{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T07:10:30Z","timestamp":1768029030147,"version":"3.49.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1016\/j.cyto.2008.10.009","type":"journal-article","created":{"date-parts":[[2008,11,22]],"date-time":"2008-11-22T10:40:12Z","timestamp":1227350412000},"page":"392-396","source":"Crossref","is-referenced-by-count":13,"title":["Cytokine profiles of HIV patients with pulmonary tuberculosis resulting from adjunct immunotherapy with herbal phytoconcentrates Dzherelo and Anemin"],"prefix":"10.1016","volume":"44","author":[{"given":"Lyudmila G.","family":"Nikolaeva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana V.","family":"Maystat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volodymyr S.","family":"Pylypchuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuri L.","family":"Volyanskii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valery M.","family":"Frolov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galyna A.","family":"Kutsyna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2008.10.009_bib1","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1128\/IAI.00602-06","article-title":"Dynamic changes in pro- and anti-inflammatory cytokine profiles and gamma interferon receptor signaling integrity correlate with tuberculosis disease activity and response to curative treatment","volume":"75","author":"Sahiratmadja","year":"2007","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.cyto.2008.10.009_bib2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.tube.2004.05.001","article-title":"Morphometric analysis of Th(1) and Th(2) cytokine expression in human pulmonary tuberculosis","volume":"84","author":"Bai","year":"2004","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.cyto.2008.10.009_bib3","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1164\/rccm.2305001","article-title":"Immunotherapy for tuberculosis: wave of the future or tilting at windmills?","volume":"168","author":"Barnes","year":"2003","journal-title":"Am J Resp Crit Care Med"},{"key":"10.1016\/j.cyto.2008.10.009_bib4","first-page":"171","article-title":"Th1\/Th2 profiles in tuberculosis, based on the proliferation and cytokine response of blood lymphocytes to mycobacterial antigens","volume":"81","author":"Surcel","year":"1994","journal-title":"Immunology"},{"key":"10.1016\/j.cyto.2008.10.009_bib5","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.cyto.2005.01.015","article-title":"Dysregulation of proinflammatory and regulatory cytokines in HIV infected persons with active tuberculosis","volume":"30","author":"Bal","year":"2005","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2008.10.009_bib6","doi-asserted-by":"crossref","first-page":"6938","DOI":"10.4049\/jimmunol.172.11.6938","article-title":"VACSEL Study. Group Healthy individuals that control a latent infection with Mycobacterium tuberculosis express high levels of Th1 cytokines and the IL-4 antagonist IL-4delta2","volume":"172","author":"Demissie","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2008.10.009_bib7","unstructured":"Melnik VP, Panasyuk OV, Pylypchuk VS, Moshich OP, Procenko NM, Leonenko OM. Deployment of herbal preparations Dzherelo and Svitanok for combination therapy of pulmonary tuberculosis. Medical Institute of Ukrainian Association of People\u2019s Medicine. Information Bulletin of the Ministry of Health of Autonomous Republic of Crimea. UDK:616.24-002.5-085-038:615.017. 1999. Kiev, Ukraine."},{"key":"10.1016\/j.cyto.2008.10.009_bib8","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1504\/IJBT.2007.014248","article-title":"Comparative effect of an immunomodulator Immunoxel (Dzherelo) when used alone or in combination with antiretroviral therapy in drug-na\u00efve HIV infected individuals","volume":"9","author":"Chechitiany","year":"2007","journal-title":"Int. J Biotechnol"},{"key":"10.1016\/j.cyto.2008.10.009_bib9","first-page":"117","article-title":"Open label trial of adjuvant immunotherapy with Dzherelo, Svitanok and Lizorm, in MDR-TB, XDR-TB and TB\/HIV co-infected patients receiving anti-tuberculosis therapy under DOT","volume":"1","author":"Prihoda","year":"2007","journal-title":"J Med Plant Res"},{"key":"10.1016\/j.cyto.2008.10.009_bib10","first-page":"59","article-title":"Adjuvant immunotherapy of tuberculosis in drug-resistant TB and TB\/HIV co-infected patients","volume":"2","author":"Prihoda","year":"2008","journal-title":"Intl J Biomed Pharm Sci"},{"key":"10.1016\/j.cyto.2008.10.009_bib11","first-page":"87","article-title":"Changes in CD4+ T-cells and HIV RNA resulting from combination of anti-TB therapy with Dzherelo in TB\/HIV dually infected patients","volume":"2","author":"Nikolaeva","year":"2008","journal-title":"Drug Design Dev Ther"},{"key":"10.1016\/j.cyto.2008.10.009_bib12","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.intimp.2008.01.029","article-title":"Effect of oral immunomodulator Dzherelo (Immunoxel) in TB\/HIV co-infected patients receiving anti-tuberculosis therapy under DOTS","volume":"8","author":"Nikolaeva","year":"2008","journal-title":"Intl Immunopharmacol"},{"key":"10.1016\/j.cyto.2008.10.009_bib13","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.immuni.2006.04.003","article-title":"Tuberculosis: back on the immunologists\u2019 agenda","volume":"24","author":"Kaufmann","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.cyto.2008.10.009_bib14","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1086\/430914","article-title":"Reconsidering adjuvant immunotherapy for tuberculosis","volume":"41","author":"Wallis","year":"2005","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cyto.2008.10.009_bib15","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1084\/jem.163.5.1162","article-title":"Defective interleukin 2 production and responsiveness in human pulmonary tuberculosis","volume":"163","author":"Toossi","year":"1986","journal-title":"J Exp Med"},{"key":"10.1016\/j.cyto.2008.10.009_bib16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0022-1759(02)00092-3","article-title":"Cytokine profiles using whole-blood assays can discriminate between tuberculosis patients and healthy endemic controls in a BCG-vaccinated population","volume":"264","author":"Hussain","year":"2002","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.cyto.2008.10.009_bib17","doi-asserted-by":"crossref","first-page":"4750","DOI":"10.4049\/jimmunol.171.9.4750","article-title":"Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-gamma","volume":"171","author":"Nagabhushanam","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2008.10.009_bib18","doi-asserted-by":"crossref","first-page":"F1","DOI":"10.1097\/01.aids.0000202648.18526.bf","article-title":"Explosion of tuberculin-specific Th1-responses induces immune restoration syndrome in tuberculosis and HIV co-infected patients","volume":"20","author":"Bourgarit","year":"2006","journal-title":"AIDS"},{"key":"10.1016\/j.cyto.2008.10.009_bib19","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1164\/ajrccm.158.4.9803065","article-title":"Effects of aerosolized interferon-alpha in patients with pulmonary tuberculosis","volume":"158","author":"Giosu\u00e9","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.cyto.2008.10.009_bib20","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1002\/art.21043","article-title":"BIOBADASER Group. Effectiveness of recommendations to prevent reactivation of latent tuberculosis infection in patients treated with tumor necrosis factor antagonists","volume":"52","author":"Carmona","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.cyto.2008.10.009_bib21","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1084\/jem.178.6.2249","article-title":"An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection","volume":"178","author":"Flynn","year":"1993","journal-title":"J Exp Med"},{"key":"10.1016\/j.cyto.2008.10.009_bib22","doi-asserted-by":"crossref","first-page":"890","DOI":"10.4049\/jimmunol.141.3.890","article-title":"Regulation of activated macrophage antimicrobial activities. Identification of lymphokines that cooperate with IFN-gamma for induction of resistance to infection","volume":"141","author":"Belosevic","year":"1988","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2008.10.009_bib23","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/S0140-6736(96)12273-X","article-title":"Treatment of multidrug-resistant pulmonary tuberculosis with interferon-gamma via aerosol","volume":"349","author":"Condos","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.cyto.2008.10.009_bib24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1471-2334-8-17","article-title":"MACGAM Study Group. Adjuvant interferon gamma in patients with pulmonary atypical Mycobacteriosis: a randomized, double-blind, placebo-controlled study","volume":"8","author":"Milan\u00e9s-Virelles","year":"2008","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.cyto.2008.10.009_bib25","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.micinf.2007.02.002","article-title":"Tumor necrosis factor is critical to control tuberculosis infection","volume":"9","author":"Jacobs","year":"2007","journal-title":"Microbes Infect"},{"key":"10.1016\/j.cyto.2008.10.009_bib26","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/sj.jidsymp.5650031","article-title":"Reactivation of latent tuberculosis by TNF blockade: the role of interferon gamma","volume":"12","author":"Wallis","year":"2007","journal-title":"J Invest Dermatol Symp Proc"},{"key":"10.1016\/j.cyto.2008.10.009_bib27","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2174\/156652407780598557","article-title":"Th2 cytokines in susceptibility to tuberculosis","volume":"7","author":"Rook","year":"2007","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.cyto.2008.10.009_bib28","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ijid.2007.02.001","article-title":"Correlates for disease progression and prognosis during concurrent HIV\/TB infection","volume":"11","author":"Djoba Siawaya","year":"2007","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.cyto.2008.10.009_bib29","first-page":"14","article-title":"Gene expression profiling by real-time system PCR analysis in hiv negative patients with multidrug-resistant tuberculosis","volume":"9","author":"Santos","year":"2003","journal-title":"Rev Port Pneumol"},{"key":"10.1016\/j.cyto.2008.10.009_bib30","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00109-007-0157-6","article-title":"Candidate biomarkers for discrimination between infection and disease caused by Mycobacterium tuberculosis","volume":"85","author":"Jacobsen","year":"2007","journal-title":"J Mol Med"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466608007680?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466608007680?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,21]],"date-time":"2023-05-21T08:07:57Z","timestamp":1684656477000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466608007680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S1043466608007680"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2008.10.009","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}