{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:25:27Z","timestamp":1790393127623,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council in Taiwan","doi-asserted-by":"crossref","award":["NSC-96-2628-B-006-006-MY3"],"award-info":[{"award-number":["NSC-96-2628-B-006-006-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1016\/j.cyto.2011.01.013","type":"journal-article","created":{"date-parts":[[2011,2,15]],"date-time":"2011-02-15T15:27:19Z","timestamp":1297783639000},"page":"222-231","source":"Crossref","is-referenced-by-count":75,"title":["Macrophage migration inhibitory factor induced by dengue virus infection increases vascular permeability"],"prefix":"10.1016","volume":"54","author":[{"given":"Yung-Chun","family":"Chuang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan-Yao","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiao-Sheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee-Shin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Fun","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trai-Ming","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2011.01.013_b0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/0470058005.ch2","article-title":"Dengue\/dengue haemorrhagic fever: history and current status","volume":"277","author":"Gubler","year":"2006","journal-title":"Novartis Found Symp"},{"key":"10.1016\/j.cyto.2011.01.013_b0010","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nrmicro1690","article-title":"Prospects for a dengue virus vaccine","volume":"5","author":"Whitehead","year":"2007","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.cyto.2011.01.013_b0015","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1473-3099(01)00171-2","article-title":"Dengue: an update","volume":"2","author":"Guzman","year":"2002","journal-title":"Lancet Infect Dis"},{"issue":"Suppl. 4","key":"10.1016\/j.cyto.2011.01.013_b0020","doi-asserted-by":"crossref","first-page":"S830","DOI":"10.1093\/clinids\/11.Supplement_4.S830","article-title":"Antibody, macrophages, dengue virus infection, shock, and hemorrhage: a pathogenetic cascade","volume":"11","author":"Halstead","year":"1989","journal-title":"Rev Infect Dis"},{"key":"10.1016\/j.cyto.2011.01.013_b0025","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/sj.embor.7400814","article-title":"Dengue-virus-infected dendritic cells trigger vascular leakage through metalloproteinase overproduction","volume":"7","author":"Luplertlop","year":"2006","journal-title":"EMBO Rep"},{"key":"10.1016\/j.cyto.2011.01.013_b0030","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1099\/vir.0.82093-0","article-title":"MCP-1, a highly expressed chemokine in dengue haemorrhagic fever\/dengue shock syndrome patients, may cause permeability change, possibly through reduced tight junctions of vascular endothelium cells","volume":"87","author":"Lee","year":"2006","journal-title":"J Gen Virol"},{"key":"10.1016\/j.cyto.2011.01.013_b0035","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1099\/vir.0.19652-0","article-title":"IL8 release, tight junction and cytoskeleton dynamic reorganization conducive to permeability increase are induced by dengue virus infection of microvascular endothelial monolayers","volume":"85","author":"Talavera","year":"2004","journal-title":"J Gen Virol"},{"key":"10.1016\/j.cyto.2011.01.013_b0040","first-page":"449","article-title":"Increased capillary permeability mediated by a dengue virus-induced lymphokine","volume":"69","author":"Khanna","year":"1990","journal-title":"Immunology"},{"key":"10.1016\/j.cyto.2011.01.013_b0045","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/nri1200","article-title":"Macrophage migration inhibitory factor: a regulator of innate immunity","volume":"3","author":"Calandra","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.cyto.2011.01.013_b0050","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/S1357-4310(97)01133-7","article-title":"Macrophage migration inhibitory factor: a regulator of glucocorticoid activity with a critical role in inflammatory disease","volume":"3","author":"Donnelly","year":"1997","journal-title":"Mol Med Today"},{"key":"10.1016\/j.cyto.2011.01.013_b0055","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1097\/00003246-200201001-00004","article-title":"Macrophage migration inhibitory factor","volume":"30","author":"Baugh","year":"2002","journal-title":"Crit Care Med"},{"key":"10.1016\/j.cyto.2011.01.013_b0060","doi-asserted-by":"crossref","first-page":"S475","DOI":"10.1097\/01.CCM.0000191278.04636.D8","article-title":"Macrophage migration inhibitory factor","volume":"33","author":"Leng","year":"2005","journal-title":"Crit Care Med"},{"key":"10.1016\/j.cyto.2011.01.013_b0065","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/377068a0","article-title":"MIF as a glucocorticoid-induced modulator of cytokine production","volume":"377","author":"Calandra","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.cyto.2011.01.013_b0070","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.4049\/jimmunol.0904104","article-title":"Macrophage migration inhibitory factor increases leukocyte\u2013endothelial interactions in human endothelial cells via promotion of expression of adhesion molecules","volume":"185","author":"Cheng","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2011.01.013_b0075","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1182\/blood-2005-05-2011","article-title":"Migration inhibitory factor up-regulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 via Src, PI3 kinase, and NF\u03baB","volume":"107","author":"Amin","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2011.01.013_b0080","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cyto.2010.09.009","article-title":"Transcription factor Ap-1 mediates proangiogenic MIF expression in human endothelial cells exposed to angiotensin II","volume":"53","author":"Shan","year":"2010","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2011.01.013_b0085","doi-asserted-by":"crossref","first-page":"142","DOI":"10.4269\/ajtmh.2006.74.142","article-title":"Correlation of serum levels of macrophage migration inhibitory factor with disease severity and clinical outcome in dengue patients","volume":"74","author":"Chen","year":"2006","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.cyto.2011.01.013_b0090","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1096\/fj.09-139469","article-title":"Contribution of macrophage migration inhibitory factor to the pathogenesis of dengue virus infection","volume":"24","author":"Assuncao-Miranda","year":"2010","journal-title":"FASEB J"},{"key":"10.1016\/j.cyto.2011.01.013_b0095","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1084\/jem.179.6.1895","article-title":"The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor","volume":"179","author":"Calandra","year":"1994","journal-title":"J Exp Med"},{"key":"10.1016\/j.cyto.2011.01.013_b0100","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1164\/ajrccm.158.2.9707086","article-title":"Effect of anti-macrophage migration inhibitory factor antibody on lipopolysaccharide-induced pulmonary neutrophil accumulation","volume":"158","author":"Makita","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.cyto.2011.01.013_b0105","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jinf.2009.02.018","article-title":"Dengue virus induces thrombomodulin expression in human endothelial cells and monocytes in vitro","volume":"58","author":"Chen","year":"2009","journal-title":"J Infect"},{"key":"10.1016\/j.cyto.2011.01.013_b0110","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1021\/jm010534q","article-title":"Inhibition of MIF bioactivity by rational design of pharmacological inhibitors of MIF tautomerase activity","volume":"45","author":"Dios","year":"2002","journal-title":"J Med Chem"},{"issue":"Pt. 14","key":"10.1016\/j.cyto.2011.01.013_b0115","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1242\/jcs.110.14.1603","article-title":"Occludin as a possible determinant of tight junction permeability in endothelial cells","volume":"110","author":"Hirase","year":"1997","journal-title":"J Cell Sci"},{"key":"10.1016\/j.cyto.2011.01.013_b0120","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/365756a0","article-title":"MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia","volume":"365","author":"Bernhagen","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.cyto.2011.01.013_b0125","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1084\/jem.189.2.341","article-title":"Targeted disruption of migration inhibitory factor gene reveals its critical role in sepsis","volume":"189","author":"Bozza","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.cyto.2011.01.013_b0130","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/72262","article-title":"Protection from septic shock by neutralization of macrophage migration inhibitory factor","volume":"6","author":"Calandra","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.cyto.2011.01.013_b0135","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1172\/JCI32218","article-title":"Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion","volume":"117","author":"Arjona","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cyto.2011.01.013_b0140","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/(SICI)1096-9071(200004)60:4<425::AID-JMV10>3.0.CO;2-A","article-title":"Infection of five human liver cell lines by dengue-2 virus","volume":"60","author":"Lin","year":"2000","journal-title":"J Med Virol"},{"key":"10.1016\/j.cyto.2011.01.013_b0145","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4269\/ajtmh.2000.63.71","article-title":"Dengue virus infects human endothelial cells and induces IL-6 and IL-8 production","volume":"63","author":"Huang","year":"2000","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.cyto.2011.01.013_b0150","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.virusres.2007.03.003","article-title":"Dengue viruses can infect human primary lung epithelia as well as lung carcinoma cells, and can also induce the secretion of IL-6 and RANTES","volume":"126","author":"Lee","year":"2007","journal-title":"Virus Res"},{"key":"10.1016\/j.cyto.2011.01.013_b0155","first-page":"483","article-title":"Sequential changes of serum transaminase and abdominal sonography in patients with suspected dengue fever","volume":"6","author":"Wang","year":"1990","journal-title":"Gaoxiong Yi Xue Ke Xue Za Zhi"},{"key":"10.1016\/j.cyto.2011.01.013_b0160","doi-asserted-by":"crossref","first-page":"265","DOI":"10.4269\/ajtmh.1992.47.265","article-title":"Liver biochemical tests and dengue fever","volume":"47","author":"Kuo","year":"1992","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.cyto.2011.01.013_b0165","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1086\/514047","article-title":"Early clinical and laboratory indicators of acute dengue illness","volume":"176","author":"Kalayanarooj","year":"1997","journal-title":"J Infect Dis"},{"key":"10.1016\/j.cyto.2011.01.013_b0170","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3844\/ajidsp.2008.22.31","article-title":"Dengue virus infection induced NF-B-dependent macrophage migration inhibitory factor production","volume":"4","author":"Chen","year":"2008","journal-title":"Am J Infect Dis"},{"key":"10.1016\/j.cyto.2011.01.013_b0175","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1084\/jem.20030286","article-title":"MIF signal transduction initiated by binding to CD74","volume":"197","author":"Leng","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.cyto.2011.01.013_b0180","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nm1567","article-title":"MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment","volume":"13","author":"Bernhagen","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.cyto.2011.01.013_b0185","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cellsig.2010.08.013","article-title":"Activation of the JNK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on CXCR4 and CD74","volume":"23","author":"Lue","year":"2011","journal-title":"Cell Signal"},{"key":"10.1016\/j.cyto.2011.01.013_b0190","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1189\/jlb.0108009","article-title":"Migration inhibitory factor (MIF) released by macrophages upon recognition of immune complexes is critical to inflammation in Arthus reaction","volume":"85","author":"Paiva","year":"2009","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.cyto.2011.01.013_b0195","first-page":"46","article-title":"Circulating immune complexes in serum from patients with dengue haemorrhagic fever","volume":"36","author":"Ruangjirachuporn","year":"1979","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.cyto.2011.01.013_b0200","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1445-5994.2005.00853.x","article-title":"New therapeutic target in inflammatory disease: macrophage migration inhibitory factor","volume":"35","author":"Morand","year":"2005","journal-title":"Intern Med J"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466611000263?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466611000263?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:31:58Z","timestamp":1637281918000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466611000263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["S1043466611000263"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2011.01.013","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5]]}}}