{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:21:36Z","timestamp":1791112896212,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1016\/j.cyto.2008.06.004","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T12:50:14Z","timestamp":1217249414000},"page":"57-64","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Flagellin stimulation suppresses IL-7 secretion of intestinal epithelial cells"],"prefix":"10.1016","volume":"44","author":[{"given":"Atsushi","family":"Yoshioka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuichi","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Oshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiichiro","family":"Tsuchiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Kanai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2008.06.004_bib1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1146\/annurev.immunol.24.021605.090727","article-title":"Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis","volume":"24","author":"Ma","year":"2006","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.cyto.2008.06.004_bib2","doi-asserted-by":"crossref","first-page":"6571","DOI":"10.4049\/jimmunol.174.11.6571","article-title":"The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance","volume":"174","author":"Fry","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2008.06.004_bib3","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.cyto.2007.07.183","article-title":"Interlinking interleukin-7","volume":"39","author":"Kittipatarin","year":"2007","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2008.06.004_bib4","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1172\/JCI115920","article-title":"Interleukin-7 is a growth factor for Sezary lymphoma cells","volume":"90","author":"Dalloul","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cyto.2008.06.004_bib5","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1084\/jem.178.3.1109","article-title":"Interleukin 7 is produced by murine and human keratinocytes","volume":"178","author":"Heufler","year":"1993","journal-title":"J Exp Med"},{"key":"10.1016\/j.cyto.2008.06.004_bib6","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1172\/JCI118002","article-title":"Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes","volume":"95","author":"Watanabe","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cyto.2008.06.004_bib7","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1126\/science.1104816","article-title":"Host\u2013bacterial mutualism in the human intestine","volume":"307","author":"Backhed","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.cyto.2008.06.004_bib8","first-page":"13","article-title":"Development and maintenance of the gut-associated lymphoid tissue (GALT): the roles of enteric bacteria and viruses","volume":"6","author":"Cebra","year":"1998","journal-title":"Dev Immunol"},{"key":"10.1016\/j.cyto.2008.06.004_bib9","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.4049\/jimmunol.172.2.1118","article-title":"Role of commensal bacteria in development of gut-associated lymphoid tissues and preimmune antibody repertoire","volume":"172","author":"Rhee","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2008.06.004_bib10","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1084\/jem.181.4.1519","article-title":"Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine","volume":"181","author":"von Freeden-Jeffry","year":"1995","journal-title":"J Exp Med"},{"key":"10.1016\/j.cyto.2008.06.004_bib11","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1084\/jem.184.4.1449","article-title":"Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit+IL-7R+Thy1+lympho-hemopoietic progenitors develop","volume":"184","author":"Kanamori","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.cyto.2008.06.004_bib12","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1084\/jem.191.9.1569","article-title":"Enterocyte expression of interleukin 7 induces development of gammadelta T cells and Peyer\u2019s patches","volume":"191","author":"Laky","year":"2000","journal-title":"J Exp Med"},{"key":"10.1016\/j.cyto.2008.06.004_bib13","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.cyto.2008.06.004_bib14","article-title":"Therapeutic impact of toll-like receptors on inflammatory bowel diseases: a multiple-edged sword","author":"Cario","year":"2007","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.cyto.2008.06.004_bib15","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1126\/science.1140488","article-title":"Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88","volume":"317","author":"Rakoff-Nahoum","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.cyto.2008.06.004_bib16","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1053\/j.gastro.2004.01.007","article-title":"Mechanisms of cross hyporesponsiveness to toll-like receptor bacterial ligands in intestinal epithelial cells","volume":"126","author":"Otte","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cyto.2008.06.004_bib17","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.4049\/jimmunol.174.8.4453","article-title":"TLR signaling in the gut in health and disease","volume":"174","author":"Abreu","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2008.06.004_bib18","doi-asserted-by":"crossref","first-page":"7010","DOI":"10.1128\/IAI.68.12.7010-7017.2000","article-title":"Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease","volume":"68","author":"Cario","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.cyto.2008.06.004_bib19","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.4049\/jimmunol.167.4.1882","article-title":"Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression","volume":"167","author":"Gewirtz","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2008.06.004_bib20","doi-asserted-by":"crossref","first-page":"13722","DOI":"10.1073\/pnas.241308598","article-title":"Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cells","volume":"98","author":"Sierro","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cyto.2008.06.004_bib21","doi-asserted-by":"crossref","first-page":"6298","DOI":"10.1128\/MCB.24.14.6298-6310.2004","article-title":"Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells","volume":"24","author":"Oshima","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cyto.2008.06.004_bib22","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1016\/j.febslet.2005.04.012","article-title":"IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome","volume":"579","author":"Namiki","year":"2005","journal-title":"FEBS Lett"},{"key":"10.1016\/j.cyto.2008.06.004_bib23","doi-asserted-by":"crossref","first-page":"6031","DOI":"10.4049\/jimmunol.154.11.6031","article-title":"IFN-gamma-dependent IL-7 gene regulation in keratinocytes","volume":"154","author":"Ariizumi","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2008.06.004_bib24","doi-asserted-by":"crossref","first-page":"8388","DOI":"10.1128\/MCB.01493-07","article-title":"Functional analysis of KSRP interaction with the AU-rich element of interleukin-8 and identification of inflammatory mRNA targets","volume":"27","author":"Winzen","year":"2007","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cyto.2008.06.004_bib25","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1074\/jbc.M707573200","article-title":"p38{alpha} stabilizes interleukin-6 mRNA via multiple AU-rich elements","volume":"283","author":"Zhao","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cyto.2008.06.004_bib26","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1128\/MCB.23.2.425-436.2003","article-title":"p38 mitogen-activated protein kinase-dependent and -independent signaling of mRNA stability of AU-rich element-containing transcripts","volume":"23","author":"Frevel","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cyto.2008.06.004_bib27","doi-asserted-by":"crossref","first-page":"D111","DOI":"10.1093\/nar\/gkj052","article-title":"ARED 3.0: the large and diverse AU-rich transcriptome","volume":"34","author":"Bakheet","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.cyto.2008.06.004_bib28","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1261\/rna.5121704","article-title":"Selection of AU-rich transiently expressed sequences: reversal of cDNA abundance","volume":"10","author":"Khabar","year":"2004","journal-title":"RNA"},{"key":"10.1016\/j.cyto.2008.06.004_bib29","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/0092-8674(86)90341-7","article-title":"A conserved AU sequence from the 3\u2032 untranslated region of GM-CSF mRNA mediates selective mRNA degradation","volume":"46","author":"Shaw","year":"1986","journal-title":"Cell"},{"key":"10.1016\/j.cyto.2008.06.004_bib30","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nri2023","article-title":"Interleukin-7 receptor expression: intelligent design","volume":"7","author":"Mazzucchelli","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.cyto.2008.06.004_bib31","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1182\/blood.V96.5.1873","article-title":"Interleukin-7 stimulates osteoclast formation by up-regulating the T-cell production of soluble osteoclastogenic cytokines","volume":"96","author":"Weitzmann","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2008.06.004_bib32","doi-asserted-by":"crossref","first-page":"117","DOI":"10.4049\/jimmunol.159.1.117","article-title":"TGF-beta down-regulates stromal IL-7 secretion and inhibits proliferation of human B cell precursors","volume":"159","author":"Tang","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2008.06.004_bib33","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.4049\/jimmunol.159.5.2259","article-title":"IL-7 activates alpha4beta1 integrin in murine thymocytes","volume":"159","author":"Kitazawa","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2008.06.004_bib34","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.cyto.2008.02.008","article-title":"Identification of a novel regulatory region in the interleukin-6 gene promoter","volume":"42","author":"Samuel","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2008.06.004_bib35","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1084\/jem.187.3.389","article-title":"Interleukin 7 transgenic mice develop chronic colitis with decreased interleukin 7 protein accumulation in the colonic mucosa","volume":"187","author":"Watanabe","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.cyto.2008.06.004_bib36","doi-asserted-by":"crossref","first-page":"G745","DOI":"10.1152\/ajpgi.00276.2004","article-title":"IL-7 exacerbates chronic colitis with expansion of memory IL-7Rhigh CD4+ mucosal T cells in mice","volume":"288","author":"Okada","year":"2005","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.cyto.2008.06.004_bib37","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.4049\/jimmunol.171.3.1556","article-title":"Mucosal T cells expressing high levels of IL-7 receptor are potential targets for treatment of chronic colitis","volume":"171","author":"Yamazaki","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2008.06.004_bib38","doi-asserted-by":"crossref","first-page":"4737","DOI":"10.4049\/jimmunol.178.8.4737","article-title":"IL-7 is essential for the development and the persistence of chronic colitis","volume":"178","author":"Totsuka","year":"2007","journal-title":"J Immunol"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466608001828?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466608001828?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:48:18Z","timestamp":1760906898000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466608001828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["S1043466608001828"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2008.06.004","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Flagellin stimulation suppresses IL-7 secretion of intestinal epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2008.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}