{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:53:49Z","timestamp":1788184429970,"version":"build-2803163510"},"reference-count":69,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100005302","name":"University of Illinois at Urbana-Champaign","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005302","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinics of North America: Small Animal Practice"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.cvsm.2025.03.003","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T11:18:38Z","timestamp":1745493518000},"page":"717-730","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Drug-Induced Liver Injury"],"prefix":"10.1016","volume":"55","author":[{"given":"Jennifer M.","family":"Reinhart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cvsm.2025.03.003_bib1","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1007\/s00204-020-02885-1","article-title":"Drug induced liver injury: an update","volume":"94","author":"Garcia-Cortes","year":"2020","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.cvsm.2025.03.003_bib2","doi-asserted-by":"crossref","first-page":"947","DOI":"10.7326\/0003-4819-137-12-200212170-00007","article-title":"Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States","volume":"137","author":"Ostapowicz","year":"2002","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.cvsm.2025.03.003_bib3","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1159\/000374090","article-title":"Acetaminophen: dose-dependent drug hepatotoxicity and acute liver failure in patients","volume":"33","author":"Jaeschke","year":"2015","journal-title":"Dig Dis"},{"key":"10.1016\/j.cvsm.2025.03.003_bib4","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1002\/hep.22272","article-title":"Relationship between daily dose of oral medications and idiosyncratic drug-induced liver injury: search for signals","volume":"47","author":"Lammert","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.cvsm.2025.03.003_bib5","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/j.cgh.2013.12.016","article-title":"Relationship between characteristics of medications and drug-induced liver disease phenotype and outcome","volume":"12","author":"Vuppalanchi","year":"2014","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cvsm.2025.03.003_bib6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cld.2019.08.003","article-title":"Genetic predisposition to drug-induced liver injury","volume":"24","author":"Stephens","year":"2020","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.cvsm.2025.03.003_bib7","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/jvp.12478","article-title":"A single-nucleotide polymorphism in the canine cytochrome b(5) reductase (CYB5R3) gene is associated with sulfonamide hypersensitivity and is overrepresented in Doberman Pinschers","volume":"41","author":"Reinhart","year":"2018","journal-title":"J Vet Pharmacol Ther"},{"key":"10.1016\/j.cvsm.2025.03.003_bib8","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1097\/FPC.0b013e3283589a76","article-title":"Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs","volume":"22","author":"Urban","year":"2012","journal-title":"Pharmacogenet Genomics"},{"key":"10.1016\/j.cvsm.2025.03.003_bib9","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1053\/j.gastro.2019.01.034","article-title":"A missense variant in PTPN22 is a risk factor for drug-induced liver injury","volume":"156","author":"Cirulli","year":"2019","journal-title":"Gastroenterology"},{"issue":"8","key":"10.1016\/j.cvsm.2025.03.003_bib10","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.3390\/genes12081265","article-title":"Whole genome sequencing reveals multiple linked genetic variants on canine chromosome 12 associated with risk for symmetrical lupoid onychodystrophy (SLO) in the bearded collie","volume":"12","author":"Gershony","year":"2021","journal-title":"Genes"},{"key":"10.1016\/j.cvsm.2025.03.003_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetimm.2021.110271","article-title":"Dog leukocyte antigen (DLA) class II genotypes associated with chronic enteropathy in French bulldogs and miniature dachshunds","volume":"237","author":"Nakazawa","year":"2021","journal-title":"Vet Immunol Immunopathol"},{"key":"10.1016\/j.cvsm.2025.03.003_bib12","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1093\/jhered\/est051","article-title":"A candidate gene analysis of canine hypoadrenocorticism in 3 dog breeds","volume":"104","author":"Short","year":"2013","journal-title":"J Hered"},{"key":"10.1016\/j.cvsm.2025.03.003_bib13","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1186\/1756-0500-4-571","article-title":"PTPN22 polymorphisms may indicate a role for this gene in atopic dermatitis in West Highland white terriers","volume":"4","author":"Roque","year":"2001","journal-title":"BMC Res Notes"},{"key":"10.1016\/j.cvsm.2025.03.003_bib14","series-title":"Kirk\u2019s current veterinary therapy","first-page":"575","article-title":"Drug-associated liver disease","author":"Trepanier","year":"2014"},{"key":"10.1016\/j.cvsm.2025.03.003_bib15","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1124\/dmd.121.000732","article-title":"Novel clinical biomarkers for drug-induced liver injury","volume":"50","author":"Chen","year":"2022","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.cvsm.2025.03.003_bib16","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3390\/ijms17010014","article-title":"RUCAM in drug and herb induced liver injury: the update","volume":"17","author":"Danan","year":"2015","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.cvsm.2025.03.003_bib17","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/clpt.1981.154","article-title":"A method for estimating the probability of adverse drug reactions","volume":"30","author":"Naranjo","year":"1981","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.cvsm.2025.03.003_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0041-008X(68)90169-5","article-title":"Azathioprine effect on normal canine liver and kidney function","volume":"12","author":"Worth","year":"1968","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.cvsm.2025.03.003_bib19","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/jvim.12543","article-title":"Incidence, timing, and risk factors of azathioprine hepatotoxicosis in dogs","volume":"29","author":"Wallisch","year":"2015","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.cvsm.2025.03.003_bib20","series-title":"Saunders handbook of veterinary drugs","author":"Papich","year":"2016"},{"key":"10.1016\/j.cvsm.2025.03.003_bib21","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.dld.2004.09.029","article-title":"Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations","volume":"37","author":"Al Hadithy","year":"2005","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.cvsm.2025.03.003_bib22","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1939-1676.2004.tb00163.x","article-title":"Thiopurine methyltransferase activity in red blood cells of dogs","volume":"18","author":"Kidd","year":"2008","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.cvsm.2025.03.003_bib23","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1939-1676.2000.tb02266.x","article-title":"Thiopurine methyltransferase in red blood cells of dogs, cats, and horses","volume":"14","author":"White","year":"2008","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.cvsm.2025.03.003_bib24","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1939-1676.1996.tb02082.x","article-title":"Treatment of blastomycosis with itraconazole in 112 dogs","volume":"10","author":"Legendre","year":"1996","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.cvsm.2025.03.003_bib25","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0300-483X(96)03560-3","article-title":"N-deacetyl ketoconazole-induced hepatotoxicity in a primary culture system of rat hepatocytes","volume":"117","author":"Rodriguez","year":"1997","journal-title":"Toxicology"},{"key":"10.1016\/j.cvsm.2025.03.003_bib26","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1080\/01480540600651535","article-title":"Involvement of phenobarbital and SKF 525A in the hepatotoxicity of antifungal drugs itraconazole and fluconazole in rats","volume":"29","author":"Somchit","year":"2008","journal-title":"Drug Chem Toxicol"},{"key":"10.1016\/j.cvsm.2025.03.003_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/6746989","article-title":"Comparative hepatotoxicity of fluconazole, ketoconazole, itraconazole, terbinafine, and griseofulvin in rats","volume":"2017","author":"Khoza","year":"2017","journal-title":"J Toxicol"},{"key":"10.1016\/j.cvsm.2025.03.003_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14740338.2017.1270264","article-title":"Clinical hepatotoxicity associated with antifungal agents","volume":"58","author":"Kyriakidis","year":"2016","journal-title":"Expert Opin Drug Saf"},{"key":"10.1016\/j.cvsm.2025.03.003_bib29","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1365-3164.2008.00675.x","article-title":"Adverse effects of ketoconazole in dogs \u2013 a retrospective study","volume":"19","author":"Mayer","year":"2008","journal-title":"Vet Dermatol"},{"key":"10.1016\/j.cvsm.2025.03.003_bib30","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1939-1676.2011.0710.x","article-title":"Retrospective comparison of the efficacy of fluconazole or itraconazole for the treatment of systemic blastomycosis in dogs","volume":"25","author":"Mazepa","year":"2011","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.cvsm.2025.03.003_bib31","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2460\/javma.252.2.201","article-title":"Clinical signs, treatment, and prognostic factors for dogs with histoplasmosis","volume":"252","author":"Wilson","year":"2018","journal-title":"J Amer Vet Med Assoc"},{"key":"10.1016\/j.cvsm.2025.03.003_bib32","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1177\/1098612X12452494","article-title":"Feline histoplasmosis: fluconazole therapy and identification of potential sources of Histoplasma species exposure","volume":"14","author":"Reinhart","year":"2012","journal-title":"J Feline Med Surg"},{"key":"10.1016\/j.cvsm.2025.03.003_bib33","series-title":"Cresemba (isavuconazonium sulfate) [package insert]","year":"2022"},{"key":"10.1016\/j.cvsm.2025.03.003_bib34","series-title":"Noxafil (posaconazole) [package insert]","year":"2015"},{"key":"10.1016\/j.cvsm.2025.03.003_bib35","series-title":"VFEND (voriconazole) [package insert]","year":"2010"},{"key":"10.1016\/j.cvsm.2025.03.003_bib36","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.2460\/javma.1998.212.12.1895","article-title":"Hepatocellular toxicosis associated with administration of carprofen in 21 dogs","volume":"212","author":"MacPhail","year":"1998","journal-title":"J Am Vet Med Assoc"},{"key":"10.1016\/j.cvsm.2025.03.003_bib37","first-page":"119","article-title":"Efficacy and safety of the long-term oral administration of carprofen in the treatment of osteoarthritis in dogs","volume":"158","author":"Autefage","year":"2007","journal-title":"Rev Med Vet-Toulouse"},{"key":"10.1016\/j.cvsm.2025.03.003_bib38","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1136\/vr.160.13.427","article-title":"Long-term treatment with carprofen of 805 dogs with osteoarthritis","volume":"160","author":"Mansa","year":"2007","journal-title":"Vet Rec"},{"key":"10.1016\/j.cvsm.2025.03.003_bib39","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1476-4431.1996.tb00030.x","article-title":"Acute hepatic necrosis and liver failure associated with benzodiazepine therapy in six cats, 1986\u20131995","volume":"6","author":"Bvsc","year":"2007","journal-title":"J Vet Emerg Crit Care"},{"key":"10.1016\/j.cvsm.2025.03.003_bib40","doi-asserted-by":"crossref","first-page":"618","DOI":"10.2460\/javma.1996.209.03.618","article-title":"Fulminant hepatic failure associated with oral administration of diazepam in 11 cats","volume":"209","author":"Center","year":"1996","journal-title":"J Am Vet Med Assoc"},{"key":"10.1016\/j.cvsm.2025.03.003_bib41","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.rvsc.2015.09.016","article-title":"Feline hepatic biotransformation of diazepam: differences between cats and dogs","volume":"103","author":"van Beusekom","year":"2015","journal-title":"Res Vet Sci"},{"key":"10.1016\/j.cvsm.2025.03.003_bib42","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1136\/vr.d4344","article-title":"Suspected side effects of doxycycline use in dogs - a retrospective study of 386 cases","volume":"169","author":"Schulz","year":"2011","journal-title":"Vet Rec"},{"key":"10.1016\/j.cvsm.2025.03.003_bib43","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1136\/vr.101031","article-title":"Side effects suspected to be related to doxycycline use in cats","volume":"172","author":"Schulz","year":"2013","journal-title":"Vet Rec"},{"key":"10.1016\/j.cvsm.2025.03.003_bib44","doi-asserted-by":"crossref","first-page":"628","DOI":"10.2460\/javma.1993.202.04.628","article-title":"Increased alanine transaminase activity associated with tetracycline administration in a cat","volume":"202","author":"Kaufman","year":"1993","journal-title":"J Am Vet Med Assoc"},{"key":"10.1016\/j.cvsm.2025.03.003_bib45","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1476-5829.2009.00197.x","article-title":"Prevalence of elevated alanine transaminase activity in dogs treated with CCNU (Lomustine)","volume":"7","author":"Hosoya","year":"2009","journal-title":"Vet Comp Oncol"},{"key":"10.1016\/j.cvsm.2025.03.003_bib46","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1939-1676.2004.tb00138.x","article-title":"Hepatotoxicity associated with CCNU (Lomustine) chemotherapy in dogs","volume":"18","author":"Kristal","year":"2004","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.cvsm.2025.03.003_bib47","doi-asserted-by":"crossref","first-page":"810","DOI":"10.2460\/ajvr.81.10.810","article-title":"Biochemical, functional, and histopathologic characterization of lomustine-induced liver injury in dogs","volume":"81","author":"Dedeaux","year":"2020","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.cvsm.2025.03.003_bib48","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1111\/j.1939-1676.2011.0743.x","article-title":"Prospective randomized clinical trial assessing the efficacy of Denamarin for prevention of CCNU-induced hepatopathy in tumor-bearing dogs","volume":"25","author":"Skorupski","year":"2011","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.cvsm.2025.03.003_bib49","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1177\/1098612X12453836","article-title":"Low apparent risk of CCNU (lomustine)-associated clinical hepatotoxicity in cats","volume":"14","author":"Musser","year":"2012","journal-title":"J Fel Med Surg"},{"key":"10.1016\/j.cvsm.2025.03.003_bib50","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1939-1676.1988.tb02812.x","article-title":"Methimazole treatment of 262 cats with hyperthyroidism","volume":"2","author":"Peterson","year":"1988","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.cvsm.2025.03.003_bib51","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.2460\/javma.1991.199.08.1060","article-title":"Hepatotoxicity of phenobarbital in dogs: 18 cases (1985-1989)","volume":"199","author":"Dayrell-Hart","year":"1991","journal-title":"J Am Vet Med Assoc"},{"key":"10.1016\/j.cvsm.2025.03.003_bib52","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/jvim.13841","article-title":"2015 ACVIM small animal consensus statement on seizure management in dogs","volume":"30","author":"Podell","year":"2016","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.cvsm.2025.03.003_bib53","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1365-3164.2011.01030.x","article-title":"Selection of antibiotics for meticillin-resistant Staphylococcus pseudintermedius: time to revisit some old drugs?","volume":"23","author":"Papich","year":"2012","journal-title":"Vet Dermatol"},{"key":"10.1016\/j.cvsm.2025.03.003_bib54","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/vde.12083","article-title":"Adverse effects of rifampicin in dogs and serum alanine aminotransferase monitoring recommendations based on a retrospective study of 344 dogs","volume":"24","author":"Bajwa","year":"2013","journal-title":"Vet Dermatol"},{"key":"10.1016\/j.cvsm.2025.03.003_bib55","doi-asserted-by":"crossref","first-page":"171-e136","DOI":"10.1111\/vde.12404","article-title":"Rifampicin treatment of canine pyoderma due to multidrug-resistant meticillin-resistant staphylococci: a retrospective study of 32 cases","volume":"28","author":"De Lucia","year":"2017","journal-title":"Vet Dermatol"},{"key":"10.1016\/j.cvsm.2025.03.003_bib56","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/vde.13105","article-title":"Rifampicin treatment of canine multidrug-resistant meticillin-resistant staphylococcal pyoderma: a retrospective study of 51 cases","volume":"33","author":"Harbour","year":"2022","journal-title":"Vet Dermatol"},{"key":"10.1016\/j.cvsm.2025.03.003_bib57","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1939-1676.2003.tb02495.x","article-title":"Clinical findings in 40 dogs with hypersensitivity associated with administration of potentiated sulfonamides","volume":"17","author":"Trepanier","year":"2003","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.cvsm.2025.03.003_bib58","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1939-1676.1997.tb00068.x","article-title":"Association of hepatic necrosis with trimethoprim sulfonamide administration in 4 dogs","volume":"11","author":"Twedt","year":"1997","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.cvsm.2025.03.003_bib59","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/BF00347744","article-title":"An in vitro investigation of predisposition to sulphonamide idiosyncratic toxicity in dogs","volume":"14","author":"Cribb","year":"1990","journal-title":"Vet Res Comm Commun"},{"key":"10.1016\/j.cvsm.2025.03.003_bib60","doi-asserted-by":"crossref","first-page":"479","DOI":"10.2460\/javma.1985.186.05.479","article-title":"Sulfadiazine-induced allergy in six Doberman pinschers","volume":"186","author":"Giger","year":"1985","journal-title":"J Amer Vet Med Assoc"},{"key":"10.1016\/j.cvsm.2025.03.003_bib61","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1365-2885.2004.00576.x","article-title":"Idiosyncratic toxicity associated with potentiated sulfonamides in the dog","volume":"27","author":"Trepanier","year":"2004","journal-title":"J Vet Pharmacol Therapeut"},{"key":"10.1016\/j.cvsm.2025.03.003_bib62","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1128\/cdli.2.2.199-204.1995","article-title":"Immune response to sulfamethoxazole in patients with AIDS","volume":"2","author":"Daftarian","year":"1995","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1016\/j.cvsm.2025.03.003_bib63","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/j.1365-2222.2006.02506.x","article-title":"Association of drug-serum protein adducts and anti-drug antibodies in dogs with sulphonamide hypersensitivity: a naturally occurring model of idiosyncratic drug toxicity","volume":"36","author":"Lavergne","year":"2006","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.cvsm.2025.03.003_bib64","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0006-2952(97)00140-8","article-title":"Cytosolic arylamine N-acetyltransferase (NAT) deficiency in the dog and other canids due to an absence of NAT genes","volume":"54","author":"Trepanier","year":"1997","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.cvsm.2025.03.003_bib65","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1111\/j.1939-1676.2011.00783.x","article-title":"Apparent acute idiosyncratic hepatic necrosis associated with zonisamide administration in a dog","volume":"25","author":"Miller","year":"2011","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.cvsm.2025.03.003_bib66","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1292\/jvms.11-0164","article-title":"Possible drug-induced hepatopathy in a dog receiving zonisamide monotherapy for treatment of cryptogenic epilepsy","volume":"73","author":"Schwartz","year":"2011","journal-title":"J Vet Med Sci"},{"key":"10.1016\/j.cvsm.2025.03.003_bib67","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/jvim.16398","article-title":"Incidence of hepatopathies in dogs administered zonisamide orally: a retrospective study of 384 cases","volume":"36","author":"Smith","year":"2022","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.cvsm.2025.03.003_bib68","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3390\/healthcare10020278","article-title":"Herb-induced liver injury-a challenging diagnosis","volume":"10","author":"Nunes","year":"2022","journal-title":"Healthcare (Basel)"},{"key":"10.1016\/j.cvsm.2025.03.003_bib69","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/NT.0000000000000399","article-title":"Veterinary pet supplements and nutraceuticals","volume":"55","author":"Finno","year":"2020","journal-title":"Nutr Today"}],"container-title":["Veterinary Clinics of North America: Small Animal Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0195561625000294?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0195561625000294?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T02:00:17Z","timestamp":1749261617000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0195561625000294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0195561625000294"],"URL":"https:\/\/doi.org\/10.1016\/j.cvsm.2025.03.003","relation":{},"ISSN":["0195-5616"],"issn-type":[{"value":"0195-5616","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Drug-Induced Liver Injury","name":"articletitle","label":"Article Title"},{"value":"Veterinary Clinics of North America: Small Animal Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cvsm.2025.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}