerosis"},{"issue":"4","key":"10.1016\/j.cvsm.2022.07.010_bib24","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1002\/eji.200535660","article-title":"Expression of the class A macrophage scavenger receptor on specific subpopulations of murine dendritic cells limits their endotoxin response","volume":"36","author":"Becker","year":"2006","journal-title":"Eur J Immunol"},{"issue":"1","key":"10.1016\/j.cvsm.2022.07.010_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016320","article-title":"Characterization of dendritic cells subpopulations in skin and afferent lymph in the swine model","volume":"6","author":"Marquet","year":"2011","journal-title":"PloS One"},{"issue":"21","key":"10.1016\/j.cvsm.2022.07.010_bib26","doi-asserted-by":"crossref","first-page":"6611","DOI":"10.1158\/0008-5472.CAN-11-1801","article-title":"Targeting the immunoregulator SRA\/CD204 potentiates specific dendritic cell vaccine-induced T-cell response and antitumor immunity","volume":"71","author":"Yi","year":"2011","journal-title":"Cancer Res"},{"issue":"6","key":"10.1016\/j.cvsm.2022.07.010_bib27","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1177\/030098588402100602","article-title":"Systemic histiocytosis of Bernese mountain dogs","volume":"21","author":"Moore","year":"1984","journal-title":"Vet Pathol"},{"issue":"1","key":"10.1016\/j.cvsm.2022.07.010_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/030098588602300101","article-title":"Malignant histiocytosis of Bernese mountain dogs","volume":"23","author":"Moore","year":"1986","journal-title":"Vet Pathol"},{"issue":"4","key":"10.1016\/j.cvsm.2022.07.010_bib29","doi-asserted-by":"crossref","first-page":"377","DOI":"10.2460\/javma.1986.188.04.377","article-title":"Cutaneous histiocytosis in dogs","volume":"188","author":"Mays","year":"1986","journal-title":"J\u00a0Am Vet Med Assoc"},{"issue":"1","key":"10.1016\/j.cvsm.2022.07.010_bib30","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/00000372-200002000-00009","article-title":"Canine cutaneous and systemic histiocytosis: reactive histiocytosis of dermal dendritic cells","volume":"22","author":"Affolter","year":"2000","journal-title":"Am J Dermatopathol"},{"issue":"12","key":"10.1016\/j.cvsm.2022.07.010_bib31","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1038\/ni731","article-title":"Dermal-resident CD14+ cells differentiate into Langerhans cells","volume":"2","author":"Larregina","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1016\/j.cvsm.2022.07.010_bib32","series-title":"Schalm's Veterinary Hematology","first-page":"540","article-title":"Histiocytic Proliferative Diseases","author":"Moore","year":"2010"},{"issue":"5","key":"10.1016\/j.cvsm.2022.07.010_bib33","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1365-3164.2007.00615.x","article-title":"Cutaneous reactive histiocytosis in dogs: a retrospective evaluation of 32 cases","volume":"18","author":"Palmeiro","year":"2007","journal-title":"Vet Dermatol"},{"issue":"1","key":"10.1016\/j.cvsm.2022.07.010_bib34","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1365-3164.2012.01106.x","article-title":"Canine inflamed nonepitheliotropic cutaneous T-cell lymphoma: a diagnostic conundrum","volume":"24","author":"Moore","year":"2013","journal-title":"Vet Dermatol"},{"issue":"1\u20132","key":"10.1016\/j.cvsm.2022.07.010_bib35","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.vetimm.2011.12.019","article-title":"A\u00a0novel clonality assay for the assessment of canine T\u00a0cell proliferations","volume":"145","author":"Keller","year":"2012","journal-title":"Vet Immunol Immunopathol"},{"issue":"1","key":"10.1016\/j.cvsm.2022.07.010_bib36","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1354\/vp.39-1-74","article-title":"Localized and disseminated histiocytic sarcoma of dendritic cell origin in dogs","volume":"39","author":"Affolter","year":"2002","journal-title":"Vet Pathol"},{"issue":"1","key":"10.1016\/j.cvsm.2022.07.010_bib37","first-page":"83","article-title":"Morphologic and biologic characteristics of the canine cutaneous histiocytoma","volume":"29","author":"Taylor","year":"1969","journal-title":"Cancer Res"},{"key":"10.1016\/j.cvsm.2022.07.010_bib38","first-page":"147","article-title":"Neoplastic diseases of dogs. II. Mast cell sarcoma, lymphosarcoma, histiocytoma","volume":"54","author":"Mulligan","year":"1948","journal-title":"Arch Path"},{"key":"10.1016\/j.cvsm.2022.07.010_bib39","series-title":"Current Veterinary therapy XIII: small Animal Practice","first-page":"588","article-title":"Canine cutaneous histiocytic disease","author":"Affolter","year":"2000"},{"issue":"10","key":"10.1016\/j.cvsm.2022.07.010_bib40","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/jsap.12531","article-title":"Retrospective characterisation of solitary cutaneous histiocytoma with lymph node metastasis in eight dogs","volume":"57","author":"Faller","year":"2016","journal-title":"J\u00a0Small Anim Pract"},{"issue":"2","key":"10.1016\/j.cvsm.2022.07.010_bib41","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0021-9975(79)90058-6","article-title":"Patterns of lymphoid infiltrate in the canine cutaneous histiocytoma","volume":"89","author":"Cockerell","year":"1979","journal-title":"J\u00a0Comp Pathol"},{"issue":"3\u20134","key":"10.1016\/j.cvsm.2022.07.010_bib42","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.vetimm.2007.06.007","article-title":"CCH cells are potent stimulators in the allogeneic mixed leucocyte reaction","volume":"119","author":"Baines","year":"2007","journal-title":"Vet Immunol Immunopathol"},{"issue":"5","key":"10.1016\/j.cvsm.2022.07.010_bib43","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1177\/030098587601300507","article-title":"Canine cutaneous histiocytoma: ultrastructural and cytochemical observations","volume":"13","author":"Glick","year":"1976","journal-title":"Vet Pathol"},{"issue":"1","key":"10.1016\/j.cvsm.2022.07.010_bib44","first-page":"12","article-title":"Canine cutaneous histiocytoma. A light and electron microscopic study","volume":"7","author":"Kelly","year":"1970","journal-title":"Pathol Vet"},{"issue":"3","key":"10.1016\/j.cvsm.2022.07.010_bib45","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1159\/000147733","article-title":"Immunophenotypic and ultrastructural evidence of the Langerhans cell origin of the canine cutaneous histiocytoma","volume":"153","author":"Marchal","year":"1995","journal-title":"Acta Anat (Basel)"},{"issue":"3\u20134","key":"10.1016\/j.cvsm.2022.07.010_bib46","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.vetimm.2008.07.012","article-title":"Langerhans cells in porcine skin","volume":"126","author":"Nfon","year":"2008","journal-title":"Vet Immunol Immunopathol"},{"issue":"3","key":"10.1016\/j.cvsm.2022.07.010_bib47","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1177\/0300985811398251","article-title":"Immunohistochemical expression of E-cadherin does not distinguish canine cutaneous histiocytoma from other canine round cell tumors","volume":"48","author":"Ramos-Vara","year":"2011","journal-title":"Vet Pathol"},{"issue":"4","key":"10.1016\/j.cvsm.2022.07.010_bib48","doi-asserted-by":"crossref","first-page":"535","DOI":"10.2460\/javma.1989.194.04.535","article-title":"Multiple, resolving, cutaneous histiocytoma in a dog","volume":"194","author":"Bender","year":"1989","journal-title":"J\u00a0Am Vet Med Assoc"},{"issue":"9","key":"10.1016\/j.cvsm.2022.07.010_bib49","first-page":"1465","article-title":"Generalized eruptive histiocytoma in a dog","volume":"155","author":"Frye","year":"1969","journal-title":"J\u00a0Am Vet Med Assoc"},{"issue":"9","key":"10.1016\/j.cvsm.2022.07.010_bib50","first-page":"1269","article-title":"Generalized cutaneous histiocytoma in a dog (a case report)","volume":"74","author":"Garma-Avina","year":"1979","journal-title":"Vet Med Small Anim Clin"},{"issue":"2","key":"10.1016\/j.cvsm.2022.07.010_bib51","doi-asserted-by":"crossref","first-page":"140","DOI":"10.2460\/javma.1970.156.02.140","article-title":"Eruptive histiocytoma in a dog","volume":"156","author":"Howard","year":"1970","journal-title":"J\u00a0Am Vet Med Assoc"},{"issue":"4","key":"10.1016\/j.cvsm.2022.07.010_bib52","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1046\/j.1365-3164.2000.00192.x","article-title":"Progressive Langerhans' cell histiocytosis in a puppy","volume":"11","author":"Nagata","year":"2000","journal-title":"Vet Dermatol"},{"issue":"2","key":"10.1016\/j.cvsm.2022.07.010_bib53","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0889-8588(05)70510-4","article-title":"Langerhans cell histiocytosis of the skin","volume":"12","author":"Munn","year":"1998","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.1016\/j.cvsm.2022.07.010_bib54","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0889-8588(05)70507-4","article-title":"Nosology and pathology of Langerhans cell histiocytosis","volume":"12","author":"Schmitz","year":"1998","journal-title":"Hematol Oncol Clin North Am"},{"issue":"9","key":"10.1016\/j.cvsm.2022.07.010_bib55","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.2460\/javma.1993.203.09.1300","article-title":"Malignant histiocytosis in a cat","volume":"203","author":"Court","year":"1993","journal-title":"J\u00a0Am Vet Med Assoc"},{"issue":"3","key":"10.1016\/j.cvsm.2022.07.010_bib56","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1939-1676.1995.tb03292.x","article-title":"Clinical vignette. Malignant histiocytosis in a cat","volume":"9","author":"Freeman","year":"1995","journal-title":"J\u00a0Vet Intern"},{"issue":"1","key":"10.1016\/j.cvsm.2022.07.010_bib57","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1939-165X.2008.00005.x","article-title":"Histiocytic sarcoma of macrophage origin in a cat: case report with a literature review of feline histiocytic malignancies and comparison with canine hemophagocytic histiocytic sarcoma","volume":"37","author":"Friedrichs","year":"2008","journal-title":"Vet Clin Pathol"},{"issue":"3","key":"10.1016\/j.cvsm.2022.07.010_bib58","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1939-1676.2001.tb02320.x","article-title":"Malignant histiocytosis in 3 cats","volume":"15","author":"Kraje","year":"2001","journal-title":"J\u00a0Vet Intern Med"},{"issue":"6","key":"10.1016\/j.cvsm.2022.07.010_bib59","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1354\/vp.43-6-1014","article-title":"Histiocytic sarcoma in the tarsus of a cat","volume":"43","author":"Pinard","year":"2006","journal-title":"Vet Pathol"},{"issue":"3","key":"10.1016\/j.cvsm.2022.07.010_bib60","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1748-5827.1995.tb02838.x","article-title":"Inheritance of histiocytosis in Bernese mountain dogs","volume":"36","author":"Padgett","year":"1995","journal-title":"J\u00a0Small Anim Pract"},{"issue":"Suppl 1","key":"10.1016\/j.cvsm.2022.07.010_bib61","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1093\/jhered\/esp039","article-title":"Epidemiology, pathology, and genetics of histiocytic sarcoma in the Bernese mountain dog breed","volume":"100","author":"Abadie","year":"2009","journal-title":"J\u00a0Hered"},{"issue":"3","key":"10.1016\/j.cvsm.2022.07.010_bib62","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1177\/0300985810385153","article-title":"The clinical presentation and histopathologic-immunohistochemical classification of histiocytic sarcomas in the Flat Coated Retriever","volume":"48","author":"Constantino-Casas","year":"2011","journal-title":"Vet Pathol"},{"issue":"12","key":"10.1016\/j.cvsm.2022.07.010_bib63","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1292\/jvms.15-0284","article-title":"Localized pulmonary histiocytic sarcomas in Pembroke Welsh Corgi","volume":"77","author":"Kagawa","year":"2016","journal-title":"J\u00a0Vet Med Sci"},{"issue":"4","key":"10.1016\/j.cvsm.2022.07.010_bib64","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1292\/jvms.15-0627","article-title":"Histological and immunohistochemical studies on primary intracranial canine histiocytic sarcomas","volume":"78","author":"Thongtharb","year":"2016","journal-title":"J\u00a0Vet Med Sci"},{"key":"10.1016\/j.cvsm.2022.07.010_bib65","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/1471-2407-11-201","article-title":"Molecular cytogenetic characterization of canine histiocytic sarcoma: a spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior","volume":"11","author":"Hedan","year":"2011","journal-title":"BMC Cancer"},{"issue":"7","key":"10.1016\/j.cvsm.2022.07.010_bib66","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1158\/1055-9965.EPI-12-0190-T","article-title":"The MTAP-CDKN2A locus confers susceptibility to a naturally occurring canine cancer","volume":"21","author":"Shearin","year":"2012","journal-title":"Cancer Epidemiol biomarkers Prev"},{"issue":"11","key":"10.1016\/j.cvsm.2022.07.010_bib67","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1158\/1535-7163.MCT-17-1273","article-title":"Targeting MEK in a translational model of histiocytic sarcoma","volume":"17","author":"Takada","year":"2018","journal-title":"Mol Cancer Ther"},{"issue":"2","key":"10.1016\/j.cvsm.2022.07.010_bib68","first-page":"220","article-title":"Gain-of-function mutation in PTPN11 in histiocytic sarcomas of Bernese Mountain Dogs. Veterinary and comparative oncology","volume":"16","author":"Thaiwong","year":"2018","journal-title":"Jun"},{"issue":"5","key":"10.1016\/j.cvsm.2022.07.010_bib69","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1354\/vp.43-5-632","article-title":"Canine hemophagocytic histiocytic sarcoma: a proliferative disorder of CD11d+ macrophages","volume":"43","author":"Moore","year":"2006","journal-title":"Vet Pathol"},{"issue":"1","key":"10.1016\/j.cvsm.2022.07.010_bib70","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1939-1676.2007.tb02937.x","article-title":"CCNU for the treatment of dogs with histiocytic sarcoma","volume":"21","author":"Skorupski","year":"2007","journal-title":"J\u00a0Vet Intern Med"},{"issue":"2","key":"10.1016\/j.cvsm.2022.07.010_bib71","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1939-165X.2008.00042.x","article-title":"Dendritic cell leukemia in a Golden Retriever","volume":"37","author":"Allison","year":"2008","journal-title":"Vet Clin Pathol"},{"issue":"1","key":"10.1016\/j.cvsm.2022.07.010_bib72","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1939-165X.2008.00104.x","article-title":"Disseminated histiocytic sarcoma with peripheral blood involvement in a Bernese Mountain dog. Case Reports","volume":"38","author":"Rossi","year":"2009","journal-title":"Vet Clin Pathol"},{"issue":"1","key":"10.1016\/j.cvsm.2022.07.010_bib73","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1354\/vp.39-1-66","article-title":"The diagnosis and prognosis of synovial tumors in dogs: 35 cases","volume":"39","author":"Craig","year":"2002","journal-title":"Vet Pathol"},{"issue":"2","key":"10.1016\/j.cvsm.2022.07.010_bib74","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/jvim.12059","article-title":"Peri-articular histiocytic sarcoma and previous joint disease in Bernese Mountain Dogs","volume":"27","author":"van Kuijk","year":"2013","journal-title":"J\u00a0Vet Intern Med"},{"issue":"2","key":"10.1016\/j.cvsm.2022.07.010_bib75","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1476-5829.2009.00186.x","article-title":"Long-term survival in dogs with localized histiocytic sarcoma treated with CCNU as an adjuvant to local therapy","volume":"7","author":"Skorupski","year":"2009","journal-title":"Vet Comp Oncol"},{"issue":"7","key":"10.1016\/j.cvsm.2022.07.010_bib76","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/jsap.12354","article-title":"Evaluation of a combination chemotherapy protocol including lomustine and doxorubicin in canine histiocytic sarcoma","volume":"56","author":"Cannon","year":"2015","journal-title":"J\u00a0Small Anim Pract"},{"issue":"7","key":"10.1016\/j.cvsm.2022.07.010_bib77","doi-asserted-by":"crossref","first-page":"e0235518","DOI":"10.1371\/journal.pone.0235518","article-title":"Development of canine PD-1\/PD-L1 specific monoclonal antibodies and amplification of canine T\u00a0cell function","volume":"15","author":"Choi","year":"2020","journal-title":"PloS One"},{"issue":"2","key":"10.1016\/j.cvsm.2022.07.010_bib78","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1177\/0300985819900352","article-title":"Generation and validation of an antibody to canine CD19 for diagnostic and future therapeutic purposes","volume":"57","author":"Haran","year":"2020","journal-title":"Vet Pathol"},{"issue":"1","key":"10.1016\/j.cvsm.2022.07.010_bib79","doi-asserted-by":"crossref","first-page":"1676615","DOI":"10.1080\/2162402X.2019.1676615","article-title":"Establishing a model system for evaluating CAR T\u00a0cell therapy using dogs with spontaneous diffuse large B cell lymphoma","volume":"9","author":"Panjwani","year":"2020","journal-title":"Oncoimmunology"},{"issue":"5","key":"10.1016\/j.cvsm.2022.07.010_bib80","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1354\/vp.43-5-646","article-title":"Feline progressive histiocytosis","volume":"43","author":"Affolter","year":"2006","journal-title":"Vet Pathol"},{"issue":"1","key":"10.1016\/j.cvsm.2022.07.010_bib81","first-page":"65","article-title":"Clinical outcome, PDGFRbeta and KIT expression in feline histiocytic disorders: a multicentre study. Veterinary and comparative oncology","volume":"15","author":"Treggiari","year":"2017","journal-title":"Mar"},{"issue":"18","key":"10.1016\/j.cvsm.2022.07.010_bib82","doi-asserted-by":"crossref","first-page":"e96101","DOI":"10.1172\/jci.insight.96101","article-title":"A\u00a0type of human skin dendritic cell marked by CD5 is associated with the development of inflammatory skin disease","volume":"2","author":"Korenfeld","year":"2017","journal-title":"JCI Insight"},{"issue":"6","key":"10.1016\/j.cvsm.2022.07.010_bib83","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1354\/vp.45-6-816","article-title":"Feline pulmonary Langerhans cell histiocytosis with multiorgan involvement","volume":"45","author":"Busch","year":"2008","journal-title":"Vet Pathol"},{"issue":"4","key":"10.1016\/j.cvsm.2022.07.010_bib84","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1177\/1098612X19842384","article-title":"Pulmonary Langerhans cell histiocytosis in cats and a literature review of feline histiocytic diseases","volume":"22","author":"Argenta","year":"2020","journal-title":"J\u00a0feline Med Surg"},{"issue":"5","key":"10.1016\/j.cvsm.2022.07.010_bib85","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1097\/00000478-200105000-00010","article-title":"Pulmonary Langerhans' cell histiocytosis: molecular analysis of clonality","volume":"25","author":"Yousem","year":"2001","journal-title":"Am J Surg Pathol"}],"container-title":["Veterinary Clinics of North America: Small Animal Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0195561622000973?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0195561622000973?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T01:47:46Z","timestamp":1759283266000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0195561622000973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":85,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S0195561622000973"],"URL":"https:\/\/doi.org\/10.1016\/j.cvsm.2022.07.010","relation":{},"ISSN":["0195-5616"],"issn-type":[{"value":"0195-5616","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histiocytic Diseases","name":"articletitle","label":"Article Title"},{"value":"Veterinary Clinics of North America: Small Animal Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cvsm.2022.07.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}