{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:57:48Z","timestamp":1766048268229},"reference-count":51,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.cyto.2011.05.004","type":"journal-article","created":{"date-parts":[[2011,6,27]],"date-time":"2011-06-27T05:25:40Z","timestamp":1309152340000},"page":"396-401","source":"Crossref","is-referenced-by-count":20,"title":["Burn-induced alterations in toll-like receptor-mediated responses by bronchoalveolar lavage cells"],"prefix":"10.1016","volume":"55","author":[{"given":"Richard F.","family":"Oppeltz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meenakshi","family":"Rani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin G.","family":"Schwacha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cyto.2011.05.004_b0005","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1164\/rccm.200907-1073OC","article-title":"Early protection from burn-induced acute lung injury by deletion of preprotachykinin-A gene","volume":"181","author":"Sio","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"10.1016\/j.cyto.2011.05.004_b0010","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jamcollsurg.2008.11.012","article-title":"Causes of mortality by autopsy findings of combat casualties and civilian patients admitted to a burn unit","volume":"208","author":"Gomez","year":"2009","journal-title":"J Am Coll Surg"},{"issue":"6","key":"10.1016\/j.cyto.2011.05.004_b0015","doi-asserted-by":"crossref","first-page":"R183","DOI":"10.1186\/cc8170","article-title":"The leading causes of death after burn injury in a single pediatric burn center","volume":"13","author":"Williams","year":"2009","journal-title":"Crit Care"},{"issue":"1","key":"10.1016\/j.cyto.2011.05.004_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.CCM.0000149854.61192.DC","article-title":"Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury","volume":"33","author":"Parsons","year":"2005","journal-title":"Crit Care Med"},{"issue":"11","key":"10.1016\/j.cyto.2011.05.004_b0025","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1007\/PL00003763","article-title":"ARDS in patients with thermal injury","volume":"25","author":"Dancey","year":"1999","journal-title":"Intensive Care Med"},{"issue":"3","key":"10.1016\/j.cyto.2011.05.004_b0030","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.burns.2004.11.003","article-title":"Inhalation injury assessed by score does not contribute to the development of acute respiratory distress syndrome in burn victims","volume":"31","author":"Liffner","year":"2005","journal-title":"Burns"},{"issue":"1","key":"10.1016\/j.cyto.2011.05.004_b0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0305-4179(02)00187-0","article-title":"Macrophages and post-burn immune dysfunction","volume":"29","author":"Schwacha","year":"2003","journal-title":"Burns"},{"issue":"3","key":"10.1016\/j.cyto.2011.05.004_b0040","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/SLA.0b013e3181856241","article-title":"Pathophysiologic response to severe burn injury","volume":"248","author":"Jeschke","year":"2008","journal-title":"Ann Surg"},{"issue":"5963","key":"10.1016\/j.cyto.2011.05.004_b0045","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1126\/science.1183021","article-title":"Regulation of adaptive immunity by the innate immune system","volume":"327","author":"Iwasaki","year":"2010","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.cyto.2011.05.004_b0050","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.smim.2009.05.005","article-title":"Modulation of adaptive immunity with Toll-like receptors","volume":"21","author":"Manicassamy","year":"2009","journal-title":"Semin Immunol"},{"issue":"2","key":"10.1016\/j.cyto.2011.05.004_b0055","doi-asserted-by":"crossref","first-page":"554","DOI":"10.4049\/jimmunol.168.2.554","article-title":"Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines","volume":"168","author":"Zarember","year":"2002","journal-title":"J Immunol"},{"issue":"11","key":"10.1016\/j.cyto.2011.05.004_b0060","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/nm1315","article-title":"Regulation of lung injury and repair by Toll-like receptors and hyaluronan","volume":"11","author":"Jiang","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.cyto.2011.05.004_b0065","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1146\/annurev.cellbio.21.122303.115827","article-title":"Recognition and signaling by toll-like receptors","volume":"22","author":"West","year":"2006","journal-title":"Ann Rev Cell Dev Biol"},{"issue":"3","key":"10.1016\/j.cyto.2011.05.004_b0070","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1189\/jlb.0503233","article-title":"Injury, sepsis, and the regulation of Toll-like receptor responses","volume":"75","author":"Murphy","year":"2004","journal-title":"J Leukoc Biol"},{"issue":"1","key":"10.1016\/j.cyto.2011.05.004_b0075","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/MOT.0b013e3282f3df04","article-title":"Activation of the innate immune system by the endogenous ligand hyaluronan","volume":"13","author":"Shirali","year":"2008","journal-title":"Curr Opin Organ Transplant"},{"issue":"3","key":"10.1016\/j.cyto.2011.05.004_b0080","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.4049\/jimmunol.171.3.1473","article-title":"Injury primes the innate immune system for enhanced Toll-like receptor reactivity","volume":"171","author":"Paterson","year":"2003","journal-title":"J Immunol"},{"issue":"11","key":"10.1016\/j.cyto.2011.05.004_b0085","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1007\/s00134-010-1983-5","article-title":"Toll-like receptors 2 and 4: initiators of non-septic inflammation in critical care medicine?","volume":"36","author":"Lorne","year":"2010","journal-title":"Intensive Care Med"},{"issue":"25","key":"10.1016\/j.cyto.2011.05.004_b0090","doi-asserted-by":"crossref","first-page":"18265","DOI":"10.1074\/jbc.M606352200","article-title":"Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2","volume":"282","author":"Taylor","year":"2007","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.cyto.2011.05.004_b0095","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.4049\/jimmunol.180.4.2531","article-title":"HMGB1 develops enhanced proinflammatory activity by binding to cytokines","volume":"180","author":"Sha","year":"2008","journal-title":"J Immunol"},{"issue":"4","key":"10.1016\/j.cyto.2011.05.004_b0100","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1097\/TA.0b013e318166b7d9","article-title":"Toll-like receptor 2 and 4 ligation results in complex altered cytokine profiles early and late after burn injury","volume":"64","author":"Cairns","year":"2008","journal-title":"J Trauma"},{"issue":"3","key":"10.1016\/j.cyto.2011.05.004_b0105","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/SHK.0b013e3181454975","article-title":"Toll-like receptor 4 contributes to microvascular inflammation and barrier dysfunction in thermal injury","volume":"29","author":"Breslin","year":"2008","journal-title":"Shock"},{"issue":"6","key":"10.1016\/j.cyto.2011.05.004_b0110","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1097\/SHK.0b013e318173f329","article-title":"Alterations in the cardiac inflammatory response to burn trauma in mice lacking a functional Toll-like receptor 4 gene","volume":"30","author":"Bruns","year":"2008","journal-title":"Shock"},{"issue":"2","key":"10.1016\/j.cyto.2011.05.004_b0115","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jss.2009.06.006","article-title":"Remote thermal injury increases LPS-induced intestinal IL-6 production","volume":"160","author":"Huber","year":"2010","journal-title":"J Surg Res"},{"issue":"3","key":"10.1016\/j.cyto.2011.05.004_b0120","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.cyto.2008.09.001","article-title":"Up-regulation of cell surface Toll-like receptors on circulating gammadelta T-cells following burn injury","volume":"44","author":"Schwacha","year":"2008","journal-title":"Cytokine"},{"issue":"18","key":"10.1016\/j.cyto.2011.05.004_b0125","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1056\/NEJM200005043421801","article-title":"The Acute Respiratory Distress Syndrome Network","volume":"342","year":"2000","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.cyto.2011.05.004_b0130","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cps.2009.05.013","article-title":"Airway management and smoke inhalation injury in the burn patient","volume":"36","author":"Cancio","year":"2009","journal-title":"Clin Plast Surg"},{"issue":"1","key":"10.1016\/j.cyto.2011.05.004_b0135","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0008-8749(03)00024-8","article-title":"Relationships between burn size, immunosuppression, and macrophage hyperactivity in a murine model of thermal injury","volume":"220","author":"Alexander","year":"2002","journal-title":"Cell Immunol"},{"issue":"7","key":"10.1016\/j.cyto.2011.05.004_b0140","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1182\/blood-2003-04-1078","article-title":"Toll-like receptors stimulate human neutrophil function","volume":"102","author":"Hayashi","year":"2003","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.cyto.2011.05.004_b0145","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1164\/rccm.200408-1078OC","article-title":"Impaired toll-like receptor 9 expression in alveolar macrophages with no sensitivity to CpG DNA","volume":"171","author":"Suzuki","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"issue":"7285","key":"10.1016\/j.cyto.2011.05.004_b0150","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature08780","article-title":"Circulating mitochondrial DAMPs cause inflammatory responses to injury","volume":"464","author":"Zhang","year":"2010","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.cyto.2011.05.004_b0155","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/ni1116","article-title":"Toll-like receptors in the pathogenesis of human disease","volume":"5","author":"Cook","year":"2004","journal-title":"Nat Immunol"},{"issue":"6640","key":"10.1016\/j.cyto.2011.05.004_b0160","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/41131","article-title":"A human homologue of the Drosophila Toll protein signals activation of adaptive immunity","volume":"388","author":"Medzhitov","year":"1997","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.cyto.2011.05.004_b0165","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.bbrc.2009.08.062","article-title":"Toll-like receptors and innate immunity","volume":"388","author":"Kumar","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1016\/j.cyto.2011.05.004_b0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cyto.2009.08.010","article-title":"Toll-like receptor signaling in cell proliferation and survival","volume":"49","author":"Li","year":"2010","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2011.05.004_b0175","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1757-7241-17-49","article-title":"IL-6 predicts organ dysfunction and mortality in patients with multiple injuries","volume":"17","author":"Frink","year":"2009","journal-title":"Scand J Trauma Resusc Emerg Med"},{"issue":"6917","key":"10.1016\/j.cyto.2011.05.004_b0180","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nature01326","article-title":"The immunopathogenesis of sepsis","volume":"420","author":"Cohen","year":"2002","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.cyto.2011.05.004_b0185","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/path.1491","article-title":"Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome","volume":"202","author":"Bhatia","year":"2004","journal-title":"J Pathol"},{"issue":"1","key":"10.1016\/j.cyto.2011.05.004_b0190","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cyto.2008.10.005","article-title":"Cytokine expression profile over time in burned mice","volume":"45","author":"Finnerty","year":"2009","journal-title":"Cytokine"},{"issue":"5","key":"10.1016\/j.cyto.2011.05.004_b0195","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1006\/cyto.2001.1003","article-title":"Differential expression and tissue compartmentalization of the inflammatory response following thermal injury","volume":"17","author":"Schwacha","year":"2002","journal-title":"Cytokine"},{"issue":"5","key":"10.1016\/j.cyto.2011.05.004_b0200","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00005373-197505000-00001","article-title":"Progressive pulmonary insufficiency and other pulmonary complications of thermal injury","volume":"15","author":"Pruitt","year":"1975","journal-title":"J Trauma"},{"issue":"9","key":"10.1016\/j.cyto.2011.05.004_b0205","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1097\/01.CCM.0000280568.61217.26","article-title":"Attenuating burn wound inflammation improves pulmonary function and survival in a burn-pneumonia model","volume":"35","author":"Ipaktchi","year":"2007","journal-title":"Crit Care Med"},{"issue":"11","key":"10.1016\/j.cyto.2011.05.004_b0210","doi-asserted-by":"crossref","first-page":"8065","DOI":"10.4049\/jimmunol.177.11.8065","article-title":"Attenuating burn wound inflammatory signaling reduces systemic inflammation and acute lung injury","volume":"177","author":"Ipaktchi","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2011.05.004_b0215","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1146\/annurev.immunol.23.021704.115816","article-title":"Macrophage receptors and immune recognition","volume":"23","author":"Taylor","year":"2005","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.cyto.2011.05.004_b0220","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/bmb\/61.1.45","article-title":"Macrophage defences against respiratory tract infections","volume":"61","author":"Gordon","year":"2002","journal-title":"Br Med Bull"},{"issue":"10","key":"10.1016\/j.cyto.2011.05.004_b0225","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/01902140701756562","article-title":"The role of the macrophage in lung disease mediated by bacteria","volume":"33","author":"Marriott","year":"2007","journal-title":"Exp Lung Res"},{"issue":"1","key":"10.1016\/j.cyto.2011.05.004_b0230","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jss.2008.07.034","article-title":"Impact of thermal injury on wound infiltration and the dermal inflammatory response","volume":"158","author":"Schwacha","year":"2010","journal-title":"J Surg Res"},{"issue":"1","key":"10.1016\/j.cyto.2011.05.004_b0235","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.cyto.2010.09.005","article-title":"Productive capacity of alveolar macrophages and pulmonary organ damage after femoral fracture and hemorrhage in IL-6 knockout mice","volume":"53","author":"Mommsen","year":"2011","journal-title":"Cytokine"},{"issue":"5","key":"10.1016\/j.cyto.2011.05.004_b0240","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.4049\/jimmunol.174.5.2957","article-title":"CD4+CD25+ regulatory T cells control innate immune reactivity after injury","volume":"174","author":"Murphy","year":"2005","journal-title":"J Immunol"},{"issue":"2","key":"10.1016\/j.cyto.2011.05.004_b0245","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/BCR.0b013e318166daa5","article-title":"Microbial contamination in burn patients undergoing urgent intubation as part of their early airway management","volume":"29","author":"Mosier","year":"2008","journal-title":"J Burn Care Res"},{"issue":"1","key":"10.1016\/j.cyto.2011.05.004_b0250","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/SHK.0b013e3181e86f10","article-title":"Hypertonic saline enhances host defense and reduces apoptosis in burn mice by increasing toll-like receptors","volume":"35","author":"Chen","year":"2011","journal-title":"Shock"},{"key":"10.1016\/j.cyto.2011.05.004_b0255","doi-asserted-by":"crossref","first-page":"628","DOI":"10.2119\/2008-00069.Schwacha","article-title":"Burn injury-induced alterations in wound inflammation and healing are associated with suppressed hypoxia inducible factor-1\u03b1 expression","volume":"14","author":"Schwacha","year":"2008","journal-title":"Mol Med"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466611001451?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466611001451?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T22:09:56Z","timestamp":1637964596000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466611001451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S1043466611001451"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2011.05.004","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}