{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:26:31Z","timestamp":1786987591878,"version":"build-2736575974"},"reference-count":47,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2003,12]]},"DOI":"10.1016\/j.cyto.2003.08.006","type":"journal-article","created":{"date-parts":[[2003,10,17]],"date-time":"2003-10-17T13:42:29Z","timestamp":1066398149000},"page":"293-303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["The negative-feedback regulation of the IL-13 signal by the IL-13 receptor \u03b12 chain in bronchial epithelial cells"],"prefix":"10.1016","volume":"24","author":[{"given":"Shin,ichiro","family":"Yasunaga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Yuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Arima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Toda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyako","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiho","family":"Goda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Sugita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroichi","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Izuhara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2003.08.006_BIB1","doi-asserted-by":"crossref","first-page":"B2","DOI":"10.1038\/35037000","article-title":"The epidemic of allergy and asthma","volume":"402","author":"Holgate","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.cyto.2003.08.006_BIB2","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1084\/jem.187.9.1537","article-title":"Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice","volume":"187","author":"Akimoto","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.cyto.2003.08.006_BIB3","doi-asserted-by":"crossref","first-page":"6178","DOI":"10.4049\/jimmunol.162.10.6178","article-title":"Th2-induced airway mucus production is dependent on IL-4R\u03b1, but not on eosinophils","volume":"162","author":"Cohn","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2003.08.006_BIB4","doi-asserted-by":"crossref","first-page":"108","DOI":"10.4049\/jimmunol.165.1.108","article-title":"Integrated signals between IL-13, IL-4, and IL-5 regulate airways hyperreactivity","volume":"165","author":"Webb","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2003.08.006_BIB5","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1126\/science.282.5397.2258","article-title":"Interleukin-13: central mediator of allergic asthma","volume":"282","author":"Wills-Karp","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.cyto.2003.08.006_BIB6","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1126\/science.282.5397.2261","article-title":"Requirement for IL-13 independently of IL-4 in experimental asthma","volume":"282","author":"Gr\u00fcnig","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.cyto.2003.08.006_BIB7","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1172\/JCI5909","article-title":"Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production","volume":"103","author":"Zhu","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cyto.2003.08.006_BIB8","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nm734","article-title":"Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma","volume":"8","author":"Kuperman","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.cyto.2003.08.006_BIB9","first-page":"368","article-title":"Interleukin-13 and interleukin-4 are coexpressed in atopic asthma","volume":"108","author":"Kotsimbos","year":"1996","journal-title":"Proc Assoc Am Physicians"},{"key":"10.1016\/j.cyto.2003.08.006_BIB10","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1034\/j.1398-9995.1999.00889.x","article-title":"Cytokine profiles of BAL T cells and T-cell clones obtained from human asthmatic airways after local allergen challenge","volume":"54","author":"Bodey","year":"1999","journal-title":"Allergy"},{"key":"10.1016\/j.cyto.2003.08.006_BIB11","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/hmg\/9.4.549","article-title":"Genetic variants of IL-13 signalling and human asthma and atopy","volume":"9","author":"Heinzmann","year":"2000","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.cyto.2003.08.006_BIB12","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1067\/mai.2002.124656","article-title":"Upregulation of IL-13 concentration in vivo by the IL13 variant associated with bronchial asthma","volume":"109","author":"Arima","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.cyto.2003.08.006_BIB13","first-page":"505","article-title":"Recent advances in understanding how interleukin-13 signals are involved in the pathogenesis of bronchial asthma","volume":"48","author":"Izuhara","year":"2000","journal-title":"Arch Immunol Ther Exp"},{"key":"10.1016\/j.cyto.2003.08.006_BIB14","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2174\/1568010023344661","article-title":"IL-4 and IL-13: their pathological roles in allergic diseases and their potential in developing new therapies","volume":"1","author":"Izuhara","year":"2002","journal-title":"Curr Drug Targets Inflamm Allergy"},{"key":"10.1016\/j.cyto.2003.08.006_BIB15","doi-asserted-by":"crossref","first-page":"20818","DOI":"10.1074\/jbc.274.30.20818","article-title":"Characterization of the cytoplasmic domain of interleukin-13 receptor-\u03b1","volume":"274","author":"Orchansky","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cyto.2003.08.006_BIB16","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1093\/intimm\/12.11.1499","article-title":"Characterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor \u03b1 chain 1: redundancy of requirement of tyrosine residue for STAT3 activation","volume":"12","author":"Umeshita-Suyama","year":"2000","journal-title":"Int Immunol"},{"key":"10.1016\/j.cyto.2003.08.006_BIB17","doi-asserted-by":"crossref","first-page":"9864","DOI":"10.1074\/jbc.273.16.9864","article-title":"Regulation of interleukin-13 receptor constituents on mature human B lymphocytes","volume":"273","author":"Ogata","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cyto.2003.08.006_BIB18","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1006\/cyto.2000.0814","article-title":"Localization of human interleukin 13 receptor in non-haematopoietic cells","volume":"13","author":"Akaiwa","year":"2001","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2003.08.006_BIB19","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1146\/annurev.iy.13.040195.002101","article-title":"Signaling through the hematopoietic cytokine receptors","volume":"13","author":"Ihle","year":"1995","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.cyto.2003.08.006_BIB20","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1182\/blood.V97.9.2673","article-title":"The interleukin-13 receptor \u03b12 chain: an essential component for binding and internalization but not for interleukin-13-induced signal transduction through the STAT6 pathway","volume":"97","author":"Kawakami","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2003.08.006_BIB21","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/labinvest.3780336","article-title":"Expression of interleukin 13 receptor in glioma and renal cell carcinoma: IL13R\u03b12 as a decoy receptor for IL13","volume":"81","author":"Bernard","year":"2001","journal-title":"Lab Invest"},{"key":"10.1016\/j.cyto.2003.08.006_BIB22","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1006\/cyto.2002.1972","article-title":"Analysis of novel disease-related genes in bronchial asthma","volume":"19","author":"Yuyama","year":"2002","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2003.08.006_BIB23","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1046\/j.1365-2222.2000.00828.x","article-title":"Allergen-induced airway inflammation and bronchial responsiveness in interleukin-5 receptor \u03b1 chain-deficient mice","volume":"30","author":"Tanaka","year":"2000","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.cyto.2003.08.006_BIB24","doi-asserted-by":"crossref","first-page":"10387","DOI":"10.1074\/jbc.M108109200","article-title":"A novel mechanism by which interferon-gamma can regulate interleukin (IL)-13 responses. Evidence for intracellular stores of IL-13 receptor \u03b1-2 and their rapid mobilization by interferon-\u03b3","volume":"277","author":"Daines","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cyto.2003.08.006_BIB25","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/S0002-9440(10)64405-7","article-title":"Interleukin-13 fusion cytotoxin arrests Schistosoma mansoni egg-induced pulmonary granuloma formation in mice","volume":"161","author":"Jakubzick","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cyto.2003.08.006_BIB26","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1084\/jem.20020903","article-title":"Regulation and function of the interleukin 13 receptor \u03b1 2 during a T helper cell type 2-dominant immune response","volume":"197","author":"Chiaramonte","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.cyto.2003.08.006_BIB27","doi-asserted-by":"crossref","first-page":"29265","DOI":"10.1074\/jbc.271.46.29265","article-title":"cDNA cloning and characterization of the human interleukin 13 receptor \u03b1 chain","volume":"271","author":"Aman","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cyto.2003.08.006_BIB28","doi-asserted-by":"crossref","first-page":"16921","DOI":"10.1074\/jbc.271.28.16921","article-title":"Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor \u03b1 chain","volume":"271","author":"Caput","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cyto.2003.08.006_BIB29","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1084\/jem.20020906","article-title":"Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor \u03b1 2","volume":"197","author":"Wood","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.cyto.2003.08.006_BIB30","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1146\/annurev.immunol.18.1.143","article-title":"Negative regulation of cytokine signaling pathways","volume":"18","author":"Yasukawa","year":"2000","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.cyto.2003.08.006_BIB31","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S1471-4906(01)01941-X","article-title":"Decoy receptors: a strategy to regulate inflammatory cytokines and chemokines","volume":"22","author":"Mantovani","year":"2001","journal-title":"Trends Immunol"},{"key":"10.1016\/j.cyto.2003.08.006_BIB32","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1126\/science.8332913","article-title":"Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4","volume":"261","author":"Colotta","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.cyto.2003.08.006_BIB33","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1172\/JCI10458","article-title":"Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema","volume":"106","author":"Zheng","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cyto.2003.08.006_BIB34","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.4049\/jimmunol.157.5.1846","article-title":"Two distinct stimulus-dependent pathways lead to production of soluble murine interleukin-4 receptor","volume":"157","author":"Blum","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2003.08.006_BIB35","doi-asserted-by":"crossref","first-page":"9474","DOI":"10.1074\/jbc.272.14.9474","article-title":"Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned IL-13 receptor and IL-4 receptor \u03b1-chains","volume":"272","author":"Zhang","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cyto.2003.08.006_BIB36","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.bi.64.070195.003201","article-title":"Transcriptional responses to polypeptide ligands: the JAK-STAT pathway","volume":"64","author":"Schindler","year":"1995","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.cyto.2003.08.006_BIB37","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1165\/ajrcmb.25.4.4522","article-title":"Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types","volume":"25","author":"Lee","year":"2001","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.cyto.2003.08.006_BIB38","first-page":"380","article-title":"Stat6 and atopic asthma","volume":"37","author":"Gao","year":"2000","journal-title":"J Med Genet"},{"key":"10.1016\/j.cyto.2003.08.006_BIB39","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/472","article-title":"Ile50Val variant of IL4R\u03b1 upregulates IgE synthesis and associates with atopic asthma","volume":"19","author":"Mitsuyasu","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.cyto.2003.08.006_BIB40","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.4049\/jimmunol.162.3.1227","article-title":"Dominant effect of Ile50Val variant of the human interleukin-4 receptor \u03b1 chain in IgE synthesis","volume":"162","author":"Mitsuyasu","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2003.08.006_BIB41","doi-asserted-by":"crossref","first-page":"407","DOI":"10.4049\/jimmunol.169.1.407","article-title":"Cooperative effects of Th2 cytokines and allergen on normal and asthmatic bronchial epithelial cells","volume":"169","author":"Lordan","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2003.08.006_BIB42","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1247\/csf.23.119","article-title":"Establishment and characterization of tracheal epithelial cell lines, TM01 and TM02-3, from transgenic mice bearing temperature-sensitive simian virus 40 large T-antigen gene","volume":"23","author":"Sugiyama","year":"1998","journal-title":"Cell Struct Funct"},{"key":"10.1016\/j.cyto.2003.08.006_BIB43","doi-asserted-by":"crossref","first-page":"5811","DOI":"10.1128\/MCB.16.10.5811","article-title":"Requirements for interleukin-4-induced gene expression and functional characterization of Stat6","volume":"16","author":"Mikita","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cyto.2003.08.006_BIB44","doi-asserted-by":"crossref","first-page":"29331","DOI":"10.1074\/jbc.M910290199","article-title":"Interleukin-15 induces rapid tyrosine phosphorylation of STAT6 and the expression of interleukin-4 in mouse mast cells","volume":"275","author":"Masuda","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cyto.2003.08.006_BIB45","doi-asserted-by":"crossref","first-page":"5561","DOI":"10.1210\/endo.138.12.5613","article-title":"Transforming growth factor-\u03b21 induces a mesenchyme-like cell shape without epithelial polarization in thyrocytes and inhibits thyroid folliculogenesis in collagen gel culture","volume":"138","author":"Toda","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.cyto.2003.08.006_BIB46","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1074\/jbc.271.2.619","article-title":"Signal transduction pathway of interleukin-4 and interleukin-13 in human B cells derived from X-linked severe combined immunodeficiency patients","volume":"271","author":"Izuhara","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cyto.2003.08.006_BIB47","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1006\/bbrc.1993.1147","article-title":"The chimeric receptor between interleukin-2 receptor \u03b2 chain and interleukin-4 receptor transduces interleukin-2 signal","volume":"190","author":"Izuhara","year":"1993","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466603003053?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466603003053?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:47:50Z","timestamp":1760906870000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466603003053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["S1043466603003053"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2003.08.006","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2003,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The negative-feedback regulation of the IL-13 signal by the IL-13 receptor \u03b12 chain in bronchial epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2003.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}