{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T21:50:41Z","timestamp":1772488241451,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1016\/j.cyto.2011.03.009","type":"journal-article","created":{"date-parts":[[2011,4,15]],"date-time":"2011-04-15T17:33:42Z","timestamp":1302888822000},"page":"98-103","source":"Crossref","is-referenced-by-count":32,"title":["The RANKL\u2013OPG system is differentially regulated by supragingival and subgingival biofilm supernatants"],"prefix":"10.1016","volume":"55","author":[{"given":"Georgios N.","family":"Belibasakis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre","family":"Meier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Guggenheim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagihan","family":"Bostanci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl 6","key":"10.1016\/j.cyto.2011.03.009_b0005","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1600-051X.2005.00790.x","article-title":"Dental plaque: biological significance of a biofilm and community life-style","volume":"32","author":"Marsh","year":"2005","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.cyto.2011.03.009_b0010","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1177\/0022034509351812","article-title":"Oral biofilms: emerging concepts in microbial ecology","volume":"89","author":"Filoche","year":"2010","journal-title":"J Dent Res"},{"key":"10.1016\/j.cyto.2011.03.009_b0015","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1600-0757.2005.00148.x","article-title":"Role of bacteria in health and disease of periodontal tissues","volume":"40","author":"Feng","year":"2006","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.cyto.2011.03.009_b0020","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1600-0757.2005.00144.x","article-title":"Host responses in maintaining periodontal health and determining periodontal disease","volume":"40","author":"Schenkein","year":"2006","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.cyto.2011.03.009_b0025","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1600-0757.1994.tb00019.x","article-title":"The bacteria of periodontal diseases","volume":"5","author":"Moore","year":"1994","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.cyto.2011.03.009_b0030","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1600-051X.1991.tb02314.x","article-title":"Dental bacterial plaques. Nature and role in periodontal disease","volume":"18","author":"Christersson","year":"1991","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.cyto.2011.03.009_b0035","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1600-0757.2009.00311.x","article-title":"Subgingival biofilm formation","volume":"52","author":"Kuboniwa","year":"2010","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.cyto.2011.03.009_b0040","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","article-title":"Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation","volume":"93","author":"Lacey","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.cyto.2011.03.009_b0045","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0092-8674(00)80209-3","article-title":"Osteoprotegerin: a novel secreted protein involved in the regulation of bone density","volume":"89","author":"Simonet","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.cyto.2011.03.009_b0050","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/j.1600-051X.2007.01061.x","article-title":"Gingival crevicular fluid levels of RANKL and OPG in periodontal diseases: implications of their relative ratio","volume":"34","author":"Bostanci","year":"2007","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.cyto.2011.03.009_b0055","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1600-0765.2006.00946.x","article-title":"Differential expression of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin mRNA in periodontal diseases","volume":"42","author":"Bostanci","year":"2007","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.cyto.2011.03.009_b0060","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1034\/j.1600-0757.2000.2240103.x","article-title":"Molecular and cell biology of the gingiva","volume":"24","author":"Bartold","year":"2000","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.cyto.2011.03.009_b0065","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1128\/IAI.73.1.342-351.2005","article-title":"The cytolethal distending toxin induces receptor activator of NF-kappaB ligand expression in human gingival fibroblasts and periodontal ligament cells","volume":"73","author":"Belibasakis","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.cyto.2011.03.009_b0070","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cyto.2004.11.008","article-title":"Cytokine responses of human gingival fibroblasts to Actinobacillus actinomycetemcomitans cytolethal distending toxin","volume":"30","author":"Belibasakis","year":"2005","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2011.03.009_b0075","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.micpath.2007.03.001","article-title":"Regulation of RANKL and OPG gene expression in human gingival fibroblasts and periodontal ligament cells by Porphyromonas gingivalis: a putative role of the Arg-gingipains","volume":"43","author":"Belibasakis","year":"2007","journal-title":"Microb Pathog"},{"key":"10.1016\/j.cyto.2011.03.009_b0080","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000057866","article-title":"An in vitro oral biofilm model for comparing the efficacy of antimicrobial mouthrinses","volume":"36","author":"Shapiro","year":"2002","journal-title":"Caries Res"},{"key":"10.1016\/j.cyto.2011.03.009_b0085","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1186\/1471-2180-9-280","article-title":"In vitro modeling of host-parasite interactions: the \u2018subgingival\u2019 biofilm challenge of primary human epithelial cells","volume":"9","author":"Guggenheim","year":"2009","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.cyto.2011.03.009_b0090","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1128\/IAI.42.2.459-470.1983","article-title":"Antigenic heterogeneity of Bacteroides intermedius as recognized by monoclonal antibodies","volume":"42","author":"Gmur","year":"1983","journal-title":"Infect Immun"},{"key":"10.1016\/j.cyto.2011.03.009_b0095","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.micpath.2010.11.002","article-title":"Oral biofilm challenge regulates the RANKL\u2013OPG system in periodontal ligament and dental pulp cells","volume":"50","author":"Belibasakis","year":"2011","journal-title":"Microb Pathog"},{"key":"10.1016\/j.cyto.2011.03.009_b0100","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1902\/jop.2005.76.5.813","article-title":"Prostaglandin E(2) is a main mediator in receptor activator of nuclear factor-kappaB ligand-dependent osteoclastogenesis induced by Porphyromonas gingivalis, Treponema denticola, and Treponema socranskii","volume":"76","author":"Choi","year":"2005","journal-title":"J Periodontol"},{"key":"10.1016\/j.cyto.2011.03.009_b0105","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1128\/IAI.72.3.1706-1714.2004","article-title":"Porphyromonas gingivalis induces receptor activator of NF-kappaB ligand expression in osteoblasts through the activator protein 1 pathway","volume":"72","author":"Okahashi","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.cyto.2011.03.009_b0110","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/j.1600-0765.2006.00905.x","article-title":"Cytokine production in human periodontal ligament cells stimulated with Porphyromonas gingivalis","volume":"41","author":"Yamamoto","year":"2006","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.cyto.2011.03.009_b0115","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.micinf.2008.08.007","article-title":"Porphyromonas gingivalis regulates the RANKL\u2013OPG system in bone marrow stromal cells","volume":"10","author":"Reddi","year":"2008","journal-title":"Microbes Infect"},{"key":"10.1016\/j.cyto.2011.03.009_b0120","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s10753-010-9216-1","article-title":"Porphyromonas gingivalis induces RANKL in T-cells","volume":"34","author":"Belibasakis","year":"2011","journal-title":"Inflammation"},{"key":"10.1016\/j.cyto.2011.03.009_b0125","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1177\/154405910408300216","article-title":"Differential expression of RANKL and osteoprotegerin in gingival crevicular fluid of patients with periodontitis 2000","volume":"83","author":"Mogi","year":"2004","journal-title":"J Dent Res"},{"key":"10.1016\/j.cyto.2011.03.009_b0130","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/j.1600-0757.1997.tb00199.x","article-title":"Advances in the pathogenesis of periodontitis: summary of developments, clinical implications and future directions","volume":"14","author":"Page","year":"1997","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.cyto.2011.03.009_b0135","first-page":"235","article-title":"Pathogenesis of inflammatory periodontal disease. A summary of current work","volume":"34","author":"Page","year":"1976","journal-title":"Lab Invest"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466611000834?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466611000834?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T09:06:34Z","timestamp":1592471194000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466611000834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["S1043466611000834"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2011.03.009","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}