{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:33:41Z","timestamp":1789947221036,"version":"4.0.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.cyto.2010.07.427","type":"journal-article","created":{"date-parts":[[2010,8,31]],"date-time":"2010-08-31T11:07:40Z","timestamp":1283252860000},"page":"100-106","source":"Crossref","is-referenced-by-count":29,"title":["Evaluation of the bioactive and total transforming growth factor \u03b21 levels in primary myelofibrosis"],"prefix":"10.1016","volume":"53","author":[{"given":"Rita","family":"Campanelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Rosti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Villani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Castagno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enza","family":"Moretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Bonetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Bergamaschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Balduini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Barosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Massa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2010.07.427_b0005","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1182\/blood.V96.6.2022","article-title":"Transforming growth factor-\u03b2: pleiotropic role in the regulation of haematopoiesis","volume":"96","author":"Fortunel","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2010.07.427_b0010","doi-asserted-by":"crossref","first-page":"4589","DOI":"10.1182\/blood-2005-10-4169","article-title":"Role of Transforming growth factor-\u03b2 in haematologic malignancies","volume":"107","author":"Dong","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2010.07.427_b0015","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1634\/stemcells.2008-0219","article-title":"A cross-talk between stromal cell-derived factor-1 and transforming growth factor-\u03b2 controls the quiescence\/cycling switch of CD34+ progenitors through FoxO3 and mammalian target of rapamycin","volume":"26","author":"Chabanon","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.cyto.2010.07.427_b0020","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1182\/blood-2002-10-3190","article-title":"Transforming growth factor-\u03b21 down-regulates expression of chemokine stromal cell-derived factor-1: functional consequences in cell migration and adhesion","volume":"102","author":"Wright","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2010.07.427_b0025","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1182\/blood-2004-10-4145","article-title":"Transforming growth factor-\u03b21 modulates responses of CD34+ cord blood cells to stromal cell-derived factor-1\/CXCL12","volume":"106","author":"Basu","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2010.07.427_b0030","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.3748\/wjg.v13.i22.3056","article-title":"Transforming growth factor-beta and fibrosis","volume":"13","author":"Verrecchia","year":"2007","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.cyto.2010.07.427_b0035","first-page":"69","article-title":"Cellular and molecular mechanisms underlying bone marrow and liver fibrosis: a review","volume":"19","author":"Le Bousse-Kerdiles","year":"2008","journal-title":"Eur Cytokine Netw"},{"key":"10.1016\/j.cyto.2010.07.427_b0040","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ccr.2005.03.023","article-title":"Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis","volume":"7","author":"Levine","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cyto.2010.07.427_b0045","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1182\/blood.V98.12.3249","article-title":"Diagnostic and clinical relevance of the number of circulating CD34+ cells in myelofibrosis with myeloid metaplasia","volume":"98","author":"Barosi","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2010.07.427_b0050","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1200\/JCO.1999.17.9.2954","article-title":"Myelofibrosis with myeloid metaplasia: diagnostic definition and prognostic classification for clinical studies and treatment guidelines","volume":"17","author":"Barosi","year":"1999","journal-title":"J Clin Onc"},{"key":"10.1016\/j.cyto.2010.07.427_b0055","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1182\/blood-2002-06-1913","article-title":"Development of myelofibrosis in mice genetically impaired for GATA-1 expression (GATA-1low mice)","volume":"100","author":"Vannucchi","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2010.07.427_b0060","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1182\/blood-2004-04-1320","article-title":"A pathologic pathway linking thrombopoietin, GATA-1 and TGF-\u03b21 in the development of myelofibrosis","volume":"105","author":"Vannucchi","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2010.07.427_b0065","doi-asserted-by":"crossref","first-page":"4534","DOI":"10.1182\/blood.V88.12.4534.bloodjournal88124534","article-title":"Differential expression of transforming growth factor-\u03b2, basic fibroblast growth factor, and their receptors in CD34+ hematopoietic progenitor cells from patients with myelofibrosis and myeloid metaplasia","volume":"88","author":"Le Bousse-Kerdiles","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2010.07.427_b0070","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.leukres.2005.06.010","article-title":"Reduced expression of TGF\u03b21RII in agnogenic myeloid metaplasia is not due to mutation or methylation","volume":"30","author":"Hemavathy","year":"2006","journal-title":"Leukemia Res"},{"key":"10.1016\/j.cyto.2010.07.427_b0075","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1365-2141.1994.tb04970.x","article-title":"Transforming growth factor-\u03b2 and megakaryocytes in the pathogenesis of idiopathic myelofibrosis","volume":"88","author":"Martyre","year":"1994","journal-title":"Br J Hematol"},{"key":"10.1016\/j.cyto.2010.07.427_b0080","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.exphem.2006.07.004","article-title":"Quantitative analysis of growth factor production in the mechanism of fibrosis in agnogenic myeloid metaplasia","volume":"34","author":"Wang","year":"2006","journal-title":"Exp Hematol"},{"key":"10.1016\/j.cyto.2010.07.427_b0085","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1182\/blood-2006-12-064626","article-title":"Pivotal contributions of megakaryocytes to the biology of idiopathic myelofibrosis","volume":"110","author":"Ciurea","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2010.07.427_b0090","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.4049\/jimmunol.153.6.2819","article-title":"Monocyte adhesion in patients with bone marrow fibrosis is required fort he production of fibrogenic cytokines","volume":"153","author":"Rameshwar","year":"1994","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2010.07.427_b0095","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1365-2141.1991.tb07952.x","article-title":"Increased intraplatelet levels of platelet-derived growth factor and transforming growth factor-\u03b2 in patients with myelofibrosis with myeloid metaplasia","volume":"77","author":"Martyre","year":"1991","journal-title":"Br J Haematol"},{"key":"10.1016\/j.cyto.2010.07.427_b0100","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1365-2141.1993.tb04624.x","article-title":"Reduced responsiveness of bone marrow megakaryocyte progenitors to platelet-derived transforming growth factor \u03b21, produced in normal amount, in patients with essential thrombocythemia","volume":"83","author":"Zauli","year":"1993","journal-title":"Br J Haematology"},{"key":"10.1016\/j.cyto.2010.07.427_b0105","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/(SICI)1096-8652(199810)59:2<133::AID-AJH6>3.0.CO;2-Z","article-title":"Systemic transforming growth factor-beta in patients with bone marrow fibrosis-pathophysiological implications","volume":"59","author":"Rameshwar","year":"1998","journal-title":"Am J Hematol"},{"key":"10.1016\/j.cyto.2010.07.427_b0110","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1182\/blood-2006-01-013540","article-title":"The JAK2-V617F mutation is frequently present at diagnosis in patients with essential thrombocythemia and polycythemia vera","volume":"108","author":"Lippert","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2010.07.427_b0115","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/path.1744","article-title":"Aberrant expression of transforming growth factor\u03b2-1 (TGF\u03b2-1) per se does not discriminate fibrotic from non-fibrotic chronic myeloproliferative disorders","volume":"205","author":"Bock","year":"2005","journal-title":"J Pathol"},{"key":"10.1016\/j.cyto.2010.07.427_b0120","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1046\/j.1365-2141.1999.01262.x","article-title":"The Italian consensus conference on diagnostic criteria for myelofibrosis with myeloid metaplasia","volume":"104","author":"Barosi","year":"1999","journal-title":"Br J Haematol"},{"key":"10.1016\/j.cyto.2010.07.427_b0125","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1136\/gut.44.5.754","article-title":"Thrombopoietin concentrations are low in patients with cirrhosis and thrombocytopenia and are restored after orthotopic liver transplantation","volume":"44","author":"Goulis","year":"1999","journal-title":"Gut"},{"key":"10.1016\/j.cyto.2010.07.427_b0130","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1182\/blood.V88.3.1013.1013","article-title":"Prognostic factors in agnogenic myeloid metaplasia: a report on 195 cases with a new scoring system","volume":"88","author":"Dupriez","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2010.07.427_b0135","first-page":"339","article-title":"Diagnosis and classification of the polycythemias","volume":"12","author":"Berlin","year":"1975","journal-title":"Semin Hematol"},{"key":"10.1016\/j.cyto.2010.07.427_b0140","first-page":"177","article-title":"Essential thrombocythemia: an interim report from the Polycythemia Vera Study Group","volume":"23","author":"Murphy","year":"1986","journal-title":"Semin Hematol"},{"key":"10.1016\/j.cyto.2010.07.427_b0145","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.yexcr.2004.07.011","article-title":"Expression, activation and subcellular localization of the Rap1 GTPase in cord blood-derived human megakaryocytes","volume":"300","author":"Balduini","year":"2004","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.cyto.2010.07.427_b0150","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/jcp.1041380112","article-title":"Immunodetection and quantitation of the two forms of transforming growth factor-beta (TGF-beta 1 and TGF-beta 2) secreted by cells in culture","volume":"138","author":"Danielpour","year":"1989","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.cyto.2010.07.427_b0155","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(05)74230-6","article-title":"Cancer genome project. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders","volume":"365","author":"Baxter","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.cyto.2010.07.427_b0160","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0022-1759(95)00151-Y","article-title":"Optimisation of CCL64-based bioassay for TGF-\u03b2","volume":"186","author":"Garrigue-Antar","year":"1995","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.cyto.2010.07.427_b0165","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1023\/A:1027330616073","article-title":"Elevation of bioactive transforming growth factor-beta in serum from patients with chronic fatigue syndrome","volume":"17","author":"Bennet","year":"1997","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.cyto.2010.07.427_b0170","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S1359-6101(99)00037-4","article-title":"TGF-\u03b2 in blood: a complex problem","volume":"11","author":"Grainger","year":"2000","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.cyto.2010.07.427_b0175","first-page":"129","article-title":"Transforming Growth Factor-\u03b21 circulates in normal human plasma and is unchanged in advanced metastatic breast cancer","volume":"1","author":"Wakefield","year":"1995","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.cyto.2010.07.427_b0180","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0009-8981(94)05995-4","article-title":"Active and acid-activable TGF-\u03b2 in human sera, platelets and plasma","volume":"235","author":"Grainger","year":"1995","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.cyto.2010.07.427_b0185","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1091\/mbc.3.2.181","article-title":"Transforming growth factor-beta complexes with thrombospondin","volume":"3","author":"Murphy-Ullrich","year":"1992","journal-title":"Mol Biol Cell"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466610006265?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466610006265?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T02:26:33Z","timestamp":1685759193000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466610006265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S1043466610006265"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2010.07.427","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}