{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:27:43Z","timestamp":1761488863293},"reference-count":48,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.cyto.2012.01.013","type":"journal-article","created":{"date-parts":[[2012,2,24]],"date-time":"2012-02-24T04:02:24Z","timestamp":1330056144000},"page":"253-260","source":"Crossref","is-referenced-by-count":24,"title":["Leptin and adiponectin, but not IL18, are related with insulin resistance in treated HIV-1-infected patients with lipodystrophy"],"prefix":"10.1016","volume":"58","author":[{"given":"Sergi","family":"Veloso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Escot\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vict\u00f2ria","family":"Ceperuelo-Mallafr\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"L\u00f3pez-Dupla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaquim","family":"Peraire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Consuelo","family":"Vilad\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pere","family":"Domingo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoni","family":"Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Olona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan-Josep","family":"Sirvent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Leal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Vendrell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crist\u00f3bal","family":"Richart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesc","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2012.01.013_b0005","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1016\/S0140-6736(98)08468-2","article-title":"Diagnosis, prediction, and natural course of HIV-1 protease-inhibitor-associated lipodystrophy, hyperlipidaemia and diabetes mellitus: a cohort study","volume":"353","author":"Carr","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.cyto.2012.01.013_b0010","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0140-6736(03)12656-6","article-title":"HIV Lipodystrophy Case Definition Study Group, an objective case definition of lipodystrophy in HIV-1-infected adults: a case-control study","volume":"361","author":"Carr","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.cyto.2012.01.013_b0015","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.molmed.2010.03.002","article-title":"HIV-associated lipodystrophy: from fat injury to premature aging","volume":"16","author":"Caron-Debarle","year":"2010","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.cyto.2012.01.013_b0020","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1177\/135965350400900206","article-title":"Adipocytes targets and actors in the pathogenesis of HIV-associated lipodystrophy and metabolic alterations","volume":"9","author":"Gougeon","year":"2004","journal-title":"Antiviral Ther"},{"key":"10.1016\/j.cyto.2012.01.013_b0025","doi-asserted-by":"crossref","first-page":"F25","DOI":"10.1097\/00002030-200002180-00001","article-title":"A syndrome of lipoatrophy, lactic acidaemia and liver dysfunction associated with HIV nucleoside analogue therapy: contribution to protease inhibitor-related lipodystrophy syndrome","volume":"14","author":"Carr","year":"2000","journal-title":"AIDS"},{"key":"10.1016\/j.cyto.2012.01.013_b0030","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1177\/135965350400900607","article-title":"Antiretroviral drugs with adverse effects on adipocyte lipid metabolism and survival alter the expression and secretion of proinflammatory cytokines and adiponectin in vitro","volume":"9","author":"Lagathu","year":"2004","journal-title":"Antiviral Ther"},{"key":"10.1016\/j.cyto.2012.01.013_b0035","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/01.qai.0000187443.30838.3e","article-title":"Assessment of adipokine expression and mitochondrial toxicity in HIV patients with lipoatrophy on stavudine- and zidovudine-containing regimens","volume":"40","author":"Jones","year":"2005","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.cyto.2012.01.013_b0040","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1097\/00002030-200307040-00011","article-title":"Serum adipocytokines are related to lipodystrophy and metabolic disorders in HIV-infected men under antiretroviral therapy","volume":"17","author":"Vigouroux","year":"2003","journal-title":"AIDS"},{"key":"10.1016\/j.cyto.2012.01.013_b0045","doi-asserted-by":"crossref","first-page":"93","DOI":"10.7326\/0003-4819-152-2-201001190-00008","article-title":"Narrative review: the role of leptin in human physiology: emerging clinical applications","volume":"152","author":"Kelesidis","year":"2010","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.cyto.2012.01.013_b0050","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1056\/NEJM199602013340503","article-title":"Serum immunoreactive-leptin concentrations in normal weight and obese humans","volume":"334","author":"Considine","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cyto.2012.01.013_b0055","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1146\/annurev.physiol.70.113006.100707","article-title":"Mechanism of leptin action and leptin resistance","volume":"70","author":"Myers","year":"2008","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.cyto.2012.01.013_b0060","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/sj.mp.4000418","article-title":"Leptin in relation to resumption of menses in women with anorexia nervosa","volume":"3","author":"Audi","year":"1998","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.cyto.2012.01.013_b0065","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1210\/jcem.87.5.8624","article-title":"Serum adiponectin and leptin levels in patients with lipodystrophies","volume":"87","author":"Haque","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.cyto.2012.01.013_b0070","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1210\/jc.2007-1155","article-title":"Relationship of fat distribution with adipokines in human immunodeficiency virus infection","volume":"93","author":"Kosmiski","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.cyto.2012.01.013_b0075","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/00042560-200201010-00004","article-title":"Leptin and adipose tissue maldistribution in HIV-infected male patients with predominant fat loss treated with antiretroviral therapy","volume":"29","author":"Estrada","year":"2002","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.cyto.2012.01.013_b0080","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1017\/S0003480000008277","article-title":"Association for the G-2548A polymorphism in the 5\u2032 region of the LEP gene with overweight","volume":"64","author":"Mamm\u00e8s","year":"2000","journal-title":"Ann Hum Genet"},{"key":"10.1016\/j.cyto.2012.01.013_b0085","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00439-010-0941-1","article-title":"Leptin expression and leptin receptor gene polymorphisms in growth hormone deficiency patients","volume":"129","author":"Su","year":"2011","journal-title":"Hum Genet"},{"key":"10.1016\/j.cyto.2012.01.013_b0090","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/sj.ijo.0803745","article-title":"Regulation of adiponectin release and demonstration of adiponectin mRNA as well as release by the non-fat cells of human omental adipose tissue","volume":"32","author":"Fain","year":"2008","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.cyto.2012.01.013_b0095","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1006\/bbrc.1999.0255","article-title":"Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity","volume":"257","author":"Arita","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.cyto.2012.01.013_b0100","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1172\/JCI29126","article-title":"Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome","volume":"116","author":"Kadowaki","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cyto.2012.01.013_b0105","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1177\/135965350300800102","article-title":"Adipocyte-derived hormone levels in HIV lipodystrophy","volume":"8","author":"Kosmiski","year":"2003","journal-title":"Antiviral Ther"},{"key":"10.1016\/j.cyto.2012.01.013_b0110","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1097\/QAD.0b013e3280adc91e","article-title":"The role of adipokines in relation to HIV lipodystrophy","volume":"21","author":"Sweeney","year":"2007","journal-title":"AIDS"},{"key":"10.1016\/j.cyto.2012.01.013_b0115","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1210\/en.2003-1140","article-title":"Adiponectin ameliorates dyslipidemia induced by the human immunodeficiency virus protease inhibitor ritonavir in mice","volume":"145","author":"Xu","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.cyto.2012.01.013_b0120","doi-asserted-by":"crossref","first-page":"893","DOI":"10.2337\/diabetes.54.3.893","article-title":"STOP-NIDDM Study Group, The common polymorphisms (single nucleotide polymorphism [SNP] +45 and SNP +276) of the adiponectin gene predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial","volume":"54","author":"Zacharova","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.cyto.2012.01.013_b0125","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00439-008-0595-4","article-title":"The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents","volume":"125","author":"Rasmussen-Torvik","year":"2009","journal-title":"Hum Genet"},{"key":"10.1016\/j.cyto.2012.01.013_b0130","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.1182\/blood-2005-05-1980","article-title":"Severe imbalance of IL-18\/IL-18BP in patients with secondary hemophagocytic syndrome","volume":"106","author":"Mazodier","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2012.01.013_b0135","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1097\/00002030-200009290-00023","article-title":"Circulating levels of IL-18 in adult and paediatric patients with HIV-1 infection","volume":"14","author":"Torre","year":"2000","journal-title":"AIDS"},{"key":"10.1016\/j.cyto.2012.01.013_b0140","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/cbf.981","article-title":"Interleukin-18 enhances HIV-1 production in a human chronically-infected T cell line (H9-V)","volume":"20","author":"Pugliese","year":"2002","journal-title":"Cell Biochem Funct"},{"key":"10.1016\/j.cyto.2012.01.013_b0145","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1086\/322805","article-title":"Interleukin-18 inhibits human immunodeficiency virus type 1 production in peripheral blood mononuclear cells","volume":"184","author":"Choi","year":"2001","journal-title":"J Infect Dis"},{"key":"10.1016\/j.cyto.2012.01.013_b0150","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.3899\/jrheum.090316","article-title":"Functional association of interleukin 18 gene -607 (C\/A) promoter polymorphisms with disease course in Chinese patients with adult-onset Still\u2019s disease","volume":"10","author":"Chen","year":"2009","journal-title":"J Rheumatol"},{"key":"10.1016\/j.cyto.2012.01.013_b0155","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/QAI.0b013e3181ecfeb7","article-title":"SNPs in the APM1 gene promoter are associated with adiponectin levels in HIV-infected individuals receiving HAART","volume":"55","author":"Trinca","year":"2010","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.cyto.2012.01.013_b0160","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1089\/aid.2010.0172","article-title":"The effect of polymorphism in candidate genes of the long-term risk of lipodystrophy and dyslipidemia in HIV-infected white patients starting antiretroviral therapy","volume":"27","author":"Marzocchetti","year":"2011","journal-title":"AIDS Res Hum Retrov"},{"key":"10.1016\/j.cyto.2012.01.013_b0165","first-page":"126","article-title":"Interleukin-18 and interferon gamma polymorphisms in Brazilian human immunodeficiency virus-1-infected patients presenting with lipodystrophy syndrome","volume":"76","author":"Castelar","year":"2010","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.cyto.2012.01.013_b0170","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1097\/QAD.0b013e3282f4dde7","article-title":"The IL-6 system in HIV-1-infection and in HAART-related fat redistribution syndromes","volume":"22","author":"Saumoy","year":"2008","journal-title":"AIDS"},{"key":"10.1016\/j.cyto.2012.01.013_b0175","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2174\/157016209789346219","article-title":"PPAR gamma polymorphism in HIV-1-infected patients with HAART-related lipodystrophy","volume":"7","author":"Saumoy","year":"2009","journal-title":"Curr HIV Res"},{"key":"10.1016\/j.cyto.2012.01.013_b0180","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1089\/aid.2009.0312","article-title":"No relationship between TNF-alpha genetic variants and combination antiretroviral therapy-related lipodystrophy syndrome in HIV-1-infected patients: a case-control study and a meta-analysis","volume":"27","author":"Veloso","year":"2011","journal-title":"AIDS Res Hum Retrov"},{"key":"10.1016\/j.cyto.2012.01.013_b0185","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1468-1293.2010.00903.x","article-title":"A study of fatty acid binding protein 4 in HIV-1 infection and in combination antiretroviral therapy-related metabolic disturbances and lipodystrophy","volume":"12","author":"Escot\u00e9","year":"2011","journal-title":"HIV Med"},{"key":"10.1016\/j.cyto.2012.01.013_b0190","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/QAI.0b013e318213312c","article-title":"Lipodystrophy and insulin resistance in combination antiretroviral treated HIV-1-infected patients: implication of resistin","volume":"57","author":"Escot\u00e9","year":"2011","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.cyto.2012.01.013_b0195","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1097\/00126334-200212150-00009","article-title":"Adiponectin and leptin levels in HIV-infected subjects with insulin resistance and body fat redistribution","volume":"31","author":"Mynarcik","year":"2002","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.cyto.2012.01.013_b0200","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1089\/aid.2009.0072","article-title":"Adiponectin and leptin levels in Chinese patients with HIV-related lipodystrophy: a 30-month prospective study","volume":"25","author":"Luo","year":"2009","journal-title":"AIDS Res Hum Retrov"},{"key":"10.1016\/j.cyto.2012.01.013_b0205","doi-asserted-by":"crossref","first-page":"E261","DOI":"10.1152\/ajpendo.00056.2003","article-title":"Increased systemic and adipose tissue cytokines in patients with HIV-associated lipodystrophy","volume":"286","author":"Johnson","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.cyto.2012.01.013_b0210","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1086\/367859","article-title":"Human immunodeficiency virus type 1-related lipoatrophy and lipohypertrophy are associated with serum concentration of leptin","volume":"36","author":"Nagy","year":"2003","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cyto.2012.01.013_b0215","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1210\/jc.2008-1588","article-title":"The effects of recombinant human leptin on visceral fat, dyslipemia, and insulin resistance in patients with human immunodeficiency virus-associated lipoatrophy and hypoleptinemia","volume":"94","author":"Mulligan","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.cyto.2012.01.013_b0220","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/90984","article-title":"The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity","volume":"7","author":"Yamauchi","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.cyto.2012.01.013_b0225","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1210\/jc.2002-021922","article-title":"Circulating concentration of adiponectin and its expression in subcutaneous adipose tissue in patients with highly active antiretroviral therapy-associated lipodystrophy","volume":"88","author":"Sutinen","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.cyto.2012.01.013_b0230","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1097\/00126334-200405010-00006","article-title":"High plasma levels of interleukin-18 in HIV-infected subjects with lipodystrophy","volume":"36","author":"Lindegaard","year":"2004","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.cyto.2012.01.013_b0235","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1097\/00002030-199911120-00008","article-title":"Subcutaneous adipocyte apoptosis in HIV-1 protease inhibitor-associated lipodystrophy","volume":"13","author":"Domingo","year":"1999","journal-title":"AIDS"},{"key":"10.1016\/j.cyto.2012.01.013_b0240","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.metabol.2010.10.002","article-title":"Leptin replacement improves postprandial glycemia and insulin sensitivity in human immunodeficiency virus-infected lipoatrophic men treated with pioglitazone: a pilot study","volume":"60","author":"Magkos","year":"2011","journal-title":"Metabolism"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466612000282?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466612000282?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T16:33:36Z","timestamp":1687278816000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466612000282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S1043466612000282"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2012.01.013","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}