{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T08:02:24Z","timestamp":1779264144489,"version":"3.51.4"},"reference-count":52,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.cyto.2011.08.038","type":"journal-article","created":{"date-parts":[[2011,10,3]],"date-time":"2011-10-03T04:39:40Z","timestamp":1317616780000},"page":"850-854","source":"Crossref","is-referenced-by-count":23,"title":["Effects of selective H.E.L.P. LDL-apheresis on plasma inflammatory markers concentration in severe dyslipidemia: Implication for anti-inflammatory response"],"prefix":"10.1016","volume":"56","author":[{"given":"Zenti","family":"Maria Grazia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanutti","family":"Claudia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.cyto.2011.08.038_b0005","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1253\/circj.CJ-09-0706","article-title":"Inflammation in atherosclerosis: transition from theory to practice","volume":"74","author":"Libby","year":"2010","journal-title":"Circ J"},{"key":"10.1016\/j.cyto.2011.08.038_b0010","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis: an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cyto.2011.08.038_b0015","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/nri2415","article-title":"The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models","volume":"8","author":"Weber","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.cyto.2011.08.038_b0020","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1161\/hq1101.098486","article-title":"Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors","volume":"21","author":"Takemoto","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.cyto.2011.08.038_b0025","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0002-9149(01)01643-5","article-title":"Pleiotropic effects of statins and their clinical significance","volume":"88","author":"LaRosa","year":"2001","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cyto.2011.08.038_b0030","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1161\/01.ATV.21.1.3","article-title":"New evidence for beneficial effects of statins unrelated to lipid lowering","volume":"21","author":"Palinski","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.cyto.2011.08.038_b0035","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1161\/CIRCULATIONAHA.105.602359","article-title":"Oxidized lipid-driven chemokine receptor switch, CCR2 to CX3CR1, mediates adhesion of human macrophages to coronary artery smooth muscle cells through a peroxisome proliferator-activated receptor gamma-dependent pathway","volume":"114","author":"Barlic","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.cyto.2011.08.038_b0040","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1161\/01.CIR.0000158484.18024.1F","article-title":"HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated monocyte recruitment in vivo","volume":"111","author":"Han","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.cyto.2011.08.038_b0045","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.ahj.2007.02.029","volume":"153","author":"Blanco-Colio","year":"2007","journal-title":"Am Heart ."},{"issue":"11","key":"10.1016\/j.cyto.2011.08.038_b0050","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1042\/CS20090488","article-title":"Inflammatory cell recruitment in cardiovascular disease: murine models and potential clinical applications","volume":"118","author":"McNeill","year":"2010","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.cyto.2011.08.038_b0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-9150(02)00251-4","article-title":"LDL apheresis","volume":"167","author":"Thompson","year":"2003","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.cyto.2011.08.038_b0060","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.atherosclerosis.2008.02.009","article-title":"Recommendations for the use of LDL apheresis","volume":"198","author":"Thompson","year":"2008","journal-title":"Atherosclerosis"},{"issue":"5","key":"10.1016\/j.cyto.2011.08.038_b0065","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S1567-5688(09)71819-7","article-title":"Treatment of symptomatic HyperLp(a)lipoproteinemia with LDL-apheresis: a multicentre study","volume":"10","author":"Stefanutti","year":"2009","journal-title":"Atherosclerosis Suppl"},{"key":"10.1016\/j.cyto.2011.08.038_b0070","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1001\/jama.2009.801","article-title":"Genetically-elevated lipoprotein (a) and increased risk of myocardial infarction","volume":"301","author":"Kamstrup","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.cyto.2011.08.038_b0075","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1093\/clinchem\/44.11.2301","article-title":"Lipoprotein(a) as a risk factor for ischaemic heart disease: metaanalysis of prospective studies","volume":"44","author":"Craig","year":"1998","journal-title":"Clin Chem"},{"issue":"10","key":"10.1016\/j.cyto.2011.08.038_b0080","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1161\/01.CIR.102.10.1082","article-title":"Lipoprotein(a) and coronary heart disease. Meta-analysis of prospective studies","volume":"102","author":"Danesh","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.cyto.2011.08.038_b0085","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0021-9150(86)90099-7","article-title":"The association between serum Lp(a) concentration and angiographically assessed coronary atherosclerosis. Dependence on serum LDL levels","volume":"62","author":"Amstrong","year":"1986","journal-title":"Atherosclerosis"},{"issue":"3","key":"10.1016\/j.cyto.2011.08.038_b0090","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2217\/17460875.1.3.299","article-title":"LDL-apheresis therapy: current therapeutic practice and potential future use","volume":"1","author":"Moriarty","year":"2006","journal-title":"Future Lipidol"},{"key":"10.1016\/j.cyto.2011.08.038_b0095","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/BF01728226","article-title":"Selective removal of low density lipoproteins (LDL) by precipitation at low pH. First clinical application of the H.E.L.P.-system","volume":"65","author":"Eisenhauser","year":"1987","journal-title":"Klin Wochenschr"},{"key":"10.1016\/j.cyto.2011.08.038_b0100","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/j.1365-2362.1994.tb01068.x","volume":"24","author":"Schuff-Werner","year":"1994","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.cyto.2011.08.038_b0105","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0026-0495(98)90127-5","article-title":"Long-term effect of low-density lipoprotein apheresis on plasma lipoproteins and coronary heart disease in native vessels and coronary bypass in severe heterozygous familial hypercholesterolemia","volume":"47","author":"Richter","year":"1998","journal-title":"Metabolism"},{"key":"10.1016\/j.cyto.2011.08.038_b0110","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1744-9987.2007.00467.x","article-title":"Effects of HELP therapy on acute ischemic stroke and vascular endothelial cell function","volume":"11","author":"Xue","year":"2007","journal-title":"Ther Apher Dial"},{"key":"10.1016\/j.cyto.2011.08.038_b0115","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1016\/j.healun.2005.05.009","article-title":"Changes in myocardial vasoreactivity after drastic reduction of plasma fibrinogen and cholesterol: a clinical study in long term heart transplant survivors using positron emission tomography","volume":"2","author":"Jaeger","year":"2005","journal-title":"J Heart Lung Transplant"},{"issue":"3","key":"10.1016\/j.cyto.2011.08.038_b0120","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1744-9987.2006.00380.x","article-title":"Does a reduction of adhesion molecules by LDL-apheresis have a role in the treatment of sudden hearing loss?","volume":"10","author":"Ramunni","year":"2006","journal-title":"Ther Apher Dial"},{"key":"10.1016\/j.cyto.2011.08.038_b0125","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1002\/lary.20835","article-title":"Treatment with HELP-apheresis in patients suffering from sudden sensorineural hearing loss: a prospective, randomized, controlled study","volume":"120","author":"Bianchin","year":"2010","journal-title":"Laringoscope"},{"issue":"4","key":"10.1016\/j.cyto.2011.08.038_b0130","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1177\/039139880402700410","article-title":"LDL-apheresis in acute anterior ischemic optic neuropathy","volume":"27","author":"Ramunni","year":"2004","journal-title":"Int J Artif Organs"},{"key":"10.1016\/j.cyto.2011.08.038_b0135","first-page":"91","article-title":"H.E.L.P. in gram-negative, refractory septic shock: first clinical experience","volume":"16","author":"Samtleben","year":"1997","journal-title":"Jpn J Apher"},{"issue":"6","key":"10.1016\/j.cyto.2011.08.038_b0140","first-page":"494","article-title":"Extracorporeal plasma treatment for the removal of endotoxin in patients with sepsis: clinical results of a pilot study","volume":"23","author":"Bengsch","year":"2005","journal-title":"Shock"},{"key":"10.1016\/j.cyto.2011.08.038_b0145","first-page":"1041","article-title":"Endotoxin removal in septicaemia using the HELP-system: first in vitro results (Abstract)","volume":"10","author":"Boos","year":"1995","journal-title":"Artif Organs"},{"key":"10.1016\/j.cyto.2011.08.038_b0150","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1126\/science.2413547","article-title":"Tumor necrosis factor (TNF)","volume":"230","author":"Old","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.cyto.2011.08.038_b0155","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev.iy.10.040192.002211","article-title":"The pathophysiology of tumor necrosis factors","volume":"10","author":"Vassali","year":"1992","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.cyto.2011.08.038_b0160","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1161\/01.RES.81.2.187","article-title":"Hemodynamic regulation of tumor necrosis factor-\u03b1 gene and protein expression in adult feline myocardium","volume":"81","author":"Kapadia","year":"1997","journal-title":"Circ Res"},{"key":"10.1016\/j.cyto.2011.08.038_b0165","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1161\/01.CIR.95.4.778","article-title":"Cytokines and cardiac contractile function","volume":"95","author":"Kelly","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.cyto.2011.08.038_b0170","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1536\/jhj.45.183","article-title":"Interleukin-6 and cardiovascular diseases","volume":"45","author":"Kanda","year":"2004","journal-title":"Jpn Heart J"},{"key":"10.1016\/j.cyto.2011.08.038_b0175","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/clc.4960241103","article-title":"Interleukin-6 and acute coronary syndrome","volume":"24","author":"Ikeda","year":"2001","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.cyto.2011.08.038_b0180","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0735-1097(97)00494-4","article-title":"Interleukin-6 spillover in the peripheral circulation increases with the severity of heart failure, and the high plasma levels of interleukin-6 is an important prognostic predictor in patients with congestive heart failure","volume":"31","author":"Tsutamoto","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cyto.2011.08.038_b0185","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0002-9149(97)89206-5","article-title":"Circulating concentrations of proinflammatory cytokines in mild or moderate heart failure secondary to ischemic or idiopathic dilated cardiomyopathy","volume":"77","author":"Munger","year":"1996","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cyto.2011.08.038_b0190","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1161\/01.CIR.99.16.2079","article-title":"Increasing levels of interleukin (IL)-1Ra and IL-6 during the first 2days of hospitalization in unstable angina are associated with increased risk of in-hospital coronary events","volume":"99","author":"Biasucci","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.cyto.2011.08.038_b0195","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0895-7061(01)02069-6","article-title":"Adhesion molecules and their role in vascular disease","volume":"14","author":"Krieglstein","year":"2001","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.cyto.2011.08.038_b0200","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.atherosclerosis.2004.03.011","article-title":"Effects of heparin-mediated extracorporeal low-density lipoprotein precipitation beyond lowering proatherogenic lipoproteins-reduction of circulating proinflammatory and procoagulatory markers","volume":"175","author":"Wang","year":"2004","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.cyto.2011.08.038_b0205","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1016\/S0022-2275(20)39941-7","article-title":"Acute and chronic effects on cholesterol biosynthesis of LDL-apheresis with or without concomitant HMG-CoA reductase inhibitor therapy","volume":"35","author":"Pfohl","year":"1994","journal-title":"J Lipid Res"},{"issue":"10","key":"10.1016\/j.cyto.2011.08.038_b0210","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1161\/01.CIR.93.10.1826","article-title":"LDL-Apheresis Atherosclerosis Regression Study (LAARS). Effect of aggressive versus conventional lipid lowering treatment on coronary atherosclerosis","volume":"93","author":"Kroon","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.cyto.2011.08.038_b0215","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1016\/S0022-2275(20)37137-6","article-title":"Decreased production of low density lipoprotein by atorvastatin after apheresis in homozygous familial hypercholesterolemia","volume":"38","author":"Marais","year":"1997","journal-title":"J Lipid Res"},{"key":"10.1016\/j.cyto.2011.08.038_b0220","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/S0002-9149(98)00692-4","article-title":"Long-term efficacy of low-density lipoprotein apheresis on coronary heart disease in familial hypercholesterolemia. Hokuriku-FH-LDL-Apheresis Study Group","volume":"82","author":"Mabuchi","year":"1998","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cyto.2011.08.038_b0225","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1042\/CS20030148","article-title":"Statins and their role in vascular protection","volume":"105","author":"Mason","year":"2003","journal-title":"Clin Sci"},{"key":"10.1016\/j.cyto.2011.08.038_b0230","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/01.mol.0000137222.23784.2a","article-title":"Current management of severe homozygous hypercholesterolaemias","volume":"15","author":"Naoumova","year":"2004","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.cyto.2011.08.038_b0235","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.jacl.2010.08.013","article-title":"Familial hypercholesterolemia: current treatment options and patient selection for low-density lipoprotein apheresis","volume":"4","author":"Hemphill","year":"2010","journal-title":"J Clin Lipidol"},{"issue":"7","key":"10.1016\/j.cyto.2011.08.038_b0240","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1111\/j.1537-2995.2009.02135.x","article-title":"Aorta and coronary angiographic follow-up of children with severe hypercholesterolemia treated with LDL apheresis","volume":"49","author":"Stefanutti","year":"2009","journal-title":"Transfusion"},{"key":"10.1016\/j.cyto.2011.08.038_b0245","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0021-9150(98)00152-X","article-title":"LPS-induced cytokine production and expression of b2-integrins and CD14 by peripheral blood mononuclear cells of patients with homozygous familial hypercholesterolemia","volume":"141","author":"Rovers","year":"1998","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.cyto.2011.08.038_b0250","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1161\/01.CIR.0000133317.49796.0E","volume":"110","author":"Grundy","year":"2004","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.cyto.2011.08.038_b0255","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0022-2275(20)32381-6","article-title":"Influence of LDL-apheresis on LDL subtypes in patients with coronary heart disease and severe hyperlipoproteinemia","volume":"41","author":"Schamberger","year":"2000","journal-title":"J Lipid Res"},{"issue":"1","key":"10.1016\/j.cyto.2011.08.038_b0260","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.atherosclerosis.2005.09.005","article-title":"Association between fast-migrating low-density lipoprotein subfraction as characterized by capillary isotachophoresis and intima-media thickness of carotid artery","volume":"187","author":"Zhang","year":"2006","journal-title":"Atherosclerosis"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466611007186?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466611007186?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T15:49:52Z","timestamp":1638978592000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466611007186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S1043466611007186"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2011.08.038","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}