{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:40:26Z","timestamp":1791276026094,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1016\/j.cyto.2007.11.022","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T20:58:42Z","timestamp":1201208322000},"page":"79-83","source":"Crossref","is-referenced-by-count":240,"title":["IL-23 and IL-17 in tuberculosis"],"prefix":"10.1016","volume":"41","author":[{"given":"Shabaana A.","family":"Khader","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea M.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2007.11.022_bib1","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1128\/IAI.70.8.4501-4509.2002","article-title":"Dissemination of Mycobacterium tuberculosis is influenced by host factors and precedes the initiation of T-cell immunity","volume":"70","author":"Chackerian","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.cyto.2007.11.022_bib2","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ni1449","article-title":"IL-23 and IL-17 in establishment of protective pulmonary CD4+ T cell responses upon vaccination and during Mycobacterium tuberculosis challenge","volume":"8","author":"Khader","year":"2007","journal-title":"Nat Immunol"},{"key":"10.1016\/j.cyto.2007.11.022_bib3","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1084\/jem.193.3.271","article-title":"The relative importance of T cell subsets in immunity and immunopathology of airborne Mycobacterium tuberculosis infection in mice","volume":"193","author":"Mogues","year":"2001","journal-title":"J Exp Med"},{"key":"10.1016\/j.cyto.2007.11.022_bib4","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1084\/jem.178.6.2243","article-title":"Disseminated tuberculosis in interferon gamma gene-disrupted mice","volume":"178","author":"Cooper","year":"1993","journal-title":"J Exp Med"},{"key":"10.1016\/j.cyto.2007.11.022_bib5","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/1074-7613(95)90001-2","article-title":"Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice","volume":"2","author":"Flynn","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/j.cyto.2007.11.022_bib6","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.4049\/jimmunol.168.3.1322","article-title":"Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present","volume":"168","author":"Cooper","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2007.11.022_bib7","doi-asserted-by":"crossref","first-page":"6879","DOI":"10.1128\/IAI.68.12.6879-6882.2000","article-title":"Expression of nitric oxide synthase 2 gene is not essential for early control of Mycobacterium tuberculosis in the murine lung","volume":"68","author":"Cooper","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.cyto.2007.11.022_bib8","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1128\/IAI.72.7.3759-3768.2004","article-title":"A limited antigen-specific cellular response is sufficient for the early control of Mycobacterium tuberculosis in the lung but is insufficient for long-term survival","volume":"72","author":"Turner","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.cyto.2007.11.022_bib9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0962-8479(97)90016-2","article-title":"Progression of chronic pulmonary tuberculosis in mice aerogenically infected with virulent Mycobacterium tuberculosis","volume":"78","author":"Rhoades","year":"1997","journal-title":"Tuberc Lung Dis"},{"key":"10.1016\/j.cyto.2007.11.022_bib10","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.4049\/jimmunol.170.4.2046","article-title":"Persistence and turnover of antigen-specific CD4 T cells during chronic tuberculosis infection in the mouse","volume":"170","author":"Winslow","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2007.11.022_bib11","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1128\/IAI.69.7.4195-4201.2001","article-title":"Tuberculosis: latency and reactivation","volume":"69","author":"Flynn","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.cyto.2007.11.022_bib12","doi-asserted-by":"crossref","first-page":"788","DOI":"10.4049\/jimmunol.175.2.788","article-title":"IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available","volume":"175","author":"Khader","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2007.11.022_bib13","doi-asserted-by":"crossref","first-page":"4662","DOI":"10.4049\/jimmunol.177.7.4662","article-title":"IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection","volume":"177","author":"Lockhart","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2007.11.022_bib14","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1128\/IAI.74.1.557-565.2006","article-title":"Plasmid interleukin-23 (IL-23), but not plasmid IL-27, enhances the protective efficacy of a DNA vaccine against Mycobacterium tuberculosis infection","volume":"74","author":"Wozniak","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.cyto.2007.11.022_bib15","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.4049\/jimmunol.177.3.1416","article-title":"CE:IFN-g regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection1","volume":"177","author":"Cruz","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2007.11.022_bib16","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.coi.2007.04.005","article-title":"Differentiation and function of Th17 T cells","volume":"19","author":"Stockinger","year":"2007","journal-title":"Curr Opin Immun"},{"key":"10.1016\/j.cyto.2007.11.022_bib17","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature04754","article-title":"Transforming growth factor-beta induces development of the T(H)17 lineage","volume":"441","author":"Mangan","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.cyto.2007.11.022_bib18","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.immuni.2006.01.001","article-title":"TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells","volume":"24","author":"Veldhoen","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.cyto.2007.11.022_bib19","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1002\/art.22866","article-title":"Distinct regulation of interleukin-17 in human T helper lymphocytes","volume":"56","author":"Chen","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.cyto.2007.11.022_bib20","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/ni1497","article-title":"Development, cytokine profile and function of human interleukin 17-producing helper T cells","volume":"8","author":"Wilson","year":"2007","journal-title":"Nat Immunol"},{"key":"10.1016\/j.cyto.2007.11.022_bib21","doi-asserted-by":"crossref","first-page":"6092","DOI":"10.1128\/IAI.00621-06","article-title":"Neutralization or absence of the interleukin-23 pathway does not compromise immunity to mycobacterial infection","volume":"74","author":"Chackerian","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.cyto.2007.11.022_bib22","doi-asserted-by":"crossref","first-page":"5782","DOI":"10.1128\/IAI.73.9.5782-5788.2005","article-title":"Pulmonary interleukin-23 gene delivery increases local T-cell immunity and controls growth of Mycobacterium tuberculosis in the lungs","volume":"73","author":"Happel","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.cyto.2007.11.022_bib23","doi-asserted-by":"crossref","first-page":"8684","DOI":"10.4049\/jimmunol.177.12.8684","article-title":"Interleukin-23 restores immunity to Mycobacterium tuberculosis infection in IL-12p40-deficient mice and is not required for the development of IL-17-secreting T cell responses","volume":"177","author":"Wozniak","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2007.11.022_bib24","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.4049\/jimmunol.178.6.3786","article-title":"IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis Bacille Calmette-Guerin infection","volume":"178","author":"Umemura","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2007.11.022_bib25","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.4049\/jimmunol.158.3.1217","article-title":"An anti-inflammatory role for gd T lymphocytes in acquired immunity to Mycobacterium tuberculosis","volume":"158","author":"D\u2019Souza","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2007.11.022_bib26","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1084\/jem.20061551","article-title":"Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia","volume":"204","author":"Michel","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.cyto.2007.11.022_bib27","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1001\/jama.271.9.698","article-title":"Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature","volume":"271","author":"Colditz","year":"1994","journal-title":"JAMA"},{"key":"10.1016\/j.cyto.2007.11.022_bib28","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0962-8479(97)90017-4","article-title":"Expression of memory immunity in the lung following re-exposure to Mycobacterium tuberculosis","volume":"78","author":"Cooper","year":"1997","journal-title":"Tuberc Lung Dis"},{"key":"10.1016\/j.cyto.2007.11.022_bib29","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1084\/jem.20050265","article-title":"Properties and protective value of the secondary versus primary T helper type 1 response to airborne Mycobacterium tuberculosis infection in mice","volume":"201","author":"Jung","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.cyto.2007.11.022_bib30","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/ni1376","article-title":"Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system","volume":"7","author":"Stumhofer","year":"2006","journal-title":"Nat Immunol"},{"key":"10.1016\/j.cyto.2007.11.022_bib31","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/ni1375","article-title":"Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells","volume":"7","author":"Batten","year":"2006","journal-title":"Nat Immunol"},{"key":"10.1016\/j.cyto.2007.11.022_bib32","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1165\/rcmb.2004-0213OC","article-title":"IL-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation","volume":"33","author":"Sergejeva","year":"2005","journal-title":"Am J Resp Cell Mol Biol"},{"key":"10.1016\/j.cyto.2007.11.022_bib33","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.immuni.2004.08.018","article-title":"Interleukin-17 family members and inflammation","volume":"21","author":"Kolls","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.cyto.2007.11.022_bib34","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.4049\/jimmunol.170.9.4665","article-title":"Endogenous IL-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways","volume":"170","author":"Miyamoto","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2007.11.022_bib35","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.immuni.2005.01.011","article-title":"Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17","volume":"22","author":"Stark","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.cyto.2007.11.022_bib36","doi-asserted-by":"crossref","first-page":"24138","DOI":"10.1074\/jbc.M604597200","article-title":"Identification of common transcriptional regulatory elements in interleukin-17 target genes","volume":"281","author":"Shen","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cyto.2007.11.022_bib37","doi-asserted-by":"crossref","unstructured":"Dragon S, Saffar A, Shan L, Gounni A. IL-17 attenuates the anti-apoptotic effects of GM-CSF in human neutrophils. Mol Immunol 2007. epub.","DOI":"10.1016\/j.molimm.2007.04.027"},{"key":"10.1016\/j.cyto.2007.11.022_bib38","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1002\/eji.200737409","article-title":"The IL-23\/IL-17 pathway promotes inflammation and impairs antifungal immune resistance","volume":"37","author":"Zelante","year":"2007","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.cyto.2007.11.022_bib39","unstructured":"Khader S, Solache A, Pearl J, Fountain J, Rangel-Moreno J, Martino C, et al. IL-27R on CD4 T cells limits the protective response to Mycobacterium tuberculosis but not as a result of limiting the generation of Th17 cells. Personal communication."},{"key":"10.1016\/j.cyto.2007.11.022_bib40","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.4049\/jimmunol.174.6.3534","article-title":"The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis","volume":"174","author":"Holscher","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2007.11.022_bib41","doi-asserted-by":"crossref","first-page":"7490","DOI":"10.4049\/jimmunol.173.12.7490","article-title":"IL-27 signaling compromises control of bacterial growth in mycobacteria-infected mice","volume":"173","author":"Pearl","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2007.11.022_bib42","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00439-002-0873-5","article-title":"Influence of interleukin-12 receptor b1 polymorphisms on tuberculosis","volume":"112","author":"Akahoshi","year":"2003","journal-title":"Hum Genet"},{"key":"10.1016\/j.cyto.2007.11.022_bib43","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1086\/422693","article-title":"Associations between IL12b polymorphisms and tuberculosis in the Hong Kong chinese population","volume":"190","author":"Tso","year":"2004","journal-title":"J Inf Dis"},{"key":"10.1016\/j.cyto.2007.11.022_bib44","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0161-5890(02)00017-2","article-title":"Inherited disorders of IL-12 and IFN-G mediated immunity: a molecular genetics update","volume":"38","author":"Doffinger","year":"2001","journal-title":"Mol Immunol"},{"key":"10.1016\/j.cyto.2007.11.022_bib45","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1182\/blood-2004-02-0584","article-title":"A novel form of complete IL-12\/IL-23 receptor b1-deficiency with cell surface-expressed non-functional receptors","volume":"104","author":"Fieschi","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2007.11.022_bib46","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1182\/blood.V97.9.2688","article-title":"Missense mutation of the interleukin-12 receptor B1 chain-encoding gene is associated with impaired immunity against Mycobacterium avium complex infection","volume":"97","author":"Sakai","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2007.11.022_bib47","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/immu.200390008","article-title":"Severe Mycobacterium bovis BCG infections in a large series of novel IL-12 receptor B1 deficient patients and evidence for the existence of partial IL-12 receptor B1 deficiency","volume":"33","author":"Lichtenauer-Kaligis","year":"2003","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.cyto.2007.11.022_bib48","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.smim.2006.07.010","article-title":"Inborn errors of IL-12\/23- and IFN-gamma-mediated immunity: molecular, cellular, and clinical features","volume":"18","author":"Filipe-Santos","year":"2006","journal-title":"Semin Immunol"},{"key":"10.1016\/j.cyto.2007.11.022_bib49","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1002\/eji.200324343","article-title":"IL-12 receptor deficiency revisited: IL-23-mediated signaling is also impaired in human genetic IL-12 receptor beta1 deficiency","volume":"33","author":"Hoeve","year":"2003","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.cyto.2007.11.022_bib50","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/eji.200535239","article-title":"Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells","volume":"36","author":"Hoeve","year":"2006","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.cyto.2007.11.022_bib51","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1126\/science.1135245","article-title":"A genome-wide association study identifies IL23R as an inflammatory bowel disease gene","volume":"314","author":"Duerr","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.cyto.2007.11.022_bib52","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S1473-3099(07)70211-6","article-title":"Mycobacterium avium subspecies paratuberculosis and Crohn\u2019s disease: a systematic review and meta-analysis","volume":"7","author":"Feller","year":"2007","journal-title":"Lancet Inf Dis"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466607005054?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466607005054?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T02:40:57Z","timestamp":1684204857000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466607005054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["S1043466607005054"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2007.11.022","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2008,2]]}}}