{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T18:55:23Z","timestamp":1761418523527},"reference-count":41,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2007,9]]},"DOI":"10.1016\/j.cyto.2007.07.004","type":"journal-article","created":{"date-parts":[[2008,1,10]],"date-time":"2008-01-10T00:03:26Z","timestamp":1199923406000},"page":"171-177","source":"Crossref","is-referenced-by-count":30,"title":["Levels of pro-inflammatory cytokines produced from cord blood in-vitro are pathogen dependent and increased in comparison to adult controls"],"prefix":"10.1016","volume":"39","author":[{"given":"Mohamed A.","family":"Mohamed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Cunningham-Rundles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles R.","family":"Dean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek A.","family":"Hammad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirjana","family":"Nesin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2007.07.004_bib1","series-title":"Infectious Diseases of the Fetus and Newborn Infant","first-page":"943","article-title":"Bacterial sepsis and meningitis","author":"Klein","year":"2005"},{"key":"10.1016\/j.cyto.2007.07.004_bib2","series-title":"Nelson Textbook of Pediatrics","first-page":"747","article-title":"Sepsis and shock","author":"Powell","year":"2000"},{"key":"10.1016\/j.cyto.2007.07.004_bib3","series-title":"Infectious Diseases of the Fetus and Newborn Infant","first-page":"20","article-title":"Developmental immunology and role of host defenses in neonatal susceptibility to infection","author":"Lewis","year":"1995"},{"key":"10.1016\/j.cyto.2007.07.004_bib4","series-title":"Avery\u2019s Neonatology; Pathophysiology and Management of the Newborn","first-page":"1235","article-title":"Bacterial and fungal infection","author":"Schelonka","year":"2005"},{"issue":"2","key":"10.1016\/j.cyto.2007.07.004_bib5","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1542\/peds.102.2.e18","article-title":"Decline in sepsis-associated neonatal and infant deaths in the United States, 1979 through 1994","volume":"102","author":"Stoll","year":"1998","journal-title":"Pediatrics"},{"key":"10.1016\/j.cyto.2007.07.004_bib6","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1542\/peds.2005-0552","article-title":"Seventy-five years of neonatal sepsis at Yale:1928\u20132003","volume":"116","author":"Bizzaro","year":"2005","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.cyto.2007.07.004_bib7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1056\/NEJM200001063420103","article-title":"Group B streptococcal disease in the era of intrapartum antibiotic prophylaxis","volume":"342","author":"Schrag","year":"2000","journal-title":"N Engl J Med."},{"key":"10.1016\/j.cyto.2007.07.004_bib8","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0022-3476(96)70192-0","article-title":"Early-onset sepsis in very low birth weight neonates: a report from the National Institute of Child Health and Human Development Neonatal Research Network","volume":"129","author":"Stoll","year":"1996","journal-title":"J Pediatr"},{"key":"10.1016\/j.cyto.2007.07.004_bib9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0022-3476(96)70191-9","article-title":"Late-onset sepsis in very low birth weight neonates: a report from the National Institute of Child Health and Human Development Neonatal Research Network","volume":"129","author":"Gordon","year":"1996","journal-title":"J Pediatr"},{"issue":"19","key":"10.1016\/j.cyto.2007.07.004_bib10","first-page":"2357","article-title":"National Institute of Child Health and Human Development Neonatal Research Network","volume":"292","author":"Stoll","year":"2004","journal-title":"Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection. JAMA."},{"key":"10.1016\/j.cyto.2007.07.004_bib11","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1203\/00006450-199810000-00002","article-title":"Plasma levels and gene expression of granulocyte colony-stimulating factor, tumor necrosis factor-\u03b1, interleukin (IL)-1\u03b2, IL-6, IL-8, and soluble intercellular adhesion molecule-1 in neonatal early onset sepsis","volume":"44","author":"Berner","year":"1998","journal-title":"Pediatr Res"},{"key":"10.1016\/j.cyto.2007.07.004_bib12","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/00006454-200003000-00013","article-title":"Umbilical vein interleukin-6 and tumor necrosis factor \u03b1 plasma concentrations in the very preterm infant","volume":"19","author":"Kashlan","year":"2000","journal-title":"Pediatr Infect Dis J"},{"issue":"5","key":"10.1016\/j.cyto.2007.07.004_bib13","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1515\/JPM.2000.049","article-title":"IL-1 \u03b2, IL-6, IL-8 and G-CSF in the diagnosis of early onset neonatal infection","volume":"28","author":"Buscher","year":"2000","journal-title":"J Perinat Med"},{"issue":"1","key":"10.1016\/j.cyto.2007.07.004_bib14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/01.mpg.0000192246.47959.b2","article-title":"Genetic polymorphisms of CD14, toll-like receptor 4, and caspase-recruitment domain 15 are not associated with necrotizing enterocolitis in very low birth weight infants","volume":"42","author":"Szebeni","year":"2006","journal-title":"J Pediatr Gastroenterol Nutr."},{"key":"10.1016\/j.cyto.2007.07.004_bib15","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/PL00008445","article-title":"Plasma levels of interleukin-6 and interleukin-10 in preterm neonates evaluated for sepsis","volume":"160","author":"Romagnoli","year":"2001","journal-title":"Eur J Pediatr"},{"issue":"1","key":"10.1016\/j.cyto.2007.07.004_bib16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000047118","article-title":"Inflammatory mediators in umbilical plasma from neonates who develop early onset sepsis","volume":"80","author":"Dollner","year":"2001","journal-title":"Biol Neonate"},{"issue":"2","key":"10.1016\/j.cyto.2007.07.004_bib17","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000047130","article-title":"Cord blood levels of IL-6 and IL-8 for the immediate diagnosis of early-onset infection in premature infants","volume":"80","author":"Krueger","year":"2001","journal-title":"Biol Neonate"},{"issue":"6","key":"10.1016\/j.cyto.2007.07.004_bib18","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1055\/s-2001-17857","article-title":"Interleukin-6 and Interleukin-8 in newborn bacterial infection","volume":"18","author":"Mehr","year":"2001","journal-title":"Am J Perinatol"},{"issue":"2","key":"10.1016\/j.cyto.2007.07.004_bib19","first-page":"320","article-title":"Cell-associated interleukin-8 in cord blood of term and preterm infants","volume":"9","author":"Dembinski","year":"2002","journal-title":"Clin Diagn Lab Immunol."},{"issue":"5","key":"10.1016\/j.cyto.2007.07.004_bib20","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1471-0528.2002.01028.x","article-title":"Histological chorioamnionitis and umbilical serum levels of pro-inflammatory cytokines and cytokines inhibitors","volume":"109","author":"Dollner","year":"2002","journal-title":"BJOG"},{"key":"10.1016\/j.cyto.2007.07.004_bib21","doi-asserted-by":"crossref","first-page":"F209","DOI":"10.1136\/fn.88.3.F209","article-title":"Pro-inflammatory and anti-inflammatory cytokine responses in preterm infants with systemic infections","volume":"88","author":"Ng","year":"2003","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.cyto.2007.07.004_bib22","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0002-9378(98)70272-8","article-title":"The fetal inflammatory response syndrome","volume":"179","author":"Gomez","year":"1998","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.cyto.2007.07.004_bib23","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1471-0528.1999.tb08088.x","article-title":"Amniotic fluid concentration of IL-1b, IL-6 and TNF-\u03b1 in chorioamnionitis before 32weeks of gestation with histologic association and neonatal outcome","volume":"106","author":"Baud","year":"1999","journal-title":"Br J Obstet Gynaecol."},{"key":"10.1016\/j.cyto.2007.07.004_bib24","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1203\/00006450-198904000-00006","article-title":"Tumor necrosis factor\/cachectin and interleukin-1 secretions by cord blood monocytes from premature and term neonates","volume":"25","author":"Weatherstone","year":"1989","journal-title":"Pediatr Res"},{"key":"10.1016\/j.cyto.2007.07.004_bib25","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1128\/IAI.60.3.749-753.1992","article-title":"Defective production of interleukin-6 in very small premature infants in response to bacterial pathogens","volume":"60","author":"Yachie","year":"1992","journal-title":"Infect Immun"},{"key":"10.1016\/j.cyto.2007.07.004_bib26","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1203\/00006450-199201000-00003","article-title":"Defective production of interleukin-6 by monocytes: a possible mechanism underlying several host defense deficiencies of neonates","volume":"31","author":"Schibler","year":"1992","journal-title":"Pediatr Res"},{"key":"10.1016\/j.cyto.2007.07.004_bib27","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/jlb.53.4.399","article-title":"Diminished transcription of interleukin-8 by monocytes from preterm neonates","volume":"53","author":"Schibler","year":"1993","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.cyto.2007.07.004_bib28","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF00724497","article-title":"Circulating cytokine concentrations and cytokine production by monocytes from newborn babies and adults","volume":"428","author":"Pillay","year":"1994","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.cyto.2007.07.004_bib29","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1093\/infdis\/172.2.420","article-title":"Group B Streptococci elicit Leukotriene B4 and Interleukin-8 from human monocytes: neonates exhibit a diminished response","volume":"172","author":"Rowen","year":"1995","journal-title":"J Infect Dis"},{"issue":"4","key":"10.1016\/j.cyto.2007.07.004_bib30","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1159\/000013980","article-title":"The production of pro- and anti-inflammatory cytokines in neonates assessed by stimulated whole cord blood culture and by plasma levels at birth","volume":"73","author":"Seghaye","year":"1998","journal-title":"Biol Neonate."},{"issue":"3","key":"10.1016\/j.cyto.2007.07.004_bib31","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1203\/00006450-200203000-00007","article-title":"Cytokine expression of cord and adult blood mononuclear cells in response to Streptococcus agalactiae","volume":"51","author":"Berner","year":"2002","journal-title":"Pediatr Res."},{"key":"10.1016\/j.cyto.2007.07.004_bib32","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0022-3476(05)81706-8","article-title":"Production of tumor necrosis factor by human cells in vitro and in vivo, induced by group B streptococci","volume":"123","author":"Williams","year":"1993","journal-title":"J Pediatr"},{"issue":"9","key":"10.1016\/j.cyto.2007.07.004_bib33","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1053\/jpsu.2001.26359","article-title":"Intracellular cytokine production by fetal and adult monocytes","volume":"36","author":"Hebra","year":"2001","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.cyto.2007.07.004_bib34","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1203\/00006450-200203000-00009","article-title":"Enhanced interleukin-6 and interleukin-8 synthesis in term and preterm infants","volume":"51","author":"Schultz","year":"2002","journal-title":"Pediatr Res"},{"issue":"2","key":"10.1016\/j.cyto.2007.07.004_bib35","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1006\/cyto.2002.0880","article-title":"Endotoxin-stimulated production of IL-6 and IL-8 is increased in short-term cultures of whole blood from healthy term neonates","volume":"18","author":"Dembinski","year":"2002","journal-title":"Cytokine"},{"issue":"5","key":"10.1016\/j.cyto.2007.07.004_bib36","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1203\/01.PDR.0000063368.16142.F9","article-title":"Neonatal inflammatory response","volume":"53","author":"Dembinski","year":"2003","journal-title":"Pediatr Res."},{"issue":"4","key":"10.1016\/j.cyto.2007.07.004_bib37","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S1043-4666(02)00498-2","article-title":"Modulation of pro- and anti-inflammatory cytokine production in very preterm infants","volume":"21","author":"Dembinski","year":"2003","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2007.07.004_bib38","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/infdis\/174.2.332","article-title":"Interleukin-6 production by human neonatal monocytes stimulated by type III group B streptococci","volume":"174","author":"Vallejo","year":"1996","journal-title":"J Infect Dis"},{"issue":"1","key":"10.1016\/j.cyto.2007.07.004_bib39","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1365-2249.2004.02313.x","article-title":"Immature anti-inflammatory response in neonates","volume":"135","author":"Schultz","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.cyto.2007.07.004_bib40","series-title":"Cellular and Molecular Immunology","first-page":"250","article-title":"Effectors mechanisms of immune responses: cytokines","author":"Abbas","year":"1997"},{"key":"10.1016\/j.cyto.2007.07.004_bib41","series-title":"Statistical methods for the analysis of biomedical data","first-page":"187","article-title":"Comparison of two groups: t-tests and rank tests","author":"Woolson","year":"1987"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466607001706?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466607001706?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T16:19:43Z","timestamp":1588263583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466607001706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["S1043466607001706"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2007.07.004","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}