{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:05:59Z","timestamp":1761487559294},"reference-count":53,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1016\/j.cyto.2006.01.009","type":"journal-article","created":{"date-parts":[[2006,3,28]],"date-time":"2006-03-28T12:10:19Z","timestamp":1143547819000},"page":"281-288","source":"Crossref","is-referenced-by-count":11,"title":["Influence of interleukin-2 and interferon-gamma in murine schistosomiasis"],"prefix":"10.1016","volume":"33","author":[{"given":"Rashika","family":"El Ridi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabab","family":"Salem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal","family":"Wagih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noha","family":"Mahana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maha","family":"El Demellawy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatem","family":"Tallima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2006.01.009_bib1","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.vaccine.2003.07.010","article-title":"IL-12 enhances protective immunity engendered by immunization with recombinant 14 kDa Schistosoma mansoni fatty acid-binding protein through an IFN-\u03b3 and TNF-\u03b1 dependent pathway","volume":"22","author":"Fonseca","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.cyto.2006.01.009_bib2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.4049\/jimmunol.152.1.193","article-title":"T and B epitope determination and analysis of multiple antigenic peptides for the Schistosoma mansoni experimental vaccine triose-phosphate isomerase","volume":"152","author":"Reynolds","year":"1994","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2006.01.009_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-3024.1997.d01-138.x","article-title":"Analysis of the immune response elicited by a multiple antigen peptide (MAP) composed of two distinct protective antigens derived from the parasite Schistosoma mansoni","volume":"10","author":"Ferru","year":"1997","journal-title":"Parasite Immunol"},{"key":"10.1016\/j.cyto.2006.01.009_bib4","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.4049\/jimmunol.142.4.1342","article-title":"Protective immunity in mice vaccinated with the Schistosoma mansoni P-28-1 antigen","volume":"142","author":"Wolowczuk","year":"1989","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2006.01.009_bib5","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1128\/IAI.62.9.3723-3730.1994","article-title":"Protective effect of rSm28GST-specific T cells in schistosomiasis: role of gamma interferon","volume":"62","author":"Pancre","year":"1994","journal-title":"Infect Immun"},{"key":"10.1016\/j.cyto.2006.01.009_bib6","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1016\/S0264-410X(03)00180-4","article-title":"Differences in immunogenicity and vaccine potential of peptides from Schistosoma mansoni glyceraldehyde 3-phosphate dehydrogenase","volume":"21","author":"Tallima","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.cyto.2006.01.009_bib7","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.0300-9475.2004.01497.x","article-title":"Immunogenicity and vaccine potential of di-peptidic multiple antigen peptides from Schistosoma mansoni glyceraldehyde 3-phosphate dehydrogenase","volume":"60","author":"El Ridi","year":"2004","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.cyto.2006.01.009_bib8","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0065-308X(08)60048-2","article-title":"The radiation-attenuated vaccine against schistosomes in animal models: paradigm for a human vaccine?","volume":"39","author":"Coulson","year":"1997","journal-title":"Adv Parasitol"},{"key":"10.1016\/j.cyto.2006.01.009_bib9","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0169-4758(00)01788-9","article-title":"Defining a schistosomiasis vaccination strategy- Is it really Th1 versus Th2?","volume":"16","author":"Wynn","year":"2000","journal-title":"Parasitol Today"},{"key":"10.1016\/j.cyto.2006.01.009_bib10","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1128\/IAI.69.1.228-236.2001","article-title":"Signaling via interleukin-4 receptor \u03b1-chain is required for successful vaccination against schistosomiasis in BALB\/c mice","volume":"69","author":"Mountford","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.cyto.2006.01.009_bib11","doi-asserted-by":"crossref","first-page":"89","DOI":"10.4269\/ajtmh.1984.33.89","article-title":"Comparison of Schistosoma mansoni migration patterns in normal and irradiated cercaria-immunized mice by means of autoradiographic analysis. Evidence that worm elimination occurs after the skin phase in immunized mice","volume":"33","author":"Dean","year":"1984","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.cyto.2006.01.009_bib12","doi-asserted-by":"crossref","first-page":"96","DOI":"10.4269\/ajtmh.1985.34.96","article-title":"The fate of challenge schistosomula in the murine anti-schistosome vaccine model","volume":"34","author":"von Lichtenberg","year":"1985","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.cyto.2006.01.009_bib13","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1017\/S0031182000063484","article-title":"Migration of the schistosomula of Schistosoma mansoni in mice vaccinated with radiation-attenuated cercariae, and normal mice: an attempt to identify the timing and site of parasite death","volume":"92","author":"Wilson","year":"1986","journal-title":"Parasitology"},{"key":"10.1016\/j.cyto.2006.01.009_bib14","doi-asserted-by":"crossref","first-page":"231","DOI":"10.4269\/ajtmh.1992.47.231","article-title":"Combined microautoradiographic and histopathologic analysis of the fate of challenge Schistosoma mansoni schistosomula in mice immunized with irradiated cercariae","volume":"47","author":"Kassim","year":"1992","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.cyto.2006.01.009_bib15","doi-asserted-by":"crossref","first-page":"238","DOI":"10.4269\/ajtmh.1992.47.238","article-title":"Evidence that both normal and immune elimination of Schistosoma mansoni take place at the lung stage of migration prior to parasite death","volume":"47","author":"Dean","year":"1992","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.cyto.2006.01.009_bib16","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2307\/3284003","article-title":"Comparison of two strains of Schistosoma mansoni with respect to the sites and kinetics of immune elimination in irradiated cercaria-immunized mice","volume":"81","author":"Dean","year":"1995","journal-title":"J Parasitol"},{"key":"10.1016\/j.cyto.2006.01.009_bib17","doi-asserted-by":"crossref","first-page":"3654","DOI":"10.4049\/jimmunol.149.11.3654","article-title":"Monoclonal antibody to IFN-\u03b3 modifies pulmonary inflammatory responses and abrogates immunity to Schistosoma mansoni in mice vaccinated with attenuated cercariae","volume":"149","author":"Smythies","year":"1992","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2006.01.009_bib18","doi-asserted-by":"crossref","first-page":"5200","DOI":"10.4049\/jimmunol.153.11.5200","article-title":"Elevated expression of Th1 cytokines and nitric oxide synthase in the lungs of vaccinated mice after challenge infection with Schistosoma mansoni","volume":"153","author":"Wynn","year":"1994","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2006.01.009_bib19","doi-asserted-by":"crossref","first-page":"345","DOI":"10.4049\/jimmunol.162.1.345","article-title":"Optimal vaccination against Schistosoma mansoni requires the induction of both B cell- and IFN-\u03b3-dependent effector mechanisms","volume":"162","author":"Jankovic","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2006.01.009_bib20","doi-asserted-by":"crossref","first-page":"927","DOI":"10.4049\/jimmunol.163.2.927","article-title":"Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni","volume":"163","author":"Hoffmann","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2006.01.009_bib21","doi-asserted-by":"crossref","first-page":"418","DOI":"10.2307\/3279991","article-title":"Decreased binding of cytotoxic antibody by developing Schistosoma mansoni. Evidence for a surface change independent of host antigen adsorption and membrane turnover","volume":"63","author":"Dean","year":"1977","journal-title":"J Parasitol"},{"key":"10.1016\/j.cyto.2006.01.009_bib22","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1017\/S0031182000066890","article-title":"Immune evasion by Schistosoma mansoni: loss of susceptibility to antibody or complement-dependent eosinophil attack by schistosomula cultured in medium free of macromolecules","volume":"82","author":"Dessein","year":"1981","journal-title":"Parasitology"},{"key":"10.1016\/j.cyto.2006.01.009_bib23","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1083\/jcb.103.3.807","article-title":"The lateral diffusion of lipid probes in the surface membrane of Schistosoma mansoni","volume":"103","author":"Foley","year":"1986","journal-title":"J Cell Biol"},{"key":"10.1016\/j.cyto.2006.01.009_bib24","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1365-3024.1989.tb00680.x","article-title":"Biophysical studies of the schistosome surface and their relevance to its properties under immune and drug attack","volume":"11","author":"Kusel","year":"1989","journal-title":"Parasite Immunol"},{"key":"10.1016\/j.cyto.2006.01.009_bib25","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1645\/GE-3122RN","article-title":"Incubation of Schistosoma mansoni lung-stage schistosomula in corn oil exposes their surface membrane antigenic specificities","volume":"89","author":"El Ridi","year":"2003","journal-title":"J Parasitol"},{"key":"10.1016\/j.cyto.2006.01.009_bib26","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1645\/GE-3334","article-title":"Depletion of Schistosoma mansoni lung-stage schistosomula cholesterol by methyl-\u03b2-cyclodextrin dramatically increases specific antibody binding to surface membrane antigens","volume":"90","author":"El Ridi","year":"2004","journal-title":"J Parasitol"},{"key":"10.1016\/j.cyto.2006.01.009_bib27","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1645\/GE-439R","article-title":"Methyl-\u03b2-cyclodextrin treatment and filipin staining reveal the role of cholesterol in surface membrane antigen sequestration of Schistosoma mansoni and S. haematobium lung-stage larvae","volume":"91","author":"Tallima","year":"2005","journal-title":"J Parasitol"},{"key":"10.1016\/j.cyto.2006.01.009_bib28","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1645\/GE-514R.1","article-title":"In vitro and in vivo effects of unsaturated fatty acids on Schistosoma mansoni and S. haematobium lung-stage larvae","volume":"91","author":"Tallima","year":"2005","journal-title":"J Parasitol"},{"key":"10.1016\/j.cyto.2006.01.009_bib29","doi-asserted-by":"crossref","first-page":"5757","DOI":"10.1016\/S0021-9258(17)37526-9","article-title":"Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor \u03b1","volume":"269","author":"Jayadev","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cyto.2006.01.009_bib30","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0166-6851(97)00151-5","article-title":"Interconversion of sphingomyelin and ceramide in adult Schistosoma mansoni","volume":"90","author":"Redman","year":"1997","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.cyto.2006.01.009_bib31","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1046\/j.1365-2567.1997.d01-2227.x","article-title":"Activation of neutral sphingomyelinase in human neutrophils by polyunsaturated fatty acids","volume":"91","author":"Robinson","year":"1997","journal-title":"Immunology"},{"key":"10.1016\/j.cyto.2006.01.009_bib32","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1074\/jbc.M102393200","article-title":"Unsaturated fatty acid-mediated decreases in sterol regulatory element-mediated gene transcription are linked to cellular sphingolipid metabolism","volume":"277","author":"Worgall","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cyto.2006.01.009_bib33","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3109\/00365529309096053","article-title":"Endotoxin, cytokines, and hyperlipidemia","volume":"28","author":"Liao","year":"1993","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.cyto.2006.01.009_bib34","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/00041433-199405030-00008","article-title":"Effects of endotoxin and cytokines on lipid metabolism","volume":"5","author":"Hardartottir","year":"1994","journal-title":"Curr Opin Lipid"},{"key":"10.1016\/j.cyto.2006.01.009_bib35","first-page":"S24","article-title":"Regulation of lipid metabolism by cytokines during host defense","volume":"12","author":"Grunfeld","year":"1996","journal-title":"Nutrition"},{"key":"10.1016\/j.cyto.2006.01.009_bib36","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/S0002-9440(10)63471-2","article-title":"The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient mice","volume":"163","author":"Davenport","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cyto.2006.01.009_bib37","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1161\/01.CIR.0000089083.61317.A1","article-title":"Induction of a regulatory T cell type 1 response reduces the development of atherosclerosis in apolipoprotein E-knockout mice","volume":"108","author":"Mallat","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.cyto.2006.01.009_bib38","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1017\/S0031182000086248","article-title":"The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms","volume":"55","author":"Smithers","year":"1965","journal-title":"Parasitology"},{"key":"10.1016\/j.cyto.2006.01.009_bib39","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal Biochem"},{"key":"10.1016\/j.cyto.2006.01.009_bib40","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1006\/cyto.1998.0426","article-title":"Quantification of murine cytokine mRNAs using real time quantitative reverse transcriptase PCR","volume":"11","author":"Overbergh","year":"1999","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2006.01.009_bib41","first-page":"33","article-title":"The use of real-time reverse transcriptase PCR for the quantification of cytokine gene expression","volume":"14","author":"Overbergh","year":"2003","journal-title":"J Biomol Tech"},{"key":"10.1016\/j.cyto.2006.01.009_bib42","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0022-1759(85)90337-0","article-title":"Detection of monoclonal antibodies specific for carbohydrate epitopes using periodate oxidation","volume":"78","author":"Woodward","year":"1985","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.cyto.2006.01.009_bib43","first-page":"601","article-title":"Relative resistance of the eggs of human schistosomes to digestion in potassium hydroxide","volume":"43","author":"Cheever","year":"1970","journal-title":"Bull World Hlth Org"},{"key":"10.1016\/j.cyto.2006.01.009_bib44","doi-asserted-by":"crossref","first-page":"S107","DOI":"10.1017\/S0031182097001765","article-title":"Cytokine induction and exploitation in schistosome infections","volume":"115","author":"McKerrow","year":"1997","journal-title":"Parasitology"},{"key":"10.1016\/j.cyto.2006.01.009_bib45","first-page":"327","article-title":"Patterns of cytokine production and proliferation by T lymphocytes differ in mice vaccinated or infected with Schistosoma mansoni","volume":"73","author":"Pemberton","year":"1991","journal-title":"Immunology"},{"key":"10.1016\/j.cyto.2006.01.009_bib46","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.4049\/jimmunol.160.4.1708","article-title":"IL-1 \u03b1 and TNF-\u03b1 are required for IL-12-induced development of Th1 cells producing high levels of IFN-\u03b3 in BALB\/c but not C57BL\/6 mice","volume":"160","author":"Shibuya","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2006.01.009_bib47","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1128\/IAI.69.1.228-236.2001","article-title":"Signaling via interleukin-4 receptor \u03b1 chain is required for successful vaccination against schistosomiasis in mice","volume":"69","author":"Mountford","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.cyto.2006.01.009_bib48","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1097\/01.shk.0000142249.08135.e9","article-title":"Innate immune response in Th1- and Th2-dominant mouse strains","volume":"22","author":"Watanabe","year":"2004","journal-title":"Shock"},{"key":"10.1016\/j.cyto.2006.01.009_bib49","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1046\/j.1365-3083.2001.00835.x","article-title":"Role of IgE in primary murine Schistosomiasis mansoni","volume":"53","author":"El Ridi","year":"2001","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.cyto.2006.01.009_bib50","doi-asserted-by":"crossref","first-page":"3880","DOI":"10.1073\/pnas.0400339101","article-title":"Interleukin 2 plays a central role in Th2 differentiation","volume":"101","author":"Cote-Sierra","year":"2004","journal-title":"Proc Nat Acad Sci USA"},{"key":"10.1016\/j.cyto.2006.01.009_bib51","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.4049\/jimmunol.172.7.3983","article-title":"IL-2, regulatory cells, and tolerance","volume":"172","author":"Nelson","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2006.01.009_bib52","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1189\/jlb.0603252","article-title":"Interferon-gamma: an overview of signals, mechanisms and functions","volume":"75","author":"Schroder","year":"2004","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.cyto.2006.01.009_bib53","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1046\/j.1365-2567.1997.00229.x","article-title":"Interleukin-7 in the skin of Schistosoma mansoni-infected mice is associated with a decrease in interferon-gamma production and leads to an aggravation of the disease","volume":"91","author":"Wolowczuk","year":"1997","journal-title":"Immunology"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466606000561?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466606000561?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T21:45:17Z","timestamp":1683409517000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466606000561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":53,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S1043466606000561"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2006.01.009","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}