{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T18:19:47Z","timestamp":1776449987801,"version":"3.51.2"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1016\/j.cyto.2008.11.015","type":"journal-article","created":{"date-parts":[[2009,1,14]],"date-time":"2009-01-14T09:32:12Z","timestamp":1231925532000},"page":"162-168","source":"Crossref","is-referenced-by-count":44,"title":["Effects of recombinant human erythropoietin (rhEPO) on JAK2\/STAT3 pathway and endothelial apoptosis in the rabbit basilar artery after subarachnoid hemorrhage"],"prefix":"10.1016","volume":"45","author":[{"given":"Gang","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jixin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinglu","family":"Ai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunhua","family":"Hang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2008.11.015_bib1","first-page":"249","article-title":"Review of medical prevention of vasospasm after aneurysmal subarachnoid hemorrhage: a problem of neurointensive care","volume":"48","author":"Treggiari-Venzi","year":"2001","journal-title":"Neurosurgery"},{"key":"10.1016\/j.cyto.2008.11.015_bib2","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1161\/01.STR.0000190021.85035.5b","article-title":"Role of endothelial NO synthase phosphorylation in cerebrovascular protective effect of recombinant erythropoietin during subarachnoid hemorrhage-induced cerebral vasospasm","volume":"36","author":"Santhanam","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.cyto.2008.11.015_bib3","doi-asserted-by":"crossref","first-page":"5627","DOI":"10.1073\/pnas.082097299","article-title":"Beneficial effects of systemic administration of recombinant human erythropoietin in rabbits subjected to subarachnoid hemorrhage","volume":"99","author":"Grasso","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cyto.2008.11.015_bib4","first-page":"7","article-title":"Neuroprotective effect of recombinant human erythropoietin in experimental subarachnoid hemorrhage","volume":"45","author":"Grasso","year":"2001","journal-title":"J Neurosurg Sci"},{"key":"10.1016\/j.cyto.2008.11.015_bib5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/978-3-7091-6232-3_7","article-title":"Apoptosis in basilar endothelial cells in a canine double hemorrhage model","volume":"77","author":"Zubkov","year":"2001","journal-title":"Acta Neurochir Suppl"},{"key":"10.1016\/j.cyto.2008.11.015_bib6","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/sj.jcbfm.9600069","article-title":"Role of p53 and apoptosis in cerebral vasospasm after experimental subarachnoid hemorrhage","volume":"25","author":"Zhou","year":"2005","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.cyto.2008.11.015_bib7","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1073\/pnas.042693799","article-title":"Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury","volume":"99","author":"Celik","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cyto.2008.11.015_bib8","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1073\/pnas.051606598","article-title":"Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress","volume":"98","author":"Siren","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cyto.2008.11.015_bib9","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1385\/CBB:41:2:207","article-title":"Jak2 tyrosine kinase: a true Jack of all trades?","volume":"41","author":"Sandberg","year":"2004","journal-title":"Cell Biochem Biophys"},{"key":"10.1016\/j.cyto.2008.11.015_bib10","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0092-8674(93)90414-L","article-title":"JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin","volume":"74","author":"Witthuhn","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.cyto.2008.11.015_bib11","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1203\/01.PDR.0000155760.88664.06","article-title":"Erythropoietin after focal cerebral ischemia activates the Janus kinase-signal transducer and activator of transcription signaling pathway and improves brain injury in postnatal day 7 rats","volume":"57","author":"Sola","year":"2005","journal-title":"Pediatr Res"},{"key":"10.1016\/j.cyto.2008.11.015_bib12","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.molmed.2006.12.002","article-title":"Role of the JAK-STAT pathway in myocardial injury","volume":"13","author":"Barry","year":"2007","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.cyto.2008.11.015_bib13","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0008-6363(00)00138-3","article-title":"Activation of JAK\/STAT pathway transduces cytoprotective signal in rat acute myocardial infarction","volume":"47","author":"Negoro","year":"2000","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.cyto.2008.11.015_bib14","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/sj.cdd.4400656","article-title":"Opposing actions of STAT-1 and STAT-3 on the Bcl-2 and Bcl-x promoters","volume":"7","author":"Stephanou","year":"2000","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.cyto.2008.11.015_bib15","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1038\/sj.jcbfm.9600456","article-title":"Potential contribution of nuclear factor-kappaB to cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits","volume":"27","author":"Zhou","year":"2007","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.cyto.2008.11.015_bib16","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/sj.bjp.0704521","article-title":"A single subcutaneous bolus of erythropoietin normalizes cerebral blood flow autoregulation after subarachnoid haemorrhage in rats","volume":"135","author":"Springborg","year":"2002","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.cyto.2008.11.015_bib17","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0014-2999(00)00691-9","article-title":"Effect of recombinant human erythropoietin on cerebral ischemia following experimental subarachnoid hemorrhage","volume":"406","author":"Alafaci","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.cyto.2008.11.015_bib18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0014-2999(00)00081-9","article-title":"In vivo evidence that erythropoietin has a neuroprotective effect during subarachnoid hemorrhage","volume":"392","author":"Buemi","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.cyto.2008.11.015_bib19","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1161\/01.STR.0000190021.85035.5b","article-title":"Role of endothelial NO synthase phosphorylation in cerebrovascular protective effect of recombinant erythropoietin during subarachnoid hemorrhage-induced cerebral vasospasm","volume":"36","author":"Santhanam","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.cyto.2008.11.015_bib20","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jneumeth.2006.07.026","article-title":"Comparison between one- and two-hemorrhage models of cerebral vasospasm in rabbits","volume":"159","author":"Zhou","year":"2007","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.cyto.2008.11.015_bib21","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.mcn.2005.04.009","article-title":"Erythropoietin promotes regeneration of adult CNS neurons via Jak2\/Stat3 and PI3K\/AKT pathway activation","volume":"29","author":"Kretz","year":"2005","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.cyto.2008.11.015_bib22","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.lfs.2007.07.013","article-title":"Erythropoietin protects post-ischemic hearts by preventing extracellular matrix degradation: role of Jak2-ERK pathway","volume":"81","author":"Chan","year":"2007","journal-title":"Life Sci"},{"key":"10.1016\/j.cyto.2008.11.015_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2005.12.003","article-title":"Activation of the JAK-STAT signaling pathway in the rat basilar artery after subarachnoid hemorrhage","volume":"1072","author":"Osuka","year":"2006","journal-title":"Brain Res"},{"key":"10.1016\/j.cyto.2008.11.015_bib24","doi-asserted-by":"crossref","first-page":"34547","DOI":"10.1074\/jbc.M405045200","article-title":"Jak2 tyrosine kinase mediates oxidative stress-induced apoptosis in vascular smooth muscle cells","volume":"279","author":"Sandberg","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cyto.2008.11.015_bib25","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1073\/pnas.041588198","article-title":"Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1","volume":"98","author":"Shen","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cyto.2008.11.015_bib26","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1172\/JCI200317970","article-title":"Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms","volume":"112","author":"Haga","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cyto.2008.11.015_bib27","doi-asserted-by":"crossref","first-page":"7432","DOI":"10.1128\/MCB.25.17.7432-7440.2005","article-title":"Role of Stat3 in regulating p53 expression and function","volume":"25","author":"Niu","year":"2005","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cyto.2008.11.015_bib28","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1468-1331.2007.02013.x","article-title":"Recombinant human erythropoietin administration protects cortical neurons from traumatic brain injury in rats","volume":"15","author":"Liao","year":"2008","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.cyto.2008.11.015_bib29","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1038\/sj.npp.1301566","article-title":"Erythropoietin prevents haloperidol treatment-induced neuronal apoptosis through regulation of BDNF","volume":"33","author":"Pillai","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.cyto.2008.11.015_bib30","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.neulet.2005.11.013","article-title":"Recombinant human erythropoietin prevents ischemia-induced apoptosis and necrosis in explant cultures of the rat organ of Corti","volume":"396","author":"Andreeva","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.cyto.2008.11.015_bib31","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1096\/fj.05-3907fje","article-title":"Erythropoietin is neuroprotective, improves functional recovery, and reduces neuronal apoptosis and inflammation in a rodent model of experimental closed head injury","volume":"19","author":"Yatsiv","year":"2005","journal-title":"FASEB J"},{"key":"10.1016\/j.cyto.2008.11.015_bib32","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/S0006-8993(99)02454-3","article-title":"Subarachnoid hemolysate produces DNA fragmentation in a pattern similar to apoptosis in mouse brain","volume":"858","author":"Matz","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.cyto.2008.11.015_bib33","first-page":"507","article-title":"Oxyhemoglobin produces necrosis in cultured smooth muscle cells","volume":"76","author":"Ogihara","year":"2000","journal-title":"Acta Neurochir Suppl"},{"key":"10.1016\/j.cyto.2008.11.015_bib34","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1046\/j.1471-4159.2001.00313.x","article-title":"Oxyhemoglobin induces caspase-mediated cell death in cerebral endothelial cells","volume":"77","author":"Meguro","year":"2001","journal-title":"J Neurochem"},{"key":"10.1016\/j.cyto.2008.11.015_bib35","doi-asserted-by":"crossref","first-page":"746","DOI":"10.3171\/jns.1997.87.5.0746","article-title":"Reversal and prevention of cerebral vasospasm by intracarotid infusions of nitric oxide donors in a primate model of subarachnoid hemorrhage","volume":"87","author":"Pluta","year":"1997","journal-title":"J Neurosurg"},{"key":"10.1016\/j.cyto.2008.11.015_bib36","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1182\/blood.V89.7.2429","article-title":"Apoptotic vascular endothelial cells become procoagulant","volume":"89","author":"Bombeli","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2008.11.015_bib37","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3171\/jns.1991.75.3.0415","article-title":"Etiology of cerebral vasospasm in primates","volume":"75","author":"Macdonald","year":"1991","journal-title":"J Neurosurg"},{"key":"10.1016\/j.cyto.2008.11.015_bib38","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/ar.1092400110","article-title":"Endothelial injury following experimental subarachnoid hemorrhage in rats: effects on brain blood flow","volume":"240","author":"Clower","year":"1994","journal-title":"Anat Rec"},{"key":"10.1016\/j.cyto.2008.11.015_bib39","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1161\/01.STR.0000053848.06436.AB","article-title":"Possible role for vascular cell proliferation in cerebral vasospasm after subarachnoid hemorrhage","volume":"34","author":"Borel","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.cyto.2008.11.015_bib40","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/00004647-200404000-00007","article-title":"Caspase inhibitors prevent endothelial apoptosis and cerebral vasospasm in dog model of experimental subarachnoid hemorrhage","volume":"24","author":"Zhou","year":"2004","journal-title":"J Cereb Blood Flow Metab"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466608008041?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466608008041?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T16:31:49Z","timestamp":1589473909000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466608008041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S1043466608008041"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2008.11.015","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}