{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:52:28Z","timestamp":1776703948032,"version":"3.51.2"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100015060","name":"Nagasaki University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.cyto.2011.08.014","type":"journal-article","created":{"date-parts":[[2011,9,6]],"date-time":"2011-09-06T17:16:33Z","timestamp":1315329393000},"page":"564-572","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Interferon regulatory factor-4 activates IL-2 and IL-4 promoters in cooperation with c-Rel"],"prefix":"10.1016","volume":"56","author":[{"given":"Hisakazu","family":"Shindo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Yasui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiri","family":"Honma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyuki","family":"Yui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Kohno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhua","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koon Jiew","family":"Chua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinao","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Aihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Nagayasu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshifumi","family":"Matsuyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2011.08.014_b0005","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00262-009-0804-6","article-title":"Regulation of immunity and oncogenesis by the IRF transcription factor family","volume":"59","author":"Savitsky","year":"2010","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.cyto.2011.08.014_b0010","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1093\/nar\/23.12.2127","article-title":"Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE)","volume":"23","author":"Matsuyama","year":"1995","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.cyto.2011.08.014_b0015","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1101\/gad.9.11.1377","article-title":"Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator","volume":"9","author":"Eisenbeis","year":"1995","journal-title":"Genes Dev"},{"key":"10.1016\/j.cyto.2011.08.014_b0020","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1128\/MCB.16.4.1283","article-title":"A novel interferon regulatory factor family transcription factor, ICSAT\/Pip\/LSIRF, that negatively regulates the activity of interferon-regulated genes","volume":"16","author":"Yamagata","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cyto.2011.08.014_b0025","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1126\/science.275.5299.540","article-title":"Requirement for the transcription factor LSIRF\/IRF4 for mature B and T lymphocyte function","volume":"275","author":"Mittrucker","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.cyto.2011.08.014_b0030","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/emboj\/18.4.977","article-title":"Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimmers","volume":"18","author":"Brass","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/j.cyto.2011.08.014_b0035","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1158\/1078-0432.CCR-08-1845","article-title":"IRF4: Immunity. Malignancy! Therapy?","volume":"15","author":"Shaffer","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.cyto.2011.08.014_b0040","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature07064","article-title":"IRF4 addiction in multiple myeloma","volume":"454","author":"Shaffer","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.cyto.2011.08.014_b0045","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1084\/jem.20011128","article-title":"Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression","volume":"195","author":"Rengarajan","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.cyto.2011.08.014_b0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/intimm\/dxg001","article-title":"Development of Th1 and not Th2 immune responses in mice lacking IFN-regulatory factor-4","volume":"15","author":"Tominaga","year":"2003","journal-title":"Int Immunol"},{"key":"10.1016\/j.cyto.2011.08.014_b0055","doi-asserted-by":"crossref","first-page":"8981","DOI":"10.1073\/pnas.0402139101","article-title":"Critical roles of interferon regulatory factor 4 in CD11b high CD8alpha-dendritic cell development","volume":"101","author":"Suzuki","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cyto.2011.08.014_b0060","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1365-2567.2008.02845.x","article-title":"Control of IL-4 expression in T helper 1 and 2 cells","volume":"124","author":"Gilmour","year":"2008","journal-title":"Immunology"},{"key":"10.1016\/j.cyto.2011.08.014_b0065","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S1074-7613(00)80166-1","article-title":"Posttranslational regulation of IRF-4 activity by the immunophilin FKBP52","volume":"12","author":"Mamane","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.cyto.2011.08.014_b0070","doi-asserted-by":"crossref","first-page":"49238","DOI":"10.1074\/jbc.M205895200","article-title":"Modulation of T cell cytokine production by interferon regulatory factor-4","volume":"277","author":"Hu","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cyto.2011.08.014_b0075","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1182\/blood-2006-07-036368","article-title":"IRF-4 and c-Rel expression in antiviral resistant adult T-cell leukemia\/lymphoma","volume":"109","author":"Ramos","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2011.08.014_b0080","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1006\/meth.2001.1183","article-title":"The tandem affinity purification (TAP) method: a general procedure of protein complex purification","volume":"24","author":"Puig","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.cyto.2011.08.014_b0085","first-page":"935","article-title":"A human rel proto-oncogene cDNA containing an Alu fragment as a potential coding exon","volume":"4","author":"Brownell","year":"1989","journal-title":"Oncogene"},{"key":"10.1016\/j.cyto.2011.08.014_b0090","doi-asserted-by":"crossref","first-page":"6420","DOI":"10.1093\/nar\/17.15.6420","article-title":"Rapid test for in vivo stability and DNA binding of mutated octamer binding proteins with \u2018mini-extracts\u2019 prepared from transfected cells","volume":"17","author":"M\u00fcller","year":"1989","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.cyto.2011.08.014_b0095","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.immuni.2005.09.012","article-title":"C-Rel-dependent priming of naive T cells by inflammatory cytokines","volume":"23","author":"Banerjee","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.cyto.2011.08.014_b0100","doi-asserted-by":"crossref","first-page":"15890","DOI":"10.1073\/pnas.0803171105","article-title":"Interferon regulatory factor 4 differentially regulates the production of Th2 cytokines in naive vs. effector\/memory CD4+ T cells","volume":"105","author":"Honma","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cyto.2011.08.014_b0105","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nri1900","article-title":"IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors","volume":"6","author":"Honda","year":"2006","journal-title":"Nat Rev Immunology"},{"key":"10.1016\/j.cyto.2011.08.014_b0110","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.immuni.2008.10.011","article-title":"IRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor","volume":"29","author":"Chen","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.cyto.2011.08.014_b0115","doi-asserted-by":"crossref","first-page":"15989","DOI":"10.1073\/pnas.0508327102","article-title":"Negative regulation of Toll-like-receptor signaling by IRF-4","volume":"102","author":"Negishi","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cyto.2011.08.014_b0120","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1111\/j.1349-7006.2001.tb02151.x","article-title":"Possible involvement of interferon regulatory factor 4 (IRF4) in a clinical subtype of adult T-cell leukemia","volume":"92","author":"Imaizumi","year":"2001","journal-title":"Jpn J Cancer Res"},{"key":"10.1016\/j.cyto.2011.08.014_b0125","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1189\/jlb.0603252","article-title":"Interferon-gamma: an overview of signals, mechanisms and functions","volume":"75","author":"Schroder","year":"2004","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.cyto.2011.08.014_b0130","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/nri1128","article-title":"Regulation of IL4 gene expression by T cells and therapeutic perspectives","volume":"3","author":"Li-Weber","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.cyto.2011.08.014_b0135","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1084\/jem.191.8.1281","article-title":"Rel induces interferon regulatory factor 4 (IRF-4) expression in lymphocytes: modulation of interferon-regulated gene expression by rel\/nuclear factor kappaB","volume":"191","author":"Grumont","year":"2000","journal-title":"J Exp Med"},{"key":"10.1016\/j.cyto.2011.08.014_b0140","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nri1632","article-title":"NFAT proteins: key regulators of T-cell development and function","volume":"5","author":"Macian","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.cyto.2011.08.014_b0145","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.cytogfr.2006.07.003","article-title":"Both integrated and differential regulation of components of the IL-2\/IL-2 receptor system","volume":"17","author":"Kim","year":"2006","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.cyto.2011.08.014_b0150","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1084\/jem.20091411","article-title":"c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells","volume":"206","author":"Isomura","year":"2009","journal-title":"J Exp Med"},{"key":"10.1016\/j.cyto.2011.08.014_b0155","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/nature07674","article-title":"Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses","volume":"458","author":"Zheng","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.cyto.2011.08.014_b0160","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.coi.2010.02.005","article-title":"Features of responding T cells in cancer and chronic infection","volume":"22","author":"Kim","year":"2010","journal-title":"Curr Opin Immunol"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466611006776?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466611006776?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:49:15Z","timestamp":1760906955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466611006776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S1043466611006776"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2011.08.014","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interferon regulatory factor-4 activates IL-2 and IL-4 promoters in cooperation with c-Rel","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2011.08.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}