{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:45:28Z","timestamp":1787237128227,"version":"build-2736575974"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1016\/j.cyto.2007.08.010","type":"journal-article","created":{"date-parts":[[2007,10,5]],"date-time":"2007-10-05T07:12:24Z","timestamp":1191568344000},"page":"82-88","source":"Crossref","is-referenced-by-count":32,"title":["Inflammatory cytokines patterns in the placenta of pregnancies complicated by HELLP (hemolysis, elevated liver enzyme, and low platelet) syndrome"],"prefix":"10.1016","volume":"40","author":[{"given":"Andrea L.","family":"Tranquilli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Landi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Corradetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano R.","family":"Giannubilo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Sartini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Pozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Emanuelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2007.08.010_bib1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1081\/PRG-100100138","article-title":"Mortality and morbidity associated with early-onset pre-eclampsia","volume":"19","author":"Murphy","year":"2000","journal-title":"Hypertens Pregnancy"},{"key":"10.1016\/j.cyto.2007.08.010_bib2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00414-004-0484-x","article-title":"HELLP syndrome as a cause of unexpected rapid maternal death-a case report and review of the literature","volume":"119","author":"Simic","year":"2005","journal-title":"Int J Legal Med"},{"key":"10.1016\/j.cyto.2007.08.010_bib3","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1093\/humrep\/dei369","article-title":"An antiphospholipid antibody in serum and follicular fluid is there a correlation with IVF implantation failure?","volume":"21","author":"Buckingham","year":"2006","journal-title":"Hum Reprod"},{"key":"10.1016\/j.cyto.2007.08.010_bib4","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0167-5699(93)90235-D","article-title":"Bidirectional cytokine interactions in the maternal\u2013fetal relationship: is successful pregnancy a TH2 phenomenon?","volume":"14","author":"Wegmann","year":"1993","journal-title":"Immunol Today"},{"key":"10.1016\/j.cyto.2007.08.010_bib5","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1161\/01.HYP.38.3.394","article-title":"Chemokines and leukocyte activation in the fetal circulation during preeclampsia","volume":"38","author":"Mellembakken","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.cyto.2007.08.010_bib6","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ejogrb.2006.08.009","article-title":"White blood cell count as a predictor of the severity of sickle cell disease during pregnancy","volume":"133","author":"Litos","year":"2007","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.cyto.2007.08.010_bib7","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1046\/j.1365-2249.2003.02082.x","article-title":"Monocytes are primed to produce the Th1 type cytokine IL-12 in normal human pregnancy: an intracellular flow cytometric analysis of peripheral blood mononuclear cells","volume":"13","author":"Sacks","year":"2003","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.cyto.2007.08.010_bib8","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1093\/molehr\/gah246","article-title":"IDO expression on decidual and peripheral blood dendritic cells and monocytes\/macrophages after treatment with CTLA-4 or interferon-gamma increase in normal pregnancy but decrease in spontaneous abortion","volume":"11","author":"Miwa","year":"2005","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.cyto.2007.08.010_bib9","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1210\/jc.86.6.2505","article-title":"Expression of inflammatory cytokines in placentas from women with preeclampsia","volume":"86","author":"Benyo","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.cyto.2007.08.010_bib10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1515\/JPM.2003.021","article-title":"Comparative study on the expression of cytokine-receptor genes in normal and preeclamptic human placentas using DNA microarrays","volume":"31","author":"Pang","year":"2003","journal-title":"J Perinat Med"},{"key":"10.1016\/j.cyto.2007.08.010_bib11","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.it.2006.06.009","article-title":"NK cells and human pregnancy\u2014an inflammatory view","volume":"27","author":"Sargent","year":"2006","journal-title":"Trends Immunol"},{"key":"10.1016\/j.cyto.2007.08.010_bib12","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1097\/01.AOG.0000126245.35811.2a","article-title":"Diagnosis, controversies, and management of the syndrome of hemolysis, elevated liver enzymes and low platelet count","volume":"103","author":"Sibai","year":"2004","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.cyto.2007.08.010_bib13","unstructured":"American College of Obstetricians and Gynecologists. Intrauterine growth restriction. In: ACOG practice bulletin no. 12. Washington, DC: American College of Obstetricians and Gynecologists; 2000."},{"key":"10.1016\/j.cyto.2007.08.010_bib14","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1084\/jem.174.4.915","article-title":"Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression","volume":"174","author":"de Waal Malefyt","year":"1991","journal-title":"J Exp Med"},{"key":"10.1016\/j.cyto.2007.08.010_bib15","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0028-2243(94)90291-7","article-title":"Increased levels of cytokines and cytokine activity modifiers in normal pregnancy","volume":"57","author":"Austgulen","year":"1994","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.cyto.2007.08.010_bib16","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jri.2006.03.002","article-title":"Regulation of chemokine production in response to pro-inflammatory cytokines in first trimester decidual cells","volume":"72","author":"Huang","year":"2006","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.cyto.2007.08.010_bib17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0002-9378(94)70077-X","article-title":"Interleukin-10 in amniotic fluid at midtrimester: immune activation and suppression in relation to fetal growth","volume":"171","author":"Heyborne","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.cyto.2007.08.010_bib18","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1093\/molehr\/5.11.1055","article-title":"Effects of interleukin-6 (IL-6) on cytotrophoblastic cells","volume":"5","author":"Meisser","year":"1999","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.cyto.2007.08.010_bib19","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1006\/dbio.1998.9122","article-title":"IL-10 is an autocrine inhibitor of human placental cytotrophoblast MMP-9 production and invasion","volume":"205","author":"Roth","year":"1999","journal-title":"Dev Biol"},{"key":"10.1016\/j.cyto.2007.08.010_bib20","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/1071-5576(95)00007-2","article-title":"Preeclampsia is associated with decreased placental interleukin-6 production","volume":"2","author":"Kauma","year":"1995","journal-title":"J Soc Gynecol Investig"},{"key":"10.1016\/j.cyto.2007.08.010_bib21","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3109\/08830189809042997","article-title":"Interleukin 6 and its receptor: ten years later","volume":"16","author":"Hirano","year":"1998","journal-title":"Int Rev Immunol"},{"key":"10.1016\/j.cyto.2007.08.010_bib22","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S1359-6101(96)00048-2","article-title":"Transforming growth factor-beta: vasculogenesis, angiogenesis, and vessel wall integrity","volume":"8","author":"Pepper","year":"1997","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.cyto.2007.08.010_bib23","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1172\/JCI6380","article-title":"Inhibition of TGF-beta 3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies","volume":"103","author":"Caniggia","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cyto.2007.08.010_bib24","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1083\/jcb.124.1.171","article-title":"Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta binding protein","volume":"124","author":"Taipale","year":"1994","journal-title":"J Cell Biol"},{"key":"10.1016\/j.cyto.2007.08.010_bib25","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1056\/NEJM199802123380706","article-title":"Chemokines\u2013chemotactic cytokines that mediate inflammation","volume":"338","author":"Luster","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cyto.2007.08.010_bib26","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1074-7613(00)80165-X","article-title":"Chemokines: a new classification system and their role in immunity","volume":"12","author":"Zlotnik","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.cyto.2007.08.010_bib27","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1146\/annurev.immunol.15.1.675","article-title":"Human chemokines: an update","volume":"15","author":"Baggiolini","year":"1997","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.cyto.2007.08.010_bib28","doi-asserted-by":"crossref","first-page":"27348","DOI":"10.1074\/jbc.270.45.27348","article-title":"The functional role of the ELR motif in CXC chemokine mediated angiogenesis","volume":"270","author":"Strieter","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cyto.2007.08.010_bib29","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1378\/chest.123.3_suppl.431S","article-title":"Immunomodulatory effect of interleukin-16 on allergic airway inflammation","volume":"123","author":"Little","year":"2003","journal-title":"Chest"},{"key":"10.1016\/j.cyto.2007.08.010_bib30","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1365-2567.2005.02269.x","article-title":"Interleukin-16 inhibits interleukin-13 production by allergen-stimulated blood mononuclear cells","volume":"117","author":"El Bassam","year":"2006","journal-title":"Immunology"},{"key":"10.1016\/j.cyto.2007.08.010_bib31","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1749-6632.2002.tb04208.x","article-title":"Regulation of leukocyte-endothelial interactions by glucocorticoids","volume":"966","author":"Pitzalis","year":"2002","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.cyto.2007.08.010_bib32","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1042\/cs0940557","article-title":"Anti-inflammatory actions of glucocorticoids: molecular mechanisms","volume":"94","author":"Barnes","year":"1998","journal-title":"Clin Sci (Lond)"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104346660700378X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104346660700378X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T11:59:28Z","timestamp":1546516768000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S104346660700378X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["S104346660700378X"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2007.08.010","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}